Black hole chemistry, the cosmological constant and the embedding tensor

We study black-hole thermodynamics in theories that contain dimensionful constants such as the cosmological constant or coupling constants in Wald's formalism. The most natural way to deal with these constants is to promote them to scalar fields introducing a (d-1)-form Lagrange multiplier that forces them to be constant on-shell. These (d-1)-form potentials provide a dual description of them and, in the context of superstring/supergravity theories, a higher-dimensional origin/explanation. In the context of gauged supergravity theories, all these constants can be collected in the embedding tensor. We show in an explicit 4-dimensional example that the embedding tensor can also be understood as a thermodynamical variable that occurs in the Smarr formula in a duality-invariant fashion. This establishes an interesting link between black-hole thermodynamics, gaugings and compactifications in the context of superstring/supergravity theories.Comment: References added, 43 pages, no figure

Komar integral and Smarr formula for axion-dilaton black holes versus S duality

We construct the Komar integral for axion-dilaton gravity using Wald’s formalism and momentum maps and we use it to derive a Smarr relation for stationary axion-dilaton black holes. While the Wald-Noether 2-form charge is not invariant under SL(2, ℝ) electric-magnetic duality transformations because Wald’s formalism does not account for magnetic charges and potentials, the Komar integral constructed with it turns out to be invariant and, in more general theories, it will be fully symplectic invariant. We check the Smarr formula obtained with the most general family of static axion-dilaton black hole

The first law of heterotic stringy black hole mechanics at zeroth order in alpha prime

We re-derive the first law of black hole mechanics in the context of the Heterotic Superstring effective action compactified on a torus to leading order in alpha prime, using Wald's formalism, covariant Lie derivatives and momentum maps. The Kalb-Ramond field strength of this theory has Abelian Chern-Simons terms which induce Nicolai-Townsend transformations of the Kalb-Ramond field. We show how to deal with all these gauge symmetries deriving the first law in terms of manifestly gauge-invariant quantities. In presence of Chern-Simons terms, several definitions of the conserved charges exist, but the formalism picks up only one of them to play a role in the first law. This work is a first step towards the derivation of the first law at first order in alpha prime where, more complicated, non-Abelian, Lorentz ("gravitational") and Yang-Mills Chern-Simons terms are included in the Kalb-Ramond field strength. The derivation of a first law is a necessary step towards the derivation of a manifestly gauge-invariant entropy formula which is still lacking in the literature. In its turn, this entropy formula is needed to compare unambiguously macroscopic and microscopic black hole entropies.Comment: A complete example in which the momentum maps of a non-extremal, charged, black ring are computed, has been added to the paper. 45 page

Clarithromycin Enhances the Antibacterial Activity and Wound Healing Capacity in Type 2 Diabetes Mellitus by Increasing LL-37 Load on Neutrophil Extracellular Traps

Background: Type 2 diabetes mellitus (T2D) is characterized by susceptibility to bacterial infections and impaired wound healing. Neutrophil extracellular traps (NETs) and the cathelicidin antimicrobial peptide LL-37 have been implicated both in defense against bacterial infections and in wound healing process. Recently, it was shown that macrolide antibiotic clarithromycin induces the release of LL-37-bearing NETs. In T2D there has not been identified any link between NETs and LL-37 and the effect of clarithromycin in neutrophils/NETs is unknown yet.Methods: Peripheral blood neutrophils were obtained from treatment-naive hyperglycemic T2D patients (naive), normoglycemic T2D patients under antidiabetic treatment (well-controlled) and healthy donors (controls). NET release and NET proteins were studied. Co-culture systems of NET structures with E. coli NCTC 9001 and primary skin fibroblasts were deployed to examine the in vitro antibacterial and fibrotic NET properties, respectively. The effect of clarithromycin was also investigated. Analysis was performed using immunofluorescence confocal microscopy, myeloperoxidase-DNA complex and LL-37 ELISA, immunoblotting and qRT-PCR.Results: NETs were characterized by the presence of LL-37, however they lacked antibacterial activity, in both groups of T2D patients. Clarithromycin significantly increased the externalization of LL-37 on NETs generated from well-controlled T2D neutrophils, thus restoring NET antibacterial capacity and promoting the wound healing process via fibroblast activation and differentiation.Conclusion: This study suggests that clarithromycin may add further advantage to well-controlled T2D patients, by enhancing their antibacterial defense and improving wound healing capacity of fibroblasts, through upregulation of LL-37 on NET structures

