Growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula in infants with cow’s milk protein allergy

ObjectiveTo evaluate growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula (eHCF) in infants with cow’s milk protein allergy (CMPA).MethodsA total of 226 infants (mean ± SD age: 106.5 ± 39.5 days, 52.7% were girls) with CMPA who received eHCF comprising at least half of the daily dietary intake were included. Data on anthropometrics [weight for age (WFA), length for age (LFA) and weight for length (WFL) z-scores] were recorded at baseline (visit 1), while data on infant feeding and stool records, anthropometrics and Infant Feeding and Stool Patterns and Formula Satisfaction Questionnaires were recorded at visit 2 (on Days 15 ± 5) and visit 3 (on Days 30 ± 5).ResultsFrom baseline to visit 2 and visit 3, WFA z-scores (from −0.60 ± 1.13 to −0.54 ± 1.09 at visit 2, and to −0.44 ± 1.05 at visit 3, p < 0.001) and WFL z-scores (from −0.80 ± 1.30 to −0.71 ± 1.22 at visit 2, and to −0.64 ± 1.13 at visit 3, p = 0.002) were significantly increased. At least half of infants never experienced irritability or feeding refusal (55.7%) and spit-up after feeding (50.2%). The majority of mothers were satisfied with the study formula (93.2%), and wished to continue using it (92.2%).ConclusionsIn conclusion, eHCF was well-accepted and tolerated by an intended use population of infants  ≤ 6 months of age with CMPA and enabled adequate volume consumption and improved growth indices within 30 days of utilization alongside a favorable gastrointestinal tolerance and a high level of parental satisfaction

Software Defect Prediction in the Cloud

Software defect prediction is one of the software quality assurance activities that can be applied during the software development life cycle. This activity helps quality assurance groups and project managers to determine risky modules which require more attention and more testing efforts. In this study, we investigated nine classification algorithms on 22 datasets which contain class-level metrics as part of our withinproject case study. After this case study, we sorted the datasets regarding their data instances and performed cross-project experiments on the large datasets, namely Apache Xalan, Xerces, and POI projects. We demonstrated that Decision Tree based algorithms are mostly superior to the other classification algorithms for within-project defect prediction and acceptable results can be achieved with Logistic Regression algorithms for cross-project defect prediction even if the data transformation approaches are not applied

Quartz Crystal Microbalance Based Histidine Sensor

Herein, quartz crystal microbalance (QCM) biosensor is prepared for the detection of L-histidine by attachment of L-histidine imprinted poly(EGDMA-MAH/Cu(II)) nanoparticles on QCM electrode. The imprinted nanoparticles with the size of 86.43 nm were synthesized via miniemulsion polymerization reaction. Prepared QCM sensors were characterized with ellipsometer, contact angle measurements and FTIR. The thickness measurements demonstrated that the particle thin films were almost mono-layer. L-histidine solutions with a concentration range between 6.44 mu M and 225.6 mu M were introduced to QCM system to determine the adsorption kinetics. Selectivity of the L-histidine imprinted nanoparticles were examined using D-histidine and L-tryptophan as competitor molecules. L-histidine imprinted QCM biosensors was also used for RNAase, lysozyme, cytochrome-C and BSA to investigate the competitive adsorption of surface histidine exposed proteins.WoSScopu

Nanocarriers for Plant-Derived Natural Compounds

WOS: 00042948380002

Non-vitamin K antagonist oral anticoagulant use at doses inappropriately lower than recommended in outpatient older adults: a real-life data

Background/Purpose There has been a rapid increase in the use of non-vitamin K-antagonist oral anticoagulants (NOAC). Current guidelines recommend dose adjustments be made in accordance with certain criteria for each NOAC. This study is aimed at determining whether or not NOAC were prescribed for non-valvular atrial fibrillation (AF) in guideline-recommended doses in community-dwelling older adults

The relationship between sarcopenia and urinary incontinence

Key summary pointsAim The purpose of this research was to investigate the relationship between urinary incontinence (stress and/or urgency) and sarcopenia in a large group of female older adults. Findings UI is independently associated with sarcopenia when muscle mass was adjusted by weight and also with presence of low muscle mass when muscle mass was adjusted by weight or BMI. Message Evaluation of sarcopenia may have a role in the management of stress and urgency urinary incontinence