74 research outputs found
Origin and Dynamics ofSaltwater Intrusion in a Regional Aquifer:Combining 3-D Saltwater Modeling With Geophysical and Geochemical Data
Saltwater intrusion in Denmark
The studies investigating saltwater intrusion in Denmark have been reviewed to identify the
main characteristics and features that have an impact on coastal aquifers interacting with the
sea. Traditionally, in regions with wet climate, saltwater intrusion is not appointed as a frequent
problem and it is more commonly linked to areas affected by water scarcity. Nevertheless, multiple
factors that can induce the salinization of coastal aquifers have been found for Denmark
such as the presence of coastal drained lowlands with the water table below the sea level or
karstic features and buried valleys in carbonate and detrital systems respectively that can act
as preferential flow paths for saline water. Eustatic changes have been also played an important
role in the salinization of aquifers, in deep aquifers saline ancient connate water can be identified
and in small islands, a delicate equilibrium of freshwater lenses is generated over saline
water. As the water supply in this country depends almost exclusively on groundwater, saltwater
intrusion can jeopardize fresh groundwater resources in coastal areas. An overview of the cases
already studied, questions about the magnitude of these issues and the future perspectives
with climate changes are discussed to put into context what is already known and what are the
next challenges.Se han revisado los estudios que han investigado la intrusión marina en Dinamarca para identificar
las principales características que afectan a los acuíferos costeros en su interacción con el
mar. Tradicionalmente, en regiones con clima húmedo, la intrusión marina no es considerada
como un problema frecuente ya que se suele asociar con áreas afectadas por la escasez de
agua. Sin embargo, se han identificado múltiples factores que pueden generar la salinización de
acuíferos costeros en Dinamarca como la presencia de tierras bajas drenadas a lo largo de la
costa con niveles freáticos por debajo del nivel del mar o el flujo preferente a través de morfologías
kársticas o paleovalles en acuíferos carbonatados o detríticos respectivamente. Los cambios
eustáticos han jugado también un papel importante en la salinización de acuíferos, en
acuíferos profundos se pueden llegar a identificar aguas connatas antiguas y en islas de reducido
tamaño, se establece un delicado equilibrio con lentes de agua dulce sobre aguas salinas.
Debido a que este país depende casi exclusivamente de las aguas subterráneas para el abastecimiento
de la población, la intrusión marina podría poner en riesgo los recursos subterráneos
de agua dulce en las zonas costeras. La revisión de casos estudiados plantea una serie de
cuestiones acerca de la magnitud de los problemas existentes y las perspectivas futuras considerando
cambios climáticos. Con esta revisión se ha puesto en contexto el estado actual de
conocimiento acerca de la intrusión marina en el país y se han identificado los desafíos que
podría ser necesario acometer en el futuroNext-Generation EU funding: Programa Maria Zambrano Senior MZSA0
Randomized comparison of gemcitabine, dexamethasone, and cisplatin versus dexamethasone, cytarabine, and cisplatin chemotherapy before autologous stem-cell transplantation for relapsed and refractory aggressive lymphomas: NCIC-CTG LY.12
PURPOSE: For patients with relapsed or refractory aggressive lymphoma, we hypothesized that gemcitabine-based therapy before autologous stem-cell transplantation (ASCT) is as effective as and less toxic than standard treatment.
PATIENTS AND METHODS: We randomly assigned 619 patients with relapsed/refractory aggressive lymphoma to treatment with gemcitabine, dexamethasone, and cisplatin (GDP) or to dexamethasone, cytarabine, and cisplatin (DHAP). Patients with B-cell lymphoma also received rituximab. Responding patients proceeded to stem-cell collection and ASCT. Coprimary end points were response rate after two treatment cycles and transplantation rate. The noninferiority margin for the response rate to GDP relative to DHAP was set at 10%. Secondary end points included event-free and overall survival, treatment toxicity, and quality of life.
