PENGEMBANGAN MODUL MENGIDENTIFIKASI SARANA DAN PRASARANA ADMINISTRASI PERKANTORAN PADA MATA DIKLAT MEMAHAMI PRINSIP-PRINSIP PENYELENGGARAAN ADMINISTRASI PERKANTORAN UNTUK SISWA SMK NEGERI 2 BUDURAN SIDOARJO

ABSTRAK Penelitian ini bertujuan untuk mengetahui model modul yang meliputi kesesuaian materi, ketertiban bahasa, dan ilustrasi modul sebelum dan setelah dikembangkan, mengetahui kelayakan modul, dan respon siswa terhadap modul yang telah dikembangkan. Penelitian ini memiliki delapan langkah pengembangan yang telah dimodifikasi, yaitu potensi dan masalah, pengumpulan data, desain produk, validasi produk, revisi produk, uji coba produk, revisi produk, dan produksi. Hasil penelitian menunujukkan bahwa model modul sebelum dikembangkan masih terdapat beberapa kekurangan dan modul yang telah dikembangkan menyempurnakan kekurangan modul yang ada pada aspek kesesuaian materi, ketertiban bahasa, dan ilustrasi modul. Modul Mengidentifikasi Sarana dan Prasarana Administrasi Perkantoran dinyatakan sangat layak dengan hasil persentase 89,58%. Dan respon siswa terhadap modul dinyatakan sangat baik dengan persentase 81,9%. Kata kunci:   pengembangan modul, sarana dan prasarana administrasi perkatoran     ABSTRACT The purpose of this research is to knowing about before and after models of module, knowing advisability of module, and students response to the module that have been developed. This research has eight-steps development which has been modified, they are potentials and problems, data collection, product design, product validation, revision of product, product testing, product revision, and production. The result showed that the models of module before developed still has some shortcomings and developed module improve existing module shortages in suitability of the materials, orderly of language, and module illustration of aspects. Identify Facilities And Infrastructure Office Administration module stated very decent with percentage of 89,58%. And students response stated very good at rating of 81,9%. Key words:  development of module, facilities and infrastructure office administration

Exploration of Xanthone Derivatives as Anti-Cancer Agents against Colorectal Cancer

Colorectal cancer currently occupies the third position of globally cancer morbidity and is the second leading cause of cancer death after lung cancer. Chemotherapy administration is still the main modality for the colorectal cancer stage I to III. Its usage is limited, since its high resistance and risk of side effects. Thus, exploration and development of novel colorectal anti-cancer drugs, including compounds derived from nature origin is needed. Xanthone becomes one natural compound which may be potentially developed as an anti-colorectal cancer due to its cytotoxic and anti-proliferative activities. The in vitro cytotoxic and anti-proliferative actions of xanthone compounds occur through a variety of mechanisms involving both apoptotic induction and inhibition of cell cycle, while in vivo may reduce the tumor size. Since colorectal cancer is frequently treated in a combination therapy, xanthone compounds have also been studied in a combination use and proven effective as co-chemotherapy with the standard chemotherapy drugs. This paper aims at providing an overview of colorectal cancer, pathology, risk factors and protective factors, as well as discussing the current therapies and potential xanthone compounds as an alternative therapy which may be developed later for the colorectal cance

Aspirin as a Chemopreventive Agent for Cancer: a New Hope?

Introduction: inflammation has been shown to play a major role in the pathogenesis of cancer. Inflammatory process activates the immune system through pro-inflammatory mediators and subsequent triggers transformation into malignant cells. Some tumors or cancers has been associated with chronic infections, such as hepatitis B and C viruses (hepatocellular carcinoma), human papilloma virus (cervical cancer), Helicobacter pylori (gastric cancer and lymphoma), and prostatitis (prostate cancer). A considerable study have investigated the benefits of aspirin for the prevention and treatment of cancer or tumors. Objectives: This paper aims to describe the relationship between inflammation and cancer incidence, so that use of aspirin as an anti-inflammatory agent is a rational choice in the treatment and prevention of cancer. Conclusion: Aspirin potential for chemoprevention of various types of cancer. Considering the high risk of side effects of aspirin, aspirin is not intended as a routine therapy to prevent the occurrence of cancer

