Tetanus, Diphtheria, And Pertussis Screening And Pertussis Prevention Throughout The Age Span

The purpose of this study was to determine the number (percentage) of boys, ages 9-21, who were educated on or who received the HPV vaccine at their local community clinic

Childhood adversity and cardiometabolic biomarkers in mid-adulthood in the 1958 British birth cohort

Studies that have examined associations between adverse childhood experiences (ACEs) and cardiometabolic biomarkers in adulthood are limited as they mainly focus on childhood maltreatment. This study aimed to examine the association between a range of prospectively and retrospectively reported ACEs and cardiometabolic biomarkers in mid-adulthood. Multiply-imputed data on 8511 participants from the National Child Development Study (1958 British birth cohort) were used. ACEs were prospectively reported at ages 7, 11 and 16, and retrospectively reported at age 33/44/45. Cardiometabolic outcomes assessed at age 44/45 included glycated haemoglobin (HbA1c), cholesterol (total, low- and high-density lipoprotein), triglycerides, blood pressure (systolic and diastolic), body mass index, waist circumference and metabolic syndrome. Parental separation/divorce, physical neglect, emotional neglect and psychological abuse were associated with lower HDL cholesterol. Parental offending and physical neglect were associated with higher triglyceride concentrations. Parental offending was also associated with increased HbA1c. Exposure to 2+ (vs. 0) prospective ACEs was associated with lower HDL cholesterol. All these associations were after adjustment for sex and multiple early life factors. To conclude, several individual ACEs are associated with poorer cardiometabolic risk factor profiles in mid-adulthood. Furthermore, exposure to two or more prospective ACEs is associated with lower HDL cholesterol concentrations in mid-adulthood

Are eccentricity fluctuations able to explain the centrality dependence of v4v_4?

The fourth harmonic of the azimuthal distribution of particles $v_4$ has been measured for Au-Au collisions at the Relativistic Heavy Ion Collider (RHIC). The centrality dependence of $v_4$ does not agree with the prediction from hydrodynamics. In particular, the ratio $v_4/(v_2)^2$, where $v_2$ denotes the second harmonic of the azimuthal distribution of particles, is significantly larger than predicted by hydrodynamics. We argue that this discrepancy is mostly due to elliptic flow ($v_2$) fluctuations. We evaluate these fluctuations on the basis of a Monte Carlo Glauber calculation. The effect of deviations from local thermal equilibrium is also studied, but appears to be only a small correction. Combining these two effects allows us to reproduce experimental data for peripheral and midcentral collisions. However, we are unable to explain the large magnitude of $v_4/(v_2)^2$ observed for the most central collisions.Comment: talk presented at the Strangeness in Quark Matter Conference, Buzios, Brazil, Sept. 27 - oct. 2, 200

Socioeconomic inequalities in the risk of infection with SARS-CoV-2 Delta and Omicron variants in United Kingdom, 2020-22

Objective: It is unknown whether SARS-CoV-2 exposure risks vary by socioeconomic deprivation within and across occupation sectors. We explored the risk of testing positive for Delta or Omicron variants, the predominantly dominant SARS-CoV-2 variants during our study period, within certain occupation sectors and deprivation groups in the UK. Methods and Analysis: We used the COVID-19 Infection Survey (CIS) to examine the risk of testing positive with SARS-CoV-2 across area-level deprivation and occupation sectors. We divided our cohort into Delta (02.07.2020–19.12.2021) and Omicron (20.12.2021–31.01.2022) cohorts as they were the predominantly dominant variants during our study period. Multivariable Poisson regression models were used to estimate adjusted incidence rate ratio (IRR) after adjusting for age, sex, ethnicity, comorbid conditions, urban/rural home address, household size, healthcare/client-facing job categories and calendar time. Results: There were 329,356 participants in the Delta cohort and 246,061 in the Omicron cohort. The crude incidence rate for Delta and Omicron cases were higher in the most deprived decile (Delta: 4.33 per 1000 person months; 95% CI: 4.09, 4.58; Omicron: 76.67; 71.60, 82.11) than in the least deprived decile (3.18; 3.05, 3.31; and 54.52; 51.93, 57.24, respectively); the corresponding adjusted IRRs were 1.37 (95% CI: 1.29, 1.47) and 1.34 (1.24, 1.46) during the Delta and Omicron period, respectively. The adjusted IRR for testing positive in the most deprived compared with the least deprived decile in the Delta cohort were 1.59 (1.25, 2.02) and 1.50 (1.19, 1.87) in healthcare and manufacturing or construction occupation sectors, respectively. Corresponding values in the Omicron cohort were 1.50 (1.15, 1.95) and 1.43 (1.09, 1.86) in healthcare and teaching and education sectors. The associations for the other employment sectors were not statistically significant or not tested due to small numbers. Conclusion: The risk of testing positive for SARS-CoV-2 in the Delta and Omicron cohorts was higher in the most deprived compared with the least deprived decile in healthcare, manufacturing or construction, and teaching and education sectors

Using stable isotopes to detect responses to environmental change in parapatric ctenomyid rodents

