The impact of the global financial turmoil and recession on Mediterranean countries’ economies

This paper reviews the impact of the global financial turmoil and the subsequent recession on the economies of southern and eastern Mediterranean countries. The major effects on the economies of this region have come through transmission channels associated with the real economy, i.e. the global recession. These are, in particular, declines in exports, oil revenues, tourism receipts, remittances and foreign direct investment (FDI) inflows, with the drop in exports so far appearing to have had the strongest impact. As a result, real GDP growth has weakened in the wake of the global crisis. However, the weakening of economic activity in the Mediterranean region has been less pronounced than in advanced economies and most other emerging market regions. The main reason for this is that the direct impact of the global financial turmoil on banking sectors and financial markets in Mediterranean countries has been relatively limited. This is mainly due to (i) their lack of exposure to US mortgage-related assets that turned “toxic”, a feature the region shares with other emerging markets, and (ii) the limited financial development of many countries in the region and their limited integration into global financial markets, a feature that distinguishes the region from other emerging markets and, in particular, from the euro area’s neighbours to the east. Notwithstanding the relative resilience of southern and eastern Mediterranean countries in the wake of the global crisis, the region faces significant challenges. In particular, many countries need significantly higher growth rates to address the employment challenge posed as a consequence of demographic developments. JEL Classification: C43, C51, D91financial sector, Global economic crisis, International spillovers, Mediterranean countries

Quality Improvement: Assessing the Gaps in Education and Training among Staff at Health, Education, and Law Project Hospital Sites in Nebraska

This research study was completed at Legal Aid of Nebraska’s Health, Education, and Law Project. The goal of this quality improvement study was to enhance the effectiveness of future Health, Education, and Law Project (HELP) training sessions for staff members of HELP sites in Nebraska. Through the use of an online survey tool, we received staff members’ input on the current training program, assessed their knowledge on relevant topics, and gave respondents an opportunity to include any appropriate suggestions. By means of this study, we were able to conclude that although staff members seemed to appreciate the training sessions overall, more trainings are needed on immigrant and family-related social and legal issues that affect patient health

Biotechnology in the Fine-Chemicals Industry: Cyclic Amino Acids by Enantioselective Biocatalysis

Enantiomerically pure cyclic amino acids are of increasing interest for the life-science industry. To meet this demand, Lonza has developed biotransformation processes with emphasis on the integration of chemistry and biocatalysis for the production of homochiral proline, piperidine-2-carboxylic acid and piperazine-2-carboxylic acid, and valuable derivatives of these compounds. The processes are designed for use on industrial scale; they have been optimised with respect to availability and cost of starting materials and biocatalyst, productivity of the process and a feasible product isolation procedure. Because of the extraordinarily high enantioselectivity of the enzymes, the (R)- and the (S)-enantiomers of the unnatural cyclic amino acids, which are both of commercial interest, can be produced in a single reaction. The examples presented demonstrate the benefit from interdisciplinary research for the production of fine chemicals by the combination of chemistry and biotechnology

Suppressing sensorimotor activity modulates the discrimination of auditory emotions but not speaker identity

Our ability to recognize the emotions of others is a crucial feature of human social cognition. Functional neuroimaging studies indicate that activity in sensorimotor cortices is evoked during the perception of emotion. In the visual domain, right somatosensory cortex activity has been shown to be critical for facial emotion recognition. However, the importance of sensorimotor representations in modalities outside of vision remains unknown. Here we use continuous theta-burst transcranial magnetic stimulation (cTBS) to investigate whether neural activity in the right postcentral gyrus (rPoG) and right lateral premotor cortex (rPM) is involved in nonverbal auditory emotion recognition. Three groups of participants completed same-different tasks on auditory stimuli, discriminating between the emotion expressed and the speakers' identities, before and following cTBS targeted at rPoG, rPM, or the vertex (control site). A task-selective deficit in auditory emotion discrimination was observed. Stimulation to rPoG and rPM resulted in a disruption of participants' abilities to discriminate emotion, but not identity, from vocal signals. These findings suggest that sensorimotor activity may be a modality-independent mechanism which aids emotion discrimination. Copyright © 2010 the authors