Black hole chemistry, the cosmological constant and the embedding tensor

We study black-hole thermodynamics in theories that contain dimensionful constants such as the cosmological constant or coupling constants in Wald's formalism. The most natural way to deal with these constants is to promote them to scalar fields introducing a (d-1)-form Lagrange multiplier that forces them to be constant on-shell. These (d-1)-form potentials provide a dual description of them and, in the context of superstring/supergravity theories, a higher-dimensional origin/explanation. In the context of gauged supergravity theories, all these constants can be collected in the embedding tensor. We show in an explicit 4-dimensional example that the embedding tensor can also be understood as a thermodynamical variable that occurs in the Smarr formula in a duality-invariant fashion. This establishes an interesting link between black-hole thermodynamics, gaugings and compactifications in the context of superstring/supergravity theories

Herpes simplex virus Type 1 encephalitis in an adolescent presenting with acute hydrocephalus

Herpes simplex virus Type 1 (HSV-1) is a human neurotropic virus causing encephalitis, corneal blindness or several peripheral nervous system disorders. Herpes Simplex encephalitis (HSE) is the most devastating clinical syndrome with severe morbidity and mortality. Hydrocephalus associated with viral meningoencephalitis is an extremely rare entity with only few documented cases, predominantly due to HSV-2 infection. HSV-1 infection of central nervous system present in the majority of the cases as encephalitis. We report a rare case of an 11-year-old child suffering from HSV-1 infection of central nervous system causing hydrocephalus without evidence of encephalitis

Primitive synovial sarcoma of suboccipital region in child

Synovial sarcoma (SS) most commonly affects the lower limbs of males in the third to fifth decades of life, with masses of the head and neck accounting for 3-10% of all cases, mainly as a metastatic lesion. The lack of specific symptoms and radiological features in addition to the diversity of their microscopic aspects may cause confusion in the diagnosis; hence, knowledge of the unusual locations of SSs is very important. The immunohistochemistry, and more recently the cytogenetic studies, contribute to the differential diagnosis. We report the case of a 12-year-old girl with a rare primary SS in the suboccipital region, which underwent complete surgical resection

Plasma levels of lipoprotein-associated phospholipase A2 are increased in patients with β-thalassemia

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an independent cardiovascular risk factor. We investigated the plasma levels of Lp-PLA2 activity and mass as a function of plasma lipid levels, LDL subclass profile, and oxidative stress in patients with β-thalassemia. Thirty-five patients with β-thalassemia major (β-TM) and 25 patients with β-thalassemia intermedia (β-TI) participated in the study. Lp-PLA2 activity and mass were measured in total plasma, in apolipoprotein (apo)B-depleted plasma (HDL-Lp-PLA2), and in LDL subclasses. Lp-PLA2 activity produced and secreted from peripheral blood monocytes in culture was also determined. Patients with β-thalassemia are characterized by a predominance of small-dense LDL particles, increased oxidative stress, and very high plasma levels of Lp-PLA2 mass and activity, despite low LDL-cholesterol levels. A significant positive correlation between plasma Lp-PLA2 activity or mass and 8-isoprostane (8-epiPGF2a) and ferritin levels as well as intima-media thickness (IMT) values was observed. An increase in secreted and cell-associated Lp-PLA2 activity from monocytes in culture was observed in both patient groups. The HDL-Lp-PLA2 activity and mass as well as the ratio of HDL-Lp-PLA2/plasma Lp-PLA2 were significantly higher in both patient groups compared with the control group. In conclusion, patients with β-thalassemia exhibit high plasma Lp-PLA2 levels, attributed to increased enzyme secretion from monocytes/macrophages and to the predominance of sdLDL particles in plasma. Plasma Lp-PLA2 is correlated with carotid IMT, suggesting that this enzyme may be implicated in premature carotid atherosclerosis observed in β-thalassemia