CBA: Contextual Background Attack against Optical Aerial Detection in the Physical World

Patch-based physical attacks have increasingly aroused concerns. However, most existing methods focus on obscuring targets captured on the ground, and some of these methods are simply extended to deceive aerial detectors. They smear the targeted objects in the physical world with the elaborated adversarial patches, which can only slightly sway the aerial detectors' prediction and with weak attack transferability. To address the above issues, we propose to perform Contextual Background Attack (CBA), a novel physical attack framework against aerial detection, which can achieve strong attack efficacy and transferability in the physical world even without smudging the interested objects at all. Specifically, the targets of interest, i.e. the aircraft in aerial images, are adopted to mask adversarial patches. The pixels outside the mask area are optimized to make the generated adversarial patches closely cover the critical contextual background area for detection, which contributes to gifting adversarial patches with more robust and transferable attack potency in the real world. To further strengthen the attack performance, the adversarial patches are forced to be outside targets during training, by which the detected objects of interest, both on and outside patches, benefit the accumulation of attack efficacy. Consequently, the sophisticatedly designed patches are gifted with solid fooling efficacy against objects both on and outside the adversarial patches simultaneously. Extensive proportionally scaled experiments are performed in physical scenarios, demonstrating the superiority and potential of the proposed framework for physical attacks. We expect that the proposed physical attack method will serve as a benchmark for assessing the adversarial robustness of diverse aerial detectors and defense methods

Interaction-Driven Active 3D Reconstruction with Object Interiors

We introduce an active 3D reconstruction method which integrates visual perception, robot-object interaction, and 3D scanning to recover both the exterior and interior, i.e., unexposed, geometries of a target 3D object. Unlike other works in active vision which focus on optimizing camera viewpoints to better investigate the environment, the primary feature of our reconstruction is an analysis of the interactability of various parts of the target object and the ensuing part manipulation by a robot to enable scanning of occluded regions. As a result, an understanding of part articulations of the target object is obtained on top of complete geometry acquisition. Our method operates fully automatically by a Fetch robot with built-in RGBD sensors. It iterates between interaction analysis and interaction-driven reconstruction, scanning and reconstructing detected moveable parts one at a time, where both the articulated part detection and mesh reconstruction are carried out by neural networks. In the final step, all the remaining, non-articulated parts, including all the interior structures that had been exposed by prior part manipulations and subsequently scanned, are reconstructed to complete the acquisition. We demonstrate the performance of our method via qualitative and quantitative evaluation, ablation studies, comparisons to alternatives, as well as experiments in a real environment.Comment: Accepted to SIGGRAPH Asia 2023, project page at https://vcc.tech/research/2023/InterReco

Optical Orbital Angular Momentum Demultiplexing and Channel Equalization by Using Equalizing Dammann Vortex Grating

A novel equalizing Dammann vortex grating (EDVG) is proposed as orbital angular momentum (OAM) multiplexer to realize OAM signal demultiplexing and channel equalization. The EDVG is designed by suppressing odd diffraction orders and adjusting the grating structure. The light intensity of diffraction is subsequently distributed evenly in the diffraction orders, and the total diffraction efficiency can be improved from 53.22% to 82%. By using the EDVG, OAM demultiplexing and channel equalization can be realized. Numerical simulation shows that the bit error rate (BER) of each OAM channel can decrease to 10-4 when the bit SNR is 22 dB, and the intensity is distributed over the necessary order of diffraction evenly

Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer

Background: Incidence of early-onset (younger than 50 years of age) colorectal cancer (CRC) is increasing in many countries. Thus, elucidating the role of traditional CRC risk factors in early-onset CRC is a high priority. We sought to determine whether risk factors associated with late-onset CRC were also linked to early-onset CRC and whether association patterns differed by anatomic subsite. Methods: Using data pooled from 13 population-based studies, we studied 3767 CRC cases and 4049 controls aged younger than 50 years and 23 437 CRC cases and 35 311 controls aged 50 years and older. Using multivariable and multinomial logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to assess the association between risk factors and early-onset CRC and by anatomic subsite. Results: Early-onset CRC was associated with not regularly using nonsteroidal anti-inflammatory drugs (OR = 1.43, 95% CI = 1.21 to 1.68), greater red meat intake (OR = 1.10, 95% CI = 1.04 to 1.16), lower educational attainment (OR = 1.10, 95% CI = 1.04 to 1.16), alcohol abstinence (OR = 1.23, 95% CI = 1.08 to 1.39), and heavier alcohol use (OR = 1.25, 95% CI = 1.04 to 1.50). No factors exhibited a greater excess in early-onset compared with late-onset CRC. Evaluating risks by anatomic subsite, we found that lower total fiber intake was linked more strongly to rectal (OR = 1.30, 95% CI = 1.14 to 1.48) than colon cancer (OR = 1.14, 95% CI = 1.02 to 1.27; P = .04). Conclusion: In this large study, we identified several nongenetic risk factors associated with early-onset CRC, providing a basis for targeted identification of those most at risk, which is imperative in mitigating the rising burden of this disease

Functional informed genome-wide interaction analysis of body mass index, diabetes and colorectal cancer risk