Analysis of Capecitabine Plus Oxaliplatin (Xelox) Combination in the Management of Metastatic Colorectal Cancer Compare with Fluorouracil and Oxaliplatin Combination (Folfox)

Background : Combinations of Fluorouracil (FU) and biomodulator Leucovorin (LV) established as a standard regimen for therapy of colorectal cancer with metastases. To give better antitumor activity in colorectal cancer therapy, oxaliplatin is combined with FU/LV and give significant improvement. Fluorouracil can only be given by intravenous administration. This limitation raised effort to find alternative drugs that can be given orally, such as capecitabine. Capecitabine is an oral FU prodrug, with high oral bioavailability, highly accumulated in neoplastic tissue to be converted in FU, and well tolerated. Some clinical studies revealed effectivity of capecitabine plus oxaliplatin (XELOX) compared to FU/LV plus oxaliplatin (FOLFOX). Objective : This article is aimed to compare non inferiority of XELOX to FOLFOX in colorectal cancer with metastases, viewed form primary outcomes and secondary outcomes. Results : XELOX was comparable to FOLFOX with some benefitsover FOLFOX. Conclusion : XELOX could be considered as FOLFOX replacement as a standard therapyfor colorectal cancer with metastases

HEDGES IN INTERVIEW OF SUNDAY TELEVISION PROGRAM JULIA GILLARD

Abstract This study examines the use of hedges in politic field, especially in interview of Sunday television program that has focus in Julia Gillard’s Utterances. The purpose of this study is to find out and describe about the types of hedges expressions and how do hedges expressions serve a function in Julia Gillard’s responds in the interview by using theories of Francoise Salager-Meyer in Miller (1994) about the typology of hedges expressions, and the function of hedges expressions. The method that is used in this research is quantitative method which is focused in analyzing the use of hedges in an interview of Julia Gillard’s at Sunday program. The result shows that the types of hedges mostly used in the interview are modal auxiliary verbs, such as can, could, will, would, should and shouldnot. The other types of hedges belong to modal lexical verbs; adjectival, adverbial, and nominal modal phrase; approximators of degree, quantity, frequency, and time; introductory phrases; and if clause. In this research the compound hedges type does not be found. While the functions are minimize the threat to face; ways of being more precise in reporting result; and as a politeness strategy. It is also possible that in each of the functions contain some of hedges types.Keywords: Hedges, Forms of Hedges, Kind of hedges Used by Julia Gillard, Sunday ProgramAbstrakPenelitian ini meneliti hedges di bidang politik, terutama dalam wawancara program televisi hari Minggu yang berfokus pada ucapan Julia Gillard. Tujuan dari penelitian ini adalah untuk mengetahui dan menjelaskan tentang jenis-jenis hedges dan bagaimana fungsi hedges bekerja dalam respon Julia Gillard dalam wawancara dengan menggunakan teori-teori Francoise Salager-Meyer dalam Miller (1994) tentang tipologi hedges, dan fungsi hedges. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif yang difokuskan dalam menganalisis penggunaan hedges dalam wawancara dengan Julia Gillard di Sunday program. Hasil penelitian menunjukkan bahwa hedges yang paling banyak digunakan dalam wawancara adalah kata kerja modal tambahan, seperti can, could, will, would, should, danshould not. Hedges lainnya termasuk modal kata kerja leksikal; frase modal kata sifat, kata keterangan, dan nominal; perkiraan derajat, kuantitas, frekuensi, dan waktu; frasa pengantar; dan jika klausa. Dalam penelitian ini, tipe gabungan hedges tidak ditemukan. Sementara fungsi hedges dalam ucapan Julia Gillard adalah meminimalkan ancaman yang akan dihadapi; cara lebih tepat dalam melaporkan hasil; dan sebagai strategi kesopanan. Dalam hal ini, memungkinkan bahwa di masing-masing fungsi bisa terdiri dari beberapa jenis hedges.Kata kunci: Hedges, Bentuk Hedges, Jenis Hedges yang Digunakanoleh Julia Gillard, Program Mingg

