Hybrid Dorsal Preservation Rhinoplasty: How We Do It

Background: A difficult to correct dorsal K-area is a frequent cause of residual and/or recurrent dorsal hump in preservation rhinoplasty. Fragile osseocartilaginous elastic connections essential in static stability of nasal pyramid structure should be at least respected. A bulging of Upper Lateral Cartilage (ULC) caudally to this area are principal cause of cartilaginous hump, difficult to correct without damaging the stability. Aim: A hybrid method of a combination of structural surgery with preservation attitude was suggested. Methods and Material: Osseocartilaginous interconnection of DKA area (Dorsal K-Area) can be totally preserved with structural correction of the same area. An incision below of DKA interconnections, with high auto-spreader grafts instead of trimming the deformity was suggested. Conclusion: Septal T-segment could be freely excised as needed, sutured with high and low autospreader graft, as well with septum in desired position, without jeopardizing static stability of nasal pyramid. In our patients, no residual and/or recurrent hump was registered in immediate and as well in long term resultsinfo:eu-repo/semantics/publishedVersio

Deviated Nose: Partial Lateral Osteotomies in a New Preservation Rhinoplasty Concept

Background: A deviated nose continues to be a problem to solve in Rhinoplasty. Various techniques were presented as a possible solution of this aesthetic and functional nasal deformation. In the light of current trend of preservation of structures and function, a modification of osteotomies was presented. Goals: The goal of this paper is to present partial lateral osteotomies surgical technique performed with piezo-electric instruments. Methods and Results: Partial and incomplete osteotomies were introduced as method to avoid disinsertion of nasal pyramid of glabellar area and to avoid bony step in areas of osteotomy cut. Rhinosculpture in its extended mode was promoted for modulation of bony structure with obtaining immediate aesthetic and structural results, minoring a surgical trauma. Conclusion: An incomplete oblique transverse, lateral and intermediate osteotomies, facilitates the "slide-down" positioning of the bone edges, without the need of bone dessinsertion in glabellar region.info:eu-repo/semantics/publishedVersio

Extended Dorsal Preservation in a New Concept of Preservational Rhinoplasty

Background: A dorsal preservation rhinoplasty concept was discussed and the benefits vs. contraindications and limitations were presented. In specific cases of severe nasal septal deformations associated with necessity of major septoplasty, focused on perpendicular plate, a New Concept of Extended Dorsal Preservation Rhinoplasty is presented (New Extended PR-D). PR-D is based on septoplasty, rhinosculpture and partial osteotomies. Goals: The objective of this paper is to present a new approach in some cases of rhinoplasty named as extended dorsal preservation rhinoplasty. Methods and Results: Partial and incomplete osteotomies were introduced as method to avoid disinsertion of nasal pyramid of glabellar area and to avoid bony step in areas off osteotomy cut. Rhinosculpture in its extended mode was promoted for modulation of bony structure with obtaining immediate aesthetic and structural results, minoring a surgical trauma. Conclusion: The principles of Preservation Concept were respected in this New Extended PR-D Concept.info:eu-repo/semantics/publishedVersio

El trabajo de la fuerza de fricción en libros de texto universitarios

Considerando una revisión de la literatura relacionada con la enseñanza de la física, estamos desarrollando una investigación que analiza cómo se presenta el trabajo de las fuerzas de roce y sus relaciones con el teorema de trabajo y energía, en libros de texto de nivel universitario básico. Si bien algunos artículos ampliamente citados destacan aspectos relevantes que deberían ser considerados en el tratamiento del tema y han sido publicados hace más de dos décadas, encontramos textos que no se han hecho eco de los mismos, otros que introducen modificaciones parciales y pocos que reflejan explícitamente los cambios sugeridos. Las tendencias mencionadas se ilustran considerando tres textos de uso muy difundido en nuestro ámbito

El trabajo de la fuerza de fricción en libros de texto universitarios

Considerando una revisión de la literatura relacionada con la enseñanza de la física, estamos desarrollando una investigación que analiza cómo se presenta el trabajo de las fuerzas de roce y sus relaciones con el teorema de trabajo y energía, en libros de texto de nivel universitario básico. Si bien algunos artículos ampliamente citados destacan aspectos relevantes que deberían ser considerados en el tratamiento del tema y han sido publicados hace más de dos décadas, encontramos textos que no se han hecho eco de los mismos, otros que introducen modificaciones parciales y pocos que reflejan explícitamente los cambios sugeridos. Las tendencias mencionadas se ilustran considerando tres textos de uso muy difundido en nuestro ámbito

