Preliminary Measurements of the Motion of Arcjet Current Channel Using Inductive Magnetic Probes

This paper covers the design and first measurements of non-perturbative, external inductive magnetic diagnostics for arcjet constrictors which can measure the motion of the arc current channel. These measurements of arc motion are motivated by previous simulations using the ARC Heater Simulator (ARCHeS), which predicted unsteady arc motion due to the magnetic kink instability. Measurements of the kink instability are relevant to characterizing motion of the enthalpy profile of the arcjet, the arcjet operational stability, and electrode damage due to associated arc detachment events. These first measurements indicate 4 mm oscillations at 0.5-2 kHz of the current profile

Development of adenocarcinoma in chronic fistula in Crohn's disease

The authors report the case of a 55 yr-old woman suffering from Crohn's disease since 31 years with stricture and fistulas developed in the ileocolic junction and anorectal portion. Long-standing anorectal fistulas and stricture led to adenocarcinoma and finally fistulisation in the vagina. Diagnosis was made by perineal examination with biopsies under general anaesthesia. Treatment was first posterior pelvectomy with resection of the anterior wall of vagina. Secondarily, radiochemotherapy was administrated. The authors discuss the incidence and risk factors of carcinoma in Crohn's disease with chronic fistulas

EAC-1A: A novel large-volume lunar regolith simulant

The European Astronaut Centre (EAC) is currently constructing the European Lunar Exploration Laboratory (LUNA), a large training and operations facility to be located adjacent to EAC at the DLR (German Aerospace Centre) campus in Cologne, Germany. With an estimated representative lunar testbed area of approximately 660 m(2), a large volume of lunar regolith simulant material is needed for this purpose. In this study, a basanitic sandy silt from a quarry located in the Siebengebirge Volcanic Field is evaluated as a large-volume source of material. The focus of this project has been to conduct a physical and chemical characterisation of the fine-grained material to be used in LUNA;the European Astronaut Centre lunar regolith simulant 1 (EAC-1A). The physical characterisation tests undertaken include sphericity, density measurements, cohesion and static angle of repose, with mineralogical investigations via petrographical analysis with optical microscope and SEM, XRF, XRD and DSC measurements. The results of the EAC-1A tests are compared to published data on existing widely used lunar regolith simulants, namely JSC-1A, JSC-2A, NU-LHT-3M, DNA and FJS-1

Preliminary Measurements of the Motion of Arcjet Current Channel Using Inductive Magnetic Probes

This paper covers the design and first measurements of non-perturbative, external inductive magnetic diagnostics for arcjet constrictors which can measure the motion of the arc current-channel. These measurements of arc motion are motivated by previous simulations using the ARC Heater Simulator (ARCHeS), which predicted unsteady arc motion due to the magnetic kink instability. Measurements of the kink instability are relevant to characterizing motion of the enthalpy profile of the arcjet, the arcjet operational stability, and electrode damage due to associated arc detachment events. These first measurements indicate $\pm4$ mm oscillations at 0.5-2 kHz of the current profile

A universal framework for Space Resource Utilisation (SRU)

Space Resource Utilisation (SRU) or In Situ Resource Utilisation (ISRU) is the use of natural resources from the Moon, Mars and other bodies for use in situ or elsewhere in the Solar System. The implementation of SRU technologies will provide the breakthrough for humankind to explore further into space. A range of extraction processes to produce usable resources have been proposed, such as oxygen production from lunar regolith, extraction of lunar ice and construction of habitation by 3D printing. Practical and successful implementation of SRU requires that all the stages of the process flowsheet (excavation, beneficiation and extraction) are considered. This requires a complete ‘mine-to-market’ type approach, analogous to that of terrestrial mineral extraction. One of the key challenges is the unique cross-disciplinary nature of SRU; it integrates space systems, robotics, materials handling and beneficiation, and chemical process engineering. This is underpinned by knowledge of the lunar or planetary geology, including mineralogy, physical characteristics, and the variability in local materials. Combining such diverse fields in a coordinated way requires the use of a universal framework. The framework will enable integration of operations and comparison of technologies, and will define a global terminology to be used across all fields. In this paper, a universal SRU flowsheet and terminology are described, and a matrix approach to describing regolith characteristics specifically for SRU is proposed. This is the first time that such an approach has been taken to unify this rapidly-developing sector

Common pathways by which non-native forest insects move internationally and domestically

