An Idealized Pulsar Magnetosphere: the Relativistic Force-Free Approximation

The non-dissipative relativistic force-free condition should be a good approximation to describe the electromagnetic field in much of the pulsar magnetosphere, but we may plausibly expect it to break down in singular domains. Self-consistent magnetospheric solutions are found with field lines closing both at and within the light-cylinder. In general, the detailed properties of the solutions may be affected critically by the physics determining the appropriate choice of equatorial boundary condition beyond the light-cylinder.Comment: 31 pages, 3 figure

Symmetry based determination of space-time functions in nonequilibrium growth processes

We study the space-time correlation and response functions in nonequilibrium growth processes described by linear stochastic Langevin equations. Exploiting exclusively the existence of space and time dependent symmetries of the noiseless part of these equations, we derive expressions for the universal scaling functions of two-time quantities which are found to agree with the exact expressions obtained from the stochastic equations of motion. The usefulness of the space-time functions is illustrated through the investigation of two atomistic growth models, the Family model and the restricted Family model, which are shown to belong to a unique universality class in 1+1 and in 2+1 space dimensions. This corrects earlier studies which claimed that in 2+1 dimensions the two models belong to different universality classes.Comment: 18 pages, three figures included, submitted to Phys. Rev.

Phase-locked modulation delay between the poles of pulsar B1055-52

We present a detailed single pulse study of PSR B1055-52 based on observations at the Parkes radio telescope. The radio emission is found to have a complex modulation dominated by a periodicity of ~20 times its rotational period P (0.197s), whose phase and strength depends on pulse longitude. This periodicity exhibits a phase-locked delay of about 2.5P between the main pulse (MP) and interpulse (IP), presumed to be the opposite poles of the pulsar. This delay corresponds to a light travel distance of many times the light cylinder radius. More complex modulations are found within the MP on timescales down to about 9P, and both these and the principal modulation vary strongly across the (at least) 7 components which the MP and IP exhibit. The nature of the single pulse emission, which ranges from smooth and longitudinally extended to `spiky', is also component-dependent. Despite these disparities, the total pulse intensity distributions at the MP and IP are virtually identical in shape, suggesting a common emission mechanism. In an attempt to account for the complex modulations we examine a number of physical models, both intrinsic (which presuppose the pulsar to be an isolated neutron star) and extrinsic (appealing to the presence of circumstellar material to modulate the emission). Significant objections can be made to each model, so this pulsar's behaviour patterns remain a crucial challenge to theorists.Comment: 13 pages, 8 figures, submitted to MNRA

Interaction of 7-acetyltaxol with different tubulin assemblies

AbstractEquilibrium microdialysis of [3PH]acetyltaxol against different tubulin assemblies showed that: (i) the binding capacity of tubulin does not depend on the temperature; (ii) two classes of ‘polymers’ exist, with respect to Ac-taxol binding. Some of them (plaques, complex cylinders induced with some polycations and spirals made with rhazinilam) bound Ac-taxol, as do normal microtubules. In contrast, spirals formed with vinblastine and griseofulvin, rings made with polycations and complex cylinders induced with spermine do not bind Ac-taxol as is the case with free tubulin

Spectroscopic Pulsational Frequency Identification and Mode Determination of Gamma Doradus Star HD135825

We present the mode identification of frequencies found in spectroscopic observations of the Gamma Doradus star HD135825. Four frequencies were successfully identified: 1.3150 +/- 0.0003 1/d; 0.2902 +/- 0.0004 1/d; 1.4045 +/- 0.0005 1/d; and 1.8829 +/- 0.0005 1/d. These correspond to (l, m) modes of (1,1), (2,-2), (4,0) and (1,1) respectively. Additional frequencies were found but they were below the signal-to-noise limit of the Fourier spectrum and not suitable for mode identification. The rotational axis inclination and vsini of the star were determined to be 87 degrees (nearly edge-on) and 39.7 km/s (moderate for Gamma Doradus stars) respectively. A simultaneous fit of these four modes to the line profile variations in the data gives a reduced chi square of 12.7. We confirm, based on the frequencies found, that HD135825 is a bona fide Gamma Doradus star.Comment: Accepted to MNRAS 2012 March

Selection of mutants with resistance or diminished susceptibility to ceftazidime/avibactam from ESBL- and AmpC- producing Enterobacteriaceae

