Thermography based breast cancer detection using texture features and minimum variance quantization

In this paper, we present a system based on feature extraction techniques and image segmentation techniques for detecting and diagnosing abnormal patterns in breast thermograms. The proposed system consists of three major steps: feature extraction, classification into normal and abnormal pattern and segmentation of abnormal pattern. Computed features based on Gray Level Co-occurrence Matrices (GLCM) are used to evaluate the effectiveness of textural information possessed by mass regions. A total of 20 GLCM features are extracted from thermograms. The ability of feature set in differentiating abnormal from normal tissue is investigated using a Support Vector Machine classifier, Naive Bayes classifier and K-Nearest Neighbor classifier. To evaluate the classification performance, five-fold cross validation method and Receiver operating characteristic analysis was performed. The verification results show that the proposed algorithm gives the best classification results using K-Nearest Neighbor classifier and a accuracy of 92.5 %. Image segmentation techniques can play an important role to segment and extract suspected hot regions of interests in the breast infrared images. Three image segmentation techniques: minimum variance quantization, dilation of image and erosion of image are discussed. The hottest regions of thermal breast images are extracted and compared to the original images. According to the results, the proposed method has potential to extract almost exact shape of tumors

Comparative Analysis of Limit Bearing Capacity of a Continuous Beam Depending on the Character of the Load

Determination of the bearing capacity of a structure, as well as the assessment related tothe structure failure is very valuable, not only as a simple control of beam bearing capacity,but also as a significant basis and factor in designing of structures. When the structure isexposed to the action of a proportionally increasing load, by applying the limit analysis it ispossible to determine the limit failure load which is one of the bearing capacity indicators. Inthe case when beam systems are exposed to repeated load, the limit theorems do not yield the adequate solutions, thus the adaptation theorems which made safe limit load determination possible were developed simultaneously. Applying the limit and shakedown analysis, the analysis of bearing capacity of a continuous beam with two spans was conducted in the paper.Also displayed is the difference between the values of failure forces depending on the character of load and the beam span value in order to assess justification for application of the shakedown method in the analysis of the limit bearing capacity of the beams

Mental distress during the COVID-19 pandemic of female students adults without a pre-existing mental health condition

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Attitudes of Consumers from Educons University toward Advertising through Sport among the Question how often Consumers purchase Sporting Goods

This research was aimed at gaining relevant knowledge about the attitudes of Educons University consumers toward advertising through sport among the question how often consumers purchase sporting goods. The sample included 200 students from Faculty of sport and tourism in Novi Sad, divided into six subsample groups: consumers who do not purchase sport goods at all, then consumers who purchase sport goods less than ones a month, next 1–3 a month, 4–6 a month, 7–9 a month, as well as consumers who purchase sport goods more than 10 times a month. The sample of variables contained the system of three general attitudes which were modelled by seven-point Likert scale. The results of the measuring were analyzed by multivariate analysis (MANOVA) and univariate analysis (ANOVA) and Post Hoc test. Based on the statistical analyses it was found that significant differences occur at multivariate level, as well as between all three variables at a significance level of (p=.000). Hence, it is interesting to highlight that it was found there were significant differences showed up between the consumers who purchase sport goods. The significant differences were found in two of three variables, while the consumers who purchase sport goods less than 3 times a moths had much more negative attitudes toward advertising though sport

Attitudes of Consumers from Subotica toward Advertising through Sport among the Frequency of Watching Sports Events

This investigation was aimed at gaining relevant knowledge about the attitudes of Subotica consumers toward advertising through sport among. The sample included 168 students from Chemical, Biotechnology and Medicine Department in Subotica, divided into six subsample groups: consumers, who do not watch sports events at all, then consumers who watch sports events 1-30 minutes, next 31-60 minutes, 61-90 minutes, 91-120 minutes, as well as consumers who watch sports events more than 120 minutes during the typical day. The sample of variables contained the system of three general attitudes which were modelled by seven-point Likert scale. The results of the measuring were analyzed by multivariate analysis (MANOVA) and univariate analysis (ANOVA) and Post Hoc test. Based on the statistical analyses it was found that significant differences occur at multivariate level, as well as between all three variables at a significance level of p=.00. Hence, it is interesting to highlight that it was found there are significant differences showed up between the attitudes of consumers toward advertising through sport among the frequency of watching sports events. The significant differences were found in two of three variables, while the consumers who do not watch sports events had much more negative attitudes toward advertising though sport

To MOOC or not to MOOC? Exploring MOOC readiness of YNSPEED project participants

Massive Open Online Courses (MOOCs) have become one of the most prominent extensions to distance learning, especially during the pandemic and in the post pandemic period. With the growth in the number of users of MOOCs (220 million users in 2021, excluding China) (Shah, 2021), educational opportunities within the field have been enhanced for both learners and course designers. The paper investigates the readiness of youth workers from 5 countries (Romania, Spain, Poland, Cyprus and Serbia) to engage in MOOCs either as learners or as instructors, after the training activities on MOOCs within the YNSPEED project have been completed. The data were collected using a questionnaire which was designed partially from the Driha et al. (2016) questionnaire and by a number of originally developed questions. Data were further analyzed using the SPSS software and descriptive statistic approach. The results suggest that although as many as 73.3% of the respondents have never completed a MOOC, MOOCs are perceived as an enhancement that might bring numerous benefits, but not offer the core value that traditional education brings. Apart from improving digital literacy skills, the results suggest, that MOOCs should provide a full course experience with high-quality content delivered by a renowned lecturer/university from abroad, at a lower cost, finalized by a certificate.Publishe