RESULTS: For the intention-to-treat population, the response rate with GDP was 45.2%; with DHAP the response rate was 44.0% (95% CI for difference, -9.0% to 6.7%), meeting protocol-defined criteria for noninferiority of GDP (P = .005). Similar results were obtained in a per-protocol analysis. The transplantation rates were 52.1% with GDP and 49.3% with DHAP (P = .44). At a median follow-up of 53 months, no differences were detected in event-free survival (HR, 0.99; stratified log-rank P = .95) or overall survival (HR, 1.03; P = .78) between GDP and DHAP. Treatment with GDP was associated with less toxicity (P < .001) and need for hospitalization (P < .001), and preserved quality of life (P = .04).
CONCLUSION: For patients with relapsed or refractory aggressive lymphoma, in comparison with DHAP, treatment with GDP is associated with a noninferior response rate, similar transplantation rate, event-free survival, and overall survival, less toxicity and hospitalization, and superior quality of life
Prognostic impact of acute pulmonary triggers in patients with Takotsubo syndrome : new insights from the International Takotsubo Registry
© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.Aims: Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes.
Methods and results: Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pulmonary trigger, chronic lung disease, and no lung disease) to compare clinical characteristics and outcomes. Of the 1670 included patients with TTS, 123 (7%) were identified with an acute pulmonary trigger, and 194 (12%) had a known history of chronic lung disease. The incidence of cardiogenic shock was highest in patients with an acute pulmonary trigger compared with those with chronic lung disease or without lung disease (17% vs. 10% vs. 9%, P = 0.017). In-hospital mortality was also higher in patients with an acute pulmonary trigger than in the other two groups, although not significantly (5.7% vs. 1.5% vs. 4.2%, P = 0.13). Survival analysis demonstrated that patients with an acute pulmonary trigger had the worst long-term outcome (P = 0.002). The presence of an acute pulmonary trigger was independently associated with worse long-term mortality (hazard ratio 2.12, 95% confidence interval 1.33-3.38; P = 0.002).
Conclusions: The present study demonstrates that TTS is related to acute pulmonary triggers in 7% of all TTS patients, which accounts for 21% of patients with physical triggers. The presence of acute pulmonary trigger is associated with a severe in-hospital course and a worse long-term outcome.C. T. has been supported by the H.H. Sheikh Khalifa binHamad Al-Thani Research Programme and the Swiss HeartFoundation. The InterTAK Registry is supported by the BissDavies Charitable Trust. L. S. M. has been supported by EUHORIZON 2020(SILICOFCM ID777204)info:eu-repo/semantics/publishedVersio
Ethnic comparison in takotsubo syndrome : novel insights from the International Takotsubo Registry
© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Background: Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes.
Methods: TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients.
Results: A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 ± 11.4 years vs. 68.0 ± 12.0 years; p < 0.001) and more likely to be male (18.5 vs. 8.4%; p < 0.001) than European TTS patients. Physical triggering factors were more common (45.5 vs. 32.0%; p < 0.001), and emotional triggers less common (17.5 vs. 31.5%; p < 0.001), in Japanese patients than in European patients. Japanese patients were more likely to experience cardiogenic shock during the acute phase (15.5 vs. 9.0%; p < 0.001) and had a higher in-hospital mortality (8.2 vs. 3.2%; p < 0.001). However, ethnicity itself did not appear to have an impact on in-hospital mortality. Machine learning approach revealed that the presence of physical stressors was the most important prognostic factor in both Japanese and European TTS patients.