Relevamiento del espesor de ozono estratosférico en la provincia de Santa Cruz a partir de imágenes satelitales

A pesar de que la provincia de Santa Cruz se ve afectada periódicamente por el “agujero de ozono”, se han realizado escasas mediciones sistemáticas de espesores totales de ozono desde tierra. Es por ello que se lleva a cabo en la UNPA un proyecto cuyo objetivo es el relevamiento de espesores de ozono tomados de imágenes satelitales del TOMS, publicados en la página web de la NASA, para diferentes regiones de la provincia, durante el período 1978/2005. En este trabajo se presenta la sistematización realizada para las localidades de Caleta Olivia, San Julián y Calafate y la correlación con las mediciones en tierra para Comodoro Rivadavia (Chubut), Ushuaia (Tierra del Fuego) y San Julián. Se observa que Calafate es la más afectada, San Julián lo es en menor medida y Caleta Olivia lo ha sido esporádicamente, sólo en los últimos años. Ha aumentado la frecuencia anual de espesores entre 220 y 300 UD, siendo más pronunciado el aumento en la zona sur. La validación con los datos en tierra muestra buena correlación.Though Santa Cruz province lies some days every year under the “ozone hole”, there are few systematic ground measurements of ozone total column. There is a project at UNPA whose aim is to analyse satellite images data from TOMS published on NASA website, for different reagions of this province., for the period 1978 to 2005. This paper presents the results obtained for three towns from different regions of Santa Cruz: Caleta Olivia, San Julián and Calatafe,. and a validation with ground measurements for Comodoro Rivavia, Ushuaia and San Julián. Statistical results show that Calafate and San Julián, which are at the centre and south of the province, have higher year frequencies of low total ozone amount, Caleta Olivia, which is at the northern part of the province, was affected only for the last three years. The frequency of thickness between 220 and 300 UD increases for every town, especially at the south. There is high correlation factors with ground measurements.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Relevamiento del espesor de ozono estratosférico en la provincia de Santa Cruz a partir de imágenes satelitales

A pesar de que la provincia de Santa Cruz se ve afectada periódicamente por el “agujero de ozono”, se han realizado escasas mediciones sistemáticas de espesores totales de ozono desde tierra. Es por ello que se lleva a cabo en la UNPA un proyecto cuyo objetivo es el relevamiento de espesores de ozono tomados de imágenes satelitales del TOMS, publicados en la página web de la NASA, para diferentes regiones de la provincia, durante el período 1978/2005. En este trabajo se presenta la sistematización realizada para las localidades de Caleta Olivia, San Julián y Calafate y la correlación con las mediciones en tierra para Comodoro Rivadavia (Chubut), Ushuaia (Tierra del Fuego) y San Julián. Se observa que Calafate es la más afectada, San Julián lo es en menor medida y Caleta Olivia lo ha sido esporádicamente, sólo en los últimos años. Ha aumentado la frecuencia anual de espesores entre 220 y 300 UD, siendo más pronunciado el aumento en la zona sur. La validación con los datos en tierra muestra buena correlación.Though Santa Cruz province lies some days every year under the “ozone hole”, there are few systematic ground measurements of ozone total column. There is a project at UNPA whose aim is to analyse satellite images data from TOMS published on NASA website, for different reagions of this province., for the period 1978 to 2005. This paper presents the results obtained for three towns from different regions of Santa Cruz: Caleta Olivia, San Julián and Calatafe,. and a validation with ground measurements for Comodoro Rivavia, Ushuaia and San Julián. Statistical results show that Calafate and San Julián, which are at the centre and south of the province, have higher year frequencies of low total ozone amount, Caleta Olivia, which is at the northern part of the province, was affected only for the last three years. The frequency of thickness between 220 and 300 UD increases for every town, especially at the south. There is high correlation factors with ground measurements.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Relevamiento del espesor de ozono estratosférico en la provincia de Santa Cruz a partir de imágenes satelitales

