Springer's theorem for tame quadratic forms over Henselian fields

A quadratic form over a Henselian-valued field of arbitrary residue characteristic is tame if it becomes hyperbolic over a tamely ramified extension. The Witt group of tame quadratic forms is shown to be canonically isomorphic to the Witt group of graded quadratic forms over the graded ring associated to the filtration defined by the valuation, hence also isomorphic to a direct sum of copies of the Witt group of the residue field indexed by the value group modulo 2

Can lactoferrin modulate the immunostimulant activity of levamisole in rats

Objective: The aim of this study was to study the immunomodulatory activity improvement of levamisole by using lactoferrin when applied to immunosuppressed rat model. Methods: The study was designed as follows, 140 male albino rats (250-280 g) 14 weeks old were used in our work. Rats were randomly divided into seven groups, 20 in each. The group I was kept as a control, group II was given cyclophosphamide (CYP) at a single intraperitoneal dose of (250 mg/kg body weight), group III CYP and lactoferrin (Lac) treated group, group IV orally administrated Lac only (0.5%) in drinking water, group V treated with CYP and levamisole, group VI administrated levamisole orally at a dose of (2.5 mg/kg body weight) and group VII was given CYP, Lac and levamisole. Animals were sacrificed and two separate blood samples were collected after 21 days from the beginning of the experiment for measuring the total and differential leukocyte count, serum total proteins, albumin, alpha globulin, beta globulin and gamma globulin, Nitric oxide (NO) production and lysozyme activity. Results: CYP group showed significant decrease in the above mentioned parameters, which were improved after administration of both lactoferrin and levamisole. Conclusion: Our study concluded that lactoferrin improve the immunostimulant effect of levamisole in CYP- immunosuppressed rats. J Clin Exp Invest 2014; 5 (1): 48-5

Myocardial bridging causing ischemia and recurrent chest pain: a case report

<p>Abstract</p> <p>Background</p> <p>Myocardial bridging is present when a segment of a major epicardial coronary artery runs intramurally through the myocardium. It usually has a benign prognosis, but in some cases myocardial ischemia, infarction and sudden cardiac death have been reported. We are here reporting a case of myocardial bridging which was complicated with recurrent chest pain and transient ST-segment elevation during exercise treadmill test.</p> <p>Case presentation</p> <p>A 40 year-old-man presented with recurrent retrosternal chest pain of 2 months duration. He had history of smoking and was obese, otherwise no physical abnormalities were detected by examination. Electrocardiogram and blood tests were normal apart from impaired glucose tolerance with elevated triglycerides and decreased level of high density lipoprotein cholesterol. While doing exercise treadmill test, the patient developed chest pain and significant ST-segment elevation in almost all precordial leads that persisted for about 15 minutes through recovery. We decided to admit the patient to the coronary care unit for further management and to perform coronary angiogram. Myocardial bridging was observed in the mid segment of the left anterior descending coronary artery. Medical treatment was decided.</p> <p>At one year follow up, our patient was healthy and had no cardiac complaints. In conclusion, myocardial bridging may predispose to coronary vasospasm that may leads to ischemic complications.</p

Root-knot nematodes: abundance in organic farming, differentiation among populations, microbes attached to juveniles in soil, and bacterial antagonists

