190 research outputs found
Micro-CernVM: Slashing the Cost of Building and Deploying Virtual Machines
The traditional virtual machine building and and deployment process is
centered around the virtual machine hard disk image. The packages comprising
the VM operating system are carefully selected, hard disk images are built for
a variety of different hypervisors, and images have to be distributed and
decompressed in order to instantiate a virtual machine. Within the HEP
community, the CernVM File System has been established in order to decouple the
distribution from the experiment software from the building and distribution of
the VM hard disk images.
We show how to get rid of such pre-built hard disk images altogether. Due to
the high requirements on POSIX compliance imposed by HEP application software,
CernVM-FS can also be used to host and boot a Linux operating system. This
allows the use of a tiny bootable CD image that comprises only a Linux kernel
while the rest of the operating system is provided on demand by CernVM-FS. This
approach speeds up the initial instantiation time and reduces virtual machine
image sizes by an order of magnitude. Furthermore, security updates can be
distributed instantaneously through CernVM-FS. By leveraging the fact that
CernVM-FS is a versioning file system, a historic analysis environment can be
easily re-spawned by selecting the corresponding CernVM-FS file system
snapshot.Comment: Conference paper at the 2013 Computing in High Energy Physics (CHEP)
Conference, Amsterda
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Priority setting in the German healthcare system: results from a discrete choice experiment
Worldwide, social healthcare systems must face the challenges of a growing scarcity of resources and of its inevitable distributional effects. Explicit criteria are needed to define the boundaries of public reimbursement decisions. As Germany stands at the beginning of such a discussion, more formalised priority setting procedures seem in order. Recent research identified multi-criteria decision analysis (MCDA) as a promising approach to inform and to guide decision-making in healthcare systems. In that regard, this paper aims to analyse the relative weight assigned to various criteria in setting priority interventions in Germany. A discrete choice experiment (DCE) was employed in 2015 to elicit equity and efficiency preferences of 263 decision makers, through six attributes. The experiment allowed us to rate different policy interventions based on their features in a composite league table (CLT). As number of potential beneficiaries, severity of disease, individual health benefits and cost-effectiveness are the most relevant criteria for German decision makers within the sample population, the results display an overall higher preference towards efficiency criteria. Specific high priority interventions are mental disorders and cardiovascular diseases
Late Little Ice Age palaeoenvironmental records from the Anzali and Amirkola Lagoons (south Caspian Sea): Vegetation and sea level changes
This is a postprint version of the article. The official published article can be found from the link below - Copyright @ 2011 Elsevier Ltd.Two internationally important Ramsar lagoons on the south coast of the Caspian Sea (CS) have been studied by palynology on short sediment cores for palaeoenvironmental and palaeoclimatic investigations. The sites lie within a small area of very high precipitation in a region that is otherwise dry. Vegetation surveys and geomorphological investigations have been used to provide a background to a multidisciplinary interpretation of the two sequences covering the last four centuries. In the small lagoon of Amirkola, the dense alder forested wetland has been briefly disturbed by fire, followed by the expansion of rice paddies from AD1720 to 1800. On the contrary, the terrestrial vegetation reflecting the diversity of the Hyrcanian vegetation around the lagoon of Anzali remained fairly complacent over time. The dinocyst and non-pollen palynomorph assemblages, revealing changes that have occurred in water salinity and water levels, indicate a high stand during the late Little Ice Age (LIA), from AD < 1620 to 1800–1830. In Amirkola, the lagoon spit remained intact over time, whereas in Anzali it broke into barrier islands during the late LIA, which merged into a spit during the subsequent sea level drop. A high population density and infrastructure prevented renewed breaking up of the spit when sea level reached its maximum (AD1995). Similar to other sites in the region around the southern CS, these two lagoonal investigations indicate that the LIA had a higher sea level as a result of more rainfall in the drainage basin of the CS.The coring and the sedimentological analyses were funded by the Iranian National Institute for Oceanography in the framework of a research project entitled “Investigation of the Holocene sediment along the Iranian coast of Caspian Sea: central Guilan”. The radiocarbon date of core HCGL02 was funded by V. Andrieu (Europôle Méditerranéen de l'Arbois, France) and that of core HCGA04 by Brunel University
The s Process: Nuclear Physics, Stellar Models, Observations
Nucleosynthesis in the s process takes place in the He burning layers of low
mass AGB stars and during the He and C burning phases of massive stars. The s
process contributes about half of the element abundances between Cu and Bi in
