Two chemical types of the red alga Plocamium cartilagineum from Chile

Examination of two close collections of Plocamium cartilagineum separated into plants bearing carposporophyte, tetrasporophyte and gametophyte yielded the same qualitative chemical composition, but the three reproductive phases have quantitative differences. We designate chemotype β to the collection which contains brominated monoterpenes and chemotype α to the group which lacks the enzymatic system which incorporates bromine. © 1988

Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking

Altres ajuts: Fundació La Marató de TV3 (SGR2014-0984)GuA1-containing AMPA receptors play a key role in synaptic plasticity and cognition. Casas et al. demonstrate that the sensing of nutrients by CPT1C regulates the phosphatase activity of SAC1, and consequently PI(4)P levels, at the contact sites between the endoplasmic reticulum and the trans-Golgi network to control the trafficking of GluA1 receptors to the cell surface of neurons. Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key role in synaptic plasticity. In the present study, we demonstrate across different metabolic stress conditions that modulate malonyl-CoA levels in cortical neurons that CPT1C regulates the trafficking of the major AMPAR subunit, GluA1, through the phosphatidyl-inositol-4-phosphate (PI(4)P) phosphatase SAC1. In normal conditions, CPT1C down-regulates SAC1 catalytic activity, allowing efficient GluA1 trafficking to the plasma membrane. However, under low malonyl-CoA levels, such as during glucose depletion, CPT1C-dependent inhibition of SAC1 is released, facilitating SAC1's translocation to ER-TGN contact sites to decrease TGN PI(4)P pools and trigger GluA1 retention at the TGN. Results reveal that GluA1 trafficking is regulated by CPT1C sensing of malonyl-CoA and provide the first report of a SAC1 inhibitor. Moreover, they shed light on how nutrients can affect synaptic function and cognition

Formación de recursos humanos

Alimentación saludable en universitarios, casino Los Notros, Universidad de la Frontera, 2009Centro de salud docente-asistencial rural modelo Universidad de la Frontera, ChileDiagnóstico de salud escolar utilizando ficha Clap-OPSExperiencia de interacción fronteriza en acciones de promoción y prevención en alcohol y drogasFomento y promoción en salud escolar: Un desafío pendienteFortalecimiento de maternidades cercanas a la familia: pabellón docente en el Servicio de Salud ÑubleIntegralidad del modelo biopsicosocial en la formación de estudiantes de enfermería, Universidad Católica del NorteJóvenes y niños insulino dependientes aprenden técnicas de autocuidado en campamentoOdontología y nutrición: dos disciplinas complementarias y sinérgicasProyectos de extensión universitaria desarrollados a través de prácticas profesionales de disciplinas de la salu