In zwei umfassenden Untersuchungen im Herbst 2009 und 2011 wurde die Verbreitung und die Abundanz pflanzenparasitärer Nematoden an den verschiedenen Feldfrüchten in einer Bio-Farm in Ägypten erfasst. Insgesamt wurden elf Genera gefunden, von denen Wurzelgallen-Nematoden (Meloidogyne spp.) in beiden Untersuchungen am häufigsten und mit der höchsten Anzahl in den Proben gefunden wurde. Weitere oft gefundene Genera waren Tylenchorhynchus, Rotylenchulus, Helicotylenchus und Pratylenchus. Davon ausgehend beschäftigten sich die weiteren Arbeiten mit Meloidogyne, und zwar mit der Differenzierung von Populationen, der Anheftung von Mikroorganismen an die Juvenile (J2) im Boden, und der biologischen Kontrolle durch Bakterienstämme, die als Antagonisten von pilzlichen Pathogenen bekannt sind. Die untersuchten Populationen und/oder Rassen von Meloidogyne incognita zeigten phänotypische Unterschiede in ihren Vermehrungsmustern an einem Set von Wirtspflanzen. Damit einhergehend konnten auch genetische Unterschiede anhand einer neu entwickelten Methode zur Amplifikation des Pathogenitätsgens msp1 und der elektrophoretischen Auftrennung der PCR-Produkte von Genvarianten im Denaturierungsgradienten (DGGE) nachgewiesen werden. Für drei Ackerböden aus verschiedenen Regionen in Deutschland wurde unterschiedliche Suppressivität ihrer mikrobiellen Gemeinschaften gegen Meloidogyne hapla im Gewächshaus gezeigt. Mit Kultivierungs-unabhängigen Methoden wurde untersucht, welche Mikroorganismen an die J2 in den Böden anheften, um die zu identifizieren, die mit J2 im suppressivsten der drei Böden spezifisch interagierten (Kleinwanzleben). Die Mikroorganismen, die an den J2 nach Inkubation im Boden haften blieben, unterschieden sich zwischen den drei Böden. In PCR-DGGE Fingerprints von ITS-Fragmenten bzw. 16S rRNA Genen wurden viele Pilze und Bakterien detektiert, die an den J2 aber nicht im umgebenden Boden abundant waren. Während sich einige davon in allen drei Böden an den J2 anreicherten, waren andere spezifisch für einen Bodentyp. Mittels Pyrosequenzierung von 16S rRNA Gen-Amplikons konnten die mit J2 im suppressivsten Boden assoziierten abundantesten Bakterienarten beschrieben werden. Viele davon waren verwandt mit infektiösen Arten wie Shigella spp., während Malikia spinosa und Rothia amarae am häufigsten detektiert wurden. Krankheitskomplexe aus Nematode und Pilz können erhebliche synergistische Ertragsverluste verursachen. Bakterienstämme, die als Antagonisten von phytopathogenen Pilzen bekannt sind, wurden auf ihr Potential zur biologischen Kontrolle von M. incognita untersucht. Sameninokulation führte bei den meisten Stämmen zu einer signifikanten Reduktion der Vermehrung des Nematoden an Tomatenwurzeln. Für die drei besten Isolate, Bacillus subtilis Sb4-23, Mc2-Re2 und Mc5- Re2, wurden die zugrundeliegenden Mechanismen untersucht. Die Stämme konnten den Nematoden sowohl direkt durch Metabolite beeinträchtigen, die im Kulturüberstand zu finden sind, als auch indirekt über Induktion systemischer Resistenz der Pflanze. Im experimentellen Vergleich der direkten und Pflanzenvermittelten Effekte zeigte sich, dass letzteres der dominierende Kontrollmechanismus dieser Antagonisten ist. Zusammen genommen könnten diese Befunde als Basis für eine verbesserte Strategie zum integrierten Management von Wurzelgallen-Nematoden im biologischen Landbau dienen.Two surveys were conducted to determine the frequency and abundance of plantparasitic nematodes associated with different crops at an organic farm in Egypt, during autumn 2009 and 2011. Eleven genera of plant-parasitic nematodes were detected. Root-knot nematodes (Meloidogyne spp.) showed the highest abundance and frequency of all plant-parasitic nematodes during the two surveys. Commonly detected genera were Tylenchorhynchus, Rotylenchulus, Helicotylenchus and Pratylenchus. Further studies on Meloidogyne were carried out with regard to discrimination among populations, attachment of microbes to juveniles (J2) in soil, and biocontrol through bacterial strains which were known as antagonists of fungal pathogens. Meloidogyne incognita populations and/or races that showed differential pattern of reproduction on a set of host plants, could be differentiated based on a newly developed PCR-DGGE system to electrophorecically separate variants of the pathogenicity gene msp1. Three arable soils from different regions of Germany were shown to vary in the suppressiveness of their indigenous microbial communities against Meloidogyne hapla. Attachment of microbes to J2 in these three soils was investigated by cultivation-independent methods to identify those which specifically interacted with J2 in the most suppressive soil (Kleinwanzleben). The three soils differed in the microbes attached to J2. PCR-DGGE fingerprints of amplified ITS fragments or 16S rRNA genes showed many fungi and bacteria that were abundant on J2 but not in the surrounding soil, some of which seemed to be present in all three soils while most were soil type specific. Many bacteria associated with J2 from the most suppressive soil were closely related to infectious species like Shigella spp., while most abundant were Malikia spinosa and Rothia amarae as determined by 16S rRNA gene amplicon pyrosequencing. Nematode-fungus disease complexes can cause dramatic synergistic yield losses. Bacterial strains known as antagonists of phytopathogenic fungi were evaluated with respect to their biocontrol potential towards M. incognita. Seed inoculation with most of the strains significantly reduced propagation of nematode on tomato roots. The best strains Bacillus subtilis Sb4-23, Mc2-Re2, and Mc5- Re2 were further studied for their mode-of-action. The strains were able to affect the nematodes directly by metabolites present in culture supernatants and indirectly by induced systemic resistance of the plant. Experimental comparison of direct and plantmediated effects suggested that the latter was the major control mechanism of these antagonists. Overall, these findings may improve the basis for integrated management strategies of root-knot nematodes in organic farming

