Characteristics of body mass index and sodium intake of adults with hypertension family history in Yogyakarta

Hypertension is a progression of prehypertension due to the accumulation of several non-genetic risk factors (environmental factors) that occur together (common underlying risk factors) or genetic factors or the interaction between the two. Risk factors for hypertension that can be controlled include high sodium intake, lack of physical activity, obesity, smoking, and alcohol consumption, while risk factors that cannot be controlled include increasing age, gender, and a family or genetic history of hypertension. This study aimed to determine the characteristics of Body Mass Index (BMI) and sodium intake in adults with a family history of hypertension in Yogyakarta. This study used a case-control design. Subjects studied were healthy individuals with a family history of hypertension as case subjects (n = 42), and control subjects were individuals without a family history of hypertension (n = 41). Body mass index (BMI) was measured with anthropometry, and sodium intake was measured using a quantitative food frequency questionnaire. Independent Sample T-test and Chi-Square test analyzed the data with a significance level of p < 0.05. The average BMI and sodium intake are higher in the case group than in the control group. There was no significant association between BMI and sodium intake and risk factors of hypertension (p>0.05). Body mass index and sodium intake in the case and control group were not significant differences (p>0.05). The BMI values and sodium intake levels were higher in the group of individuals with a family history of hypertension compared to those without a family history of hypertension, but not statistically significant

Effect of nasal irrigation on eosinophil and recurrence in allergic rhinitis

Until now, the treatment of allergic rhinitis has not been satisfactory. Patients with allergic rhinitis are highly dependent on medical pharmacological treatment. Nasal irrigation is expected to help reduce symptoms due to decreased eosinophil counts and recurrence of allergic rhinitis. This study aims to determine the effect of nasal irrigation on eosinophils and the recurrence of allergic rhinitis—experimental research by pre – post-test group design. Twenty samples of allergic rhinitis patients were trained to wash their nose once a day at home—nasal mucosal secretion was collected to count eosinophils before and after intervention. The degree of recurrence was assessed based on the symptoms of nasal congestion, runny nose, sneezing, and itchy nose. The degree is divided into three groups: decrease, remain, and increase. The statistical analysis used in this study for bivariate analysis was Wilcoxon Test. There was a significant decrease in eosinophil count (p = 0.00) and recurrence of nasal congestion (p = 0.00), runny nose (p = 0.00), sneezing (p = 0.001) and itchy nose (p = 0.00) in allergic rhinitis after nasal irrigation intervention. Nasal irrigation treatment can help decrease eosinophil count and recurrence of allergic rhinitis

Factors influencing infections caused by Extended Spectrum Beta Lactamase (ESBL) producing bacteria in patients with urinary tract infections at RSUD dr. R. Soetijono Blora

Urinary tract infection (UTI) is a bacterial infection that is often found in pediatric patients. The prevalence of infections due to ESBL-producing Enterobacterales is increasing worldwide. This study aims to identify and analyze the factors that influence Extended Spectrum Beta Lactamase (ESBL) producing bacteria in UTI patients at RSUD dr. R. Soetijono Blora. A cross-sectional study has been carried out at RSUD dr. R. Soetijono Blora in January-March 2023. The results of this study showed that 58 respondents with urine culture results found Enterobacterales pathogenic bacteria. Based on the sensitivity test for the Extended Spectrum Beta Lactamase (ESBL) enzyme producer, 39 people (67.2%) were categorized as ESBLs and 19 people (32.8%) Non-ESBLs. The study variables included age, gender, history of catheter insertion, history of stones or urinary tract surgery and history of taking antibiotics in the last 6 months. The chi-square test to determine the relationship between variables was used to determine significant risk factors. Bivariate logistic regression showed that history of catheter insertion and history of use of antibiotics in the last 6 months were significant risk factors. Prevalence of UTIs due to ESBL-producing Enterobacterales in RSUD dr. R. Soetijono Blora is high and the wise use of antibiotics, especially the third generation cephalosporins as therapy, is needed for preventive strategies to reduce antibiotic resistanc

Potential therapy of umbilical cord mesenchymal stem cells (UC-MSC) in renal fibrosis

Renal fibrosis (RF) is a severe kidney pathology defined by myofibroblast anomalies that create extracellular material on the interstitial and glomerular surfaces. The current therapy for treating renal disease has not achieved excellent results. A new theory about applying umbilical cord mesenchymal stem cells (UC-MSC) to treat renal fibrosis and other fibrosis-affected organs has been developed. This review aims to elucidate the role of UC-MSC in the therapy of renal fibrosis and summarize the numerous biological mechanisms involved. A search was undertaken using PubMed and Google Scholar from 2003 to 2021 to gather information regarding the Potential therapy with UC-MSC in renal fibrosis. Multiple studies on rat models of renal fibrosis have demonstrated a considerable improvement in fibrotic kidneys following UC-MSC treatment. It can transfer functional proteins and genetic information to recipient cells that suppress the fibrosis process. UC-MSC is considered a superior approach to MSC for therapeutic purposes due to its straightforward collection, minimum immunogenicity, and solid paracrine potency. The UC-MSC cellular treatment for renal impairment is a feasible option in the future