Satellite constellation design for mid-course ballistic missile intercept

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2004.Includes bibliographical references (p. 223-228).This thesis will establish a conceptual approach to the design of constellations for satellite-based mid-course missile defense. The ballistic missile intercept problem leads to a new paradigm of coverage where interceptor "reachability" replaces line-of-sight coverage. Interceptors in this concept are limited in their time of flight and AV capabilities. Classical design approaches, based on ground coverage, are employed to provide a priori constellations for ballistic missile defense from a postulated North Korean attack. Both symmetric and asymmetric constellation types, designed for Earth coverage, provide bounds on the number of satellites required. A detailed parametric analysis is used to explore the constellation design space. Various constellation types are optimized to maximize missile defense coverage. Both genetic algorithms and gradient-based optimization techniques are employed. Satellite-based mid-course ballistic missile defense from a regional threat is achievable with as few as 21 satellites. Additional constellation intercept statistics, such as: the number of intercepts per missile, and interceptor closing velocities, are compiled to provide a lethality index. The effective capabilities of these constellations to defend CONUS, beyond the original regional threat, are also explored. It will be demonstrated that the constellations constructed in this work are capable of providing defense from an array of threatening states about the globe. This research illustrates how known design methods and astrodynamics techniques can be used to create new and viable methods of space-based missile defense.by Luke Michael Sauter.S.M

Systematic experimental study of quantum interference effects in anthraquinoid molecular wires

In order to translate molecular properties in molecular-electronic devices, it is necessary to create design principles that can be used to achieve better structure-function control oriented toward device fabrication. In molecular tunneling junctions, cross-conjugation tends to give rise to destructive quantum interference effects that can be tuned by changing the electronic properties of the molecules. We performed a systematic study of the tunneling charge-transport properties of a series of compounds characterized by an identical cross-conjugated anthraquinoid molecular skeleton but bearing different substituents at the 9 and 10 positions that affect the energies and localization of their frontier orbitals. We compared the experimental results across three different experimental platforms in both single-molecule and large-area junctions and found a general agreement. Combined with theoretical models, these results separate the intrinsic properties of the molecules from platform-specific effects. This work is a step towards explicit synthetic control over tunneling charge transport targeted at specific functionality in (proto-) devices

Impaired kidney function at ED admission: a comparison of bleeding complications of patients with different oral anticoagulants.

BACKGROUND Up to a fourth of patients at emergency department (ED) presentation suffer from acute deterioration of renal function, which is an important risk factor for bleeding events in patients on oral anticoagulation therapy. We hypothesized that outcomes of patients, bleeding characteristics, therapy, and outcome differ between direct oral anticoagulants (DOACs) and vitamin-K antagonists (VKAs). METHODS All anticoagulated patients older than 17 years with an impaired kidney function treated for an acute haemorrhage in a large Swiss university ED from 01.06.2012 to 01.07.2017 were included in this retrospective cohort study. Patient, treatment, and bleeding characteristics as well as outcomes (length of stay ED, intensive care unit and in-hospital admission, ED resource consumption, in-hospital mortality) were compared between patients on DOAC or VKA anticoagulant. RESULTS In total, 158 patients on DOAC and 419 patients on VKA with acute bleeding and impaired renal function were included. The renal function in patients on VKA was significantly worse compared to patients on DOAC (VKA: median 141 μmol/L vs. DOAC 132 μmol/L, p = 0.002). Patients on DOAC presented with a smaller number of intracranial bleeding compared to VKA (14.6% DOAC vs. 22.4% VKA, p = 0.036). DOAC patients needed more emergency endoscopies (15.8% DOAC vs, 9.1% VKA, p = 0.020) but less interventional emergency therapies to stop the bleeding (13.9% DOAC vs. 22.2% VKA, p = 0.027). Investigated outcomes did not differ significantly between the two groups. CONCLUSIONS DOAC patients were found to have a smaller proportional incidence of intracranial bleedings, needed more emergency endoscopies but less often interventional therapy compared to patients on VKA. Adapted treatment algorithms are a potential target to improve care in patients with DOAC

Multiplexed Covalent Patterns on Double‐Reactive Porous Coating

We have conceptualized and demonstrated an approach based on the combination of hydrophobicity, a substrate‐independent dip coating as porous material with double residual chemical reactivities for implementing multiplexed, miniaturized and unclonable bulk‐infused patterns of different fluorophores following distinct reaction pathways. The embedded hydrophobicity (∼102°) restricted the unwanted spreading of beaded aqueous ink on the coating. The constructions of micropatterns on porous dip‐coating via ink‐jet printing or microchannel cantilever spotting offered orthogonal read‐out and remained readable even after removal of the exterior of the coating

Retrospective audit of antibiotic use in a university general pediatrics department using hospital pharmacy dispensing data

Antibiotics are among the most frequently prescribed drugs in children’s hospitals, which is why regular monitoring of antibiotic use in hospitals is of great importance. This retrospective audit (60 months, January 2014 – December 2018) analyzes the antibiotic consumption at a university inpatient department of general pediatrics including neonatal and pediatric intensive care based on pharmacy dispensing data in units of grams per 100 patient days and in Defined Daily Doses per 100 patient days. The results provide potential targets for Antibiotic Stewardship interventions. Conversely, this audit elicits methodological limitations of the method of antibiotic surveillance in pediatrics recommended by the Robert Koch Institute, Berlin