Dabco containing acidic poly(ionic liquid): An efficient catalyst for the one-pot Preparation of 2,3-dihydroquinazoline-4(1H)-ones

1,4-Diazabicyclo[2.2.2]octane (DABCO) containing acidic poly(ionic liquid) (DAIL) has been prepared via condensation of 1,4-dichloro butane and DABCO, as an efficient acidic catalyst and has been applied in the one-pot preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives. This catalyst has been characterized by FT-IR and TGA. According to the obtained results including time, yield and recyclability, DAIL could be considered as an efficient catalyst for organic transformations

A Compact Array Antenna: Explicit Design for C and X Band Applications

A novel and compact design of a circularly polarized slot antenna (CPSA) is elaborated. With the aim of generating CP feature and enhancing the impedance bandwidth, four rectangular stubs are wisely embedded in the antenna feed line structure and slotted ground plane to excite two orthogonal E vectors. Subsequently, a suitable arrangement of CPSAs in the form of 2 × 2 and 4 × 4 array antennas provokes higher functionalities in C and X band applications, respectively. Sequentially rotated (SR) feed technique is adopted to excite the antenna structure in array configurations. Measured and simulated results confirm outperformance of the array antennas with respect to the previously proposed designs. Compact size, wider impedance and axial ratio (AR) bandwidth, higher gain, and suitable radiation characteristics, both in single and array configurations, confirm suitability of the proposed designs for communication systems

Identification and Clinical Implications of a Novel MYO15A Variant in a Consanguineous Iranian Family by Targeted Exome Sequencing

BACKGROUND AND OBJECTIVES: Hereditary hearing loss (HL) is known by a very high genetic heterogeneity, which makes a molecular diagnosis problematic. Next-generation sequencing (NGS) is a new strategy that can overcome this problem. METHOD: A comprehensive family history was obtained, and clinical evaluations and pedigree analysis were performed in the family with 3 affected members. After excluding mutations in the GJB2 and 7 other most common autosomal recessive nonsyndromic HL genes via Sanger sequencing and genetic linkage analysis in the family, we applied the Otogenetics deafness NGS panel in the proband of this family. RESULTS: NGS results showed a novel rare variant (c.7720C>T) in the MYO15A gene. This nonsense variant in the exon 40 of the MYO15A gene fulfills the criteria of being categorized as pathogenic according to the American College of Medical Genetics and Genomics guideline. CONCLUSIONS: New DNA sequencing technologies could lead to identification of the disease causing variants in highly heterogeneous disorders such as HL

The study of establishment of rainbow trout culture and hatchery farms on Zayanderood’s River region in Caharmahal and Bakhtiyari Province

The aim of this study was to find the best location for establishment of rainbow trout culture and hatcheries farms on Zayanderood’s river region in Charmahal and Bakhtiyari province. This survey carried out over ten station along Zayanderood’s river. The result of physical and chemical analysis showd that the annual average of air temperature varied from 9.5oC - 10oC where the pH annual average value were between 7.5 and 8.8. the dissolve oxygen concentration in stations except in rainbow trout farm effluent were above 10 mg/l. the other chemical , pollutant as well as pesticides levels were under the limiting concentration for rainbow trout culture and Hatcheries activity. The plankton survey showed that the Bacillurophyta were the dominant group of phytoplankton where protozoa constituted the most abundant group of zooplankton the Benthic organisms sensitive to pollutant in particular Epirus were dominant group in all stations. In regard to fishes presence in river, five species of Ciprinidae, one species from Balitoridae and one species from salmonidae families were identified. The capacity for development of rainbow trout culture for tow phase period in Zayanderood’s river region with respect to self purification potential (self purification potential were determined from the oxidation of the effluent of the only active trout farm of the river region), minimum of 10 L/s water requirement for production of trout in concrete canal and pond system and 1 L/S water need for production in semi circular closed system were estimated to be 5202 metric tons

Targeting Wideband Circular Polarization: An Efficient 2×2 Sequentially-Phase-Fed Rotated Array Antenna

This paper outlines an efficient design of a wideband sequential-phase (SP) fed circularly polarized corner-truncated patch array antenna (CPCTPAA) with sequentially rotated (SR) array elements. The SP feed network is composed of a circular ring with an inner section of 270°. Four shorting strips are attached to the circular ring to the end of which corner-truncated patches (CTPs) are appended. Through the proposed feed structure, stable phase difference is attained at the end of the shorting strips which in turn ends in CP generation. Each array element of 2×2 CPCTPAA is a CTP printed on the top side of the FR4 substrate. On the backside, rectangular slots are removed from the ground plane to enhance the bandwidth characteristics of the proposed design. Moreover, suitable rectangular slots are embedded at the crossing points of CTPs and feed lines which instigate extra improvements in CPCTPAA performance. These amendments, all together, are deemed for achieving an efficient and cost-effective CPCTPAA design with smaller occupied implementation space. Simulation and experimental studies are conducted on a 70×70×1.6 mm3 prototype to evaluate performance of the proposed array antenna. Results are discussed in depth

A pathogenic variant in SLC26A4 is associated with Pendred syndrome in a consanguineous Iranian family

Objective: Hearing loss (HL) is a common sensory deficit with high phenotypic and genotypic heterogeneity. A large Iranian family with HL was genetically assessed in this study. Design: A proband from a consanguineous multiplex HL family from Iran was examined via Targeted Next-Generation Sequencing (TNGS). Sanger sequencing allowed the segregation analysis of the variant of interest and the investigation of its presence in a cohort of 50 ethnicity-matched healthy control individuals. The gene was previously associated with HL. Therefore, to determine whether the variant was specifically associated with Pendred Syndrome (PDS) or DFNB4, biochemical analyses, PTA, thyroid scans by Tc99m, perchlorate discharge test and high-resolution CT scan of the temporal bone were carried out on the affected family members. Study sample: Ten members of a large multiplex Iranian family with HL were recruited in this study. In addition, 50 unrelated healthy controls of the same ethnic group were randomly selected to genotype the variant. Results: A homozygous missense variant (NM_000441.1: c.1211C > T/p.Thr404Ile) in exon 10 was found segregating in the family. Based on the ACMG's guidelines, the variant was classified as pathogenic. Conclusion: This study expands the spectrum of SLC26A4 pathogenic variants in hearing los