Marijuana Use by Juveniles: The Effects of Peers, Parents Race, & Drug Abuse Resistance Education.

The purpose of this study was to analyze the factors that affect the use of marijuana by juveniles and how outside influences such as peer pressure, race, parental influence, and prevention programs such as the Drug Abuse Resistance Education (D.A.R.E.) contribute to the use of marijuana by juveniles. All of the variables used in this study came from the Gang Resistance Education and Training (G.R.E.A.T.) data collected by Esbensen and Osgood (1999). The analysis indicated that juveniles are most influenced by their peers such as friends, that African American juveniles would be less likely than Whites and Hispanics to become regular users of marijuana, that juveniles living with both parents would be less likely to use marijuana compared to those with alternative living conditions, and that the programs such as the D.A.R.E. program would have little long-term effect on marijuana usage by juveniles

The Changing Nature of Regional Poverty

We’re witnessing a dramatic change in the social geography of greater Richmond. It’s becoming more like that of the global south, where wealth is centered in the cities and poverty rings the outskirts of the city

Pulse confinement in optical fibers with random dispersion

Short range correlated uniform noise in the dispersion coefficient, inherent in many types of optical fibers, broadens and eventually destroys all initially ultra-short pulses. However, under the constraint that the integral of the random component of the dispersion coefficient is set to zero, or pinned, periodically or quasi-periodically along the fiber, the nature of the pulse propagation changes dramatically. For the case that randomness is added to constant positive dispersion, the pinning restriction significantly reduces pulse broadening. If the randomness is added to piecewise constant periodic dispersion, the pinning may even provide probability distributions of pulse parameters that are numerically indistinguishable from the statistically steady case. The pinning method can be used to both manufacture better fibers and upgrade existing fiber links.Comment: 4 pages, 2 figure

Increasing Diversity in the City Schools: Unexplored Paths of Opportunity

In its school rezoning and closure process from May 6 - June 3, 2013, the Richmond School Board voted to close 3 schools and change 14 elementary school zones despite opposition that overwhelmingly outweighed support at both public hearings. Though there were a wide range of concerns cited, including the rushed timeline, lack of transparency and absence of clear criteria for closing and rezoning these schools, many stakeholders expressed particular disapproval related to the potential increase in racial isolation that would result from the plan, formally known as Option C. While regional efforts to promote school diversity—a central theme of the Looking Back, Moving Forward conference—remain critical, the school board actions present a specific challenge which could be addressed within a single school system through innovative policies with a record of success in other locales. To that end, this memo has three broad purposes. We identify key demographic changes that present opportunities and challenges for promoting school diversity in Richmond Public Schools (RPS). We also provide a synthesis of more than six decades of social science research showing that integration is still a deeply worthy policy goal. We outline the racial impact of current student assignment policies, in addition to the projected impact of the June 2013 rezoning. And perhaps most importantly, we close with a vision for moving forward in a way that more comprehensively fosters the many benefits of school diversity in Richmond City

Loss of Bladder Epithelium Induced by Cytolytic Mast Cell Granules

Programmed death and shedding of epithelial cells is a powerful defense mechanism to reduce bacterial burden during infection but this activity cannot be indiscriminate because of the critical barrier function of the epithelium. We report that during cystitis, shedding of infected bladder epithelial cells (BECs) was preceded by the recruitment of mast cells (MCs) directly underneath the superficial epithelium where they docked and extruded their granules. MCs were responding to interleukin-1β (IL-1β) secreted by BECs after inflammasome and caspase-1 signaling. Upon uptake of granule-associated chymase (mouse MC protease 4 [mMCPT4]), BECs underwent caspase-1-associated cytolysis and exfoliation. Thus, infected epithelial cells require a specific cue for cytolysis from recruited sentinel inflammatory cells before shedding

A trust approach for sharing research reagents

The core feature of trusts-holding property for the benefit of others-is well suited to constructing a research community that treats reagents as public goods

Early Life Stress Triggers Persistent Colonic Barrier Dysfunction and Exacerbates Colitis in Adult IL-10−/− Mice:

It has become increasingly evident that disease flares in the human inflammatory bowel diseases (IBD) are influenced by life stress. It is known that life stress can trigger disturbances in intestinal barrier function and activate proinflammatory signaling pathways, which are important contributors to intestinal inflammation and clinical disease; however, the exact mechanisms of stress-induced IBD exacerbations remain to be elucidated. Here we present a model of early life stress-induced exacerbation of colitis in IL-10-/- mice

On non-local variational problems with lack of compactness related to non-linear optics

