Jugendliche bei der XX-Jahrhundertwende

Iako je izvornik objavljen prije petnaest godina, posthumnim objavljivanjem njegova hrvatskog prijevoda želi se ukazati na trajnu vrijednost temeljnih postavki autora, koji je bio vrstan poznavatelj svijeta mladih. Autor podsjeća kako razne znanstvene discipline proučavaju i opisuju mladež, dok se on sam usredotočuje na opis društveno-političko-kulturalnog stanja mladih. Dok jedni mlade promatraju na temelju strukturalnog čitanja svijeta, drugi analiziraju njihov život govoreći o specifičnoj kulturi i supkulturi mladih. Socio-kulturalno promatranje podsjeća na relativnost pojma mladeži uočavajući namjerno produljeno trajanje mladosti u suvremenom društvu. Boljem upoznavanju mladeži doprinosi opis obilježja mladeži. U svrhu upoznavanja svijeta mladih autor spominje i izabrane interpretativne kategorije kao što su rubnost, rascjepkanost, kulturalna promjena, preobilje mogućnosti. Razmatra se i pitanje identiteta mladih, kao i neke posebne teme i problemi povezani s mladima, primjerice religija, posao, institucije, slobodno vrijeme. Vizionarskim prikazom mogućeg budućeg razvoja mladih autor ukazuje na brojne pozitivne vidove rješenja postojećih problema.Obwohl das Original vor fünfzehn Jahren veröffentlicht wurde, möchte man durch die Posthumpublikationen seiner kroatischen Übersetzung auf den dauerhaften Wert der grundlegenden Einstellungen des Autoren hinweisen, welcher ein ausgezeichneter Kenner der Jugendwelt war. Der Autor erinnert daran, wie die verschiedenartigen wissenschaftlichen Disziplinen die Jugend forschen und schildern, während er sich selbst auf die Schilderung des gesellschaftlich-politisch-kulturellen Zustands der Jugendlichen konzentriert. Während die ersten die Jugendlichen aufgrund des strukturellen Lesens der Welt betrachten, analysieren die anderen ihr Leben von der spezifischen Kultur und Subkultur der Jugendlichen sprechend. Sozial-kulturelles Betrachten macht auf die Relativität des Begriffs "Jugend" aufmerksam, einsehend das absichtlich verlängerte Dauern der Jugend in der zeitgenössischen Gesellschaft. Zu einem näheren Kennenlernen der Jugend trägt auch die deskriptive Darstellung der Jugendeigenschaften. Zum Zweck des Kennenlernens der Jugendwelt erwähnt der Autor auch die ausgewählten interpretativen Kategorien, wie z.B. am Randesein, Zerspaltung, kulturelle Änderung, Überschuß von Möglichkeiten. Die Frage der Jugendidentität wird genauso geschildert, wie auch manche speziellen Themen und Probleme mit der Jugend zusammenhängend, wie z.B. Religion, Arbeit, Insitutionen, Freizeit. Durch eine visionäre Darstellung der möglichen, künftigen Entwicklung der Jugendlichen, weist der Autor auf die zahlreichen positiven Sichten von der Lösung der bestehenden Probleme hin

BITS 2015: The annual meeting of the Italian Society of Bioinformatics

This preface introduces the content of the BioMed Central journal Supplements related to the BITS 2015 meeting, held in Milan, Italy, from the 3th to the 5th of June, 2015

Overview of BITS2005, the Second Annual Meeting of the Italian Bioinformatics Society

The BITS2005 Conference brought together about 200 Italian scientists working in the field of Bioinformatics, students in Biology, Computer Science and Bioinformatics on March 17–19 2005, in Milan. This Editorial provides a brief overview of the Conference topics and introduces the peer-reviewed manuscripts accepted for publication in this Supplement

Biowep: a workflow enactment portal for bioinformatics applications

<p>Abstract</p> <p>Background</p> <p>The huge amount of biological information, its distribution over the Internet and the heterogeneity of available software tools makes the adoption of new data integration and analysis network tools a necessity in bioinformatics. ICT standards and tools, like Web Services and Workflow Management Systems (WMS), can support the creation and deployment of such systems. Many Web Services are already available and some WMS have been proposed. They assume that researchers know which bioinformatics resources can be reached through a programmatic interface and that they are skilled in programming and building workflows. Therefore, they are not viable to the majority of unskilled researchers. A portal enabling these to take profit from new technologies is still missing.</p> <p>Results</p> <p>We designed biowep, a web based client application that allows for the selection and execution of a set of predefined workflows. The system is available on-line. Biowep architecture includes a Workflow Manager, a User Interface and a Workflow Executor. The task of the Workflow Manager is the creation and annotation of workflows. These can be created by using either the Taverna Workbench or BioWMS. Enactment of workflows is carried out by FreeFluo for Taverna workflows and by BioAgent/Hermes, a mobile agent-based middleware, for BioWMS ones. Main workflows' processing steps are annotated on the basis of their input and output, elaboration type and application domain by using a classification of bioinformatics data and tasks. The interface supports users authentication and profiling. Workflows can be selected on the basis of users' profiles and can be searched through their annotations. Results can be saved.</p> <p>Conclusion</p> <p>We developed a web system that support the selection and execution of predefined workflows, thus simplifying access for all researchers. The implementation of Web Services allowing specialized software to interact with an exhaustive set of biomedical databases and analysis software and the creation of effective workflows can significantly improve automation of in-silico analysis. Biowep is available for interested researchers as a reference portal. They are invited to submit their workflows to the workflow repository. Biowep is further being developed in the sphere of the Laboratory of Interdisciplinary Technologies in Bioinformatics – LITBIO.</p

