Case report: gestational melioidosis through perinatal transmission

Burkholderia pseudomallei is an emerging pathogen in the Americas. Cases of mother-to-child transmission of B. pseudomallei are rare and probably occur by placental or perinatal infection. We report the first case of native gestational and neonatal melioidosis in the Western hemisphere. The isolated strains in the mother and newborn were confirmed by whole-genome sequencing and identified as a novel sequence type ST1748. The comparison of both genomes revealed a nucleotide similarity of 100%. Melioidosis should be considered within the differential diagnosis of febrile illness or pneumonia in pregnant women and newborns from endemic areas of the Americas.Burkholderia pseudomallei is an emerging pathogen in the Americas. Cases of mother-to-child transmission of B. pseudomallei are rare and probably occur by placental or perinatal infection. We report the first case of native gestational and neonatal melioidosis in the Western hemisphere. The isolated strains in the mother and newborn were confirmed by whole-genome sequencing and identified as a novel sequence type ST1748. The comparison of both genomes revealed a nucleotide similarity of 100%. Melioidosis should be considered within the differential diagnosis of febrile illness or pneumonia in pregnant women and newborns from endemic areas of the Americas

Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn)

International audienceBackground : First-line antifungal treatment for invasive mucormycosis (IM) consists of liposomal amphotericin B. Salvage treatment options are limited and often based on posaconazole oral suspension. With the approval of posaconazole new formulations, patients could benefit from improved pharmacokinetics, safety and tolerability.Objectives: Our aim was to assess the effectiveness of posaconazole new formulations for IM treatment.Methods : We performed a case-matched analysis with proven or probable IM patients from the FungiScope® Registry. First-line posaconazole new formulations (1st-POSnew) and first-line amphotericin B plus posaconazole new formulations (1st-AMB+POSnew) cases were matched with first-line amphotericin B-based (1st-AMB) treatment controls. Salvage posaconazole new formulations (SAL-POSnew) cases were matched with salvage posaconazole oral suspension (SAL-POSsusp) controls. Each case was matched with up to three controls (based on severity, haematological/oncological malignancy, surgery and/or renal dysfunction).Results : Five patients receiving 1st-POSnew, 18 receiving 1st-AMB+POSnew and 22 receiving SAL-POSnew were identified. By day 42, a favourable response was reported for 80.0% (n = 4/5) of patients receiving 1st-POSnew, for 27.8% (n = 5/18) receiving 1st-AMB+POSnew and for 50.0% (n = 11/22) receiving SAL-POSnew. Day 42 all-cause mortality of patients receiving posaconazole new formulations was lower compared with controls [20.0% (n = 1/5) in 1st-POSnew versus 53.3% (n = 8/15) in 1st-AMB; 33.3% (n = 6/18) in 1st-AMB+POSnew versus 52.0% (n = 26/50) in 1st-AMB; and 0.0% (n = 0/22) in SAL-POSnew versus 4.4% (n = 2/45) in SAL-POSsusp].Conclusions : Posaconazole new formulations were effective in terms of treatment response and associated mortality of IM. While posaconazole new formulations may be an alternative for treatment of IM, the limited sample size of our study calls for a cautious interpretation of these observations

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScopeⓇ—Global Registry for Emerging Fungal Infections

International audienc

VIII Semana de la Facultad de Educación : Desafíos de las pedagogías, las prácticas y las perspectivas investigativas en el siglo XXI.

Estas memorias de la viii Semana de la Educación Desafíos de las pedagogías, las prácticas y las perspectivas investigativas en el siglo XXI, publicadas por la editorial de la Corporación Universitaria Minuto de Dios (uniminuto), contienen las ponencias, los talleres y los foros sobre las tendencias actuales de la pedagogía, las prácticas y la investigación que desarrollan los maestros y estudiantes de licenciaturas en las instituciones educativas a nivel preescolar, básica, media y superior. Son ponencias con carácter innovador e incluyente, que responden a los retos actuales de la sociedad y que conducen a la mejora de las condiciones de formación de los ciudadanos que requiere el país, dadas las particularidades de pluralismo propias de nuestras regiones. Durante el encuentro, también se compartieron experiencias artísticas, culturales y deportivas

VIII Semana de la Facultad de Educación : Desafíos de las pedagogías, las prácticas y las perspectivas investigativas en el siglo XXI.

Estas memorias de la viii Semana de la Educación Desafíos de las pedagogías, las prácticas y las perspectivas investigativas en el siglo XXI, publicadas por la editorial de la Corporación Universitaria Minuto de Dios (uniminuto), contienen las ponencias, los talleres y los foros sobre las tendencias actuales de la pedagogía, las prácticas y la investigación que desarrollan los maestros y estudiantes de licenciaturas en las instituciones educativas a nivel preescolar, básica, media y superior. Son ponencias con carácter innovador e incluyente, que responden a los retos actuales de la sociedad y que conducen a la mejora de las condiciones de formación de los ciudadanos que requiere el país, dadas las particularidades de pluralismo propias de nuestras regiones. Durante el encuentro, también se compartieron experiencias artísticas, culturales y deportivas