We give a simple proof of existence of solutions of the dispersion manage- ment and diffraction management equations for zero average dispersion, respectively diffraction. These solutions are found as maximizers of non-linear and non-local vari- ational problems which are invariant under a large non-compact group. Our proof of existence of maximizer is rather direct and avoids the use of Lions' concentration compactness argument or Ekeland's variational principle.Comment: 30 page

Phytochemicals as antibiotic alternatives to promote growth and enhance host health

There are heightened concerns globally on emerging drug-resistant superbugs and the lack of new antibiotics for treating human and animal diseases. For the agricultural industry, there is an urgent need to develop strategies to replace antibiotics for food-producing animals, especially poultry and livestock. The 2nd International Symposium on Alternatives to Antibiotics was held at the World Organization for Animal Health in Paris, France, December 12-15, 2016 to discuss recent scientific developments on strategic antibiotic-free management plans, to evaluate regional differences in policies regarding the reduction of antibiotics in animal agriculture and to develop antibiotic alternatives to combat the global increase in antibiotic resistance. More than 270 participants from academia, government research institutions, regulatory agencies, and private animal industries from >25 different countries came together to discuss recent research and promising novel technologies that could provide alternatives to antibiotics for use in animal health and production; assess challenges associated with their commercialization; and devise actionable strategies to facilitate the development of alternatives to antibiotic growth promoters (AGPs) without hampering animal production. The 3-day meeting consisted of four scientific sessions including vaccines, microbial products, phytochemicals, immune-related products, and innovative drugs, chemicals and enzymes, followed by the last session on regulation and funding. Each session was followed by an expert panel discussion that included industry representatives and session speakers. The session on phytochemicals included talks describing recent research achievements, with examples of successful agricultural use of various phytochemicals as antibiotic alternatives and their mode of action in major agricultural animals (poultry, swine and ruminants). Scientists from industry and academia and government research institutes shared their experience in developing and applying potential antibiotic-alternative phytochemicals commercially to reduce AGPs and to develop a sustainable animal production system in the absence of antibiotics.Fil: Lillehoj, Hyun. United States Department of Agriculture. Agricultural Research Service; ArgentinaFil: Liu, Yanhong. University of California; Estados UnidosFil: Calsamiglia, Sergio. Universitat Autònoma de Barcelona; EspañaFil: Fernandez Miyakawa, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; ArgentinaFil: Chi, Fang. Amlan International; Estados UnidosFil: Cravens, Ron L.. Amlan International; Estados UnidosFil: Oh, Sungtaek. United States Department of Agriculture. Agricultural Research Service; ArgentinaFil: Gay, Cyril G.. United States Department of Agriculture. Agricultural Research Service; Argentin

Review: innovation through research in the North American pork industry

This article involved a broad search of applied sciences for milestone technologies we deem to be the most significant innovations applied by the North American pork industry, during the past 10 to 12 years. Several innovations shifted the trajectory of improvement or resolved significant production limitations. Each is being integrated into practice, with the exception being gene editing technology, which is undergoing the federal approval process. Advances in molecular genomics have been applied to gene editing for control of porcine reproductive and respiratory syndrome and to identify piglet genome contributions from each parent. Post-cervical artificial insemination technology is not novel, but this technology is now used extensively to accelerate the rate of genetic progress. A milestone was achieved with the discovery that dietary essential fatty acids, during lactation, were limiting reproduction. Their provision resulted in a dose-related response for pregnancy, pregnancy maintenance and litter size, especially in maturing sows and ultimately resolved seasonal infertility. The benefit of segregated early weaning (12 to 14 days of age) was realized for specific pathogen removal for genetic nucleus and multiplication. Application was premature for commercial practice, as piglet mortality and morbidity increased. Early weaning impairs intestinal barrier and mucosal innate immune development, which coincides with diminished resilience to pathogens and viability later in life. Two important milestones were achieved to improve precision nutrition for growing pigs. The first involved the updated publication of the National Research Council nutrient requirements for pigs, a collaboration between scientists from America and Canada. Precision nutrition advanced further when ingredient description, for metabolically available amino acids and net energy (by source plant), became a private sector nutrition product. The past decade also led to fortuitous discoveries of health-improving components in ingredients (xylanase, soybeans). Finally, two technologies converged to facilitate timely detection of multiple pathogens in a population: oral fluids sampling and polymerase chain reaction (PCR) for pathogen analysis. Most critical diseases in North America are now routinely monitored by oral fluid sampling and prepared for analysis using PCR methods