Conclusion: Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers.Open Access funding provided by Universität Zürich. CT has been supported by the H.H. Sheikh Khalifa bin Hamad Al-Thani Research Programme and the Swiss Heart Foundation. L.S.M. has been supported by EU HORIZON 2020 (SILICOFCM ID777204). J.R.G has received a grant “Filling the gap” from the University of Zurich. The InterTAK Registry is supported by The Biss Davies Charitable Trust.info:eu-repo/semantics/publishedVersio
Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation
Acetylcholine (ACh) has been shown to modulate neuronal differentiation during early development. Both muscarinic and nicotinic acetylcholine receptors (AChRs) regulate a wide variety of physiological responses, including apoptosis, cellular proliferation and neuronal differentiation. However, the intracellular mechanisms underlying these effects of AChR signaling are not fully understood. It is known that activation of AChRs increase cellular proliferation and neurogenesis and that regulation of intracellular calcium through AChRs may underlie the many functions of ACh. Intriguingly, activation of diverse signaling molecules such as Ras-mitogen-activated protein kinase, phosphatidylinositol 3-kinase-Akt, protein kinase C and c-Src is modulated by AChRs. Here we discuss the roles of ACh in neuronal differentiation, cell proliferation and apoptosis. We also discuss the pathways involved in these processes, as well as the effects of novel endogenous AChRs agonists and strategies to enhance neuronal-differentiation of stem and neural progenitor cells. Further understanding of the intracellular mechanisms underlying AChR signaling may provide insights for novel therapeutic strategies, as abnormal AChR activity is present in many diseases
Insulin-like growth factor-I induces the phosphorylation and nuclear exclusion of forkhead transcription factors in human neuroblastoma cells
Akt-mediated phosphorylation of forkhead transcription factors is linked to growth factor-stimulated cell survival. We investigated whether the survival activity of insulin-like growth factor-I (IGF-I) in SH-SY5Y human neuroblastoma (NBL) cells is associated with phosphorylation and/or localization changes in forkhead proteins. IGF-I induced phosphorylation of Erks (p42/p44), FKHR (FOXO1a) (Ser 253), FKHRL1 (FOXO3a) (Ser 256), and Akt (Ser 473). PI3-K inhibitor, LY294002, reduced IGF-I-stimulated phosphorylation of FKHR, FKHRL1, and Akt, but did not affect Erk phosphorylation. Using a GFP-FKHR construct, FKHR imported into the nucleus during growth factor withdrawal-induced apoptosis. In addition, IGF-I rescue from serum withdrawal-induced apoptosis is associated with a rapid export of GFP-FKHR into the cytoplasm. Leptomycin B, an inhibitor of Crm1-mediated nuclear export, decreased the level of FKHRL1 phosphorylation in the presence of IGF-I in vector and FKHR overexpressing cells, but had no effect on the phosphorylation status of FKHR. In addition, leptomycin B prevented IGF-I stimulated nuclear export of GFP-FKHR. These studies show IGF-I phosphorylation of FKHR and FKHRL1 via a PI3-K-dependent pathway in NBL cells.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44353/1/10495_2005_Article_429.pd
Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry
Background Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes.Methods TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients.Results A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 +/- 11.4 years vs. 68.0 +/- 12.0 years; p Conclusion Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers.</p
Identification and rejection of pile-up jets at high pseudorapidity with the ATLAS detector
The rejection of forward jets originating from
additional proton–proton interactions (pile-up) is crucial for
a variety of physics analyses at the LHC, including Standard
Model measurements and searches for physics beyond
the Standard Model. The identification of such jets is challenging
due to the lack of track and vertex information in
the pseudorapidity range |η| > 2.5. This paper presents a
novel strategy for forward pile-up jet tagging that exploits
jet shapes and topological jet correlations in pile-up interactions.
Measurements of the per-jet tagging efficiency are
presented using a data set of 3.2 fb−1 of proton–proton collisions
at a centre-of-mass energy of 13 TeV collected with the
ATLAS detector. The fraction of pile-up jets rejected in the
range 2.5 < |η| < 4.5 is estimated in simulated events with
an average of 22 interactions per bunch-crossing. It increases
with jet transverse momentum and, for jets with transverse
momentum between 20 and 50 GeV, it ranges between 49%
and 67% with an efficiency of 85% for selecting hard-scatter
jets. A case study is performed in Higgs boson production
via the vector-boson fusion process, showing that these techniques
mitigate the background growth due to additional
proton–proton interactions, thus enhancing the reach for such
signatures
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