Roteiros de práticas ambientais para monitorias de visitas escolares ao jardim botânico da UFSM na perspectiva da ecoalfabetização

Ecological Literacy is the reading and interpretation of nature that allows to see the man as anintegral part of the life’s web. This approach sets up a great contribution to the practice ofenvironmental education in both formal and informal education. In this sense, the environmentalpractices find in the botanical gardens, natural areas of big biodiversity and educational value. Theobjective of this work was offer to environmental education monitors of the Botanic Garden UFSM, scripts for monitoring of environmental practices of school visits, directed to students fromkindergarten and elementary school. The research methodology was done in practical activities inelectronic and printed bibliographies, as well as preparation of the selected activities according tothe National Curricular Parameters (PCNs). These practices have been adapted to the context ofthe Botanical Garden UFSM and organized from the perspective of Ecoliteracy. The itinerariesinclude twenty-eight environmental practices, six of them, indicated for kindergarten and twentytwofor elementary school. One of them, was selected for exemplification, implemented with thethird graders of elementary school of the Riachuello School. The results showed that theenvironmental practices beyond being facilitators of environmental education work of themonitors of the Botanical Garden UFSM are also teaching strategies for teachers and learning forstudents. This monograph of Specialization in Environmental Education (PPGEA-UFSM) wassubmitted in December 2010.A Alfabetização ecológica é a leitura e interpretação da natureza que permite ver o homem como parte integrante da teia da vida. Tal abordagem configura-se numa grande contribuição para a prática da educação ambiental tanto no ensino formal quanto informal. Neste sentido, as práticas ambientais encontram nos jardins botânicos espaços naturais de grande biodiversidade e valor educativo. O objetivo deste trabalho foi oferecer aos monitores de educação ambiental do Jardim Botânico da UFSM, roteiros de práticas ambientais para monitoria de visitas escolares, direcionadas aos estudantes da educação infantil e ensino fundamental. A metodologia do trabalho consistiu no levantamento de atividades práticas em bibliografias eletrônicas e impressas, assim como elaboração de atividades selecionadas conforme os Parâmetros Curriculares Nacionais (PCNs). Estas práticas foram adaptadas ao contexto do Jardim Botânico da UFSM e organizadas sob a perspectiva da Ecoalfabetização. Os roteiros compreendem vinte e oito práticas ambientais, sendo seis indicadas para a educação infantil e vinte e duas para o ensino fundamental. Destas, foi selecionada uma prática para exemplificação, implementada com os alunos da terceira série do ensino fundamental do Colégio Riachuello. Os resultados demonstraram que as práticas ambientais além de serem facilitadoras do trabalho de educação ambiental dos monitores do Jardim Botânico da UFSM, também são estratégias de ensino para os professores e de aprendizagem para os estudantes. Esta monografia de Especialização em Educação Ambiental (PPGEA-UFSM), foi defendida em dezembro de 2010.

Tricuspid regurgitant velocity elevation in a three-year old child with sickle cell anemia and recurrent acute chest syndromes reversed not by hydroxyurea but by bone marrow transplantation

Elevated Tricuspid Regurgitant Velocity (TRV) has been related to higher mortality in adults and to hemolysis, lower oxygen saturation during 6-minute walk test and acute chest syndrome (ACS) in children with sickle cell disease (SCD). Hydroxyurea (HU) has reduced TRV value in children and adults. We describe a three year old HbSS child with recurrent ACS, hypoperfusion of the left lung, mild hemolysis and persistent TRV elevation. TRV did not normalize after HU, despite improvement in clinical conditions and in baseline laboratory parameters related to hemolysis and blood viscosity, but normalized after bone marrow transplantation (BMT). Our experience suggests that in young patients, TRV reduction can be a positive concomitant effect of BMT

Combination antifungal therapy and surgery for the treatment of invasive pulmonary aspergillosis after hematopoietic stem cell transplantation