Detection of human bocavirus (HBoV) in children with acute respiratory infection (ARI) during the covid-19 transition period

Acute respiratory infections (ARIs) are the highest cause of death in children in the world. Based on the 2018 Riset Kesehatan Dasar Nasional, ARI cases in Indonesia showed a prevalence of 4.4%, with the highest cases occurring in children. One of the new viruses first identified in 2005 in human nasopharyngeal samples is the human bocavirus (HBoV). HBoV is a single-strand DNA virus belonging to the Parvoviridae family. This study aimed to assess the prevalence of HBoV in children presenting with ARI during the transitional period of the Covid-19 era. HBoV detection was conducted using multiplex PCR and reverse hybridization methods on nasopharyngeal and oropharyngeal swab samples collected from symptomatic children. This study reported a prevalence rate of 4.94% for HBoV in 2022 and 5.04% in 2023. Furthermore, the study identified favorable detection rates for HBoV in children with ARIs as 14.81% in 2022 and 8.45% in 2023. These rates ranked 2nd and 5th highest among other pathogens detected in ARIs. Additionally, there was an increase in positive HBoV samples from 4 samples in 2022 to 6 samples in 2023, which was attributed to the relaxation of nonpharmaceutical Covid-19 interventions by mid-2022. HBoV was identified at a significant rate among children with ARI in Jakarta during the transitional phase of the Covid-19 era (2022-2023). Given its potential to induce severe ARI, HBoV necessitates heightened attention as an etiological agent

Disaster Prone Areas and Stunting Prevalence in Indonesia: Ecological Study of 34 Provinces

Indonesia has a high intensity of disaster events. The prevalence of under-five stunting in Indonesia is also high. One of the targets of the Ministry of Health's Medium-Term Development Plan for 2020-2024 is to reduce stunting in children by 14% in 2024. This study aims to look at the relationship between disaster risk and the prevalence of stunting in 34 provinces in Indonesia. The study design is an ecological study approach sourced from the 2021 Indonesian Disaster Risk Index (IRBI), the 2021 Indonesian Nutritional Status Survey (SSGI), the 2018 Basic Health Research and the 2021 National Socioeconomic Survey (Susenas). This study conducted a spatial analysis, scatter plots, pearson correlation test and multivariable linear regression. From the results, it found that the higher risk of disaster increased the tendency for the prevalence of under-five stunting. It was concluded that disaster risk has a positive relationship with the prevalence of under-five stunting in Indonesia. We suggest that a disaster management program can be considered to reduce stunting in Indonesia

Probiotic Lactobacillus Acidophilus, Streptococcus Thermophilus, and Bifidobacterium Longum Effect on Bilirubin Levels of Neonates With Hyperbilirubinemia

ABSTRACT Introduction: Hyperbilirubinemia, a prevalent condition in neonates, is associated with the potential for hospital readmission. Recent research has spotlighted probiotics as a promising alternative for mitigating bilirubin levels. This study aims to scrutinize the impact of probiotics, specifically Lactobacillus acidophilus, Streptococcus thermophilus, and Bifidobacterium longum, on bilirubin levels in neonates grappling with hyperbilirubinemia.Objective: The primary objective of this study is to investigate the effects of the combination 0f phototeraphy with probiotic of Lactobacillus acidophilus, Streptococcus thermophilus, and Bifidobacterium longum on bilirubin levels in neonates with hyperbilirubinemia.Methods: The study at RSI Sultan Agung Semarang used a prospective observational design with pre-post-test groups. Neonates hospitalized from August to November 2022 for hyperbilirubinemia were consecutively sampled. Licensing, ethical clearance, and data collection focused on hyperbilirubinemia status, routine blood tests, and mean bilirubin reduction. The control group received phototherapy, while the treatment group had phototherapy and probiotics (Lactobacillus acidophilus, Streptococcus thermophilus, and Bifidobacterium longum) for 7 days. SPSS software analyzed the data, using Paired T-Test or Wilcoxon test based on normality, with Mann Whitney test for group comparison (p<0.05).Results: The study assessed bilirubin levels in neonates with hyperbilirubinemia using the Shapiro-Wilk test for normality. While some variables showed non-normal distribution, the Wilcoxon non-parametric test revealed significant differences (p<0.05) in Total and Indirect Bilirubin within both control and treatment groups post-treatment. Direct Bilirubin did not exhibit a significant difference (p>0.05). The Mann-Whitney test demonstrated no significant difference (p>0.05) in mean values between the treatment group (receiving phototherapy and probiotics) and the control group. However in this study, it was found that there was a lower average decrease of total bilirubin and indirect bilirubin in the intervention group (6,50 mg/dl) ; (7,20 mg/dl) during the intervention period compared to the control group (6,70 mg/dl); (7,48 mg/dl). Although  Furthermore, the use of probiotics was identified as safe and well-tolerated among the study participants.Conclusion: In conclusion, the findings suggest that the administration of probiotics, specifically Lactobacillus acidophilus, Streptococcus thermophilus, and Bifidobacterium longum, could serve as an adjuvant and safe alternative therapy for neonates grappling with hyperbilirubinemia. Although there is no significant difference compared to therapy using phototherapy alone, a faster average decrease was observed with phototherapy combined with Lactobacillus acidophilus, Streptococcus thermophilus, and Bifidobacterium longum . This has implications for the management and treatment of hyperbilirubinemia, potentially reducing the need for hospital readmissions.Keywords: hyperbilirubinemia, neonates, probiotics, Lactobacillus acidophilus, Streptococcus thermophilus, Bifidobacterium longum.