International trade and movement of people are largely responsible for increasing numbers of non-native insect introductions to new environments. For forest insects, trade in live plants and transport of wood packaging material (WPM) are considered the most important pathways facilitating long-distance invasions. These two pathways as well as trade in firewood, logs, and processed wood are commonly associated with insect infestations, while “hitchhiking” insects can be moved on cargo, in the conveyances used for transport (e.g., containers, ships), or associated with international movement of passengers and mail. Once established in a new country, insects can spread domestically through all of the above pathways. Considerable national and international efforts have been made in recent years to reduce the risk of international movement of plant pests. International Standards for Phytosanitary Measures (ISPMs) No. 15 (WPM), 36 (plants for planting), and 39 (wood) are examples of phytosanitary standards that have been adopted by the International Plant Protection Convention to reduce risks of invasions of forest pests. The implementation of ISPMs by exporting countries is expected to reduce the arrival rate and establishments of new forest pests. However, many challenges remain to reduce pest transportation through international trade, given the ever-increasing volume of traded goods, variations in quarantine procedures between countries, and rapid changes in distribution networks. It is therefore likely that many more human-assisted invasions of forest insects will take place. New geographic expansions by natural modes are also made possible due to changes in host distribution and/or climate.http://link.springer.com/journal/103402020-01-01hj2018Forestry and Agricultural Biotechnology Institute (FABI)Zoology and Entomolog

Fluropyrimidine single agent or doublet chemotherapy as second line treatment in advanced biliary tract cancer

Fluoropyrimidine (FP) plus platinum chemotherapy has been recently established as a second-line (L2) preferred option in advanced biliary tract cancer (aBTC) (ABC-06 phase III trial). However, the overall survival (OS) benefit was limited and comparison with FP monotherapy was not available. Our aim was to assess the OS of patients treated with a FP monotherapy compared to a doublet with irinotecan or platinum in L2. We performed a retrospective analysis of two large multicenter prospective cohorts: a French cohort (28 centers) and an Italian cohort (9 centers). All consecutive patients with aBTC receiving FP-based L2 after gemcitabine plus cisplatin/gemcitabine plus oxaliplatin L1 between 2003 and 2016 were included. A subgroup analysis according to performance status (PS) and an exploratory analysis according to platinum sensitivity in L1 were planned. In the French cohort (n = 351), no significant OS difference was observed between the FP monotherapy and doublet groups (median OS: 5.6 vs 6.8 months, P =.65). Stratification on Eastern Cooperative Oncology Group (ECOG) PS showed similar results in PS 0-1 and 2. Median OS was not different between FP monotherapy, platinum- and irinotecan-based doublets (5.6 vs 7.1 vs 6.7 months, P =.68). Similar findings were observed in the Italian cohort (n = 174) and in the sensitivity analysis in pooled cohorts (n = 525). No L2 regimen seemed superior over others in the platinum resistant/refractory or sensitive subgroups. Our results suggest that FP monotherapy is as active as FP doublets in aBTC in L2, regardless of the patient PS and country, and could be a therapeutic option in this setting

prediction of overall survival with 2nd line l2os chemotherapy ct in patients with advanced biliary tract cancer abtc ageo ct2bil cohort update and international multicenter external validations

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Recent advances toward the sustainable management of invasive Xylosandrus ambrosia beetles

We provide an overview of both traditional and innovative control tools for management of three Xylosandrus ambrosia beetles (Coleoptera: Curculionidae: Scolytinae), invasive species with a history of damage in forests, nurseries, orchards and urban areas. Xylosandrus compactus, X. crassiusculus and X. germanus are native to Asia, and currently established in several countries around the globe. Adult females bore galleries into the plant xylem inoculating mutualistic ambrosia fungi that serve as food source for the developing progeny. Tunneling activity results in chewed wood extrusion from entry holes, sap outflow, foliage wilting followed by canopy dieback, and branch and trunk necrosis. Maintaining plant health by reducing physiological stress is the first recommendation for long-term control. Baited traps, ethanol-treated bolts, trap logs and trap trees of selected species can be used to monitor Xylosandrus species. Conventional pest control methods are mostly ineffective against Xylosandrus beetles because of the pests’ broad host range and rapid spread. Due to challenges with conventional control, more innovative control approaches are being tested, such as the optimization of the push–pull strategy based on specific attractant and repellent combinations, or the use of insecticide-treated netting. Biological control based on the release of entomopathogenic and mycoparasitic fungi, as well as the use of antagonistic bacteria, has yielded promising results. However, these technologies still require validation in real field conditions. Overall, we suggest that management efforts should primarily focus on reducing plant stress and potentially be combined with a multi-faceted approach for controlling Xylosandrus damage