Medical oncology, history and its future in Iran

Systemic therapy is one of the cornerstones of cancer treatment. In 1972, following representations by American Society of Clinical Oncology (ASCO), the American Board of Internal Medicine (ABIM) recognized medical oncology as a new subspecialty of internal medicine. Subspecialty of Hematology and Medical Oncology was emerged in Iran in 1983. In the past, modern medical treatments and education were started in Dar Al-fonun school and then in Tehran University; now six universities in Iran are training in Subspecialty of Hematology and Medical Oncology. There are also ten active hematopoietic stem cell transplantation centers, thirty-one provincial medical schools, as well as medical oncology and hematology care services. Future goals for Hematology and Medical Oncology in Iran include expansion and reinforcement of multidisciplinary teams across the country, early detection and prevention of cancer, providing educational program and conducting cancer researches. To achieve these goals, it is necessary to establish Cancer Hospitals in each province that link together through a network. © 2015, Academy of Medical Sciences of the I.R. Iran. All rights reserved

Manoyloxide Sesterterpenoids from <i>Salvia mirzayanii</i>

Five new manoyloxide-type sesterterpenes were isolated from aerial parts of <i>Salvia mirzayanii,</i> a species endemic to Iran. The planar structures were established by means of 1D and 2D NMR and HRESIMS. Compounds <b>1</b>–<b>3</b> differed only in their configurations at C-13 and C-14. Assignment of relative and absolute configurations was achieved by NOESY experiments and by comparison of experimental and simulated ECD spectra of possible stereoisomers. The absolute configurations of <b>4</b> and <b>5</b> were established in a similar manner