Genome-wide patterns of genetic variation in sweet and grain sorghum (Sorghum bicolor)

10.1186/gb-2011-12-11-r114Genome Biology1211-GNBL

Conservation and variation in mitochondrial genomes of gastropods Oncomelania hupensis and Tricula hortensis, intermediate host snails of Schistosoma in China

The complete mitochondrial genomes of intermediate host snails for Schistosoma in China were sequenced, including the sub-species Oncomelania hupensis hupensis in two types, and O. hupensis robertsoni, intermediate hosts for 5, japonicum, and Tricula hortensis, the intermediate host of S. sinensium. Four genomes have completely the same gene order as in other caenogastropods, containing 13 protein-coding genes and 22 transfer RNAs. The gene size, start codon and termination codon are mostly the same for all protein-coding genes. However, pairwise sequence alignments revealed quite different degrees of variation. The ribbed-shelled O. hupensis hupensis and the smooth-shelled but with varix O. hupensis hupensis had a lower level of genetic distance (3.1% for protein-coding genes), but the coden usages differed obviously in the mitochondrial genomes of these two types of snails, implying that their genetic difference may be larger than previously recognized. The mean genetic distance between O. hupensis hupensis and O. hupensis robertsoni was 12% for protein-coding genes, indicating a higher degree of genetic difference. In consideration of the difference in morphology and distribution, we considered that O. hupensis hupensis and O. hupensis robertsoni can be considered as separate species. The ribbed-shelled O. hupensis hupensis and smooth-shelled O. hupensis robertsoni were phylogenetically clustered together within a same clade, which was then clustered with T. hortensis, confirming their close relationship. However, species or sub-species in the Oncomelania from southeastern Asian countries should be included in future study in order to resolve the phylogenetic relationship and origination of all snails in the genus. (C) 2010 Elsevier Inc. All rights reserved

Testing super-eddington accretion on to a supermassive black hole : reverberation mapping of PG 1119+120

KH and JVHS acknowledge support from STFC grant ST/R000824/1. CH acknowledges support from the National Science Foundation of China (12122305). PD acknowledges support from NSFC grant 12022301, 11991051, and 11991054, and from National Key R&D Program of China (grant 2021YFA1600404). LCH was supported by the National Science Foundation of China (grants 11721303, 11991052,12011540375, and 12233001) and the China Manned Space Project (CMS-CSST-2021-A04, CMS-CSST-2021-A06).We measure the black hole mass and investigate the accretion flow around the local (z = 0.0502) quasar PG 1119+120. Spectroscopic monitoring with Calar Alto provides H β lags and linewidths from which we estimate a black hole mass of log (M•/M⊙) = 7.0, uncertain by ∼0.4 dex. High cadence photometric monitoring over 2 yr with the Las Cumbres Observatory provides light curves in seven optical bands suitable for intensive continuum reverberation mapping. We identify variability on two time-scales. Slower variations on a 100-d time-scale exhibit excess flux and increased lag in the u′ band and are thus attributable to diffuse bound-free continuum emission from the broad-line region. Faster variations that we attribute to accretion disc reprocessing lack a u′-band excess and have flux and delay spectra consistent with either τ ∝ λ4/3, as expected for a temperature structure of T(R) ∝ R−3/4 for a thin accretion disc, or τ ∝ λ2 expected for a slim disc. Decomposing the flux into variable (disc) and constant (host galaxy) components, we find the disc SED to be flatter than expected with ƒv ∼ const. Modelling the SED predicts an Eddington ratio of λEdd > 1, where the flat spectrum can be reproduced by a slim disc with little dust extinction or a thin disc that requires more dust extinction. While this accretion is super-Eddington, the geometry is still unclear; however, a slim disc is expected due to the high radiation pressure at these accretion rates, and is entirely consistent with our observations.Publisher PDFPeer reviewe

Ex Vivo Liver Resection and Autotransplantation as Surgical Option for Zone II–III Leiomyosarcoma of IVC: A Case Report and Literature Review

We report the first documented case of leiomyosarcoma at zone II-III of inferior vena cava with thrombi in three hepatic veins undergoing ex vivo liver resection and autotransplantation (ELRA) and hepatic veins thrombectomy. A 33-year-old female patient presented with abdominal distention and lower extremities edema. Abdominal wall varicosis and shifting dullness were positive on physical examination. Her liver function was classified as Child-Pugh B and a solid tumor at retro-hepatic vena cava extending to right atrium with thrombi in three hepatic veins were confirmed. The diagnosis of leiomyosarcoma with Budd-Chiari syndrome was highly suspected with preoperative ultrasound, echocardiogram, CT scan, and three-dimensional reconstruction. A zone II-III leiomyosarcoma of IVC origin was confirmed at surgery and ex vivo liver resection and autotransplantation, and hepatic vein thrombectomy with atrial reconstruction were performed under cardiopulmonary bypass (CPB). Operative time, anhepatic time, and CPB time were 12 h, 128 min, and 84 min, respectively. The patients experienced post-operative liver dysfunction and was cured with conservative therapy. Hepatic recurrence two years after surgery was managed with radiofrequency. The patient was alive with liver metastasis three years after surgery. Despite being regarded as an extremely aggressive procedure, ELRA could be considered in the treatment of advanced leiomyosarcoma with Budd-Chiari syndrome and hepatic vein thrombi

White blood cell subsets are associated with carotid intima-media thickness and pulse wave velocity in an older Chinese population: the Guangzhou Biobank Cohort Study

Cross-sectional associations between white blood cell (WBC) count, lymphocyte and granulocyte numbers, and carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (PWV) were examined in a novel older Chinese community sample. A total of 817 men and 760 women from a sub-study of the Guangzhou Biobank Cohort Study had a full blood count measured by an automated hematology analyzer, carotid IMT by B-mode ultrasonography and brachial-ankle PWV by a non-invasive automatic waveform analyzer. Following adjustment for confounders, WBC count (β=0.07,

A Note on Local GUT Models in F-Theory

We construct non-minimal GUT local models in the F-theory configuration. The gauge group on the bulk G_S is one rank higher than the GUT gauge group. The line bundles on the curves are non-trivial to break G_S down to the GUT gauge groups. We demonstrate examples of SU(5) GUT from G_S=SU(6) and G_S=SO(10), the flipped SU(5) from G_S=SO(10), and the SO(10) GUT from G_S=SO(12) and G_S=E_6. We obtain complete GUT matter spectra and couplings, with minimum exotic matter contents. GUT gauge group breaking to MSSM is achievable by instanton configurations.Comment: 33 pages, 6 tables; form adjusted, typos corrected, reference added, and new examples presente