Location analysis to suggest new warehouse for Best Furniture shop

Best Furniture operates as a retail furniture outlet in Hamilton, established in 2015, selling furniture manufactured in China and distributed to New Zealand through a network operated from Australia. While the business has tremendous opportunities to grow and outlast its competition, it does not have enough retail space to store its inventory to effectively service all the customer requests it receives. This research aims at identifying and recommending a location to situate a new warehouse for the business such that its operational capacities can be fully utilized. Qualitative research in the form of interview of business manager, and observation, were used to identify a new location and also to provide guidelines on warehouse management. Based on the research conducted, it is recommended that the business operates it new warehouse from a location proximal to Auckland port. It is also recommended that the business creates and implements a warehouse management process and policy document and utilizes available warehouse management software for efficient management of inventory and to streamline the supply chain after the centre is established

Design, crystal structure determination, molecular dynamic simulation and MMGBSA calculations of novel p38-alpha MAPK inhibitors for combating Alzheimer's disease

The hallmark of the Alzheimer's disease (AD) is the accumulation of aggregated, misfolded proteins. The cause for this accumulation is increased production of misfolded proteins and impaired clearance of them. Amyloid aggregation and tau hyperphosphorylation are the two proteinopathies which accomplish deprivation of cell and tissue hemostasis during neuropathological process of the AD, as a result of which progressive neuronal degeneration and the loss of cognitive functions. p38 mitogen-activated protein kinase (p38 MAPK) has been implicated in both the events associated with AD: tau protein phosphorylation and inflammation. p38 alpha MAPK pathway is activated by a dual phosphorylation at Thr180 and Tyr182 residues. Clinical and preclinical evidence implicates the stress related kinase p38 alpha MAPK as a potential neurotherapeutic target. Drug design of p38 alpha MAPK inhibitors is mainly focused on small molecules that compete for Adenosine triphosphate in the catalytic site. Here we have carried out the synthesis of phenyl sulfonamide derivatives Sulfo (I) and Sulfo (II). Crystal structures of Sulfo (I) and Sulfo (II) were solved by direct methods using SHELXS-97. Sulfo (I) and Sulfo (II) have R(int)values of 0.0283 and 0.0660, respectively, indicating good quality of crystals and investigated their ability against p38 alpha MAPK. Docking studies revealed that the Sulfo (I) had better binding affinity (-62.24 kcal/mol) as compared to Sulfo (II) and cocrystal having binding affinity of -54.61 kcal/mol and -59.84 kcal/mol, respectively. Molecular dynamics simulation studies of Sulfo (I) and cocrystal of p38 alpha MAPK suggest that during the course of 30 ns simulation run, compound Sulfo (I) attained stability, substantiating the consistency of its binding to p38 alpha MAPK compared to cocrystal. Binding free energy analysis suggests that the compound Sulfo (I) is better than the cocrystal. Thus, this study corroborates the therapeutic potential of synthesized Sulfo (I) in combatting AD

Coverage Path Planning And Control For Autonomous Mobile Robots

Coverage control has many applications such as security patrolling, land mine detectors, and automatic vacuum cleaners. This Thesis presents an analytical approach for generation of control inputs for a non-holonomic mobile robot in coverage control. Neural Network approach is used for complete coverage of a given area in the presence of stationary and dynamic obstacles. A complete coverage algorithm is used to determine the sequence of points. Once the sequences of points are determined a smooth trajectory characterized by fifth order polynomial having second order continuity is generated. And the slope of the curve at each point is calculated from which the control inputs are generated analytically. Optimal trajectory is generated using a method given in research literature and a qualitative analysis of the smooth trajectory is done. Cooperative sweeping of multirobots is achieved by dividing the area to be covered into smaller areas depending on the number of robots. Once the area is divided into sub areas, each robot is assigned a sub area for cooperative sweeping

9-Ethyl-2,3-dihydro-9H-carbazol-4(1H)-one

In the title compound, C28H30N2O2, the cyclo­hexene ring system adopts a sofa conformation. The crystal structure is stabilized by C—H⋯O inter­actions between methyl H atoms of the ethyl substituents and the O atoms of carbonyl groups of adjacent mol­ecules, and by an inter­molecular carbon­yl–carbonyl inter­actions [3.207 (2) Å

Spatial and temporal variability of bacterial communities within a combined sewer system.