solar system material. Depending on stellar mass and metallicity the resulting
s-abundance patterns exhibit characteristic features, which provide
comprehensive information for our understanding of the stellar life cycle and
for the chemical evolution of galaxies. The rapidly growing body of detailed
abundance observations, in particular for AGB and post-AGB stars, for objects
in binary systems, and for the very faint metal-poor population represents
exciting challenges and constraints for stellar model calculations. Based on
updated and improved nuclear physics data for the s-process reaction network,
current models are aiming at ab initio solution for the stellar physics related
to convection and mixing processes. Progress in the intimately related areas of
observations, nuclear and atomic physics, and stellar modeling is reviewed and
the corresponding interplay is illustrated by the general abundance patterns of
the elements beyond iron and by the effect of sensitive branching points along
the s-process path. The strong variations of the s-process efficiency with
metallicity bear also interesting consequences for Galactic chemical evolution.Comment: 53 pages, 20 figures, 3 tables; Reviews of Modern Physics, accepte
Data Integration for Open Data on the Web
In this lecture we will discuss and introduce challenges of
integrating openly available Web data and how to solve them. Firstly,
while we will address this topic from the viewpoint of Semantic Web
research, not all data is readily available as RDF or Linked Data, so
we will give an introduction to different data formats prevalent on the
Web, namely, standard formats for publishing and exchanging tabular,
tree-shaped, and graph data. Secondly, not all Open Data is really completely
open, so we will discuss and address issues around licences, terms
of usage associated with Open Data, as well as documentation of data
provenance. Thirdly, we will discuss issues connected with (meta-)data
quality issues associated with Open Data on the Web and how Semantic
Web techniques and vocabularies can be used to describe and remedy
them. Fourth, we will address issues about searchability and integration
of Open Data and discuss in how far semantic search can help to overcome
these. We close with briefly summarizing further issues not covered
explicitly herein, such as multi-linguality, temporal aspects (archiving,
evolution, temporal querying), as well as how/whether OWL and RDFS
reasoning on top of integrated open data could be help
Prepared to react? Assessing the functional capacity of the primary health care system in rural Orissa, India to respond to the devastating flood of September 2008
Background: Early detection of an impending flood and the availability of countermeasures to deal with it can significantly reduce its health impacts. In developing countries like India, public primary health care facilities are frontline organizations that deal with disasters particularly in rural settings. For developing robust counter reacting systems evaluating preparedness capacities within existing systems becomes necessary. Objective: The objective of the study is to assess the functional capacity of the primary health care system in Jagatsinghpur district of rural Orissa in India to respond to the devastating flood of September 2008. Methods: An onsite survey was conducted in all 29 primary and secondary facilities in five rural blocks (administrative units) of Jagatsinghpur district in Orissa state. A pre-tested structured questionnaire was administered face to face in the facilities. The data was entered, processed and analyzed using STATA® 10. Results: Data from our primary survey clearly shows that the healthcare facilities are ill prepared to handle the flood despite being faced by them annually. Basic utilities like electricity backup and essential medical supplies are lacking during floods. Lack of human resources along with missing standard operating procedures; pre-identified communication and incident command systems; effective leadership; and weak financial structures are the main hindering factors in mounting an adequate response to the floods. Conclusion: The 2008 flood challenged the primary curative and preventive health care services in Jagatsinghpur. Simple steps like developing facility specific preparedness plans which detail out standard operating procedures during floods and identify clear lines of command will go a long way in strengthening the response to future floods. Performance critiques provided by the grass roots workers, like this one, should be used for institutional learning and effective preparedness planning. Additionally each facility should maintain contingency funds for emergency response along with local vendor agreements to ensure stock supplies during floods. The facilities should ensure that baseline public health standards for health care delivery identified by the Government are met in non-flood periods in order to improve the response during floods. Building strong public primary health care systems is a development challenge. The recovery phases of disasters should be seen as an opportunity to expand and improve services and facilities
A decomposition of the outlier detection problem into a set of supervised learning problems
Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics
Distributed Drug Discovery, Part 1: Linking Academia and Combinatorial Chemistry to Find Drug Leads for Developing World Diseases
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