The Ethics of Digital Being: Vulnerability, Invulnerability, and ‘Dangerous Surprises’

This chapter will engage with the notion that one of the key defining features of digital being, at least in terms of ethical engagement with others via technological interfaces and networks, is a heightened state of both invulnerability and vulnerability. Merleau-Ponty suggested that embodied existence in the world is defined by a stance of vulnerability and the anticipation of ‘dangerous surprises’. In digital existence, I suggest that our continuous, archived, digital presence, distributed in a multitude of networks, archives, databases and servers, opens us up to increased vulnerabilities of which we are only partially aware. These vulnerabilities become more present to us when we hear of, or are the victims of trolling, a data breach, hacking scandal or other form of ‘dangerous surprise’. This chapter looks in detail at two incidents: the five-year long trolling campaign against Nicola Brookes, and the ‘Ashley Madison hack’ of 2015. Using these examples, this paper will investigate the notion of vulnerability as one way to investigate being in the digital age. I argue that digital being consists of a contradictory stance to the world: of heightened invulnerability in our social encounters with others, alongside a heightened vulnerability to a host of unknown ‘dangerous surprises’. I suggest further that the negotiation of this stance is fundamental to any development of an ethics for the digital age

What does globalization do to religion?

Both of these dynamisms pose profound challenges to contemporary religious communities. The challenges of homogenization are well recognized. The erosion of local cultures impoverishes individuals and communities, reducing them to consumers bereft of traditional wisdom. Heterogenization, on the other hand, involves the increasing purification and differentiation of communities. Rather than syncretism, it threatens sectarianism; that the intimacy brought about by globalization will bring not communion, but polarization and strife. This can undermine the desire of many religions to be sources of social harmony. The heterogenizing effects of globalization foster a cultural ecology where communities close in on themselves, becoming ever-purer enclaves of the similar and thus less able to deal with difference, making religion more likely to function as a source of polarization and division both in global geopolitics and in local communitie

A Cathedral Not Made by Hands

In Laudato si’, Pope Francis offers a vision of moral responsibility rooted in awareness of the world around us. He points to St. Francis, who “looked with love” on all creatures, as a model. He writes of an “attitude of the heart, one which approaches life with serene attentiveness, which is capable of being fully present” to everyone and everything. And he also calls for an “intense dialogue” between religion and science, which has its own “gaze.” The H.J. Andrews Experimental Forest in Oregon, one of the world’s most studied ecosystems, offers an especially rich opportunity for such dialogue. Here scientists have cultivated their own gaze of “serene attentiveness.” What can theology learn by looking with scientists at such a complex ecosystem

Tears & Ashes: Three Ways of Looking at the Recent Wildfires in the West

As life in the Anthropocene unfolds ever more rapidly, what were once called “biblical” disasters — fires, floods, locusts, and whirlwinds — have become a daily reality. We watch anxiously as catastrophes occur, at least as much as our screens allow, but still go about our business: reading the next story in our newsfeed or wading into half-flooded subways to avoid being late for work. The problem we face is more difficult than mere inattentiveness: we need to cultivate a way of seeing adequate to the changed world being revealed in these catastrophes

On the relevance of bubbles and potential flows for stellar convection

Recently Pasetto et al. have proposed a new method to derive a convection theory appropriate for the implementation in stellar evolution codes. Their approach is based on the simple physical picture of spherical bubbles moving within a potential flow in dynamically unstable regions, and a detailed computation of the bubble dynamics. Based on this approach the authors derive a new theory of convection which is claimed to be parameter free, non-local and time-dependent. This is a very strong claim, as such a theory is the holy grail of stellar physics. Unfortunately we have identified several distinct problems in the derivation which ultimately render their theory inapplicable to any physical regime. In addition we show that the framework of spherical bubbles in potential flows is unable to capture the essence of stellar convection, even when equations are derived correctly.Comment: 14 pages, 3 figures. Accepted for publication in Monthly Notices of the Royal Astronomical Society. (Comments and criticism are welcomed