Introduction: Difficult Gram-negative infections are increasingly treated with new β-lactamase inhibitor combinations, e.g. ceftazidime/avibactam. Disturbingly, mutations in KPC carbapenemases can confer ceftazidime/avibactam resistance, which is sometimes selected during therapy. We explored whether this risk extended to AmpC and ESBL enzymes. Methods: Mutants were selected by plating AmpC-derepressed strains, ESBL producers and ceftazidime-susceptible controls on agar containing ceftazidime + avibactam (1 or 4 mg/L). MICs were determined by CLSI agar dilution; WGS was by Illumina methodology. Results: Using 2× MIC of ceftazidime + 1 mg/L avibactam, mutants were selected from all strain types at frequencies of 10−7–10−9. Rates diminished to <10−9 with 4 mg/L avibactam or higher MIC multiples, except with AmpC-derepressed Enterobacteriaceae. Characterized mutants (n = 10; MICs 4–64 mg/L) of AmpC-derepressed strains had modifications in ampC, variously giving Arg168Pro/His, Gly176Arg/Asp, Asn366Tyr or small deletions around positions 309–314. Mutants of ESBL producers (n = 19; MICs 0.5–16 mg/L) mostly had changes affecting permeability, efflux or β-lactamase quantity; only one had an altered β-lactamase, with an Asp182Tyr substitution in CTX-M-15, raising the ceftazidime/avibactam MIC, but abrogating other cephalosporin resistance. Mutants of ceftazidime-susceptible strains were not sequenced, but phenotypes suggested altered drug accumulation or, for Enterobacter cloacae only, AmpC derepression. In further experiments, avibactam reduced, but did not abolish, selection of AmpC-derepressed Enterobacteriaceae by ceftazidime. Conclusions: Most mutants of AmpC-derepressed Enterobacteriaceae had structural mutations in ampC; those of ESBL producers mostly had genetic modifications outside β-lactamase genes, commonly affecting uptake, efflux, or β-lactamase quantity. The clinical significance of these observations remains to be determined

Drosophila melanogaster γ-TuRC is dispensable for targeting γ-tubulin to the centrosome and microtubule nucleation

In metazoans, γ-tubulin acts within two main complexes, γ-tubulin small complexes (γ-TuSCs) and γ-tubulin ring complexes (γ-TuRCs). In higher eukaryotes, it is assumed that microtubule nucleation at the centrosome depends on γ-TuRCs, but the role of γ-TuRC components remains undefined

Spatial Patterns and Sequential Sampling Plans for Estimating Densities of Stink Bugs (Hemiptera: Pentatomidae) in Soybean in the North Central Region of the United States

Stink bugs are an emerging threat to soybean (Fabales: Fabaceae) in the North Central Region of the United States. Consequently, region-specific scouting recommendations for stink bugs are needed. The aim of this study was to characterize the spatial pattern and to develop sampling plans to estimate stink bug population density in soybean fields. In 2016 and 2017, 125 fields distributed across nine states were sampled using sweep nets. Regression analyses were used to determine the effects of stink bug species [Chinavia hilaris (Say) (Hemiptera: Pentatomidae) and Euschistus spp. (Hemiptera: Pentatomidae)], life stages (nymphs and adults), and field locations (edge and interior) on spatial pattern as represented by variance–mean relationships. Results showed that stink bugs were aggregated. Sequential sampling plans were developed for each combination of species, life stage, and location and for all the data combined. Results for required sample size showed that an average of 40–42 sample units (sets of 25 sweeps) would be necessary to achieve a precision of 0.25 for stink bug densities commonly encountered across the region. However, based on the observed geographic gradient of stink bug densities, more practical sample sizes (5–10 sample units) may be sufficient in states in the southeastern part of the region, whereas impractical sample sizes (\u3e100 sample units) may be required in the northwestern part of the region. Our findings provide research-based sampling recommendations for estimating densities of these emerging pests in soybean

An Empirical Model for the Radio Emission from Pulsars

A model for slow radio pulsars is proposed which involves the entire magnetosphere in the production of the observed radio emission. It is argued that observations of pulsar profiles suggest that a feedback mechanism exists between the star surface and the null charge surface, requiring particle flow in both directions. In their flow to and from the surface the particles execute an azimuthal drift around the magnetic pole, thereby creating a ring of discrete `emission nodes' close to the surface. Motion of the nodes is observed as the well-known subpulse `drift', but is interpreted here as a small residual component of the real particle drift. The nodes can therefore move in either direction, or even remain stationary. A precise fit is found for the pulsar PSR0943+10. Azimuthal interactions between different regions of the magnetosphere depend on the angle between the magnetic and rotation axes and influence the conal type, as observed. The requirement of intermittent weak pair-production in an outergap suggests a natural evolutionary link between radio and gamma-ray pulsars.Comment: 17 pages 8 figure