WICER Infographics Comprehension Testing, 2015-2017

The purpose of this document is to present the full collection of infographics used for the WICER comprehension testing study, many of which have not previously been published. The introduction contains a capsule summary of the WICER study, the purpose and development of the infographics, the comprehension testing study, characteristics of the infographics, and a note about colors. References to related scholarly articles are provided as well as a list of key contributors, funding acknowledgments, and contact information. The remainder of the document contains English and Spanish samples of the tailored infographics along with explanatory notes

Gender and preferences at a young age: evidence from Armenia

We look at gender differences in competitiveness, risk preferences and altruism in a large sample of children and adolescents aged 7 to 16 in Armenia. Post-Soviet Armenia has few formal barriers to gender equality but is also characterized by a patrilineal kinship system and traditional gender roles. In contrast to research conducted in Western countries, we find that girls increase their performance more than boys in response to competition in a running task. We find no gender differences in the other three tasks we explore: skipping rope, a mathematical task, and a verbal task. We also find no difference in the willingness to compete in either the mathematical or the verbal task. In line with previous research, we find that boys are less altruistic and more risk taking than girls, and that the latter gap appears around the age of puberty

Configuring robust DNA strand displacement reactions for in situ molecular analyses

The number of distinct biomolecules that can be visualized within individual cells and tissue sections via fluorescence microscopy is limited by the spectral overlap of the fluorescent dye molecules that are coupled permanently to their targets. This issue prohibits characterization of important functional relationships between different molecular pathway components in cells. Yet, recent improved understandings of DNA strand displacement reactions now provides opportunities to create programmable labeling and detection approaches that operate through controlled transient interactions between different dynamic DNA complexes. We examined whether erasable molecular imaging probes could be created that harness this mechanism to couple and then remove fluorophore-bearing oligonucleotides to and from DNA-tagged protein markers within fixed cell samples. We show that the efficiency of marker erasing via strand displacement can be limited by non-toehold mediated stand exchange processes that lower the rates that fluorophore-bearing strands diffuse out of cells. Two probe constructions are described that avoid this problem and allow efficient fluorophore removal from their targets. With these modifications, we show one can at least double the number of proteins that can be visualized on the same cells via reiterative in situ labeling and erasing of markers on cells

A Crew Resource Management Program Tailored to Trauma Resuscitation Improves Team Behavior and Communication

BACKGROUND: Crew Resource Management (CRM) is a team-building communication process first implemented in the aviation industry to improve safety. It has been used in health care, particularly in surgical and intensive care settings, to improve team dynamics and reduce errors. We adapted a CRM process for implementation in the trauma resuscitation area. STUDY DESIGN: An interdisciplinary steering committee developed our CRM process to include a didactic classroom program based on a preimplementation survey of our trauma team members. Implementation with new cultural and process expectations followed. The Human Factors Attitude Survey and Communication and Teamwork Skills assessment tool were used to design, evaluate, and validate our CRM program

Safety and Reactogenicity of Canarypox ALVAC-HIV (vCP1521) and HIV-1 gp120 AIDSVAX B/E Vaccination in an Efficacy Trial in Thailand

A prime-boost vaccination regimen with ALVAC-HIV (vCP1521) administered intramuscularly at 0, 4, 12, and 24 weeks and gp120 AIDSVAX B/E at 12 and 24 weeks demonstrated modest efficacy of 31.2% for prevention of HIV acquisition in HIV-uninfected adults participating in a community-based efficacy trial in Thailand.Reactogenicity was recorded for 3 days following vaccination. Adverse events were monitored every 6 months for 3.5 years, during which pregnancy outcomes were recorded. Of the 16,402 volunteers, 69% of the participants reported an adverse event any time after the first dose. Only 32.9% experienced an AE within 30 days following any vaccination. Overall adverse event rates and attribution of relatedness did not differ between groups. The frequency of serious adverse events was similar in vaccine (14.3%) and placebo (14.9%) recipients (p = 0.33). None of the 160 deaths (85 in vaccine and 75 in placebo recipients, p = 0.43) was assessed as related to vaccine. The most common cause of death was trauma or traffic accident. Approximately 30% of female participants reported a pregnancy during the study. Abnormal pregnancy outcomes were experienced in 17.1% of vaccine and 14.6% (p = 0.13) of placebo recipients. When the conception occurred within 3 months (estimated) of a vaccination, the majority of these abnormal outcomes were spontaneous or elective abortions among 22.2% and 15.3% of vaccine and placebo pregnant recipients, respectively (p = 0.08). Local reactions occurred in 88.0% of vaccine and 61.0% of placebo recipients (p<0.001) and were more frequent after ALVAC-HIV than AIDSVAX B/E vaccination. Systemic reactions were more frequent in vaccine than placebo recipients (77.2% vs. 59.8%, p<0.001). Local and systemic reactions were mostly mild to moderate, resolving within 3 days.The ALVAC-HIV and AIDSVAX B/E vaccine regimen was found to be safe, well tolerated and suitable for potential large-scale use in Thailand.ClinicalTrials.govNCT00223080

Verifiable Agreement: Limits of Non-Repudiation in Mobile Peer-to-Peer Ad Hoc Networks

En analyse av hvordan de- og re-branding forholder seg til enerettens innhold etter vml. § 4 (1) litra a), med utgangspunkt i EU-domstolens avgjørelse i sak C-129/17 (Mitsubishi). Avhandlingen viser at de-branding (fjerning av varemerker) vanskelig tilfredsstiller inngrepsvilkårene om "bruk" av varemerket "for varer eller tjenester", jf. vml. § 4 (1) litra a). Tredjemanns de- og re-branding er ytterligere en handling som vanskelig kan forstyrre varemerkets overordnede opprinnelsesgarantifunksjon