105 research outputs found
152 Hsp90 AND p130cas: NOVEL REGULATORY FACTORS OF MMP-13 EXPRESSION IN HUMAN OSTEOARTHRITIC CHONDROCYTES
14 PROTEINASE-ACTIVATED RECEPTOR (PAR)-2 IN OSTEOARTHRITIC SUBCHONDRAL BONE OSTEOBLASTS: IDENTIFICATION OF A NEW THERAPEUTIC TARGET
Relaxation to thermal equilibrium in the self-gravitating sheet model
We revisit the issue of relaxation to thermal equilibrium in the so-called
"sheet model", i.e., particles in one dimension interacting by attractive
forces independent of their separation. We show that this relaxation may be
very clearly detected and characterized by following the evolution of order
parameters defined by appropriately normalized moments of the phase space
distribution which probe its entanglement in space and velocity coordinates.
For a class of quasi-stationary states which result from the violent relaxation
of rectangular waterbag initial conditions, characterized by their virial ratio
R_0, we show that relaxation occurs on a time scale which (i) scales
approximately linearly in the particle number N, and (ii) shows also a strong
dependence on R_0, with quasi-stationary states from colder initial conditions
relaxing much more rapidly. The temporal evolution of the order parameter may
be well described by a stretched exponential function. We study finally the
correlation of the relaxation times with the amplitude of fluctuations in the
relaxing quasi-stationary states, as well as the relation between temporal and
ensemble averages.Comment: 37 pages, 24 figures; some additional discussion of previous
literature and other minor modifications, final published versio
Collisionless Relaxation in Galactic Dynamics and the Evolution of Long Range Order
This talk provides a critical assessment of collisionless galactic dynamics,
focusing on the interpretation and limitations of the collisionless Boltzmann
equation and the physical mechanisms associated with collisionless relaxation.
Numerical and theoretical arguments are presented to motivate the idea that the
evolution of a system far from equilibrium should be interpreted as involving
nonlinear gravitational Landau damping, which implies a greater overall
coherence and remembrance of initial conditions than is implicit in the
conventional theory of violent relaxation.Comment: 20 pages, plain latex, no macros required, no figures a talk
presented at the 1997 Florida Workshop on Nonlinear Astronomy and Physics, to
appear in Annals of the New York Academy of Science
The health impact of remarriage behavior on chronic obstructive pulmonary disease: findings from the US longitudinal survey
<p>Abstract</p> <p>Background</p> <p>Chronic obstructive pulmonary disease (COPD) is a major disease among adults, and its deterioration was reported to be associated with psychological imbalance. Meanwhile, bereavement and divorce have proven harmful to the health status of a surviving spouse. But few studies have been conducted to evaluate the remedial effect on survivors' health outcome by remarriage after bereavement. The present study thus examined the associations between remarriage and the onset of COPD.</p> <p>Methods</p> <p>Our cohort was drawn from Health and Retirement Study participants in the United States, and consisted of 2676 subjects who were divorced or bereaved from 1992 to 2002. We then followed them for up to 11 years and assessed the incidence rate of COPD using a Cox proportional hazard model after adjusting for marital status, age, gender, education and the number of cigarettes smoked.</p> <p>Results</p> <p>Among all subjects, 224 who remarried after bereavement or divorce tended to be younger and more male dominated. Remarriage after bereavement/divorce was associated with significantly decreased risk of COPD onset for overall subjects [hazard ratio (HR): 0.51, 95% confidence interval (95% CI): 0.28-0.94], female subjects [HR: 0.36, 95% CI: 0.13-0.98], and for those under 70 years old [HR: 0.36, 95% CI: 0.17-0.79].</p> <p>Conclusion</p> <p>This study investigates the impact of remarriage on health outcome based on a large-scale population survey and indicates that remarriage significantly correlates with reduced risk of COPD incidence, even after adjusting smoking habit.</p
Conclusions of the Worldwide Integrated Assessment on the risks of neonicotinoids and fipronil to biodiversity and ecosystem functioning
Widowhood and Mortality: A Meta-Analysis