Artificial neural network technique to predict the power output of photovoltaic for monocrystalline and polycrystalline

The demand for energy is predicted to rise rapidly in the near future as a result of population development and industrialization around the world. However, increased use of fossil fuels is responsible for the majority of environmental pollution and greenhouse gas emissions, which are widely believed to be the primary drivers of global warming and are contributing to it. This project represent the design of artificial neural network model (ANN) that predict the power output of the photovoltaic (PV) for monocrystalline and polycrystalline. The objectives of this project is to develop ANN model, to evaluate power and efficiency of two different photovoltaic panel. The data was collectedfrom 5 May 2018 to 6 May 2020. However, the input parameters are metreological data is used as input for ANN model. The voltage produced by polycrystalline is much more lager than monocrystalline voltage. In contrast, monocrystalline PV panel tend to have a higher current values compared to polycrystalline PV pnael. Mean square error (MSE) training of this model was equal to MSE testing and MSE validation. It means the data of model have been learning very well during training and zero means that it has an overestamte the prediction of the network. It is clear that the two models have a very good fit curve of the data as the correaltion coefficient, R value is equal to 1. However, the atual and predeictd values show a similarity in trends for both PV modules. The estimated voltage, current and power when compared to the actual value has no significant differences. Overall, polycrystalline panel has a better performance and the efficiency was 0.999% and 0.997% for moncrystalline

A Comparative Study Of Literary Translation From Arabic Into English And French [PJ7694.E1 M697 2006 f rb].

Kajian ini adalah satu kajian perbandingan sastera yang bertujuan menjelaskan perbezaan dan persamaan antara tiga bahasa – bahasa Arab, bahasa Inggeris dan bahasa Perancis - bagi mengwujudkan satu model penterjemahan. This study is a comparative study on literary translation which aims at describing differences and similarities between three languages – Arabic, English and French – to establish a translation modelling

