Adaptación al Español Europeo de la Evaluación Automatizada de la Memoria Operativa (Automated Working Memory Test Battery -AWMA).

The current study presents the adaptation of Automated Working Memory Assessment into European Spanish, considering the need of calibration for accent and linguistic issues not supported by the version available. For this purpose, verbal material was carefully and properly selected, considering specificities of the European Spanish, in order to control possible effects of psycholinguistic factors, such as word length or lexical frequency, and technical aspects such as stimuli presentation speed and sound quality were also tuned. An exploratory sample of 81 children from 7- to 9-year-old was assessed to confirm that the adaptation is suitable for further use, besides, their scores were contrasted with the Argentinean children. The data showed proper validity and reliability scores, which characterize this version as a useful instrument for research purposes, and its usage in further studies should be encourage to gather normative data for Spaniards.En el presente estudio se presenta la adaptación al idioma Es-pañol Europeo de la Evaluación Automatizada de la Memoria Operativa, habiéndose tenido en cuenta la necesidad de calibración para cuestiones de acento y lingüística que no son compatibles con la versión disponible. Con este propósito, el material verbal fue seleccionado cuidadosa y apropiada-mente, teniendo en cuenta las especificidades del Español Europeo y con el fin de controlar los posibles efectos de los factores psicolingüísticos, tales como la longitud de las palabras o la frecuencia léxica, y aspectos técnicos, como la velocidad de presentación de los estímulos y la calidad de sonido también fueron controlados. Una muestra exploratoria de 81 niños de 7 a 9 años de edad se evaluó para confirmar que la adaptación es adecuada para su empleo posterior. Además las puntuaciones obtenidas se contrastaron con las de niños argentinos. Los datos mostraron una validez adecuada y una puntuación fiable, lo que permite considerar a esta versión como un instrumento útil para fines de investigación, y su empleo en futuros estu-dios debería incentivar la recopilación de datos normativos para españoles.This research was supported mainly by two grants from the Fundacion Seneca, Murcia Regional Government Agency for Science and Technology (visiting research grant 2010 to Flavia Heloisa Dos Santos and research grant 19463/PI/14), and by a grant from the Spanish Minister of Science and Innovation (research grant PSI2008-03481/PSIC)

Controlled trial of balance training using a video game console in community-dwelling older adults

gamification is a potentially attractive option for improving balance and reducing falls. to assess the effect of balance training using the NintendoTM Wii game console on balance (primary outcome), falls and fear of falling. quasi-randomised, open-label, controlled clinical trial in parallel groups, carried out on community-dwelling patients over 70 years, able to walk independently. Participants were assigned 1:1 to the intervention or control group. Balance training was conducted using the Nintendo WiiFit TM twice a week for 3 months. Balance was assessed using the Tinetti balance test (primary outcome), the unipedal stance and the Wii balance tests at baseline, 3 months and 1 year. Falls were recorded and Fear of falling was assessed by the Falls Efficacy Scale (Short-FES-I). 1,016 subjects were recruited (508 in both the intervention and the control group; of whom 274 and 356 respectively completed the 3-month assessment). There was no between-group difference in the Tinetti balance test score, with a baseline mean of 14.7 (SD 1.8) in both groups, and 15.2 (1.3) at 3 months in the intervention group compared to 15.3 (1.7) in controls; the between-group difference was 0.06 (95% CI 0.30-0.41). No differences were seen in any of the other balance tests, or in incident falls. There was a reduction in the fear of falling at 3 months, but no effect at 1 year. the study found no effect of balance training using the Nintendo TM Wii on balance or falls in older community-dwelling patients. The study protocol is available at clinicaltrials.gov under the code NCT02570178

Yo cuento, tú cuentas ... con números y letras : cinco cuentos infantiles

Las ilustraciones son de María Elisa Campuzano Rodríguez, Francisca Fe Montoya, José Ángel Jiménez García y David Belando FernándezLibro que contiene cinco cuentos infantiles con una introducción que, a modo de carta dirige a los niños, animándoles a su lectura y a dejar volar su imaginación con ella..MurciaConsejería de Educación, Formación y Empleo. Servicio de Publicaciones; Avda, de la Fama, 15; 30006 Murcia; +34 968279685; +34 968279835; [email protected]

Adaptation into European Spanish of the Automated Working Memory Test Battery

En el presente estudio se presenta la adaptación al idioma Es- pañol Europeo de la Evaluación Automatizada de la Memoria Operativa, habiéndose tenido en cuenta la necesidad de calibración para cuestiones de acento y lingüística que no son compatibles con la versión disponible. Con este propósito, el material verbal fue seleccionado cuidadosa y apropiada- mente, teniendo en cuenta las especificidades del Español Europeo y con el fin de controlar los posibles efectos de los factores psicolingüísticos, tales como la longitud de las palabras o la frecuencia léxica, y aspectos técnicos, como la velocidad de presentación de los estímulos y la calidad de sonido también fueron controlados. Una muestra exploratoria de 81 niños de 7 a 9 años de edad se evaluó para confirmar que la adaptación es adecuada para su empleo posterior. Además las puntuaciones obtenidas se contrastaron con las de niños argentinos. Los datos mostraron una validez adecuada y una puntuación fiable, lo que permite considerar a esta versión como un instrumento útil para fines de investigación, y su empleo en futuros estu- dios debería incentivar la recopilación de datos normativos para españoles.The current study presents the adaptation of Automated Work- ing Memory Assessment into European Spanish, considering the need of calibration for accent and linguistic issues not supported by the version available. For this purpose, verbal material was carefully and properly se- lected, considering specificities of the European Spanish, in order to con- trol possible effects of psycholinguistic factors, such as word length or lex- ical frequency, and technical aspects such as stimuli presentation speed and sound quality were also tuned. An exploratory sample of 81 children from 7- to 9-year-old was assessed to confirm that the adaptation is suitable for further use, besides, their scores were contrasted with the Argentinean children. The data showed proper validity and reliability scores, which characterize this version as a useful instrument for research purposes, and its usage in further studies should be encourage to gather normative data for Spaniards

Inhibition of liver trans-sulphuration pathway by propargylglycine mimics gene expression changes found in the mammary gland of weaned lactating rats: role of glutathione.