While the "widowhood effect" is well known, there is substantial heterogeneity in the magnitude of effects reported in different studies. We conducted a meta-analysis of widowhood and mortality, focusing on longitudinal studies with follow-up from the time of bereavement.A random-effects meta-analysis was conducted to calculate the overall relative risk (RR) for subsequent mortality among 2,263,888 subjects from 15 prospective cohort studies. We found a statistically significant positive association between widowhood and mortality, but the widowhood effect was stronger in the period earlier than six months since bereavement (overall RR = 1.41, 95% CI: 1.26, 1.57) compared to the effect after six months (overall RR = 1.14, 95% CI: 1.10, 1.18). Meta-regression showed that the widowhood effect was not different for those aged younger than 65 years compared to those older than 65 (P = 0.25). There was, however, a difference in the magnitude of the widowhood effect by gender; for women the RR was not statistically significantly different from the null (overall RR = 1.04, 95% CI: 1.00, 1.08), while it was for men (overall RR = 1.23, 95% CI: 1.18, 1.28).The results suggest that further studies should focus more on the mechanisms that generate this association especially among men
Assessing survival in widowers, and controls -A nationwide, six- to nine-year follow-up
To access full text version of this article. Please click on the hyperlink "View/open" at the bottom of this pageThe aim of this study was to assess if widowers had an increased mortality rate during the first 6 to 9 years after the death of their wife, compared initially to an age-matched control group and also compared to the general population of Iceland. The study base was comprised of all 371 men born in 1924-1969 who were widowed in Iceland in 1999-2001 and 357 controls, married men, who were matched by age and residence.The widowers and controls were followed through the years 2002-2007 using information from Statistics Iceland. Mortality rates were compared between the groups and also with the general population. The mortality rate comparisons were: study group vs. control group, on the one hand, and study group vs. general population on the other. Causes of death were also compared between widowers and their wives. A statistically significant increase in mortality in the widowers' group, compared to controls, was observed.Lifestyle-related factors could not be excluded as contributing to cause of death in these cases. Being a widower was related to an increased risk of death for at least 9 years after the death of their wife.Landspitali - National University Hospital in Reykjavik Iceland,
Rannis, the Icelandic Centre for Research (provides assistance to Icelandic science & technology, Reykjavik, Iceland),
Utfararstofa Islands (a funeral home, Reykjavik, Iceland),
Swedish Cancer Society (Cancerfonden),
Styrktarsjodur Lifsins samtaka um liknarmedferd (Palliative Care Association, Iceland),
Utfarastofa Kirkjugardanna (a funeral home, Reykjavik, Iceland
An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems
New information on the lethal and sublethal effects of neonicotinoids and fipronil on organisms is presented in this review, complementing the previous WIA in 2015. The high toxicity of these systemic insecticides to invertebrates has been confirmed and expanded to include more species and compounds. Most of the recent research has focused on bees and the sublethal and ecological impacts these insecticides have on pollinators. Toxic effects on other invertebrate taxa also covered predatory and parasitoid natural enemies and aquatic arthropods. Little, while not much new information has been gathered on soil organisms. The impact on marine coastal ecosystems is still largely uncharted. The chronic lethality of neonicotinoids to insects and crustaceans, and the strengthened evidence that these chemicals also impair the immune system and reproduction, highlights the dangers of this particular insecticidal classneonicotinoids and fipronil. , withContinued large scale – mostly prophylactic – use of these persistent organochlorine pesticides has the potential to greatly decreasecompletely eliminate populations of arthropods in both terrestrial and aquatic environments. Sublethal effects on fish, reptiles, frogs, birds and mammals are also reported, showing a better understanding of the mechanisms of toxicity of these insecticides in vertebrates, and their deleterious impacts on growth, reproduction and neurobehaviour of most of the species tested. This review concludes with a summary of impacts on the ecosystem services and functioning, particularly on pollination, soil biota and aquatic invertebrate communities, thus reinforcing the previous WIA conclusions (van der Sluijs et al. 2015)
Elliptical Galaxy Dynamics
A review of elliptical galaxy dynamics, with a focus on nonintegrable models.
Topics covered include torus construction; modelling axisymmetric galaxies;
triaxiality; collisionless relaxation; and collective instabilities.Comment: 97 Latex pages, 14 Postscript figures, uses aastex. To appear in
Publications of the Astronomical Society of the Pacific, February 199
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