Understanding how interspecific differences in a community play out in response to historical environmental changes provides a useful foundation for predicting the evolutionary and conservation outcomes of future changes in environmental conditions. Ecological studies have increasingly utilized stable isotopes to gain insights into the diets, and hence, the floristic composition that historical populations of mammals utilized. Here, we report on the use of stable isotope analyses of rodent teeth to explore the potential role that interspecific differences in response to past environmental changes have played in shaping observed differences in genetic structure between two parapatric species of ctenomyid rodents.Fil: Takenaka, R.. University of California at Berkeley; Estados UnidosFil: Miller, M.J.. University of California at Berkeley; Estados UnidosFil: Tammone, Mauro Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto de Diversidad y Evolución Austral; ArgentinaFil: Lacey, E. A.. University of California at Berkeley; Estados UnidosFil: Dawson,T. E.. University of California at Berkeley; Estados Unidos96th Annual Meeting of the American Society of MammalogistsMinneapolisEstados UnidosAmerican Society of MammalogistsUniversity of Minnesot

Mechanistic Insight into the Early Stages of Toroidal Pore Formation by the Antimicrobial Peptide Smp24

The antimicrobial peptide Smp24, originally derived from the venom of Scorpio maurus palmatus, is a promising candidate for further drug development. However, before doing so, greater insight into the mechanism of action is needed to construct a reliable structure–activity relationship. The aim of this study was to specifically investigate the critical early stages of peptide-induced membrane disruption. Single-channel current traces were obtained via planar patch-clamp electrophysiology, with multiple types of pore-forming events observed, unlike those expected from the traditional, more rigid mechanistic models. To better understand the molecular-level structures of the peptide-pore assemblies underlying these observed conductance events, molecular dynamics simulations were used to investigate the peptide structure and orientation both before and during pore formation. The transition of the peptides to transmembrane-like states within disordered toroidal pores occurred due to a peptide-induced bilayer-leaflet asymmetry, explaining why pore stabilization does not always follow pore nucleation in the experimental observations. To fully grasp the structure–activity relationship of antimicrobial peptides, a more nuanced view of the complex and dynamic mechanistic behaviour must be adopted

Citrullination Inactivates Nicotinamide-N-methyltransferase

Nicotinamide-N-methyl transferase (NNMT) catalyzes the irreversible methylation of nicotinamide (NAM) to form N-methyl nicotinamide (MeNAM) using SAM as a methyl donor. NNMT is implicated in several chronic disease conditions, including cancers, kidney disease, cardiovascular disease, and Parkinson\u27s disease. Although phosphorylation of NNMT in gastric tumors is reported, the functional effects of this post-translational modification has not been investigated. We previously reported that citrullination of NNMT by Protein Arginine Deiminases (PADs) abolished its methyltransferase activity. Herein, we investigate the mechanism of inactivation. Using tandem MS, we identified three sites of citrullination in NNMT. With this information in hand, we used a combination of site-directed mutagenesis, kinetics, and CD experiments to demonstrate that citrullination of R132 leads to a structural perturbation that ultimately promotes NNMT inactivation

Voices for food: Methodologies for Implementing a Multi-state Community-based Intervention in Rural, High Poverty communities.

BACKGROUND: Rural communities experience unique barriers to food access when compared to urban areas and food security is a public health issue in rural, high poverty communities. A multi-leveled socio-ecological intervention to develop food policy councils (FPCs), and improve food security in rural communities was created. Methods to carry out such an intervention were developed and are described.METHODS: A longitudinal, matched treatment and comparison study was conducted in 24 rural, high poverty counties in South Dakota, Indiana, Missouri, Michigan, Nebraska and Ohio. Counties were assigned to a treatment (n = 12) or comparison (n = 12) group. Intervention activities focus on three key components that impact food security: 1) community coaching by Extension Educators/field staff, 2) FPC development, and 3) development of a MyChoice food pantry. Community coaching was only provided to intervention counties. Evaluation components focus on three levels of the intervention: 1) Community (FPCs), 2) Food Pantry Organization, and 3) Pantry Client & Families. Participants in this study were community stakeholders, food pantry directors, staff/volunteers and food pantry clients. Pantry food access/availability including pantry food quality and quantity, household food security and pantry client dietary intake are dependent variables.DISCUSSION: The results of this study will provide a framework for utilizing a multi-leveled socio-ecological intervention with the purpose of improving food security in rural, high poverty communities. Additionally, the results of this study will yield evidence-based best practices and tools for both FPC development and the transition to a guided-client choice model of distribution in food pantries. TRIAL REGISTRATION: ClinicalTrials.gov; NCT03566095 . Retrospectively registered on June, 21, 2018

Block Structured Adaptive Mesh and Time Refinement for Hybrid, Hyperbolic + N-body Systems

We present a new numerical algorithm for the solution of coupled collisional and collisionless systems, based on the block structured adaptive mesh and time refinement strategy (AMR). We describe the issues associated with the discretization of the system equations and the synchronization of the numerical solution on the hierarchy of grid levels. We implement a code based on a higher order, conservative and directionally unsplit Godunov's method for hydrodynamics; a symmetric, time centered modified symplectic scheme for collisionless component; and a multilevel, multigrid relaxation algorithm for the elliptic equation coupling the two components. Numerical results that illustrate the accuracy of the code and the relative merit of various implemented schemes are also presented.Comment: 40 pages, 10 figures, JPC in press. Extended the code test section, new convergence tests, several typos corrected. Full resolution version available at http://www.exp-astro.phys.ethz.ch/miniati/charm.pd