Drug utilization of corticosteroid in post-operative cataract patients at Klinik Mata Utama (KMU) Madura

A cataract is contributed to 51% of blindness in the world. Cataract surgery is needed to restore the normal eye function. Therapeutic management post cataract operative is generally carried out 1-4 weeks by administering antibiotics, corticosteroids or NSAIDs by oral or topical routes. Corticosteroids administration increase intraocular pressure (IOP), therefore should be taken into account in post-operative cataract. The aim of this study was to observe the pattern of corticosteroid use in post-cataract surgery patients at the Klinik Mata Utama (KMU) Madura. Observational retrospective research involved 153 patients who consumed corticosteroids during their post operative cataract period. The results showed that 122 patients (79.7%) received combination therapy of topical dexamethasone and oral methylprednisolone, while 31 (20.3%) received combination therapy of topical dexamethasone and oral prednisone. 140 Patients (91,6%) showed good recovery with corticosteroids, and 13 patients (8,4%) experienced the IOP as a side effect of topical corticosteroids. In conclusion, the corticosteroids therapy for post-operative cataract patients should be managed properly to prevent the side effects of increasing IOP

Multiple intrathoracic thrombosis detected on ct scan in patient with antiphospholipid antibody syndrome: case report

Antiphospholipid antibody syndrome (APS) is the clinical correlation between antiphospholipid antibodies and hypercoagulability syndrome. The prevalence of APS in the general population is undetermined. APS disease carries a notable risk of vascular thrombosis. CT scan is the preferred imaging method for assessing thrombosis, although the timing of image acquisition should be considered. The case report detailed the discovery of many intrathoracic thromboses on a CT scan of a patient diagnosed with the uncommon condition APS. Case study: A 34-year-old woman was hospitalized due to dyspnea, cough, and a 3 kg weight loss over a three-month period. She has a background in Deep Vein Thrombosis (DVT). The test results showed abnormalities in protein C, protein S, and high D-dimer levels. The CT scan revealed numerous intrathoracic thrombi. Antiphospholipid syndrome (APS) is an immunological condition that elevates the likelihood of blood clot formation, resulting in thrombosis inside the arteries and veins. The approximate occurrence rate of APS is five occurrences per 100,000 individuals annually. Antiphospholipid syndrome (APS) leads to the formation of blood clots in the legs, a condition referred to as deep vein thrombosis (DVT). This patient had a history of deep vein thrombosis (DVT) and many blood clots within the chest cavity. A CT scan revealed persistent blood clots in the main pulmonary artery and the right and left pulmonary arteries. Antiphospholipid syndrome (APS) can lead to the formation of blood clots in both arteries and veins. CT scan is the preferred method for evaluating thrombosis, and numerous phases are required to examine all blood arteries

Case Study: Disseminated intravascular coagulation at autopsy of a child with severe burns resulting in death

Childhood is a time of growth and development, both intellectually and emotionally. The Indonesian Child Protection Commission has observed a growing number of cases of violence against children, including physical and verbal abuse, which require special attention and handling. Physical violence can include burns, which are particularly dangerous in developing countries, where the mortality rate is high. Severe burns can result in inhalation injury and sepsis, which can cause coagulation disorders, making it easier for Disseminated Intravascular Coagulation (DIC) to occur. This study aims to describe the coagulation function of severely burnt patients, investigate the potential causes of DIC, and examine other clinical data. The study used a case study approach, analyzing the corpse of a child who suffered from severe burns. An autopsy was performed and supporting examinations were conducted to determine the cause of death. The examination of the patient's laboratory results, treatment records, corpse, and anatomical pathology revealed the presence of DIC. The autopsy of the child's corpse showed severe burns, pale coloring in the tissues under the nails, and blood clots in the epidural, left ventricle, right ventricle, and veins. The cause of death was determined to be severe burns causing multiple organ dysfunction