Pengalaman Perawatan Postpartum pada Ibu yang Mengkonsumsi Rujak dan Obat Balanga

This study explores the postpartum care experience in mothers who consume rujak and balanga drugs in Banda Neira District. The method used is qualitative research using a phenomenological design. The results of this study indicate that there is research showing that the five themes include; 1) There are physical, psychological, and sexual changes after postpartum care related to culture; 2) There are cultural restrictions such as strenuous activity, food, and sexuality in postpartum care; 3) The cost factor is a reason to consider in choosing postpartum care; 4) Mothers and parents-in-law dominate sources of decision-making for postpartum care related to culture; 5) There is ambivalence in following postpartum care related to culture. This study concluded that the mother's ability to adapt to the changes in toddlers is very influential in overcoming stunting. The experience of postpartum care for mothers who consume salad and herbal medicine related to culture is influenced by several factors, namely abstinence, which includes: strenuous activity, food taboos, and sexuality.   Keywords: Culture; Consumption of Rujak and Balanga Medicine; Postpartum Car

Adaptasi Fisiologis Bayi Baru Lahir melalui Persalinan Normal dengan Lotus Birth dan Tanpa Lotus Birth

This study aims to determine the differences in the physiological adaptation of newborns through expected delivery with lotus birth and without lotus birth at Kandai Public Health Center, Kendari City. The method used is quantitative research using a comparative study with a cross-sectional approach. The results showed differences in physiological adaptation (heart rate, respiratory rate, thermoregulated frequency, or body temperature) of newborns through expected delivery with lotus birth and without lotus birth. Respondent statistical data obtained from each physiological system of newborns showed a p-value of 0.013. In conclusion, there are differences in the physiological adaptation of newborns through expected delivery with lotus birth and without lotus birth at the Kandai Public Health Center, Kendari City.   Keywords: Physiological Adaptation, Newborn, Lotus Birth, Without Lotus Birt

Identifikasi Jenis Kegagalan Persalinan Normal pada Ibu Remaja

This study aims to identify the incidence of failure of normal delivery in teenage mothers at the Masyita Women's and Children's Hospital in Makassar City. The method used is quantitative research with a cross-sectional approach. The results of this study showed that there were 46 cases of uterine inertia (25.0%), 70 cases of premature rupture of membranes (38.0%), 24 cases of severe preeclampsia (13.0%), 24 cases of preeclampsia placenta previa as many as 8 people (4.3%). the incidence of prolonged labor was 36 people (19.6%). The conclusion of this study is that there are several findings of failure of normal delivery in teenage mothers including inertia, premature rupture of membranes, severe preeclampsia, placenta previsa and prolonged parturition.   Keywords: Adolescent Mothers, Types of Childbirth, Failure of Normal Childbirt

Patterns of Using Masks in Prevention of Covid-19 Transmission in Makassar, Indonesia

The case of Covid-19 infection rate in Makassar, Indonesia is still high. Recently, the government is still implementing community activity restriction to reduce the rate of the pandemic. However, this is not enough, the policy needs to be accompanied by increasing the effectiveness of other intervention measures, including masks. This study aims to provide an overview of the behavioral pattern of using masks in the public area in Makassar. The results of this study are expected to be used as basic data in taking appropriate steps in increasing efforts to prevent the transmission of Covid-19 in Makassar. The results of the study showed that public awareness in using masks is quite high, the motivation to use masks mostly comes from intrinsic motivation, and dominantly of the subject has been able to adapt to the behavior of wearing masks. However, some behaviors of wearing masks still need to be improved with health education, including frequently put on and take off behavior when using masks, the length of time using masks replacing with new or clean ones, management of masks that have been used so those masks are disposed of in a closed container as much as possible. To maintain the behavior of wearing masks in the public, it is necessary to conduct further research on the proper technique of wearing masks to reduce the feeling of shortness of breath and discomfort that mask users complain about and the prevention of condensation on glasses users when wearing masks.

Harmonização fiscal da tributação directa na União Europeia e os preços de transferência