This study describes the temporal and spatial variability of bacterial communities within a combined sewer system in England. Sampling was conducted over 9 months in a sewer system with intensive monitoring of hydraulic conditions. The bacterial communities were characterized by 16S rRNA gene-targeted terminal restriction fragment length polymorphism analysis. These data were related to the hydraulic data as well as the sample type, location, and time. Temporal and spatial variation was observed between and within wastewater communities and biofilm communities. The bacterial communities in biofilm were distinctly different from the communities in wastewater and exhibited greater spatial variation, while the wastewater communities exhibited variability between different months of sampling. This study highlights the variation of bacterial communities between biofilm and wastewater, and has shown both spatial and temporal variations in bacterial communities in combined sewers. The temporal variation is of interest for in-sewer processes, for example, sewer odor generation, as field measurements for these processes are often carried out over short durations and may therefore not capture the influence of this temporal variation of the bacterial communities

Functional Outcome of closed metacarpal fractures treated with mini fragment plates and screws: A Prospective study

BACKGROUND: Accurate open reduction and internal fixation of metacarpal fractures are required in unstable fractures where closed treatment technique yield poor functional outcome which usually is less than 5% of hand fractures. Minifragment plates and screws when used in properly selected cases provide rigid fixation allowing early mobilisation of joints and hence good functional outcome. PATIENTS AND METHODS: In 20 patients with closed unstable metacarpal fractures treated with minifragment plates and screws , functional outcome was assessed using American society for surgery of the hand (ASSH) total active flexion (TAF) score over a period of two years in prospective manner. RESULTS: In our study of unstable metacarpal fractures treated with plate osteosynthesis all the cases showed bone union (100%). The functional result is excellent in 80% of the patients (16 of 20 cases), good in 10% of cases (2 of 20 cases), poor in 10% of cases(2 of 20 cases). 2 patients developed superficial wound infection which settled with daily dressing and antibiotics and this does not affect the final outcome. CONCLUSIONS: Plate and screw fixation is a good option for treating closed unstable metacarpal fractures, where other modalities of fixation are less effective, the rigid stable fixation provided by plating withstands load without failure allowed early mobilization and achieved good functional results

2,3,4,9-Tetra­hydro-1H-carbazole

In the title compound, C12H13N, two methyl­ene C atoms of the cyclo­hexene ring are disordered over two sites with occupancies of 0.591 (10) and 0.409 (10); both disorder components adopt half-chair conformations. The crystal structure is stabilized by inter­molecular N—H⋯π and C—H⋯π inter­actions

[2-(4-Methylbenzoyl)phenyl](4-methylphenyl)methanone

The asymmetric unit of the title compound, C22H18O2, contains one half-mol­ecule, the complete mol­ecule being generated by the operation of a crystallographic twofold rotation axis. The carbonyl group and the two C atoms attached to it forms inter­planar angles of 23.67 (7)° with the methyl-substituted phenyl ring and 50.74 (8)° with the central ring. In the crystal, mol­ecules are linked into infinite chains along the b-axis direction by inter­molecular C—H⋯O inter­actions, generating R 2 2(10) graph-set motifs

3-(2,4,6-Trimethyl­benzo­yl)-2-naphthoic acid

The asymmetric unit of the title compound, C21H18O3, contains two crystallographically independent mol­ecules. The two mol­ecules are linked into cyclic centrosymmetric dimers R 2 2(8) by O—H⋯O hydrogen bonds. The dihedral angles between the naphthalene ring system and the benzene ring are 87.0 (8) and 84.4 (2)° in the two mol­ecules. The crystal packing is stabilized by O—H⋯O, C—H⋯π and π–π inter­actions [centroid–centroid distance = 3.664 (11) Å]. In one mol­ecule, the mesityl ring is disordered over two positions [occupancy ratio 0.690 (3):0.690 (3)]