154 research outputs found
Deep space experiment to measure
Responding to calls from the National Science Foundation (NSF) for new
proposals to measure the gravitational constant , we offer an interesting
experiment in deep space employing the classic gravity train mechanism. Our
setup requires three bodies: a larger layered solid sphere with a cylindrical
hole through its center, a much smaller retroreflector which will undergo
harmonic motion within the hole and a host spacecraft with laser ranging
capabilities to measure round trip light-times to the retroreflector but
ultimately separated a significant distance away from the sphere-retroreflector
apparatus. Measurements of the period of oscillation of the retroreflector in
terms of host spacecraft clock time using existing technology could give
determinations of nearly three orders of magnitude more accurate than
current measurements here on Earth. However, significant engineering advances
in the release mechanism of the apparatus from the host spacecraft will likely
be necessary. Issues with regard to the stability of the system are briefly
addressed.Comment: 13 pp, 3 figs, accepted CQ
Cerebellar volume is linked to cognitive function in temporal lobe epilepsy: A quantitative MRI study
AbstractIntroductionChronic intractable temporal lobe epilepsy (TLE) is associated with certain comorbidities including cognitive impairment. A less common condition among patients with TLE is intermittent explosive disorder (IED), a specific form of aggressive behavior that has been linked to low intelligence and structural pathology in the amygdala. We aimed to identify other neuroanatomical substrates of both cognitive dysfunction and IED in patients with TLE, with special focus on the cerebellum, a brain region known to participate in functional networks involved in neuropsychological and affective processes.MethodsMagnetic resonance imaging-based volumetric data from 60 patients with temporal lobe epilepsy (36 with and 24 without IED) were evaluated. Cerebellar, hippocampal, and total brain volumes were processed separately. In a total of 50 patients, the relationship between volumetric measurements and clinical and neuropsychological data (full-scale, verbal, and performance intelligence quotients) was analyzed.ResultsIntermittent explosive disorder in patients with TLE was not significantly linked to any of the regional volumes analyzed. However, cognitive performance showed a significant association both with total brain volume and cerebellar volume measurements, whereby the left cerebellar volume showed the strongest association. A deviation from normal cerebellar volumes was related to lower intelligence. Of note, left cerebellar volume was influenced by age and duration of epilepsy. Hippocampal volumes had a minor influence on cognitive parameters.ConclusionOur findings suggest that cerebellar volume is not linked to IED in patients with TLE but is significantly associated with cognitive dysfunction. Our findings support recent hypotheses proposing that the cerebellum has a relevant functional topography
The functional neuroimaging correlates of psychogenic versus organic dystonia
The neurobiological basis of psychogenic movement disorders remains poorly understood and the management of these conditions difficult. Functional neuroimaging studies have provided some insight into the pathophysiology of disorders implicating particularly the prefrontal cortex, but there are no studies on psychogenic dystonia, and comparisons with findings in organic counterparts are rare. To understand the pathophysiology of these disorders better, we compared the similarities and differences in functional neuroimaging of patients with psychogenic dystonia and genetically determined dystonia, and tested hypotheses on the role of the prefrontal cortex in functional neurological disorders. Patients with psychogenic (n = 6) or organic (n = 5, DYT1 gene mutation positive) dystonia of the right leg, and matched healthy control subjects (n = 6) underwent positron emission tomography of regional cerebral blood flow. Participants were studied during rest, during fixed posturing of the right leg and during paced ankle movements. Continuous surface electromyography and footplate manometry monitored task performance. Averaging regional cerebral blood flow across all tasks, the organic dystonia group showed abnormal increases in the primary motor cortex and thalamus compared with controls, with decreases in the cerebellum. In contrast, the psychogenic dystonia group showed the opposite pattern, with abnormally increased blood flow in the cerebellum and basal ganglia, with decreases in the primary motor cortex. Comparing organic dystonia with psychogenic dystonia revealed significantly greater regional blood flow in the primary motor cortex, whereas psychogenic dystonia was associated with significantly greater blood flow in the cerebellum and basal ganglia (all P < 0.05, family-wise whole-brain corrected). Group × task interactions were also examined. During movement, compared with rest, there was abnormal activation in the right dorsolateral prefrontal cortex that was common to both organic and psychogenic dystonia groups (compared with control subjects, P < 0.05, family-wise small-volume correction). These data show a cortical-subcortical differentiation between organic and psychogenic dystonia in terms of regional blood flow, both at rest and during active motor tasks. The pathological prefrontal cortical activation was confirmed in, but was not specific to, psychogenic dystonia. This suggests that psychogenic and organic dystonia have different cortical and subcortical pathophysiology, while a derangement in mechanisms of motor attention may be a feature of both condition
Neuropsychiatry of creativity.
