Evidence for antibiotic induced Clostridium perfringens diarrhoea

Clostridium difficile is a well documented cause of antibiotic associated diarrhoea in hospitalised patients, but may account for only approximately 20% of all cases. This leader reviews the current knowledge and understanding of the pathogenesis, epidemiology, and diagnosis of non-food borne Clostridium perfringens diarrhoea. Although enterotoxigenic C perfringens has been implicated in some C difficile negative cases of antibiotic associated diarrhoea, C perfringens enterotoxin detection methods are not part of the routine laboratory investigation of such cases. Testing for C perfringens enterotoxin in faecal samples from patients with antibiotic associated diarrhoea and sporadic diarrhoea on a routine basis would have considerable resource implications. Therefore, criteria for initiating investigations and optimum laboratory tests need to be established. In addition, establishing the true burden of C perfringens antibiotic associated diarrhoea is important before optimum control and treatment measures can be defined

Analysis of neonatal mortality data for year 2016

This report presents an analysis of neonatal mortality in infants born in 2016 at a gestational age (GA) less that 32 weeks, and who were admitted to neonatal units that form the UK Neonatal Collaborative in England, Wales and Scotland (part). Every neonatal unit was informed of the analysis in advance and was requested to confirm the accuracy and completeness, or make amendments, in the data they had entered on the Badger.Net platform. The analysis in this report is based on these data, held in the National Neonatal Research Database (NNRD)

Transmitter precoding for multi-antenna multi-user communications

Emerging wireless sensor networks and existing wireless cellular and ad hoc networks motivate the design of low-power receivers. Multi-user interference drastically reduces the energy efficiency of wireless multi-user communications by introducing errors in the bits being detected at the receiver. Interference rejection algorithms and multiple antenna techniques can significantly reduce the bit-error-rate at the receiver. Unfortunately, while interference rejection algorithms burden the receiver with heavy signal processing functionalities, thereby increasing the power consumption at the receiver, the small size of receivers, specifically in sensor networks and in downlink cellular communications, prohibits the use of multiple receive antennas. In a broadcast channel, where a central transmitter is transmitting independent streams to decentralized receivers, it is possible for the transmitter to have a priori knowledge of the interference. Multiple antennas can be used at the transmitter to enhance energy efficiency. In some systems, the transmitter has access to virtually an infinite source of power. A typical example would be the base station transmitter for the downlink of a cellular system. The power consumption at receivers can be reduced if some of the signal processing functionality of the receiver is moved to the transmitter.;In this thesis, we consider a wireless broadcast channel with a transmitter equipped with multiple antennas and having a priori knowledge of interference. Our objective is to minimize the receiver complexity by adding extra signal processing functions to the transmitter. We need to determine the optimal signal that should be transmitted so that interference is completely eliminated, and the benefits that can be obtained by using multiple transmit antennas can be maximized. We investigate the use of linear precoders, linear transformations made on the signal before transmission, for this purpose

Analyzing Molecular Pathways between Maternal Obesity and Risk of Endometrial Cancer in F1 Mice Generations

From the Washington University Office of Undergraduate Research Digest (WUURD), Vol. 12, 05-01-2017. Published by the Office of Undergraduate Research. Joy Zalis Kiefer, Director of Undergraduate Research and Associate Dean in the College of Arts & Sciences; Lindsey Paunovich, Editor; Helen Human, Programs Manager and Assistant Dean in the College of Arts and Sciences Mentor: Kelle Mole

Preterm nutritional intake and MRI phenotype at term age: a prospective observational study

Objective: To describe (1) the relationship between nutrition and the preterm-at-term infant phenotype, (2) phenotypic differences between preterm-at-term infants and healthy term born infants and (3) relationships between somatic and brain MRI outcomes. Design: Prospective observational study. Setting: UK tertiary neonatal unit. Participants: Preterm infants (<32 weeks gestation) (n=22) and healthy term infants (n=39) Main outcome measures: Preterm nutrient intake; total and regional adipose tissue (AT) depot volumes; brain volume and proximal cerebral arterial vessel tortuosity (CAVT) in preterm infants and in term infants. Results: Preterm nutrition was deficient in protein and high in carbohydrate and fat. Preterm nutrition was not related to AT volumes, brain volume or proximal CAVT score; a positive association was noted between human milk intake and proximal CAVT score (r=0.44, p=0.05). In comparison to term infants, preterm infants had increased total adiposity, comparable brain volumes and reduced proximal CAVT scores. There was a significant negative correlation between deep subcutaneous abdominal AT volume and brain volume in preterm infants (r=−0.58, p=0.01). Conclusions: Though there are significant phenotypic differences between preterm infants at term and term infants, preterm macronutrient intake does not appear to be a determinant. Our preliminary data suggest that (1) human milk may exert a beneficial effect on cerebral arterial vessel tortuosity and (2) there is a negative correlation between adiposity and brain volume in preterm infants at term. Further work is warranted to see if our findings can be replicated and to understand the causal mechanisms

Biodiversity Conservation Through Urban Green Spaces: A Case Study of Gujarat University Campus in Ahmedabad

The present study deals with the phytodiversity of Gujarat University campus and the surrounding region which forms an important green space in the urban environment of Ahmedabad city in Gujarat state, India. The extensive field surveys were carried out in the vast study area during 2004 to 2006 covering four different seasons viz. summer, winter, monsoon and spring to cover annual, biennial and perennial plants. A total of 451 species of flowering plants belonging to 338 genera and 101 families were recorded in the study area. Along with these three pteridophytes, two gymnosperms and the algae and fungi group appearing mostly in the monsoon season were also recorded in the study. Among the flowering plants, the herbs were found to be dominant, indicating they favored the climatic factors like less rainfall and high temperature in the study area. Raunkier’s biological life forms revealed the dominance of therophytes and phanerophytes, indicating ‘Thero-Phanerophytic’ phytoclimate in the region. The urban green spaces with such rich plant diversity need to be conserved, especially with the help of the local population, in order to maintain a good environment and biodiversity, thereby improving the overall quality of life