Auction Design Enhancements for Non-Combinatorial Auctions

We evaluate a number of possible enhancements to the FCC auctions. We consider only changes to the current auction rules that stay within the basic format of the simultaneous multiple round auction for individual licenses. This report summarizes and extends our e-mail exchanges with FCC staff on this topic. A subsequent report will cover auctions with combination bids. Overall, the FCC spectrum auctions have been an enormous success. However, there are two design goals in the auction where important improvement can be achieved within the basic rules structure. These are restricting collusion among bidders and reducing the time taken to complete the auction. This report focuses on enhancements that help to achieve these two goals. Some of the suggested changes also streamline the auction process so large auctions can be conducted more quickly without sacrificing efficiency.Auctions; Spectrum Auctions; Multiple-Round Auctions; Efficiency

Package Bidding for Spectrum Licenses

The FCC was an innovator in adopting the rules of the simultaneous ascending-price auction for its sales of spectrum licenses. While these rules have performed well in the auctions conducted so far (and would perform even better with the design improvements suggested in our first report), there are two inherent limitations in any design that seeks to assign and price the licenses individually. First, such designs create strategic incentives for bidders interested in multiple licenses that are substitutes to reduce their demands for some of the licenses in order to reduce the final prices of the others; this is the demand reduction problem. Second, even if bidders behave non-strategically, there is a fundamental problem with the basic concept of individual-license pricing when licenses are complementary. In simultaneous ascending-price auctions, from a bidder's perspective this is the exposure problem. A bidder who is unsuccessful in bidding for a large package of licenses may be left with a partial package whose total price cannot be justified in the absence of those complementary licenses it failed to win. This problem is present in any auction mechanism that sells licenses individually, with no opportunity to bid on packages. In this report our task is confined to analyses of the merits of package bidding and the practical problems of implementation. In our next report, we will outline proposals for the details of the procedural rules and other aspects of implementing a practical design, as well as the software development that would be necessary.Auctions; Spectrum Auctions; Multiple-Round Auctions; Efficiency

Phosphatidylinositol 3-kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities.

BackgroundThe phosphatidylinositol 3-kinase (PI3K) pathway is frequently altered in cancer. This report describes the landscape of PI3K alterations in solid tumors as well as co-alterations serving as potential resistance/attenuation mechanisms.MethodsConsecutive samples were analyzed in a commercial Clinical Laboratory Improvement Amendment-certified laboratory using comprehensive genomic profiling performed by next-generation sequencing (315 genes). The co-alterations evaluated included the Erb-B2 receptor tyrosine kinase 2 (ERBB2), ERBB3, ERBB4, RAS, MET proto-oncogene tyrosine kinase (MET), and mitogen-activated protein kinase kinase (MAP2K) genes as well as tumor protein 53 (TP53), estrogen receptor 1 (ESR1), and androgen receptor (AR).ResultsAlterations in any of 18 PI3K-pathway associated genes were identified in 44% of 60,991 tumors. Although single base and insertions/deletions (indels) were the most frequent alterations, copy number changes and rearrangements were identified in 11% and 0.9% of patients, respectively. Overall, the most frequently altered genes were PIK3 catalytic subunit α (PIK3CA) (13%), phosphatase and tensin homolog (PTEN) (9%), and serine/threonine kinase 11 (STK11) (5%). Tumor types that frequently harbored at least 1 PI3K alteration were uterine (77%), cervical (62%), anal (59%), and breast (58%) cancers. Alterations also were discerned frequently in tumors with carcinosarcoma (89%) and squamous cell carcinoma (62%) histologies. Tumors with a greater likelihood of co-occurring PI3K pathway and MAPK pathway alterations included colorectal cancers (odds ratio [OR], 1.64; P < .001), mesotheliomas (OR, 2.67; P = .024), anal cancers (OR, 1.98; P = .03), and nonsquamous head and neck cancers (OR, 2.03; P = .019). The co-occurrence of ESR1 and/or AR alterations with PI3K alterations was statistically significant in bladder, colorectal, uterine, prostate, and unknown primary cancers.ConclusionsComprehensive genomic profiling reveals altered PI3K-related genes in 44% of solid malignancies, including rare disease and histology types. The frequency of alterations and the co-occurrence of resistance pathways vary by tumor type, directly affecting opportunities for targeted therapy

The interaction of reading, spelling and handwriting difficulties with writing development

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