Modeling the pion Generalized Parton Distribution

We compute the pion Generalized Parton Distribution (GPD) in a valence dressed quarks approach. We model the Mellin moments of the GPD using Ans\"atze for Green functions inspired by the numerical solutions of the Dyson-Schwinger Equations (DSE) and the Bethe-Salpeter Equation (BSE). Then, the GPD is reconstructed from its Mellin moment using the Double Distribution (DD) formalism. The agreement with available experimental data is very good.Comment: 8 pages, 4 figures, proceeding of the 21st International Symposium on Spin Physics, October 20-24 2014, Beijing, Chin

Pion's valence-quark GPD and its extension beyond DGLAP region

We briefly report on a recent computation, with the help of a fruitful algebraic model, sketching the pion valence dressed-quark generalized parton distribution and, very preliminary, discuss on a possible avenue to get reliable results in both Dokshitzer-Gribov-Lipatov-Altarelli-Parisi (DGLAP) and Efremov-Radyushkin-Brodsky-Lepage (ERBL) kinematial regions.Comment: 6 pages, 4 figures, contribution to 21st International conference on Few-Body Problem

Test of two new parameterizations of the Generalized Parton Distribution HH

In 2011 Radyushkin outlined the practical implementation of the One-Component Double Distribution formalism in realistic Generalized Parton Distribution models. We compare the One-Component Double Distribution framework to the standard one and compute Deeply Virtual Compton Scattering observables for both. In particular the new implementation is more flexible, offering a greater range of variation of the real and imaginary parts of the associated Compton Form Factor while still allowing to recover results similar to the classical approach. Moreover the polynomiality property is satisfied up to the highest order. Although the comparison to experimental data may be improved, the One-Component Double Distribution modeling is thus an attractive alternative.Comment: 38 pages, 12 figure

A Nakanishi-based model illustrating the covariant extension of the pion GPD overlap representation and its ambiguities

A systematic approach for the model building of Generalized Parton Distributions (GPDs), based on their overlap representation within the DGLAP kinematic region and a further covariant extension to the ERBL one, is applied to the valence-quark pion’s case, using light-front wave functions inspired by the Nakanishi representation of the pion Bethe–Salpeter amplitudes (BSA). This simple but fruitful pion GPD model illustrates the general model building technique and, in addition, allows for the ambiguities related to the covariant extension, grounded on the Double Distribution (DD) representation, to be constrained by requiring a soft-pion theorem to be properly observed.This work is partly supported by the Commissariat à l’Energie Atomique et aux Energies Alternatives, the GDR QCD “Chromodynamique Quantique”, the ANR-12-MONU-0008-01 “PARTONS” and the Span-ish ministry Research Project FPA2014-53631-C2-2-P

Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells

A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author’s publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml.Background HTLV-I is associated with the development of an aggressive form of lymphocytic leukemia known as adult T-cell leukemia/lymphoma (ATLL). A major obstacle for effective treatment of ATLL resides in the genetic diversity of tumor cells and their ability to acquire resistance to chemotherapy regimens. As a result, most patients relapse and current therapeutic approaches still have limited long-term survival benefits. Hence, the development of novel approaches is greatly needed. Methods In this study, we found that a small molecule inhibitor of poly (ADP-ribose) polymerase (PARP), PJ-34, is very effective in activating S/G2M cell cycle checkpoints, resulting in permanent cell cycle arrest and reactivation of p53 transcription functions and caspase-3-dependent apoptosis of HTLV-I-transformed and patient-derived ATLL tumor cells. We also found that HTLV-I-transformed MT-2 cells are resistant to PJ-34 therapy associated with reduced cleaved caspase-3 activation and increased expression of RelA/p65. Conclusion Since PJ-34 has been tested in clinical trials for the treatment of solid tumors, our results suggest that some ATLL patients may be good candidates to benefit from PJ-34 therapy