ІНФОРМАЦІЙНО-АНАЛІТИЧНА СИСТЕМА ЗАКЛАДІВ ОХОРОНИ ЗДОРОВ'Я "ЕЛЕКТРОННА ЛІКАРНЯ"

Problems of creating a modern information and analytical system for establishments of public health service in Ukraine are considered.It is shown on a concrete example that exactly information is a basis for decision-making in a hospital. Therefore, the automatization of establishment will sure to result in increase of efficiency of its workand, consequently, to improved quality of rendering medical care. The development of information and analytical system "Electronic hospital" was carried out in two stages and the following step of its development should be connected to telemedicine.It is noted, that under new social and economic conditions a weak part in information system in public health service in Ukraine is the absence of authorized integral standards in medical information. The necessity of developing the integral unified medical documentation is emphasized.Рассмотрены проблемы создания современной информационно - аналитической системы для учреждений здравоохранения.Показано на конкретном примере, что именно информация является основой для принятия решений в больнице. Поэтому автоматизация учреждения обязательно приведет к повышению эффективности его работы и, как следствие, - к улучшению качества оказания медицинской помощи. Разработка информационно-аналитической системы «Электронная больница» осуществлялась в два этапа и следующая ступень её развития должна быть связана с телемедициной.Отмечается, что в новых социально - экономических условиях слабым звеном в информатизации системы здравоохранения в Украине является отсутствие утвержденного единого стандарта медицинской информации.Подчеркивается необходимость разработки единой медицинской унифицированной документации.Затронуты также важные вопросы использования международных стандартов обмена информацией.Розглянуті проблеми створення сучасної інформаційно - аналітичної системи для установ охорони здоров'я в Україні.Показано на конкретному прикладі, що саме інформація є основою для прийняття рішень в лікарні. Тому автоматизація установи обов'язково приведе до підвищення ефективності її роботи і, як наслідок, - до поліпшення якості надання медичної допомоги. Розробка інформаційно - аналітичної системи «Електронна лікарня» здійснювалася в два етапи і наступний ступінь її розвитку повинен бути пов'язаний з телемедициною.Наголошується, що в нових соціально - економічних умовах слабкою ланкою в інформатизації системи охорони здоров'я в Україні є відсутність затвердженого єдиного стандарту медичної інформації.Підкреслюється необхідність розробки єдиної медичної уніфікованої документації

Analogue of the quantum hanle effect and polarization conversion in non-hermitian plasmonic metamaterials

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Nano Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/page/policy/articlesonrequest/index.htmlThe Hanle effect, one of the first manifestations of quantum theory introducing the concept of coherent superposition between pure states, plays a key role in numerous aspects of science varying from applicative spectroscopy to fundamental astrophysical investigations. Optical analogues of quantum effects help to achieve deeper understanding of quantum phenomena and, in turn, to develop cross-disciplinary approaches to realizations of new applications in photonics. Here we show that metallic nanostructures can be designed to exhibit a plasmonic analogue of the quantum Hanle effect and the associated polarization rotation. In the original Hanle effect, time-reversal symmetry is broken by a static magnetic field. We achieve this by introducing dissipative level crossing of localized surface plasmons due to nonuniform losses, designed using a non-Hermitian formulation of quantum mechanics. Such artificial plasmonic "atoms" have been shown to exhibit strong circular birefringence and circular dichroism which depends on the value of loss or gain in the metal-dielectric nanostructure. © 2012 American Chemical Society.This work has been supported in part by EPSRC (UK). P.G. acknowledges Royal Society for a Newton International Fellowship. F.J.R.-F. acknowledges support from grant FPI of GV and the Spanish MICINN under contracts CONSOLIDER EMET CSD2008-00066 and TEC2011-28664-C02-02.Ginzburg, P.; Rodríguez Fortuño, FJ.; Martínez Abietar, AJ.; Zayats, AV. (2012). Analogue of the quantum hanle effect and polarization conversion in non-hermitian plasmonic metamaterials. Nano Letters. 12(12):6309-6314. https://doi.org/10.1021/nl3034174S63096314121

The population history of northeastern Siberia since the Pleistocene.

Northeastern Siberia has been inhabited by humans for more than 40,000 years but its deep population history remains poorly understood. Here we investigate the late Pleistocene population history of northeastern Siberia through analyses of 34 newly recovered ancient genomes that date to between 31,000 and 600 years ago. We document complex population dynamics during this period, including at least three major migration events: an initial peopling by a previously unknown Palaeolithic population of 'Ancient North Siberians' who are distantly related to early West Eurasian hunter-gatherers; the arrival of East Asian-related peoples, which gave rise to 'Ancient Palaeo-Siberians' who are closely related to contemporary communities from far-northeastern Siberia (such as the Koryaks), as well as Native Americans; and a Holocene migration of other East Asian-related peoples, who we name 'Neo-Siberians', and from whom many contemporary Siberians are descended. Each of these population expansions largely replaced the earlier inhabitants, and ultimately generated the mosaic genetic make-up of contemporary peoples who inhabit a vast area across northern Eurasia and the Americas

Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

Modern humans have populated Europe for more than 45,000 years1,2. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period3. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4, but resembles that of preceding individuals associated with the Aurignacian culture. This ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean culture, and with the following Magdalenian culture that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers, who were also characterized by marked differences in phenotypically relevant variants

Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

Modern humans have populated Europe for more than 45,000 years(1,2). Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period(3). Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe(4), but resembles that of preceding individuals associated with the Aurignacian culture. This ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean culture, and with the following Magdalenian culture that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers, who were also characterized by marked differences in phenotypically relevant variants.Molecular Technology and Informatics for Personalised Medicine and Healt

Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers

Modern humans have populated Europe for more than 45,000 years. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe, but resembles that of preceding individuals associated with the Aurignacian culture. This ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean culture, and with the following Magdalenian culture that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers, who were also characterized by marked differences in phenotypically relevant variants.Archaeological Heritage Managemen

Clinical and morphological diagnostics of skin manifestations in case of graft-versus-host disease

The graft-versus-host disease is a life-threatening complication of allogeneic bone marrow transplantation, which demands fast and reliable diagnostics. Goal. To study clinical features of the graft-versus-host disease as well as differential and diagnostic value of histological and immunohistochemical signs in skin biopsy samples in case of graft-versus-host disease (GvHD). Materials and methods. The authors made a comparative assessment of clinical data available for patients suffering from acute GvHD (50 patients) and toxic dermatitis (10 patients). Skin biopsy samples taken from patients from both groups underwent postmortem and immunohistochemistry examinations: the drugs were stained with hematoxylin and eosin as well as by using anti-CD3, CD20, CD4, CD8, FOXP3, CD56, CD1a and CD 68 antibodies. Results. Based on the results of clinical data assessments, no significant differences in the groups were revealed. The morphological examination revealed that the number of eosinophils, CD8+, CD1a+, CD3+ and FOXP3+ cells and share of FOXP3+ cells among Т lymphocytes was higher in the group with toxic dermatitis. Conclusion. An integrated assessment of clinical data and morphological examination results accompanied by the analysis of the population composition of the infiltrate is needed to diagnose the acute GvHD