Kognitiiv-käitumuslik koolitusprogramm Parkinsoni tõve patsientidele ja tugiisikutele: projekt EduPark

Parkinsoni tõbi kroonilise neuroloogilise haigusena põhjustab lisaks füüsilistele vaevustele ka psühholoogilisi probleeme, millega toimetulek mõjutab otseselt patsientide elukvaliteeti. Toimetuleku soodustamiseks kasutatakse mitmesuguseid psühholoogilisi sekkumismeetodeid, sealhulgas kognitiivset käitumisteraapiat. Eesti Arst 2005; 84 (6): 402-40

Differentielle Tierpsychologie: Hypo- und hyperphage Reaktionen unter Streß

no abstract availabl

Proteomics through integrated MALDI and ESI

Comunicaciones a congreso

Средства всережимного анализа устойчивости узлов двигательной нагрузки систем электроснабжения и условий ее обеспечения

Научный доклад посвящен проблеме достаточно полного и достоверного анализа устойчивости синхронных и асинхронных двигателей (СД и АД) узлов нагрузки систем электроснабжения (СЭС) и условий ее обеспечения, в значительной мере определяющих технологическую, экономическую эффективность и нередко безопасность функционирования большинства промышленных предприятий, особенно нефте-, газо-, химических отраслей.The scientific report is devoted to the problem of sufficiently complete and reliable analysis of the stability of synchronous and induction motors (SM and IM) load nodes of power supply systems (PSS) and its provision conditions, which to a considerable extent determine the technological, economic efficiency and often operation safety of large industrial enterprises, oil-, gas- and chemical

A spatiotemporal analysis of gait freezing and the impact of pedunculopontine nucleus stimulation

Gait freezing is an episodic arrest of locomotion due to an inability to take normal steps. Pedunculopontine nucleus stimulation is an emerging therapy proposed to improve gait freezing, even where refractory to medication. However, the efficacy and precise effects of pedunculopontine nucleus stimulation on Parkinsonian gait disturbance are not established. The clinical application of this new therapy is controversial and it is unknown if bilateral stimulation is more effective than unilateral. Here, in a double-blinded study using objective spatiotemporal gait analysis, we assessed the impact of unilateral and bilateral pedunculopontine nucleus stimulation on triggered episodes of gait freezing and on background deficits of unconstrained gait in Parkinson’s disease. Under experimental conditions, while OFF medication, Parkinsonian patients with severe gait freezing implanted with pedunculopontine nucleus stimulators below the pontomesencephalic junction were assessed during three conditions; off stimulation, unilateral stimulation and bilateral stimulation. Results were compared to Parkinsonian patients without gait freezing matched for disease severity and healthy controls. Pedunculopontine nucleus stimulation improved objective measures of gait freezing, with bilateral stimulation more effective than unilateral. During unconstrained walking, Parkinsonian patients who experience gait freezing had reduced step length and increased step length variability compared to patients without gait freezing; however, these deficits were unchanged by pedunculopontine nucleus stimulation. Chronic pedunculopontine nucleus stimulation improved Freezing of Gait Questionnaire scores, reflecting a reduction of the freezing encountered in patients’ usual environments and medication states. This study provides objective, double-blinded evidence that in a specific subgroup of Parkinsonian patients, stimulation of a caudal pedunculopontine nucleus region selectively improves gait freezing but not background deficits in step length. Bilateral stimulation was more effective than unilateral

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Kovariation und Dissoziation psychophysiologischer Variablen unter kurzzeitig verminderter Energiezufuhr

no abstract availabl

Psychophysiological effects of a short-term reduction of energy supply

No abstract availabl