In this paper, we review in brief the development of ideas that over time have tried to explain why some individuals are more creative than others and what may be the neurobiological links underlying artistic creativity. We note associations with another unique human idea, that of genius. In particular, we discuss frontotemporal dementia and bipolar, cyclothymic mood disorder as clinical conditions that are helping to unravel the underlying neuroanatomy and neurochemistry of human creativity. This article is part of a Special Issue entitled "Epilepsy, Art, and Creativity"
Perspectives on Astrophysics Based on Atomic, Molecular, and Optical (AMO) Techniques
About two generations ago, a large part of AMO science was dominated by
experimental high energy collision studies and perturbative theoretical
methods. Since then, AMO science has undergone a transition and is now
dominated by quantum, ultracold, and ultrafast studies. But in the process, the
field has passed over the complexity that lies between these two extremes. Most
of the Universe resides in this intermediate region. We put forward that the
next frontier for AMO science is to explore the AMO complexity that describes
most of the Cosmos.Comment: White paper submission to the Decadal Assessment and Outlook Report
on Atomic, Molecular, and Optical (AMO) Science (AMO 2020
An Ethnohistorical Perspective on Cheyenne Demography
Administrative censuses of the Southern Cheyenne Indians from 1880,1891, and 1900 permit family reconstitution, identification of residence groups, and comparisons of fertility between monogamous and polygynous women, when the records are approached by ethnohistori cal methods. This approach includes an awareness of the aboriginal adoption practices, kinship system, and naming practices. It is argued that the biases and distortions of administrative records can be effectively corrected to add to our store of information on band and tribal societies.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
LSST Science Book, Version 2.0
A survey that can cover the sky in optical bands over wide fields to faint
magnitudes with a fast cadence will enable many of the exciting science
opportunities of the next decade. The Large Synoptic Survey Telescope (LSST)
will have an effective aperture of 6.7 meters and an imaging camera with field
of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over
20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with
fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a
total point-source depth of r~27.5. The LSST Science Book describes the basic
parameters of the LSST hardware, software, and observing plans. The book
discusses educational and outreach opportunities, then goes on to describe a
broad range of science that LSST will revolutionize: mapping the inner and
outer Solar System, stellar populations in the Milky Way and nearby galaxies,
the structure of the Milky Way disk and halo and other objects in the Local
Volume, transient and variable objects both at low and high redshift, and the
properties of normal and active galaxies at low and high redshift. It then
turns to far-field cosmological topics, exploring properties of supernovae to
z~1, strong and weak lensing, the large-scale distribution of galaxies and
baryon oscillations, and how these different probes may be combined to
constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at
http://www.lsst.org/lsst/sciboo
Halo Cold Dark Matter and Microlensing
There is good evidence that most of the baryons in the Universe are dark and
some evidence that most of the matter in the Universe is nonbaryonic with cold
dark matter (cdm) being a promising possibility. We discuss expectations for
the abundance of baryons and cdm in the halo of our galaxy and locally. We show
that in plausible cdm models the local density of cdm is at least
10^{-25}\gcmm3. We also discuss what one can learn about the the local cdm
density from microlensing of stars in the LMC by dark stars in the halo and,
based upon a suite of reasonable two-component halo models, conclude that
microlensing is not a sensitive probe of the local cdm density.Comment: 11 pages Latex, 2 ps figures. FNAL-Pub-93/357-
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