PENGARUH HARGA, CITRA MEREK DAN KUALITAS PRODUK TERHADAP MINAT BELI PAKAIAN DI H&M SUMMARECON MALL BEKASI

This research aims to determine simultaneously and partially the independent variables, namely price, brand image and product quality, the dependent variable is buying interest. The method used in this study is a quantitative method, which in this study uses purposive sampling calculations with the hair formula. The population in this study were all consumers of H&M clothing with a sample of 95 respondents. Based on the results of the study, in the partial test (T) the price variable has a partial negative effect on Purchase Intention with a value of 0.534 (t-count) < 1.66140 (t-table) with a significant value of 0.594 > 0.05. Brand Image variable has a negative effect on Purchase Intention with a value (t-count) of 1.461 < 1.66140 (t-table) with a significant value of 0.148 > 0.05 and Product Quality Variable has a partial positive effect on Purchase Intention with a value of 5.409 (t-count) > 1.66140 (t-table) with a significant value of 0.000 <0.05. Furthermore, in the simultaneous test (f) the price, brand image and product quality variables simultaneously have a positive effect on the purchase intention variable with a value (f-count) of 34.195 > 2.70 (f-table) with a significant value of 0.000 <0.05. Then the determination test (R2) resulted in a correlation between the three variables Price (X1), Brand Image (X2) and Product Quality (X3) on Purchase Intention (Y) of 52.8%.Penelitian yang dilakukan ini bertujuan untuk mengetahui secara simultan dan parsial dari variabel bebas yaitu Harga, Citra Merek dan kualitas produk, variabel terikat minat beli. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif, dimana dalam penelitian ini menggunakan perhitungan Purposive Sampling dengan rumus hair. Populasi dalam penelitian ini adalah seluruh konsumen pakaian H&M dengan sampel 95 responden. Berdasarkan hasil penelitian, dalam uji parsial (T) variabel Harga memiliki pengaruh negatif secara parsial terhadap Minat Beli dengan nilai 0,534 (t-hitung) < 1.66140 (t-tabel) dengan nilai signifikan 0.594 > 0.05. variabel Citra Merek memiliki pengaruh negatif terhadap Minat Beli dengan nilai (t-hitung) 1.461 < 1.66140 (t-tabel) dengan nilai signifikan 0.148 > 0.05 dan Variabel Kualitas Produk memiliki pengaruh positif secara parsial terhadap Minat Beli dengan nilai 5.409 (t-hitung) > 1.66140 (t-tabel) dengan nilai signifikan 0.000 < 0.05. Selanjutnya dalam uji simultan (f) Variabel Harga, Citra merek dan Kualitas produk secara simultan berpengaruh positif terhadap Variabel Minat Beli dengan nilai (f-hitung) sebesar 34.195 > 2.70 (f-tabel) dengan nilai signifikan 0.000 < 0.05. Kemudian uji determinasi (R2) dihasilkan bahwa korelasi antara tiga variabel Harga (X1), Citra Merek (X2) dan Kualitas Produk (X3) terhadap Minat Beli (Y) sebesar 52.8%

PENGARUH PENGETAHUAN INTEGRITAS AKADEMIK DAN KECERDASAN SPIRITUAL TERHADAP PERFORMA AKADEMIK MAHASISWA PROGRAM STUDI PENDIDIKAN DOKTER