Background: Body mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbations in metabolic traits (e.g. insulin resistance and glucose homeostasis). Identification of interactions between variation in genes and these metabolic risk factors may identify novel biologic insights into CRC etiology. Methods: To improve statistical power and interpretation for gene-environment interaction (G × E) testing, we tested genetic variants that regulate expression of a gene together for interaction with BMI (kg/m2 ) and diabetes on CRC risk among 26 017 cases and 20 692 controls. Each variant was weighted based on PrediXcan analysis of gene expression data from colon tissue generated in the Genotype-Tissue Expression Project for all genes with heritability ≥1%. We used a mixed-effects model to jointly measure the G × E interaction in a gene by partitioning the interactions into the predicted gene expression levels (fixed effects), and residual G × E effects (random effects). G × BMI analyses were stratified by sex as BMI-CRC associations differ by sex. We used false discovery rates to account for multiple comparisons and reported all results with FDR <0.2. Results: Among 4839 genes tested, genetically predicted expressions of FOXA1 (P = 3.15 × 10-5 ), PSMC5 (P = 4.51 × 10-4 ) and CD33 (P = 2.71 × 10-4 ) modified the association of BMI on CRC risk for men; KIAA0753 (P = 2.29 × 10-5 ) and SCN1B (P = 2.76 × 10-4 ) modified the association of BMI on CRC risk for women; and PTPN2 modified the association between diabetes and CRC risk in both sexes (P = 2.31 × 10-5 ). Conclusions: Aggregating G × E interactions and incorporating functional information, we discovered novel genes that may interact with BMI and diabetes on CRC risk

Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expand PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS are 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1681-3651 cases and 8696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They are significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values < 0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice

Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer.

BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC. METHODS: We studied risk for CRC associated with a weighted PRS in 12,197 participants younger than 50 years old vs 95,865 participants 50 years or older. PRS was calculated based on single nucleotide polymorphisms associated with CRC in a large-scale genome-wide association study as of January 2019. Participants were pooled from 3 large consortia that provided clinical and genotyping data: the Colon Cancer Family Registry, the Colorectal Transdisciplinary Study, and the Genetics and Epidemiology of Colorectal Cancer Consortium and were all of genetically defined European descent. Findings were replicated in an independent cohort of 72,573 participants. RESULTS: Overall associations with CRC per standard deviation of PRS were significant for early-onset cancer, and were stronger compared with late-onset cancer (P for interaction = .01); when we compared the highest PRS quartile with the lowest, risk increased 3.7-fold for early-onset CRC (95% CI 3.28-4.24) vs 2.9-fold for late-onset CRC (95% CI 2.80-3.04). This association was strongest for participants without a first-degree family history of CRC (P for interaction = 5.61 × 10-5). When we compared the highest with the lowest quartiles in this group, risk increased 4.3-fold for early-onset CRC (95% CI 3.61-5.01) vs 2.9-fold for late-onset CRC (95% CI 2.70-3.00). Sensitivity analyses were consistent with these findings. CONCLUSIONS: In an analysis of associations with CRC per standard deviation of PRS, we found the cumulative burden of CRC-associated common genetic variants to associate with early-onset cancer, and to be more strongly associated with early-onset than late-onset cancer, particularly in the absence of CRC family history. Analyses of PRS, along with environmental and lifestyle risk factors, might identify younger individuals who would benefit from preventive measures

Genetic architectures of proximal and distal colorectal cancer are partly distinct.

OBJECTIVE: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined. DESIGN: To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases and 64 159 controls of European ancestry. We characterised effect heterogeneity at CRC risk loci using multinomial modelling. RESULTS: We identified 13 loci that reached genome-wide significance (p<5×10-8) and that were not reported by previous GWASs for overall CRC risk. Multiple lines of evidence support candidate genes at several of these loci. We detected substantial heterogeneity between anatomical subsites. Just over half (61) of 109 known and new risk variants showed no evidence for heterogeneity. In contrast, 22 variants showed association with distal CRC (including rectal cancer), but no evidence for association or an attenuated association with proximal CRC. For two loci, there was strong evidence for effects confined to proximal colon cancer. CONCLUSION: Genetic architectures of proximal and distal CRC are partly distinct. Studies of risk factors and mechanisms of carcinogenesis, and precision prevention strategies should take into consideration the anatomical subsite of the tumour

Design and Experiment of a Portable Near-infrared Spectrum Detection System for Fruits and Vegetables Quality-inspection

To meet the practical needs of rapid and non-destructive detection in fruit and vegetable processing, this paper designs a developed portable near-infrared spectrum quality-detection device. In this design, the digital micromirror device of the near-infrared micro-electromechanical system is used as the light splitting element, and the detection information is obtained by a single-point detector, to realize the miniaturization design of the spectrum detection system and significantly reduce the cost. Moreover, the quality inspection model is established based on the PLS method and the principal component analysis method. From the results of the prediction set, the model established by the logarithm of the original absorption spectrum (1/R) and the PLS method is applicable, with a high correlation coefficient (0.9537) and low corrected root mean square error (0.3776). This research can provide reference data for the design of low-cost, practical, and miniaturized near-infrared spectrum detection systems

Experimental study on the galloping characteristics of single ice-coated transmission lines under oblique flows

Abstract Galloping of ice-coated transmission lines is occasionally observed under oblique wind directions. However, most current investigations on the galloping mechanisms are for flow perpendicular to the span of the transmission lines. In order to address this gap, this research studies the galloping characteristics of ice-coated transmission lines under oblique flows based on wind tunnel tests. The wind-induced displacement of an aero-elastic iced-coated transmission line model was measured with a noncontact displacement measurement equipment in a wind tunnel at different wind speeds and directions. The results show that galloping is characterized by elliptical trajectories and negative damping, which is more likely to occur under oblique flows than the direct flow (0°). At 15° wind direction, a galloping in vertical direction was observed at wind speeds above 5 m/s. At 30° wind direction, galloping was observed over the entire range of the tested wind speeds. Moreover, the galloping amplitudes under oblique flows are observed to be larger than that at the direct flows. Consequently, when the wind direction between the major winter monsoon azimuth and the lateral direction of transmission line route is between 15° and 30°, appropriate anti-galloping devices are highly recommended in practice