Hrobka Achethotepem Hemiho usurpovaná Nebkauhorem Iduem

Ve své disertaci se zabývám hrobkou vezíra Achethotepa v Sakkáře, již si posléze zabral princ Nebkauhor (přezdívaný Idu). Hrobku prozkoumal v archeologcké sezóně let 1937-8 egyptský archeolog Selim Hassan a později ji neadekvátně, jen povrchně publikoval. Vzhledem k historickému významu nápisl a scén v hrobce jsem se rozhodl ji důkladně zpracovat v rámci své doktorské dissertace. Hrobka prince Nebkauhora se nachází severně od vzestupné cesty Venisovy pyramidy a jižně od ohradní zdi Stupňovité pyramidy krále Džosera, na západ od hrobky muže jménem Nianchba a na východ od skalní hrobky Hermeruovy. První kapitolu této studie tvoří stručný úvod k sakkárskému pohřebišti. Druhá kapitola se zabývá tzv. Venisovým pohřebištěm a architekturou hrobky. Třetí kapitola obsahuje popis a interpretaci scén a nápisů. Čtvrtá kapitola je svého druhu dodatek se seznamem fragmentů náležejících k hrobce. Poslední, pátá kapitola obsahuje přehled hlavních událostí na přelomu turbulentního období konce 5. a počátku 6. dynastie a poznámky o postavení obou majitelů hrobky, Achethotepa a Nebkauhora. Tato část rovněž zahrnuje diskusi k materiálu relevantnímu pro dataci hrobky.In my thesis I focus on the Saqqara tomb of the vizier Akhethotep, which was usurped by the prince Nebkauhor (with the intimate name of Idu). The tomb, located in the area north of the causeway of Unis and south of the enclosure wall of the step pyramid of king Djoser, was excavated by Egytian archaeologist Selim Hassan during the archaeological season of 1937-8. Unfortunately, the tomb was later unadequately, only summarily published. With regard to the historical importance of the inscriptions and scenes which survived in the tomb, I decided to work up these important archaeological and epigraphic materials in my PhD dissertation. The first chapter of the dissertation includes a brief introduction to the Saqqara Cemetery. The second chapter deals with the history of the so-called Unis Cemetery and the architecture of the tomb. The third chapter contains description and interpretation of the scenes and inscriptions. The fourth chapter is a sort of an appendix with the list fragments of reliefs found in the tomb and belonging to its original decoration. And the final fifth chapter contains an overview of the turbulent times at the end of the Fifth Dynasty and the beginning of the Sixth Dynasty, and notes on the life of the two tomb owners, Akhethotep and Nebkauhor. This section also includes an analysis of...Czech Institute of EgyptologyČeský egyptologický ústavFaculty of ArtsFilozofická fakult

Aerodynamic, Structural and Aeroelastic Design of Wind Turbine Blades

With the negative impact of conventional energy resources that have been used worldwide, there is a demand for using other resources such as wind energy. Tons of researches have been applied around the globe on the process of designing and manufacturing wind energy conversion systems. In the present chapter, we are concentrating on wind turbine blades’ structural design process. The structural design of a wind turbine blade includes defining the wind turbine loads, selecting a suitable material, creating a structural model, and solving the model using the finite element method. This process will be repeated several times until a final design is achieved. The present chapter includes a discussion on the finite element method and wind turbine aeroelasticity

JUVENILE HORMONE BIOSYNTHESIS AND SIGNALING PATHWAY IN DROSOPHILA MELANOGASTER

Insect development and metamorphosis are controlled by two major hormones; 20-hydroxyecdysone (20E) and juvenile hormone (JH). 20E signaling pathway is well recognized while JH signaling is still ambiguous. For a better understanding of JH biosynthesis and signaling we worked on two parallel projects; reverse genetic and forward genetic studies. In the reverse genetic study, we have tested the potential functional redundancy between Methoprene-tolerant (Met) and germ cell-expressed (gce), two paralog bHLH-PAS transcription factors in Drosophila that were suggested to be JH receptors. Met null mutants are viable, resistant to JH and low fecundity. No gce mutant was available at the begening of this project. We generated a gce null allele and found that it phenocopies Met mutants. Met-gce double mutants are lethal at prepupal stage, which is similar to the JH-deficient flies. Krüppel homolog1 (Kr-h1) and broad (br) are two known JH signaling componets. Further investigations revealed that Met-gce double mutant diminishes Kr-h1 expression, induces precocious br expression, and causes premature and enhanced caspase-dependent programmed cell death. Therefore, we conclude that Met and Gce are functionally redundant in transducing JH signals. Expression of br is induced by 20E, but its induction can be suppressed by JH. In the forward genetic study, we designed and conducted a novel genetic screen to isolate mutations that can de-repress br expression at early larval stages. From 4,400 lethal lines, 55 mutations were isolated based on the precocious br expression in 2nd instar larvae. Genes associated with these 55 mutations include apterous, InR, NMAR1, Fpps and Kr-h1, which are known to be involved in JH biosynthesis or signaling. Other genes encode proteins with various molecular functions, including enzymes, signal transduction molecules, and transcriptional factors. Among them, there are three Wnt signaling components, Axin (Axn), supernumerary limbs (slmb), and naked cuticle (nkd) and two TGF-&#946; signaling components, thick vein (tkv) and mothers against Dpp (mad). We further demonstrated that Wnt signaling mediates JH signaling by regulating Met and gce expression, and that TGF-&#946; signaling controls JH biosynthesis by upregulating transcription of JH acid methyltransferase (jhamt), a key regulatory enzyme of JH biosynthesis