ABSTRAKLatar Belakang: Mahasiswa kedokteran Universitas Islam Malang diharapkan mempunyai konsep profesionalisme diantaranya pengetahuan integritas akademik dan kecerdasan spiritual dalam menunjang performa akademiknya. Kedua konsep tersebut memiliki pengaruh terhadap performa akademik. Penelitan ini bertujuan meneliti pengaruh antara pengetahuan integritas akademik dan kecerdasan spiritual terhadap performa akademik mahasiswa.Metode: Desain penelitian ini adalah deskriptif analitik dengan pendekatan cross-sectional. Sampel penelitian adalah mahasiswa Fakultas Kedokteran Unisma angkatan tingkat pertama, kedua, dan ketiga. Untuk data pengetahuan integritas akademik menggunakan kuesioner yang telah dimodifikasi oleh peneliti Syifana dan untuk data kecerdasan spiritual  menggunakan kuesioner Spiritual Intelligence Self-Report Inventory (SISRI-24). Analisa data menggunakan uji Kendall’s tau dan uji regresi linier dengan tingkat signifikansi α = 0,05Hasil: Pada uji Kendall’s tau hubungan pengetahuan integritas akademik didapatkan nilai p = 0,035 dengan α = 0,05 atau (Sig <α) dan kecerdasan spiritual dengan nilai p 0,013 =  dengan α = 0,05 atau (Sig <α) terhadap performa akademik. Pada uji regresi linear didapatkan hasil R square 0.007 pada pengetahuan integritas akademik, sedangkan pada kecerdasan spiritual didapatkan R square 0.025..Kesimpulan: Pengetahuan integritas akademik dan kecerdasan spiritual berhubungan dengan performa akademik, adapun faktor yang dominan adalah kecerdasan spiritual.  Kata Kunci : Pengetahuan Integritas Akademik, kecerdasan spiritual, performa akademi

Therapeutic Drug Monitoring (TDM) in The Use of Aspirin as Antirheumatoid Drugs

Therapeutic drug monitoring (TDM) is used in drug therapy for selected drugs with narrow therapeutic index, or a broad range of kinetics variation, or drugs with strong correlation between plasma concentration and clinical effects or toxicity. Aspirin is one of the widely used old generation drugs, with a broad range of activity spectrum: analgesic, antipyretic, antiâ€inflammatory, and antiplatelet. As antiâ€inflammatory drug, aspirin directed as therapy for many of chronic inflammation, such as rheumatoid arthritis. As an antirheumatic agent, aspirin shows a wide variation in the pharmacokinetic of aspirin metabolism, and has a narrow therapeutic index because it effectives at concentration of 10â€30 mg/dl, but at more than 40 mg/dl intoxication occurs (metabolic acidosis, hyperpnea, and death). Those are why aspirin use as antirheumatic agent need therapeutic drug monitoring, so that doctors can guarantee that plasma aspirin concentration is in the therapeutic range, to achieve optimilization of therapy with minimal side effects. This article reveals about use of aspirin as antirheumatoid drugs and why therapeutic drug monitoring is needed in aspirin use (Sains Medika, 4(2):210â€226)

Potency of Xanthone Derivatives as Antibacterial Agent Against Methicillin-Resistant Staphylococcus Aureus (MRSA)

Antibiotic resistance is increasing worldwide and becoming a serious problem for the treatment of patients and also affecting their economy. One instance of bacteria that is resistant to the antibiotic is Methicillin- Resistant Staphylococcus aureus (MRSA). MRSA infections are fatal and even deadly. Some MRSA strain has shown resistance towards currently available antibacterial agents. To overcome this, we need new compound alternatives. One of the compounds currently being developed is xanthone derivatives. Xanthones can be found in many kinds of plants, including Garcinia mangostana , in which the active compounds are mangostanin and α-mangostin. Xanthones is effective against several types of Grampositive and Gram-negative bacterias, including Staphylococcus species. Some studies have shown that xanthone derivatives are effective against Staphylococcus aureus, including MRSA. One of the proposed mechanisms of xanthone's antibacterial activity is the involvement of the bacteria's cytoplasmic membrane. Xanthone amphiphilic compounds are capable of disrupting bacterial membrane through a mechanism called interfacial activity models. Xanthone can also act as the antioxidant and by inducing the release of lipoteichoic acid (LTA) from the cell wall of MRSA. LTA is the main constituent of the cell wall of Gram-positive bacteria, which are covalently bonded to the outside of peptidoglycan. This structure is important for cell division and bacterial osmotic protection. Thus, it is believed that the mechanism of action of xanthones involved damaging bacterial cell membrane