Thirty percent of ductal carcinoma in situ of the breast in Japan is extremely low-grade ER(+)/HER2(-) type without comedo necrosis

Background Overdiagnosis in mammography (MMG) is a problem. Combination of MMG and ultrasonography for breast cancer screening may increase overdiagnosis. Most cases of overdiagnosis are low-grade ductal carcinoma in situ (LGD), but no reports have focused on them. Materials and methods We immunostained 169 ductal carcinoma in situ (DCIS) cases for ER, PgR, HER2 and Ki67 and classified them into 4 subtypes : ER(+)/ HER2(-), ER(+)/HER2(+), ER(-)/HER2(-) and ER(-)/HER2(+). The Ki67 index was used to evaluate the grade of malignancy and examined for correlations with each ER/HER2 subtype and the nuclear grade (NG), with/without comedo necrosis. Results The Ki67 index correlated significantly with NG, both with/without comedo necrosis, and reliably evaluated the grade of malignancy. The index for ER(+)/HER2(-) (n=117, 69.2%) was 7.45±7.10, which was significantly lower than for each of the other types. The index was 5.71±6.94 for ER(+)/HER2(-) without comedo necrosis (n=52, 30.8%), which was significantly lower than with comedo necrosis. This was considered LGD, characterized by absence of microcalcification in MMG and either presence of a solid mass or cystic lesion or absence of hypoechoic areas in ultrasound. Conclusion In Japan, ER(+)/HER2(-) without comedo necrosis accounts for about 30% of DCIS and is LGD. This may be being overdiagnosed

三重県地域住民に対するみそ汁の減塩指導の実践についての検討

昭和55年において,三重県地域住民に対する各保健所の健康教室,集団検診などの参加者1,201世帯を対象とし,参加者に持参させたみそ汁の食塩濃度を測定した。その結果について検討をおこなった。(1)三重県下地域住民のみそ汁の食塩濃度の平均値は1.08%であったが,各保健所ともにその値に著しいバラツキがみられた。(2)上記みそ汁の適正濃度(0.8%)以上のからずき世帯率を保健所別にみた場合は,桑名では67.8%,四日市では62.5%,鈴鹿では79.5%,津では74.6%,松阪では72.8%,上野では81.2%であった。このからすぎ世帯率において,高血圧者在宅世帯と非高血圧者在宅世帯との間には相関関係はみられなかった。(3)ついで,保健所別脳血管疾患死亡率とからずき世帯率との間には相関関係は認められなかった。In 1980 having 1,201 families participated in the health school and mass examination was held by the Regional Health Centers in Mie Prefecture. And, salt concentrations of miso soup brought by those participants were measured. The results were analyzed as follows: (1) The mean concentration of salt in miso soup referring to the regional inhabitants in Mie Prefecture was 1.08%, however, the values were markedly fluctuated by Health Centers. (2) Those families in favor of the saltier taste than the adequate concentration (0.8%) of the miso soup were noted at 67.8% in Kuwana, 62.5% in Yokkaichi, 79.5% in Suzuka, 74.6% in Tsu, 72.8% in Matsuzaka and 81.2% in Ueno. Among those families of salty taste lovers, no correlation was observed between hypertension and nonhypertension. (3) When classified by Health Centers, no correlation was observed between the mortality from cerebrovascular diseases and the percentage of salty taste loving families

The status of crop-livestock systems and evolution towards integration

This article presents the current state of crop-livestock systems in developing countries, and reviews the recent literature on “ crop-livestock integration” as an alternative land use option for agro-pastoralists to cope with the changing environment in sub-saharan Africa and other developing regions. Mixed crop-livestock systems are one of the dominant agricultural systems in the developing world. While crop-livestock systems tremendously vary across different biophysical and demographic settings, agro-pastoralists face challenges such as population growth and globalisation. Changes in the lifestyles of agro-pastoralists and market access tend to lead to commercialised farming, while population pressures lead to scarcities and degradation of resources for conventional extensive farming. Crop-livestock integration is viewed as an economically feasible and environmentally sound solution for poor agro-pastoralists to achieve sustainable agricultural production. Optimal pathways for crop-livestock integration should achieve the best utilisation of locally available resources without much reliance on external inputs through recycling of crop/animal residuals. Although such pathways may be determined by use of systems analysis, it is recognised that the realities of the system are often more complicated than the predicted optimal pathways suggest, due to diversities in agro-ecological, demographic, and market conditions as well as to socio-economic factors. Hence, this review investigates the determinants of crop-livestock intensification and summarizes inferences for future research challenges. It draws the conclusion that crop-livestock integration should be analysed from a holistic/integrated perspective