In the lactating mammary gland, weaning produces mitochondrial cytochrome c release and nuclear DNA fragmentation, as determined by gel electrophoresis. This is followed by a significant decrease in lactation. Weaning for 2 h produces an early induction of the tumour suppressor/transcription factor p53, whereas the oncoprotein c-Jun and c-Jun N-terminal kinase are elevated after 24 h of weaning when compared with controls. The expression of p21(cip1) and p27(kip1), cyclin-dependent kinase inhibitors, was significantly higher in weaned rats when compared with control lactating rats. All the changes mentioned above also happen in the lactating mammary gland when propargylglycine, an inhibitor of the liver trans-sulphuration pathway, is administered. This effect is partially reversed by N -acetylcysteine administration. The administration of buthionine sulphoximine, an irreversible inhibitor of gamma-glutamylcysteine synthetase, to lactating rats produces a decrease in GSH levels and changes in protein concentrations and gene transcripts similar to those in rats with impaired trans-sulphuration pathway. These data suggest that the inter-tissue flux of GSH is an important mechanism of L-cysteine delivery to the lactating mammary gland and emphasize the importance of this physiological event in maintaining the gene expression required to sustain lactation

Weaning induces NOS-2 expression through NF-κB modulation in the lactating mammary gland: importance of GSH

At the end of lactation the mammary gland undergoes involution, a process characterized by apoptosis of secretory cells and tissue remodelling. To gain insight into this process, we analysed the gene expression profile by oligonucleotide microarrays during lactation and after forced weaning. Up-regulation of inflammatory mediators and acute-phase response genes during weaning was found. Expression of IκBα (inhibitory κBα), a protein known to modulate NF-κB (nuclear factor-κB) nuclear translocation, was significantly up-regulated. On the other hand, there was a time-dependent degradation of IκBα protein levels in response to weaning, suggesting a role for NF-κB. Furthermore, we have demonstrated, using chromatin immunoprecipitation assays, binding of NF-κB to the NOS-2 (inducible nitric oxide synthase) promoter at the early onset of events triggered during weaning. The three isoforms of NOS are constitutively present in the lactating mammary gland; however, while NOS-2 mRNA and protein levels and, consequently, NO production are increased during weaning, NOS-3 protein levels are diminished. Western blot analyses have demonstrated that protein nitration is increased in the mammary gland during weaning, but this is limited to a few specific tyrosine-nitrated proteins. Interestingly, inhibition of GSH synthesis at the peak of lactation partially mimics these findings, highlighting the role of NO production and GSH depletion during involution

COVID-19 in hospitalized HIV-positive and HIV-negative patients : A matched study

CatedresObjectives: We compared the characteristics and clinical outcomes of hospitalized individuals with COVID-19 with [people with HIV (PWH)] and without (non-PWH) HIV co-infection in Spain during the first wave of the pandemic. Methods: This was a retrospective matched cohort study. People with HIV were identified by reviewing clinical records and laboratory registries of 10 922 patients in active-follow-up within the Spanish HIV Research Network (CoRIS) up to 30 June 2020. Each hospitalized PWH was matched with five non-PWH of the same age and sex randomly selected from COVID-19@Spain, a multicentre cohort of 4035 patients hospitalized with confirmed COVID-19. The main outcome was all-cause in-hospital mortality. Results: Forty-five PWH with PCR-confirmed COVID-19 were identified in CoRIS, 21 of whom were hospitalized. A total of 105 age/sex-matched controls were selected from the COVID-19@Spain cohort. The median age in both groups was 53 (Q1-Q3, 46-56) years, and 90.5% were men. In PWH, 19.1% were injecting drug users, 95.2% were on antiretroviral therapy, 94.4% had HIV-RNA < 50 copies/mL, and the median (Q1-Q3) CD4 count was 595 (349-798) cells/μL. No statistically significant differences were found between PWH and non-PWH in number of comorbidities, presenting signs and symptoms, laboratory parameters, radiology findings and severity scores on admission. Corticosteroids were administered to 33.3% and 27.4% of PWH and non-PWH, respectively (P = 0.580). Deaths during admission were documented in two (9.5%) PWH and 12 (11.4%) non-PWH (P = 0.800). Conclusions: Our findings suggest that well-controlled HIV infection does not modify the clinical presentation or worsen clinical outcomes of COVID-19 hospitalization

How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort

CatedresBackground: To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45-60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods: Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results: Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45-50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38-6.55 and 2.63; 1.44-4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13-4.14) and urogenital symptoms (2.54; 1.42-4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74-13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p = 0.032) were found among the three groups. Conclusions: Women living with HIV experienced a wide variety of menopausal symptoms, some of them initiated before women had any menstrual irregularity. We found a higher likelihood of somatic symptoms in peri- and post-menopausal women, while a higher likelihood of psychological and urogenital symptoms was found in post-menopausal women. Most somatic symptoms were of low or moderate severity, probably due to the good clinical and immunological situation of these women