Mestrado em Economia e Estudos EuropeusA Problemática dos “ Preços de Transferência “, numa perspectiva fiscal tem sido objecto de diversos estudos levados a cabo pela Comissão Europeia. Tendo em conta as caracterís-ticas extremamente diversas dos regimes fiscais dos Estados – Membros, bem como as diferentes preferências nacionais, levantamos duas questões que são analisadas na presente dissertação, através de um Case Study de uma empresa multinacional do sector alimentar e que constituem os dois eixos da dissertação: 1º - Será a Harmonização Fiscal da Tributação Directa necessária ou desejável; 2º - Os “Preços de Transferência” nos Bens Intangíveis e o seu impacto nos resultados apurados para efeitos de tributação; Assim, a presente disserta-ção é dedicada à análise da definição e quantificação de “Preço “ nos bens intangíveis – Royalties numa empresa multinacional cuja empresa mãe se situa num outro Estado Mem-bro com uma diferente taxa de tributação sobre o imposto das sociedades. A análise empí-rica realizada numa empresa multinacional, permitiu verificar a complexidade na quantifi-cação do “Preço de Transferência “ no pagamento de Royalties, a aplicação do “Princípio de Plena Concorrência “ e a morosidade do processo na resolução de conflitos quando sur-ge a Dupla Tributação. Assim: Harmonização, Preço de Transferência, Princípio de Plena Concorrência, Royalties e a forma como estes conceitos interagem, constituem para o case study os grandes temas de análise.The process of “Transfer Pricing”, from the fiscal perspective has been subject of many studies by the European Commission. According to the different caracteristics of the fiscal regimes of member states, and with regards to the different national preferences, we need to pose two questions which will be analysed in this dissertation. We will be using a case study by a multinacional firm in the food industry sector which constitues two major sec-tions of the dissertation. 1º Will Fiscal Harmonization make direct taxation necessary or desirable? 2º The “Transfer Pricing” in the intangibles property and its impact on the results of the effects on taxation. It is the objective of this dissertation to analyse the definition and quantification of the term “ price” in the Intangibles such as Royalties , within a multinational companies whose headquarters are located in another member state with a different form of taxation or corporate income tax. The empirical analysis realised in a multinacional company, permitted us to check the complexity in quantification of the “transfer pricing”, royalty payments and the application of the “arm´s of length principle”, the long process in the resolution of conflicts when there double taxation occurs. Harmoni-zation, Transfer Pricing, the arm´s of length principle, royalties, and the ways that these concepts interact, contribute for the analysis of this case stud

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors.

Autophagy, particularly with BECN1, has paradoxically been highlighted as tumor promoting in Ras-driven cancers, but potentially tumor suppressing in breast and ovarian cancers. However, studying the specific role of BECN1 at the genetic level is complicated due to its genomic proximity to BRCA1 on both human (chromosome 17) and murine (chromosome 11) genomes. In human breast and ovarian cancers, the monoallelic deletion of these genes is often co-occurring. To investigate the potential tumor suppressor roles of two of the most commonly deleted autophagy genes in ovarian cancer, BECN1 and MAP1LC3B were knocked-down in atypical (BECN1+/+ and MAP1LC3B+/+) ovarian cancer cells. Ultra-performance liquid chromatography mass-spectrometry metabolomics revealed reduced levels of acetyl-CoA which corresponded with elevated levels of glycerophospholipids and sphingolipids. Migration rates of ovarian cancer cells were increased upon autophagy gene knockdown. Genomic instability was increased, resulting in copy-number alteration patterns which mimicked high grade serous ovarian cancer. We further investigated the causal role of Becn1 haploinsufficiency for oncogenesis in a MISIIR SV40 large T antigen driven spontaneous ovarian cancer mouse model. Tumors were evident earlier among the Becn1+/- mice, and this correlated with an increase in copy-number alterations per chromosome in the Becn1+/- tumors. The results support monoallelic loss of BECN1 as permissive for tumor initiation and potentiating for genomic instability in ovarian cancer

La Ética y la Función Pública

Abstract Ethics in the public function determines different areas in which the State and public servants face the uncertainty of knowing how to act based on the legitimacy of the facts. In this ethical aspect, it is necessary to act out of conviction supported by laws and norms that govern the actions of the public employee, convinced that applying a law or norm is beneficial for both the public servant and the State. This research aims to analyze the current state of ethics in the public function and how it has been oriented towards the creation of a Code of Ethics to regulate situations presented in the public sphere. From a bibliographic approach, credit is given to the research of other authors through documentary review, thus bringing together the most important studies on ethics and public function. As a result, it is highlighted that these issues have been dealt with for decades, despite the existence of codes, ways are sought to violate the laws and justify wrong human acts. Therefore, ethical participation in the development of the processes of the State and public servants has not been achieved.   Keywords: Ethics, Public Function, State, Code of EthicsLa ética en la función pública determina diferentes áreas en las cuales el Estado y los servidores públicos se enfrentan con la incertidumbre de saber cómo actuar en función de la legitimidad de los hechos. En este aspecto ético, se necesita actuar por convicción apoyado en leyes y normas que rigen el accionar del empleado público, convencidos de que aplicar una ley o norma es beneficioso tanto para el servidor público como para el Estado. Esta investigación tiene el objetivo de analizar el estado actual de la ética en la función pública y de cómo se ha ido orientando hacia la creación de un Código Deontológico para normar situaciones presentadas en el ámbito público. Desde un enfoque bibliográfico se da crédito a las investigaciones de otros autores a través de la revisión documental, reuniendo así los más importantes estudios sobre la ética y la función pública. Como resultado se resalta que estos temas se han venido tratando desde décadas atrás, a pesar de existir códigos, se buscan maneras de infringir las leyes y justificar los actos humanos errados. Por tanto, no se ha logrado una participación ética en el desarrollo de los procesos del Estado y los servidores públicos.                        

