Comparison of two-dimensional and three-dimensional droplet trajectory calculations in the vicinity of finite wings

Computational predictions of ice accretion on flying aircraft most commonly rely on modeling in two dimensions (2D). These 2D methods treat an aircraft geometry either as wing-like with infinite span, or as an axisymmetric body. Recently, fully three dimensional (3D) methods have been introduced that model an aircrafts true 3D shape. Because 3D methods are more computationally expensive than 2D methods, 2D methods continue to be widely used. However, a 3D method allows us to investigate whether it is valid to continue applying 2D methods to a finite wing. The extent of disagreement between LEWICE, a 2D method, and LEWICE3D, a 3D method, in calculating local collection efficiencies at the leading edge of finite wings is investigated in this paper

CDASH: Community Data Analytics for Social Harm Prevention

Communities are adversely affected by heterogeneous social harm events (e.g., crime, traffic crashes, medical emergencies, drug use) and police, fire, health and social service departments are tasked with mitigating social harm through various types of interventions. Smart cities of the future will need to leverage IoT, data analytics, and government and community human resources to most effectively reduce social harm. Currently, methods for collection, analysis, and modeling of heterogeneous social harm data to identify government actions to improve quality of life are needed. In this paper we propose a system, CDASH, for synthesizing heterogeneous social harm data from multiples sources, identifying social harm risks in space and time, and communicating the risk to the relevant community resources best equipped to intervene. We discuss the design, architecture, and performance of CDASH. CDASH allows users to report live social harm events using mobile hand-held devices and web browsers and flags high risk areas for law enforcement and first responders. To validate the methodology, we run simulations on historical social harm event data in Indianapolis illustrating the advantages of CDASH over recently introduced social harm indices and existing point process methods used for predictive policing

HATS-5b: A Transiting hot-Saturn from the HATSouth Survey

We report the discovery of HATS-5b, a transiting hot-Saturn orbiting a G type star, by the HAT-South survey. HATS-5b has a mass of Mp=0.24 Mj, radius of Rp=0.91 Rj, and transits its host star with a period of P=4.7634d. The radius of HATS-5b is consistent with both theoretical and empirical models. The host star has a V band magnitude of 12.6, mass of 0.94 Msun, and radius of 0.87 Rsun. The relatively high scale height of HATS-5b, and the bright, photometrically quiet host star, make this planet a favourable target for future transmission spectroscopy follow-up observations. We reexamine the correlations in radius, equilibrium temperature, and metallicity of the close-in gas-giants, and find hot Jupiter-mass planets to exhibit the strongest dependence between radius and equilibrium temperature. We find no significant dependence in radius and metallicity for the close-in gas-giant population.Comment: 10 pages, submitted to A

The Mass-Radius Relationship for Very Low Mass Stars: Four New Discoveries from the HATSouth Survey

We report the discovery of four transiting F-M binary systems with companions between 0.1-0.2 Msun in mass by the HATSouth survey. These systems have been characterised via a global analysis of the HATSouth discovery data, combined with high-resolution radial velocities and accurate transit photometry observations. We determined the masses and radii of the component stars using a combination of two methods: isochrone fitting of spectroscopic primary star parameters, and equating spectroscopic primary star rotation velocity with spin-orbit synchronisation. These new very low mass companions are HATS550-016B (0.110 -0.006/+0.005 Msun, 0.147 -0.004/+0.003 Rsun), HATS551-019B (0.17 -0.01/+0.01 Msun, 0.18 -0.01/+0.01 Rsun), HATS551-021B (0.132 -0.005/+0.014 Msun, 0.154 -0.008/+0.006 Rsun), HATS553-001B (0.20 -0.02/+0.01 Msun, 0.22 -0.01/+0.01 Rsun). We examine our sample in the context of the radius anomaly for fully-convective low mass stars. Combining our sample with the 13 other well-studied very low mass stars, we find a tentative 5% systematic deviation between the measured radii and theoretical isochrone models.Comment: 17 pages, 8 figures, accepted for publication in MNRA

Increased Expression of Androgen Receptor Coregulator MAGE-11 in Prostate Cancer by DNA Hypomethylation and Cyclic AMP

Melanoma antigen gene protein-A11 (MAGE-11) of the MAGE family of cancer-germline antigens increases androgen receptor (AR) transcriptional activity through its interaction with the AR NH2-terminal FXXLF motif. The present study investigated the regulatory mechanisms that control MAGE-11 expression during androgen deprivation therapy and prostate cancer progression. Studies include the CWR22 xenograft model of human prostate cancer, clinical specimens of benign and malignant prostate, and prostate cancer cell lines. MAGE-11 mRNA levels increased 100 to 1500 fold during androgen deprivation therapy and prostate cancer progression, with highest levels in the castration-recurrent CWR22 xenograft and clinical specimens of castration-recurrent prostate cancer. Pyrosequencing of genomic DNA from prostate cancer specimens and cell lines indicated the increase in MAGE-11 resulted from DNA hypomethylation of a CpG island in the 5´ promoter of the MAGE-11 gene. Sodium bisulfite sequencing of genomic DNA from benign and malignant prostate tumors and prostate cancer cell lines revealed DNA hypomethylation at individual CpG sites at the transcription start site were most critical for MAGE-11 expression. Cyclic AMP also increased MAGE-11 expression and AR transcriptional activity in prostate cancer cell lines. However, cyclic AMP did not alter DNA methylation of the promoter and its effects were inhibited by extensive DNA methylation in the MAGE-11 promoter region. Increased expression of the AR coregulator MAGE-11 through promoter DNA hypomethylation and cyclic AMP provides a novel mechanism for increased AR signaling in castration-recurrent prostate cancer

Flux front penetration in disordered superconductors

We investigate flux front penetration in a disordered type II superconductor by molecular dynamics (MD) simulations of interacting vortices and find scaling laws for the front position and the density profile. The scaling can be understood performing a coarse graining of the system and writing a disordered non-linear diffusion equation. Integrating numerically the equation, we observe a crossover from flat to fractal front penetration as the system parameters are varied. The value of the fractal dimension indicates that the invasion process is described by gradient percolation.Comment: 5 pages, 4 figures, to appear in Phys. Rev. Let