Early Exploration of One’s Own Body, Exploration of Objects, and Motor, Language, and Cognitive Development Relate Dynamically Across the First Two Years of Life

Early exploratory behaviors have been proposed to facilitate children’s learning, impacting motor, cognitive, language, and social development. This study related the performance of behaviors used to explore oneself to behaviors used to explore objects, and then related both types of exploratory behaviors to motor, language, and cognitive measures longitudinally from 3 through 24 months of age via secondary analysis of an existing dataset. Participants were 52 children (23 full-term, 29 preterm). Previously published results from this dataset documented delays for preterm relative to full-term infants in each assessment. The current results related performance among the assessments throughout the first 2 years of life. They showed that the developmental trajectories of behaviors children used for self-exploration closely related to the trajectories of behaviors they employed to explore objects. The trajectories of both self and object exploration behaviors significantly related to trajectories of children’s motor, language, and cognitive development. Specifically, significant relations to global development were observed for self-exploratory head lifting, midline head and hand positioning, hand opening, and behavioral variability, as well as for object-oriented bimanual holding, mouthing, looking, banging, manipulating, transferring of objects, and behavioral intensity and variability. These results demonstrate continuity among the early exploratory behaviors infants perform with their bodies alone, exploratory behaviors with portable objects, and global development. The findings identify specific self- and object-exploration behaviors that may serve as early indicators of developmental delay and could be targeted by interventions to advance motor, language, and cognitive outcomes for infants at risk for delay

Moving from "they" to "we" - A qualitative case study of the perspectives and interactions of teams who support children with complex communication needs to contribute to the generalization of communication skills

Children with complex communication needs (CCN) face many challenges in their daily life. They can struggle academically and socially if their communicative needs are not supported consistently by those who provide care for them. They frequently use Augmentative or Alternative Communication (AAC) systems or devices to communicate. The purposes of this qualitative case study were to 1) explore the types and meanings of interactions which occurred among the stakeholders as part of their participation on the federally mandated educational team that supports a child with CCN; and 2) to examine how collaborative communicative exchanges transpired among the stakeholders which could potentially support the child with CCN to generalize communication skills. The study is significant because, while much research has examined the efficacy of generalization training with children who have a variety of disabilities, no research has investigated the types and meaning of stakeholder interactions and their potential to influence the child's generalization of skills. This qualitative research design used an instrumental, collective, multiple case study of four teams of stakeholders (n=23) who provide support for children with CCN. Methods included individual interviews, observations in the home and school, and document analysis of IEP communication goals and objectives. Findings for the four cases showed a wide difference in the types and meaning of interactions among teams/stakeholders toward meeting the generalization goals of children with CCN. More specifically, the most cohesive teams were characterized by the consistent sharing of both personal/routine and clinical information among the stakeholders, engaging in informal peer coaching with each other, treating paraprofessionals as integral members of the team, and having IEPs with specific and measurable communication goals. The findings suggest that children are best supported by teams who engage in collaborative interactive exchanges focused on supporting a child's generalization goals. Further research should be conducted into the frequency and type of communication shared, possible peer coaching models in special education, increasing the roles of paraprofessionals, and clarity of IEP goals and objectives

Modeling Ertapenem: The Impact of Body Mass Index on Distribution of the Antibiotic in the Body

Ertapenem is an antibiotic commonly used to treat a broad spectrum of infections and is part of a broader class of antibiotics called carbapenems. Unlike other carbapenems, ertapenem has a longer half-life and thus only has to be administered once a day. Previously, a physiologically-based pharmacokinetic (PBPK) model was developed to investigate the uptake, distribution, and elimination of ertapenem following a single one gram dose in normal height, normal weight males. Due to the absorption properties of ertapenem, the amount of fat in the body can influence how the drug binds, how quickly the drug passes through the body, and thus how effective the drug might be. Thus, we have revised the model so that it is applicable to males and females of differing body mass index (BMI). Simulations were performed to consider the distribution of the antibiotic in males and females with varying body mass indexes. These results could help to determine if there is a need for altered dosing regimens in the future

The Bias and Mass Function of Dark Matter Halos in Non-Markovian Extension of the Excursion Set Theory

The excursion set theory based on spherical or ellipsoidal gravitational collapse provides an elegant analytic framework for calculating the mass function and the large-scale bias of dark matter haloes. This theory assumes that the perturbed density field evolves stochastically with the smoothing scale and exhibits Markovian random walks in the presence of a density barrier. Here we derive an analytic expression for the halo bias in a new theoretical model that incorporates non-Markovian extension of the excursion set theory with a stochastic barrier. This model allows us to handle non-Markovian random walks and to calculate perturbativly these corrections to the standard Markovian predictions for the halo mass function and halo bias. Our model contains only two parameters: kappa, which parameterizes the degree of non-Markovianity and whose exact value depends on the shape of the filter function used to smooth the density field, and a, which parameterizes the degree of stochasticity of the barrier. Appropriate choices of kappa and a in our new model can lead to a closer match to both the halo mass function and halo bias in the latest N-body simulations than the standard excursion set theory.Comment: 10 pages, 1 figure, MNRAS, in press. Minor change