Effects of citric ion on hexagonal NaYF4: Yb/Er phase formation during solvothermal synthesis

Up-converting nanoparticles (UCNPs) which have ability to emit a visible light upon excitation with NIR photons are with wide applications in optoelectronic devices, forensic, biomedicine and security. The synthesis of the most efficient hexagonal β- NaYF4:Yb/Er phase in shape of uniformly sized spherical nanoparticles is usually performed through thermal decomposition of complex organic precursor in high-boiling organic solvents, which rise deep concerns regarding their potential citotoxicity. In this work, citric acid and Na-citrate are used for the stabilization of hexagonal polymorph during solvothermal processing of NaYF4:Yb/Er phase from common inorganic precursor (rare earth nitrate salts). Additionally, effect of precipitation agent, i.e. fluorine source (NaF, NH4F and NH4HF2) on the final particle morphology is deduced based on comprehensive scanning and transmission electron microscopy analyses. Detailed refinement of the X-ray powder diffraction data (XRPD) revealed simultaneous nucleation of a cubic and hexagonal phase during solvothermal reaction. The use of citric acid resulted in formation of micro- and nano- spherical particles of a hexagonal and cubic NaYF4:Yb/Er phase, respectively, while Na-citrate provoked nucleation of well crystallized hexagonal crystals of β-NaYF4:Yb/Er phase. Size of the crystallites is determined by the choice of the precipitant, and is smallest in the case when NH4F is used. All synthesized powders emit bright and intense green light due to the intensification of the 2H11/2,4S3/2 →4I15/2 electronic transitions upon the excitation by the infrared light (λ=978 nm)

Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL

BACKGROUND: Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thrombosis and death, due to the advanced age, the presence of comorbidities, and the disease and treatment-related immune deficiency. The aim of this study was to assess the risk of thrombosis and bleeding in patients with CLL affected by severe COVID-19. METHODS: This is a retrospective multicenter study conducted by ERIC, the European Research Initiative on CLL, including patients from 79 centers across 22 countries. Data collection was conducted between April and May 2021. The COVID-19 diagnosis was confirmed by the real-time polymerase chain reaction (RT-PCR) assay for SARS-CoV-2 on nasal or pharyngeal swabs. Severe cases of COVID-19 were defined by hospitalization and the need of oxygen or admission into ICU. Development and type of thrombotic events, presence and severity of bleeding complications were reported during treatment for COVID-19. Bleeding events were classified using ISTH definition. STROBE recommendations were used in order to enhance reporting. RESULTS: A total of 793 patients from 79 centers were included in the study with 593 being hospitalized (74.8%). Among these, 511 were defined as having severe COVID: 162 were admitted to the ICU while 349 received oxygen supplementation outside the ICU. Most patients (90.5%) were receiving thromboprophylaxis. During COVID-19 treatment, 11.1% developed a thromboembolic event, while 5.0% experienced bleeding. Thrombosis developed in 21.6% of patients who were not receiving thromboprophylaxis, in contrast to 10.6% of patients who were on thromboprophylaxis. Bleeding episodes were more frequent in patients receiving intermediate/therapeutic versus prophylactic doses of low-molecular-weight heparin (LWMH) (8.1% vs. 3.8%, respectively) and in elderly. In multivariate analysis, peak D-dimer level and C-reactive protein to albumin ratio were poor prognostic factors for thrombosis occurrence (OR?=?1.022, 95%CI 1.007?1.038 and OR?=?1.025, 95%CI 1.001?1.051, respectively), while thromboprophylaxis use was protective (OR?=?0.199, 95%CI 0.061?0.645). Age and LMWH intermediate/therapeutic dose administration were prognostic factors in multivariate model for bleeding (OR?=?1.062, 95%CI 1.017-1.109 and OR?=?2.438, 95%CI 1.023-5.813, respectively). CONCLUSIONS: Patients with CLL affected by severe COVID-19 are at a high risk of thrombosis if thromboprophylaxis is not used, but also at increased risk of bleeding under the LMWH intermediate/therapeutic dose administration

COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study

Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated

The evolving landscape of COVID‐19 and post‐COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL

In this retrospective international multicenter study, we describe the clinical characteristics and outcomes of patients with chronic lymphocytic leukemia (CLL) and related disorders (small lymphocytic lymphoma and high-count monoclonal B lymphocytosis) infected by SARS-CoV-2, including the development of post-COVID condition. Data from 1540 patients with CLL infected by SARS-CoV-2 from January 2020 to May 2022 were included in the analysis and assigned to four phases based on cases disposition and SARS-CoV-2 variants emergence. Post-COVID condition was defined according to the WHO criteria. Patients infected during the most recent phases of the pandemic, though carrying a higher comorbidity burden, were less often hospitalized, rarely needed intensive care unit admission, or died compared to patients infected during the initial phases. The 4-month overall survival (OS) improved through the phases, from 68% to 83%, p = .0015. Age, comorbidity, CLL-directed treatment, but not vaccination status, emerged as risk factors for mortality. Among survivors, 6.65% patients had a reinfection, usually milder than the initial one, and 16.5% developed post-COVID condition. The latter was characterized by fatigue, dyspnea, lasting cough, and impaired concentration. Infection severity was the only risk factor for developing post-COVID. The median time to resolution of the post-COVID condition was 4.7 months. OS in patients with CLL improved during the different phases of the pandemic, likely due to the improvement of prophylactic and therapeutic measures against SARS-CoV-2 as well as the emergence of milder variants. However, mortality remained relevant and a significant number of patients developed post-COVID conditions, warranting further investigations