Estrés y procrastinación académica en mujeres víctimas de violencia en el noviazgo de una universidad en Lima Norte, 2023

La presente investigación tuvo como objetivo principal determinar la relación entre el estrés y la procrastinación académica en víctimas de violencia en el noviazgo en una universidad de Lima norte, 2023. La investigación fue de tipo correlacional descriptiva y de diseño no experimental, de corte transversal. La población específica del estudio estuvo conformada por 350 estudiantes, a través de un muestreo no probabilístico. Los instrumentos utilizados fueron el inventario SISCO SV-21 para medir el estrés académico y la Escala de Procrastinación Académica (EPA) para la medir la procrastinación académica. Adicionalmente se usó el inventario CUVINO-R para segmentar a la población que sufre violencia en el noviazgo. De los resultados obtenidos, se pudo identificar que el estrés y la procrastinación académica se relacionan de forma directa moderada (Rho r=.692). También se identificaron los niveles de estrés académico demostrando un nivel de intensidad moderado de estrés académico en las mujeres víctimas de violencia en el noviazgo (78.6%), nivel alto de procrastinación académica en mujeres víctimas de violencia en el noviazgo (90%). Así mismo, se pudo notar que existe relación directa y moderada entre el estrés académico y la dimensión postergación de actividades (rs=.492; p<.001) y con la dimensión autorregulación académica (rs=.631; p<.001) en mujeres víctimas de violencia en noviazgo. Por otro lado, se pudo apreciar que existe relación directa y moderada entre procrastinación académica y la dimensión estresores (rs=.344; p<.001), y con la dimensión de síntomas (rs=.746; p<.001); sin embargó, se halló una relación inversa y significativa con la dimensión estrategias de afrontamiento (rs=-.237; p<.001) en mujeres víctimas de violencia en el noviazgo en una universidad de Lima Norte, 2023. En conclusión, se confirmó que existe correlación directa moderada entre estrés y procrastinación académica

Reduction of hexavalent chromium by fasted and fed human gastric fluid. I. Chemical reduction and mitigation of mutagenicity

Abstract Evaluation of the reducing capacity of human gastric fluid from healthy individuals, under fasted and fed conditions, is critical for assessing the cancer hazard posed by ingested hexavalent chromium [Cr(VI)] and for developing quantitative physiologically-based pharmacokinetic models used in risk assessment. In the present study, the patterns of Cr(VI) reduction were evaluated in 16 paired pre- and post-meal gastric fluid samples collected from 8 healthy volunteers. Human gastric fluid was effective both in reducing Cr(VI), as measured by using the s-diphenylcarbazide colorimetric method, and in attenuating mutagenicity in the Ames test. The mean (± SE) Cr(VI)-reducing ability of post-meal samples (20.4 ± 2.6 μg Cr(VI)/mL gastric fluid) was significantly higher than that of pre-meal samples (10.2 ± 2.3 μg Cr(VI)/mL gastric fluid). When using the mutagenicity assay, the decrease of mutagenicity produced by pre-meal and post-meal samples corresponded to reduction of 13.3 ± 1.9 and 25.6 ± 2.8 μg Cr(VI)/mL gastric fluid, respectively. These data are comparable to parallel results conducted by using speciated isotope dilution mass spectrometry. Cr(VI) reduction was rapid, with > 70% of total reduction occurring within 1 min and 98% of reduction is achieved within 30 min with post-meal gastric fluid at pH 2.0. pH dependence was observed with decreasing Cr(VI) reducing capacity at higher pH. Attenuation of the mutagenic response is consistent with the lack of DNA damage observed in the gastrointestinal tract of rodents following administration of ≤ 180 ppm Cr(VI) for up to 90 days in drinking water. Quantifying Cr(VI) reduction kinetics in the human gastrointestinal tract is necessary for assessing the potential hazards posed by Cr(VI) in drinking water

Risk and protective factors of depression in the general population during the COVID-19 epidemic in Korea

Background: The risk of depression has risen in the general population during the COVID-19 epidemic. This study was conducted to explore risk and protective factors associated with depression among the general population uninfected by COVID-19. Methods: A cross-sectional study was conducted with 1,500 representative South Korean citizens aged 19–65 years through an anonymous online survey. Depression was defined as a Patient Health Questionnaire-9 score of 10 or higher. Other questionnaires included one measuring psycho-behavioural and social changes, and stress, due to COVID-19, a six-item version of the Gratitude Questionnaire (GQ-6), and a three-item version of the UCLA loneliness scale. Results: Of the 1492 participants not infected by COVID-19, 312 (20.9%) exhibited depression. Multiple logistic regression analysis revealed that depression was positively associated with COVID-19-related stress and psycho-behavioural variables such as disturbances in eating and sleeping, younger age, smoking, underlying mental illness, and loneliness scale scores. In contrast, exercise three or more times per week and GQ-6 scale scores were inversely associated with depression. Conclusion: During the COVID-19 pandemic, maintaining daily routines including eating, sleeping, and regular exercise and focusing on gratitude may be important for the prevention of depression. In addition, more attention should be paid to vulnerable populations, including young people, those with mental illnesses, and smokers, who might be more susceptible to depression