An 8-year old boy, affected by severe aplastic anemia, developed a probable pulmonary invasive aspergillosis (IA) early after a second unrelated allogeneic hematopoietic stem cell transplant (HSCT). He was treated promptly with the combination of liposomal amphotericin B and caspofungin. Despite the initial stabilization, the patient deteriorated and the antifungal therapy was switched to voriconazole and caspofungin. The patient gradually improved and was discharged home on day +29 post-HSCT on oral voriconazole. On day +119, a sudden episode of hemoptysis occurred and a right superior lobectomy was decided to remove the residual aspergilloma. The patient is now alive and well more than 24 months from HSCT. This case demonstrated that antifungal combination therapy and surgery are valid options to cure pulmonary IA even in patients at high-risk and severely immunosuppressed

179. Correcting the Bleeding Phenotype in Hemophilia Ausing Lentivirally FVIII-Corrected Endothelial Cells Differentiated from Hemophilic Induced Pluripotent Stem Cell (iPSC)

Hemophilia A (HA) is a bleeding disorder caused by factor VIII (FVIII) gene mutations.Somatic cells can be reprogrammed to generate autologous, disease-free iPSCs, then differentiated into cell targetsrelevant for gene and cell therapy. Our aim is to develop a novel HA treatment strategy generating FVIII-corrected patient-specific iPSCs from peripheral blood cells anddifferentiating them into functional endothelial cells (ECs), secreting FVIII after transplantation

Improvement of health-related quality of life and psychological well-being after HCV eradication with direct-acting antiviral agents. Real life setting data of an Italian cohort valued by Hepatitis Quality of Life Questionnaire (HQLQv2)

HCV (Hepatitis C Virus) decreases Health-Related Quality of Life with detriments to physical, mental and social health domains. Interferon and Ribavirin treatment is associated with depression and anxiety that further impairs HRQoL (Health- Related Quality of Life). IFN-free (interferon-free) regimes (Direct Acting Antivirals, DAAs) are safe and highly effective drugs, with improvement also of HRQoL and related Psychological Well-Being. Our aim is to describe how the latest generation IFN-free treatment can change quality of life and related Psychological Well-Being in Italian Chronic Hepatitis C/Cirrhosis affected patients. SF-36v2 (Short Form Health Survey is a 36-item, patient-reported survey of patient health) – HQLQv2 (Hepatitis Quality of Life Questionnaire) was administered at two time points: baseline (n=72) and 12 weeks after the end of therapy [n=72, SVR=72 - Sustained Virologic Response (SVR)]. Patients with chronic HCV undergoing DAAs treatment from two Italian centers were enrolled. The overall average of the answers is configured for most of the domains that make up the questionnaire, with scores above 50. The quality of life of this sample is very close to the average of the US population, with a minimum average score of 45.9 for the Role Emotional scale and an average maximum score of 56.4 for the Vitality scale. Both are significant results from statistical analysis. It seems that DAAs treatment therapy does not affect but improves the general quality and psychological state of adult patients with Chronic HCV infection