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Jugendliche bei der XX-Jahrhundertwende

Iako je izvornik objavljen prije petnaest godina, posthumnim objavljivanjem njegova hrvatskog prijevoda želi se ukazati na trajnu vrijednost temeljnih postavki autora, koji je bio vrstan poznavatelj svijeta mladih. Autor podsjeća kako razne znanstvene discipline proučavaju i opisuju mladež, dok se on sam usredotočuje na opis društveno-političko-kulturalnog stanja mladih. Dok jedni mlade promatraju na temelju strukturalnog čitanja svijeta, drugi analiziraju njihov život govoreći o specifičnoj kulturi i supkulturi mladih. Socio-kulturalno promatranje podsjeća na relativnost pojma mladeži uočavajući namjerno produljeno trajanje mladosti u suvremenom društvu. Boljem upoznavanju mladeži doprinosi opis obilježja mladeži. U svrhu upoznavanja svijeta mladih autor spominje i izabrane interpretativne kategorije kao što su rubnost, rascjepkanost, kulturalna promjena, preobilje mogućnosti. Razmatra se i pitanje identiteta mladih, kao i neke posebne teme i problemi povezani s mladima, primjerice religija, posao, institucije, slobodno vrijeme. Vizionarskim prikazom mogućeg budućeg razvoja mladih autor ukazuje na brojne pozitivne vidove rješenja postojećih problema.Obwohl das Original vor fünfzehn Jahren veröffentlicht wurde, möchte man durch die Posthumpublikationen seiner kroatischen Übersetzung auf den dauerhaften Wert der grundlegenden Einstellungen des Autoren hinweisen, welcher ein ausgezeichneter Kenner der Jugendwelt war. Der Autor erinnert daran, wie die verschiedenartigen wissenschaftlichen Disziplinen die Jugend forschen und schildern, während er sich selbst auf die Schilderung des gesellschaftlich-politisch-kulturellen Zustands der Jugendlichen konzentriert. Während die ersten die Jugendlichen aufgrund des strukturellen Lesens der Welt betrachten, analysieren die anderen ihr Leben von der spezifischen Kultur und Subkultur der Jugendlichen sprechend. Sozial-kulturelles Betrachten macht auf die Relativität des Begriffs "Jugend" aufmerksam, einsehend das absichtlich verlängerte Dauern der Jugend in der zeitgenössischen Gesellschaft. Zu einem näheren Kennenlernen der Jugend trägt auch die deskriptive Darstellung der Jugendeigenschaften. Zum Zweck des Kennenlernens der Jugendwelt erwähnt der Autor auch die ausgewählten interpretativen Kategorien, wie z.B. am Randesein, Zerspaltung, kulturelle Änderung, Überschuß von Möglichkeiten. Die Frage der Jugendidentität wird genauso geschildert, wie auch manche speziellen Themen und Probleme mit der Jugend zusammenhängend, wie z.B. Religion, Arbeit, Insitutionen, Freizeit. Durch eine visionäre Darstellung der möglichen, künftigen Entwicklung der Jugendlichen, weist der Autor auf die zahlreichen positiven Sichten von der Lösung der bestehenden Probleme hin

Stochastic simulations on a grid framework for parameter sweep applications in biological models

Stochastic modelling and simulations play a major role in Systems Biology because, at molecular level, biological systems exhibit noise coming both from within the cell (intrinsic) and from the environment (extrinsic). Stochastic modelling takes into account the effects of noise over the system dynamics, that can strongly affect the behavior of the system in conditions of relatively low amounts of molecular species. Stochastic simulations provide an effective way to describe the system dynamics, and can be applied on systems where specified chemical species are processed by a set of biochemical reactions, each one characterized by a stochastic constant. In the context of stochastic modelling, Parameter Sweep Applications (PSAs) can be a useful way to explore the huge spaces generated by the combinations of variables and parameters values in order to test their effects on systems dynamics. PSAs are common in the scientific community and are structured as sets of instances, each one characterized by a distinct parametrisation. A PSA that aims to sample such large spaces must involve a large number of instances and hence the problem becomes very time consuming. However, the independence of each instance of a particular PSA makes the distributed computing paradigm a very useful solution for large scale PSAs. In this work we present a grid based version of a multi-volume stochastic simulator, tau-DPP, implemented on the EGEE project platform. The aim of the proposed work is to exploit this platform for testing the reliability of PSAs over the grid, pointing out critical factors, bottlenecks and scalability by providing data about our experience in this kind of biological modelling and simulations. As a case study, we present a number of PSAs for a stochastic model of bacterial chemotaxis composed of 59 reactions and 31 chemical species. © 2009 IEEE