A pesar de que la provincia de Santa Cruz se ve afectada periódicamente por el “agujero de ozono”, se han realizado escasas mediciones sistemáticas de espesores totales de ozono desde tierra. Es por ello que se lleva a cabo en la UNPA un proyecto cuyo objetivo es el relevamiento de espesores de ozono tomados de imágenes satelitales del TOMS, publicados en la página web de la NASA, para diferentes regiones de la provincia, durante el período 1978/2005. En este trabajo se presenta la sistematización realizada para las localidades de Caleta Olivia, San Julián y Calafate y la correlación con las mediciones en tierra para Comodoro Rivadavia (Chubut), Ushuaia (Tierra del Fuego) y San Julián. Se observa que Calafate es la más afectada, San Julián lo es en menor medida y Caleta Olivia lo ha sido esporádicamente, sólo en los últimos años. Ha aumentado la frecuencia anual de espesores entre 220 y 300 UD, siendo más pronunciado el aumento en la zona sur. La validación con los datos en tierra muestra buena correlación.Though Santa Cruz province lies some days every year under the “ozone hole”, there are few systematic ground measurements of ozone total column. There is a project at UNPA whose aim is to analyse satellite images data from TOMS published on NASA website, for different reagions of this province., for the period 1978 to 2005. This paper presents the results obtained for three towns from different regions of Santa Cruz: Caleta Olivia, San Julián and Calatafe,. and a validation with ground measurements for Comodoro Rivavia, Ushuaia and San Julián. Statistical results show that Calafate and San Julián, which are at the centre and south of the province, have higher year frequencies of low total ozone amount, Caleta Olivia, which is at the northern part of the province, was affected only for the last three years. The frequency of thickness between 220 and 300 UD increases for every town, especially at the south. There is high correlation factors with ground measurements.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Active Cage Mechanism of Chaperonin-Assisted Protein Folding Demonstrated at Single-Molecule Level

The cylindrical chaperonin GroEL and its lid-shaped cofactor GroES of Escherichia coil have an essential role in assisting protein folding by transiently encapsulating non-native substrate in an ATP-regulated mechanism. It remains controversial whether the chaperonin system functions solely as an infinite dilution chamber, preventing off-pathway aggregation, or actively enhances folding kinetics by modulating the folding energy landscape. Here we developed single-molecule approaches to distinguish between passive and active chaperonin mechanisms. Using low protein concentrations (100 pM) to exclude aggregation, we measured the spontaneous and GroEL/ES-assisted folding of double-mutant maltose binding protein (DM-MBP) by single-pair fluorescence resonance energy transfer and fluorescence correlation spectroscopy. We find that GroEL/ES accelerates folding of DM-MBP up to 8-fold over the spontaneous folding rate. Accelerated folding is achieved by encapsulation of folding intermediate in the GroEL/ES cage, independent of repetitive cycles of protein binding and release from GroEL. Moreover, photoinduced electron transfer experiments provided direct physical evidence that the confining environment of the chaperonin restricts polypeptide chain dynamics. This effect is mediated by the net-negatively charged wall of the GroEL/ES cavity, as shown using the GroEL mutant EL(KKK2) in which the net-negative charge is removed. EL(KKK2)/ES functions as a passive cage in which folding occurs at the slow spontaneous rate. Taken together our findings suggest that protein encapsulation can accelerate folding by entropically destabilizing folding intermediates, in strong support of an active chaperonin mechanism in the folding of some proteins. Accelerated folding is biologically significant as it adjusts folding rates relative to the speed of protein synthesis. (C) 2014 The Authors. Published by Elsevier Ltd

Delayed Care and Mortality Among Women and Men with Myocardial Infarction

Background-Women with ST-segment-elevation myocardial infarction (STEMI) have higher mortality rates than men. We investigated whether sex-related differences in timely access to care among STEMI patients may be a factor associated with excess risk of early mortality in women. Methods and Results-We identified 6022 STEMI patients who had information on time of symptom onset to time of hospital presentation at 41 hospitals participating in the ISACS-TC (International Survey of Acute Coronary Syndromes in Transitional Countries) registry (NCT01218776) from October 2010 through April 2016. Patients were stratified into time-delay cohorts. We estimated the 30-day risk of all-cause mortality in each cohort. Despite similar delays in seeking care, the overall time from symptom onset to hospital presentation was longer for women than men (median: 270 minutes [range: 130-776] versus 240 minutes [range: 120-600]). After adjustment for baseline variables, female sex was independently associated with greater risk of 30-day mortality (odds ratio: 1.58; 95% confidence interval, 1.27-1.97). Sex differences in mortality following STEMI were no longer observed for patients having delays from symptom onset to hospital presentation of (odds ratio: 0.77; 95% confidence interval, 0.29-2.02). Conclusions-Sex difference in mortality following STEMI persists and appears to be driven by prehospital delays in hospital presentation. Women appear to be more vulnerable to prolonged untreated ischemia