Acute alcohol intoxication: a clinical overview

Alcohol is a legal and yet detrimental psychoactive substance, capable of establishing addiction and impacting the physical, mental, social, and economic health of people. Alcohol intake causes a large variety of tissue damages severely impacting the nervous system, digestive and cardiovascular systems and causing oral cavity, oropharyngeal, hypopharyngeal, esophageal, colon-rectal, laryngeal, liver and intrahepatic bile duct, and breast cancers. Alcohol can also play a role in the pathogenesis of diabetes mellitus, cardiomyopathy and hemorrhagic strokes. When drunk during pregnancy it is proved to be responsible for serious damage to fetuses causing a wide range of pathological conditions from miscarriage to Fetal Alcoholic Spectrum Disorder (FASD). Acute ethanol intoxication happens when the amount of alcohol consumed is greater than the disposal capacity of the liver, causing an accumulation of its metabolites displayed by initial dysphoria and disinhibition. Nausea, vomiting, memory loss could happen. Although, it can lead to more serious conditions like impaired speaking, impaired coordination, unstable gait, nystagmus, stupor, or coma. Respiratory depression and death could also happen in such cases. Unfortunately, diagnosis of acute alcohol intoxication is difficult because most of the drinkers deny or minimize their assumption. It is dramatically important to assess when the last intake happened to avoid withdrawal syndrome. Alcohol acute intoxication can be considered a serious harm to health and a relevant issue for healthcare provid-ers working in emergency rooms. Differential diagnosis is crucial to avoid serious outcomes. There is no consensus about therapies for acute intoxication, but supportive and symptomatic treatments were proved effective. The repercussions of alcohol misuse over drinkers' social, familiar, economical and working life enhance the importance of a multidisciplinary approach in such cases

Creditação da extensão universitária no currículo dos cursos de graduação: estado do conhecimento

graduação. O objetivo foi construir o estado do conhecimento das produções científicas acerca da temática “creditação da extensão nos currículos dos cursos de graduação”, com aderência na área da educação. A metodologia ancora-se no estado do conhecimento e na análise bibliométrica, no período de 2007 a 2017 no banco de teses e dissertações do IBICIT e da CAPES, artigos científicos e trabalhos publicados em anais de eventos. Os descritores de busca foram: “extensão universitária e currículo” e “curricularização da extensão”. Como resultados foram encontradas treze produções, das quais constata-se que a creditação da extensão no currículo dos cursos de graduação contribui para: a reflexão conceitual; a ampliação do interesse pela extensão; a promoção da formação cidadã; o fortalecimento do processo de ensino-aprendizagem e compromisso social das IES; o impacto na formação profissional; o desafio da relação entre teoria e prática; o currículo como agente transformador e o envolvimento dos sujeitos na própria construção curricular formativa. Conclui-se que tema é recente, relevante e precisa ser amplamente investigado, sendo emergente ao contexto universitário nos processos de [re]construção curricular na graduação, especialmente em função da meta 12.7 do Plano Nacional de Educação (2014-2024)

Effects of Dietary Supplementation with Honeybee Pollen and Its Supercritical Fluid Extract on Immune Response and Fillet’s Quality of Farmed Gilthead Seabream (Sparus aurata)

The awareness of the correlation between administered diet, fish health and products’ quality has led to the increase in the research for innovative and functional feed ingredients. Herein, a plant-derived product rich in bioactive compounds, such as honeybee pollen (HBP), was includ-ed as raw (HBP) and as Supercritical Fluid Extracted (SFE) pollen (HBP_SFE) in the diet for gilt-head seabream (Sparus aurata). The experiment was carried out on 90 fish with an average body weight of 294.7 ± 12.8 g, divided into five groups, according to the administration of five diets for 30 days: control diet (CTR); two diets containing HBP at 5% (P5) and at 10% (P10) level of in-clusion; two diets containing HBP_SFE, at 0.5% (E0.5) and at 1% (E1) level of inclusion. Their ef-fects were evaluated on 60 specimens (336.2 ± 11.4 g average final body weight) considering the fish growth, the expression of some hepatic genes involved in the inflammatory response (il-1β, il-6 and il-8) through quantitative real-time PCR, and physico-chemical characterization (namely color, texture, water holding capacity, fatty acid profile and lipid peroxidation) of the fish fillets monitored at the beginning (day 0) and after 110 days of storage at −20 °C. The results obtained showed that the treatment with diet E1 determined the up-regulation of il-1β, il-6, and il-8 (p < 0.05); however, this supplementation did not significantly contribute to limiting the oxidative stress. Nevertheless, no detrimental effect on color and the other physical characteristics was observed. These results suggest that a low level of HBP_SFE could be potentially utilized in aq-uaculture as an immunostimulant more than an antioxidant, but further investigation is neces-sary