Seroprevalence of SARS-CoV-2 Antibodies Among Healthcare Workers With Differing Levels of COVID-19 Patient Exposure

Healthcare employees were tested for antibodies against SARS-CoV-2. Among 734 employees, the prevalence of SARS-CoV-2 antibodies was 1.6%. Employees with heavy COVID-19 exposure had similar antibody prevalence as those with limited or no exposure. Guidelines for PPE use seem effective for preventing COVID-19 infection in healthcare workers.Antibody testing was paid for by Indiana University Health,as part of an internal quality assessment initiative

The Dynamics and Metallicity Distribution of the Distant Dwarf Galaxy VV124

VV124 (UGC 4879) is an isolated, dwarf irregular/dwarf spheroidal (dIrr/dSph) transition-type galaxy at a distance of 1.36 Mpc. Previous low-resolution spectroscopy yielded inconsistent radial velocities for different components of the galaxy, and photometry hinted at the presence of a stellar disk. In order to quantify the stellar dynamics, we observed individual red giants in VV124 with the Keck/DEIMOS spectrograph. We validated members based on their positions in the color-magnitude diagram, radial velocities, and spectral features. Our sample contains 67 members. The average radial velocity is = −29.1 ± 1.3 km s^(−1), in agreement with the previous radio measurements of H I gas. The velocity distribution is Gaussian, indicating that VV124 is supported primarily by velocity dispersion inside a radius of 1.5 kpc. Outside that radius, our measurements provide only an upper limit of 8.6 km s^(−1) on any rotation in the photometric disk-like feature. The velocity dispersion is σ_v = 9.4± 1.0 km s^(−1), from which we inferred a mass of M_(1/2) = (2.1 ± 0.2)× 10^7 M_⊙ and a mass-to- light ratio of (M/L_V)_(1/2) = 5.2 ± 1.1 M_⊙/L_⊙, both measured within the half-light radius. Thus, VV124 contains dark matter. We also measured the metallicity distribution from neutral iron lines. The average metallicity, = −1.14 ± 0.06, is consistent with the mass-metallicity relation defined by dwarf spheroidal galaxies. The dynamics and metallicity distribution of VV124 appear similar to dSphs of similar stellar mass

Three-Body and One-Body Channels of the Auger Core-Valence-Valence decay: Simplified Approach

We propose a computationally simple model of Auger and APECS line shapes from open-band solids. Part of the intensity comes from the decay of unscreened core-holes and is obtained by the two-body Green's function $G^{(2)}_{\omega}$, as in the case of filled bands. The rest of the intensity arises from screened core-holes and is derived using a variational description of the relaxed ground state; this involves the two-holes-one-electron propagator $G_{\omega}$, which also contains one-hole contributions. For many transition metals, the two-hole Green's function $G^{(2)}_{\omega}$ can be well described by the Ladder Approximation, but the three-body Green's function poses serious further problems. To calculate $G_{\omega}$, treating electrons and holes on equal footing, we propose a practical approach to sum the series to all orders. We achieve that by formally rewriting the problem in terms of a fictitious three-body interaction. Our method grants non-negative densities of states, explains the apparent negative-U behavior of the spectra of early transition metals and interpolates well between weak and strong coupling, as we demonstrate by test model calculations.Comment: AMS-LaTeX file, 23 pages, 8 eps and 3 ps figures embedded in the text with epsfig.sty and float.sty, submitted to Phys. Rev.

STAR FORMATION HISTORY OF THE SMALL MAGELLANIC CLOUD: SIX HUBBLE SPACE TELESCOPE/ADVANCED CAMERA FOR SURVEY FIELDS

We observed six fields of the Small Magellanic Cloud (SMC) with the Advanced Camera for Survey on board the Hubble Space Telescope in the F555W and F814W filters. These fields sample regions characterized by very different star and gas densities, and, possibly, by different evolutionary histories. We find that the SMC was already forming stars similar to 12 Gyr ago, even if the lack of a clear horizontal branch suggests that in the first few billion years the star formation activity was low. Within the uncertainties of our two-band photometry, we find evidence of a radial variation in chemical enrichment, with the SMC outskirts characterized by lower metallicity than the central zones. From our color-magnitude diagrams, we also infer that the SMC formed stars over a long interval of time until similar to 2-3 Gyr ago. After a period of modest activity, star formation increased again in the recent past, especially in the bar and the wing of the SMC, where we see an enhancement in the star-formation activity starting from similar to 500 Myr ago. The inhomogeneous distribution of stars younger than similar to 100 Myr indicates that recent star formation has mainly developed locally