Aplicabilidad de la plataforma Moodle para la enseñanza y aprendizaje de las ciencias morfológicas en tiempos de pandemia por covid-19

Introducción/ El diseño de un programa donde el estudiante vincule el conocimiento que adquiere por medio del empleo de entornos virtuales de enseñanza y aprendizaje con fines educativos, facilita la comunicación pedagógica entre los participantes en el proceso docente educativo; ya sea a distancia, semipresencial, presencial o de naturaleza mixta. Las condiciones impuestas por las medidas adoptadas durante la pandemia de la COVID-19, conllevó a cambiar las actividades docentes prácticas presenciales a una implementación especial virtualizada utilizando para ello la plataforma MOODLE. Objetivo/ Aplicar el uso de la plataforma MOODLE para la elaboración y desarrollo de las clases prácticas virtuales en la asignatura Célula, Tejidos y Sistema Tegumentario en la educación médica.Facultad de Odontologí

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

The global retinoblastoma outcome study : a prospective, cluster-based analysis of 4064 patients from 149 countries

DATA SHARING : The study data will become available online once all analyses are complete.BACKGROUND : Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS : We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS : The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). INTERPRETATION : This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes.The Queen Elizabeth Diamond Jubilee Trust and the Wellcome Trust.https://www.thelancet.com/journals/langlo/homeam2023Paediatrics and Child Healt

Mobile application with augmented reality to improve learning in the science and technology course for students in sixth grade of elementary education at I.E.P. Magister

La indagación titulada Aplicación móvil con realidad aumentada para mejorar el aprendizaje en el curso de ciencia y tecnología para los estudiantes de sexto grado de educación primaria de la I.E.P. Magister, tuvo como objetivo principal establecer mejoras en el aprendizaje de los estudiantes en el Curso de Ciencia y Tecnología en la I.E.P. Magister. Fue desarrollada con el marco de trabajo Mobile-D enfocado en la elaboración de software para dispositivos móviles. Se determinó su modelo de investigación como Aplicada y diseño Pre Experimental sobre un conjunto de 20 alumnos de 6to grado de educación primaria de la I.E.P. Magister, donde obtuvo una significancia de 0,002 - 0,021 menor 0,050. Se concluyó que la aplicación móvil con realidad aumentada mejora considerablemente la enseñanza en el curso de Ciencia y Tecnología para los estudiantes de 6to grado de educación primaria

Mobile Application with Augmented Reality to Improve Learning in Science and Technology

Education has taken a big turn due to the current health situation, and as a result the use of technology has become a great ally of education, achieving important benefits. Augmented reality is being used by teachers and students especially in distance and/or face-to-face learning through didactic learning, self-instruction and the promotion of research. This article shows the development and influence of a mobile application with augmented reality that serves as a reinforcement for the learning of Science and Technology in students of sixth grade of Primary and first year of Secondary School. The Mobile D methodology is used during the development process of the application, the research design is Pre-Experimental since the Pre-Test and Post-Test tests are performed to a single group of students being the total of 30, obtaining as final result the increase in the level of interest of the students to 100%, in the level of understanding there was an improvement of 50% and the level of satisfaction is maintained in a range of 40% satisfaction and very satisfied of 60%, which implies that the application helps them to improve their learning

Effects of D-003 on lipopolysaccharides-induced osteonecrosis in rabbits

D-003, a mixture of high molecular weight acids, inhibits cholesterol synthesis prior to mevalonate and prevents osteoporosis induced by ovariectomy in rats, and both osteoporosis and osteonecrosis induced by corticoids in rats. The aim of this study was to investigate effects of D-003 on lipopolysaccharides-induced osteonecrosis in rabbits. Animals were randomized into 5 groups: a sham and four groups injected with lipopolysaccharides: one treated orally with vehicle and three with D-003 (5, 25 and 200 mg/kg, respectively) during four weeks. We assessed the effects of treatments on the incidence of osteonecrosis (number of animals with osteonecrosis lesions/animals per group), the mean numbers and areas of osteonecrosis per animal and on the mean sizes of the bone marrow fat cells. The incidence of osteonecrosis in the groups of D-003 25 and 200 mg/kg was significantly lower than in the positive controls. The reduction of osteonecrosis increased with the doses, but significant dose-dependence relationship was not achieved. D-003 significantly and dose-dependently decreased the number of osteonecrosis lesions per animal as compared to the positive controls. Likewise, the mean osteonecrosis areas in the proximal femoral and humeral bones were significantly decreased by D-003. The injection of lipopolysaccharides significantly increased the average size of bone marrow fat cells as compared to the negative controls, and such increase was significantly and markedly reduced with D-003. It is concluded that D-003 reduced the incidence, number and percent areas of osteonecrosis lesions, and the size of bone marrow fat cells, a marker of adipogenesis, in rabbits with lipopolysaccharides-induced ostenonecrosis

A comparison of the effects of D-003, a mixture of high molecular weight (16

Abstract Osteonecrosis (ON) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. Corticoid-induced ON in rats and lipopolysaccharide (LPS)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. D-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the osteoclast apoptosis. This study investigated the effects of D-003 on corticoid-and LPS-induced ON in rats and rabbits. Corticoi

Comportamiento de disfunción sexual en adultos mayores masculinos

A cross-sectional descriptive study was performed to characterize the sexuality of older adults who attend sexual dysfunction consultation in Baracoa during 2014. The sample of 80 male patients diagnosed with erectile sexual dysfunction in consultation of Sexology, Baracoa. The variables were used: most frequent diseases, risk factors, sources of knowledge and most affected areas. The primary data was obtained from the interview and serological survey. Hypertension and chronic disease and smoking as a risk factor in the elderly studied with erectile sexual dysfunction. The most affected was in the emotional sphere. Information on sexuality came to them to friends demonstrating less information about the physiological changes that affect the quality of sexual function. It is recommended to implement a strategy of educational intervention on lifestyle and sexuality.Se realizó un estudio descriptivo transversal para caracterizar la sexualidad de adultos mayores que asisten a la consulta de disfunción sexual de Baracoa durante el 2014. Se trabajó con una muestra intencionada de 80 pacientes de sexo masculino diagnosticados con disfunción sexual eréctil en la consulta de sexología del municipio. Las variables utilizadas fueron: enfermedades más frecuentes, factores de riesgo, fuentes de conocimiento y esferas más afectadas. El dato primario se obtuvo de la entrevista y la encuesta sexológica. La hipertensión arterial como enfermedad crónica y el tabaquismo como factor de riesgo prevalecieron en los ancianos estudiados con disfunción sexual eréctil. La mayor afectación fue en la esfera emocional. La información sobre sexualidad les llegó a los senectos por vía de amigos evidenciándose desinformación sobre los cambios fisiológicos que afectan la calidad de la función sexual. Se recomienda implementar una estrategia de intervención educativa sobre estilo de vida y sexualidad