Major decline in marine and terrestrial animal consumption by brown bears (Ursus arctos).

北海道のヒグマ、肉食から草食傾向へ。明治以降の開発が影響か？ －考古試料の安定同位体分析から－ 京都大学プレスリリース. 2015-03-27.Human activities have had the strongest impacts on natural ecosystems since the last glacial period, including the alteration of interspecific relationships such as food webs. In this paper, we present a historical record of major alterations of trophic structure by revealing millennium-scale dietary shifts of brown bears (Ursus arctos) on the Hokkaido islands, Japan, using carbon, nitrogen, and sulfur stable isotope analysis. Dietary analysis of brown bears revealed that salmon consumption by bears in the eastern region of Hokkaido significantly decreased from 19% to 8%. In addition, consumption of terrestrial animals decreased from 56% to 5% in western region, and 64% to 8% in eastern region. These dietary shifts are likely to have occurred in the last approximately 100-200 years, which coincides with the beginning of modernisation in this region. Our results suggest that human activities have caused an alteration in the trophic structure of brown bears in the Hokkaido islands. This alteration includes a major decline in the marine-terrestrial linkage in eastern region, and a loss of indirect-interactions between bears and wolves, because the interactions potentially enhanced deer predation by brown bears

Major decline in marine and terrestrial animal consumption by brown bears (Ursus arctos)

Human activities have had the strongest impacts on natural ecosystems since the last glacial period, including the alteration of interspecific relationships such as food webs. In this paper, we present a historical record of major alterations of trophic structure by revealing millennium-scale dietary shifts of brown bears (Ursus arctos) on the Hokkaido islands, Japan, using carbon, nitrogen, and sulfur stable isotope analysis. Dietary analysis of brown bears revealed that salmon consumption by bears in the eastern region of Hokkaido significantly decreased from 19% to 8%. In addition, consumption of terrestrial animals decreased from 56% to 5% in western region, and 64% to 8% in eastern region. These dietary shifts are likely to have occurred in the last approximately 100-200 years, which coincides with the beginning of modernisation in this region. Our results suggest that human activities have caused an alteration in the trophic structure of brown bears in the Hokkaido islands. This alteration includes a major decline in the marine-terrestrial linkage in eastern region, and a loss of indirect-interactions between bears and wolves, because the interactions potentially enhanced deer predation by brown bears

Short-term strength adaptation in isometric training to volitional failure depends on initial specific tension in elbow flexors

We tested a hypothesis that individuals with low maximal voluntary isometric contraction relative to muscle cross-sectional area (MVC/mCSA) would have greater strength gain compared to those with high MVC/mCSA in an early stage from beginning of isometric training to volitional failure. Male adults (n = 24; 22.4 ± 2.5 years, 174.1 ± 6.5 cm, 75.8 ± 14.1 kg) conducted a 3-week isometric training to volitional failure (60-80% MVC, 2-3 times/week, 3 sets/session) in elbow joint flexion with 90° flexion of each arm. Based on the relationship between MVC and mCSA before the intervention, we assigned 16 arms to the higher group (HIGH), 14 to the lower group (LOW) and 18 to the mean group (MEAN). Before the intervention and at the beginning of every week, we measured MVC (myometer) and muscle thickness of anterior upper arm (ultrasound). The mCSA was derived from muscle thickness. The 3-week isometric training to volitional failure increased MVC in all groups, but the relative change in MVC through the intervention was higher in LOW than in HIGH and MEAN groups. The current findings of this study support the abovementioned hypothesis