Single-longitudinal-mode optical parametric oscillator for spectroscopic applications

500 MHz) in the wavelength range 435 to 2000 ran with energy of 3.5 mJ at a pump energy of 22 mJ. Continuous scanning over 30 to 100 GHz (depending on wavelength) is demonstrated by recording of the resonance line of the Hg atom at 253.7 nm and a vibrational transition of the CO2 molecule at 1528 nm. (C) 2002 Optical Society of America

Frequency conversion by nonlinear optics: narrow bandwidth sources and applications

Hogervorst, W. [Promotor]Duijn, E.J. [Copromotor]van Heuvel, J.C. van de [Copromotor

Resolution studies of cosmic-ray tracks in a TPC with GEM readout

A large volume TPC is a leading candidate for the central tracking detector at a future high energy linear collider. To improve the resolution a new readout based on micro-pattern gas detectors is being developed. Measurements of the spatial resolution of cosmic-ray tracks in a GEM TPC are presented. We find that the resolution suffers if the readout pads are too wide with respect to the charge distribution at the readout plane due to insufficient charge sharing. For narrow pads of 2 x 6 mm**2 we measure a resolution of 100 micometer at short drift distances in the absence of an axial magnetic field. The dependence of the spatial resolution as a function of drift distance allows the determination of the underlying electron statistics. Our results show that the present technique uses about half the statistical power available from the number of primary electrons. The track angle effect is observed as expected.Comment: 18 pages, 8 figures, version as published in Nucl. Inst. Met

Third-harmonic generation of a continuous-wave Ti : Sapphire laser in external resonant cavities

An all-solid-state tunable continuous-wave (cw) laser operating near 272 nm with a bandwidth Gamma approximate to 3 MHz has been developed. The third harmonic of light from a single-cw Ti:Sapphire laser has been generated using two external enhancement cavities. An output power of 175 mW has been produced, corresponding to an overall conversion efficiency of 8%. (C) 2003 American Institute of Physics

Measurement of electron screening in muonic lead

Energies of the transitions between high-lying (n≥6) states of muonic lead were accurately determined. The results are interpreted as a ∼2% test of the electron screening. The agreement between experiment and theory is good if it is assumed that the refilling of the electron K shell is fast. The present results furthermore severely restrict possible ionization of the electron L shell

Patient admission planning using Approximate Dynamic Programming

Tactical planning in hospitals involves elective patient admission planning and the allocation of hospital resource capacities. We propose a method to develop a tactical resource allocation and patient admission plan that takes stochastic elements into consideration, thereby providing robust plans. Our method is developed in an Approximate Dynamic Programming (ADP) framework and copes with multiple resources, multiple time periods and multiple patient groups with uncertain treatment paths and an uncertain number of arrivals in each time period. As such, the method enables integrated decision making for a network of hospital departments and resources. Computational results indicate that the ADP approach provides an accurate approximation of the value functions, and that it is suitable for large problem instances at hospitals, in which the ADP approach performs significantly better than two other heuristic approaches. Our ADP algorithm is generic, as various cost functions and basis functions can be used in various hospital setting

Crystal Structure of Agaricus bisporus Mushroom Tyrosinase: Identity of the Tetramer Subunits and Interaction with Tropolone

Tyrosinase catalyzes the conversion of phenolic compounds into their quinone derivatives, which are precursors for the formation of melanin, a ubiquitous pigment in living organisms. Because of its importance for browning reactions in the food industry, the tyrosinase from the mushroom Agaricus bisporus has been investigated in depth. In previous studies the tyrosinase enzyme complex was shown to be a H2L2 tetramer, but no clues were obtained of the identities of the subunits, their mode of association, and the 3D structure of the complex. Here we unravel this tetramer at the molecular level. Its 2.3 Å resolution crystal structure is the first structure of the full fungal tyrosinase complex. The complex comprises two H subunits of ~392 residues and two L subunits of ~150 residues. The H subunit originates from the ppo3 gene and has a fold similar to other tyrosinases, but it is ~100 residues larger. The L subunit appeared to be the product of orf239342 and has a lectin-like fold. The H subunit contains a binuclear copper-binding site in the deoxy-state, in which three histidine residues coordinate each copper ion. The side chains of these histidines have their orientation fixed by hydrogen bonds or, in the case of His85, by a thioether bridge with the side chain of Cys83. The specific tyrosinase inhibitor tropolone forms a pre-Michaelis complex with the enzyme. It binds near the binuclear copper site without directly coordinating the copper ions. The function of the ORF239342 subunits is not known. Carbohydrate binding sites identified in other lectins are not conserved in ORF239342, and the subunits are over 25 Å away from the active site, making a role in activity unlikely. The structures explain how calcium ions stabilize the tetrameric state of the enzyme.

THE EUROPEAN PHYSICAL JOURNAL D High-resolution spectroscopy on ground-state transitions of samarium-I

Abstract. A high resolution laser-induced fluorescence study has been performed on thirteen ground-state transitions in samarium, using a frequency-doubled Ti:sapphire laser in the wavelength range 350-440 nm. From each spectrum isotope shifts and hyperfine structure constants A and B are derived. The results are used to determine the nuclear parameter λ AA . PACS. 32.30.Jc Visible and ultraviolet spectra -32.10.Fn Fine and hyperfine structure -32.70.Jz Line shapes, widths, and shift