29 research outputs found
Ariel - Volume 9 Number 6
Executive Editor
Seth B. Paul
Associate Editor
Warren J. Ventriglia
Business Manager
Fredric Jay Matlin
University News
John Patrick Welch
World News
George Robert Coar
Editorials Editor
Steve Levine
Features
Mark Rubin
Sports Editor
Eli Saleeby
Photo Editor
Ken Buckwalter
Circulation
Victor Onufreiczuk
Lee Wugofski
Graphics and Art
Steve Hulkower
Commons Editor
Brenda Peterso
Ariel - Volume 8 Number 3
Executive Editor
James W. Lockard, Jr.
Business Manager
Neeraj K. Kanwal
University News
Richard J . Perry
World News
Doug Hiller
Opinions
Elizabeth A. McGuire
Features
Patrick P. Sokas
Sports Desk
Shahab S. Minassian
Managing Editor
Edward H. Jasper
Managing Associate
Brenda Peterson
Photography Editor
Robert D. Lehman. Jr.
Graphics
Christine M. Kuhnl
Ariel - Volume 8 Number 4
Executive Editor
James W. Lockard Jr.
Issues Editor
Neeraj K. Kanwal
Business Manager
Neeraj K. Kanwal
University News
Martin Trichtinger
World News
Doug Hiller
Opinions
Elizabeth A. McGuire
Features
Patrick P. Sokas
Sports Desk
Shahab S. Minassian
Managing Editor
Edward H. Jasper
Managing Associate
Brenda Peterson
Photography Editor
Robert D. Lehman, Jr.
Graphics
Christine M. Kuhnl
Ariel - Volume 8 Number 2
Executive Editor
James W. Lockard , Jr.
Issue Editor
Doug Hiller
Business Manager
Neeraj K. Kanwal
University News
Richard J. Perry
World News
Doug Hiller
Opinions
Elizabeth A. McGuire
Features
Patrick P. Sokas
Sports Desk
Shahab S. Minassian
Managing Editor
Edward H. Jasper
Managing Associate
Brenda Peterson
Photography Editor
Robert D. Lehman, Jr.
Graphics
Christine M. Kuhnl
Colour moult phenology and camouflage mismatch in polymorphic populations of Arctic foxes
Species that seasonally moult from brown to white to match snowy backgrounds become conspicuous and experience increased predation risk as snow cover duration declines. Long-term adaptation to camouflage mismatch in a changing climate might occur through phenotypic plasticity in colour moult phenology and or evolutionary shifts in moult rate or timing. Also, adaptation may include
evolutionary shifts towards winter brown phenotypes that forgo the winter white moult. Most studies of these processes have occurred in winter white populations, with little attention to polymorphic populations with sympatric winter brown and winter white morphs. Here, we used remote camera traps to record moult phenology and mismatch in two polymorphic populations of Arctic foxes in Sweden over 2 years. We found that the colder, more northern population moulted earlier in the autumn and later in the spring. Next, foxes
moulted earlier in the autumn and later in the spring during colder and snowier years. Finally, white foxes experienced relatively low camouflage mismatch while blue foxes were mismatched against snowy backgrounds most of the autumn through the spring. Because the brown-on-white mismatch imposes no evident costs, we predict that as snow duration decreases, increasing blue morph frequencies might help facilitate species persistence
The Biochemical Basis of CDK Phosphorylation-independent Regulation of E2F1 by the Retinoblastoma Protein
The pRB (retinoblastoma protein) has a central role in the control of the G(1)-S phase transition of the cell cycle that is mediated in part through the regulation of E2F transcription factors. Upon S-phase entry pRB is phosphorylated extensively, which in turn releases bound E2Fs to drive the expression of the genes required for S-phase progression. In the present study, we demonstrate that E2F1-maintains the ability to interact with ppRB (hyperphosphorylated pRB). This interaction is dependent upon the \u27specific\u27 E2F1-binding site located in the C-terminal domain of pRB. A unique region of the marked box domain of E2F1 contacts the \u27specific\u27 site to mediate the interaction with ppRB. The mechanistic basis of the interaction between E2F1 and ppRB is subtle. A single substitution between valine and proline residues in the marked box distinguishes E2F1\u27s ability to interact with ppRB from the inability of E2F3 to bind to the \u27specific\u27 site in ppRB. The E2F1-pRB interaction at the \u27specific\u27 site also maintains the ability to regulate the transcriptional activation of E2F1 target genes. These data reveal a mechanism by which E2F1 regulation by pRB can persist, when pRB is hyperphosphorylated and presumed to be inactive
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Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data.
BACKGROUND: The implementation of multimodality monitoring in the clinical management of patients with disorders of consciousness (DoC) results in physiological measurements that can be collected in a continuous and regular fashion or even at waveform resolution. Such data are considered part of the "Big Data" available in intensive care units and are potentially suitable for health care-focused artificial intelligence research. Despite the richness in content of the physiological measurements, and the clinical implications shown by derived metrics based on those measurements, they have been largely neglected from previous attempts in harmonizing data collection and standardizing reporting of results as part of common data elements (CDEs) efforts. CDEs aim to provide a framework for unifying data in clinical research and help in implementing a systematic approach that can facilitate reliable comparison of results from clinical studies in DoC as well in international research collaborations. METHODS: To address this need, the Neurocritical Care Society's Curing Coma Campaign convened a multidisciplinary panel of DoC "Physiology and Big Data" experts to propose CDEs for data collection and reporting in this field. RESULTS: We report the recommendations of this CDE development panel and disseminate CDEs to be used in physiologic and big data studies of patients with DoC. CONCLUSIONS: These CDEs will support progress in the field of DoC physiologic and big data and facilitate international collaboration