The Pingding segment of the Altyn Tagh Fault (91E): Holocene slip-rate determination from cosmogenic radionuclide dating of offset fluvial terraces

International audienceMorphochronologic slip-rates on the Altyn Tagh Fault (ATF) along the southern front of the Pingding Shan at 90.5E are determined by cosmogenic radionuclide (CRN) dating of seven offset terraces at two sites. The terraces are defined based upon morphology, elevation and dating, together with fieldwork and high-resolution satellite analysis. The majority of the CRN model ages fall within narrow ranges (<2 ka) on the four main terraces (T1, T2, T3 and T3′), and allow a detailed terrace chronology. Bounds on the terrace ages and offsets of 5 independent terraces yield consistent slip-rate estimates. The long-term slip-rate of 13.9+/-1.1 mm/yr is defined at the 95% confidence level, as the joint rate probability distribution of the rate derived from each independent terrace. It falls within the bounds of all the rates defined on the central Altyn Tagh Fault between the Cherchen He (86.4E) and Akato Tagh (88E) sites. This rate is 10 mm/yr less than the upper rate determined near Tura at 87E, in keeping with the inference of an eastward decreasing rate due to progressive loss of slip to thrusts branching off the fault southwards but it is greater than the 9+/-4 mm/yr rate determined at 90E by GPS surveys and other geodetic short-term rates defined elsewhere along the ATF. Whether such disparate rates will ultimately be reconciled by a better understanding of fault mechanics, resolved transient deformations during the seismic cycle or by more accurate measurements made with either approach remains an important issue

Applications of Morphochronology to the Active Tectonics of Tibet

The Himalayas and the Tibetan Plateau were formed as a result of the collision of India and Asia, and provide an excellent opportunity to study the mechanical response of the continental lithosphere to tectonic stress. Geophysicists are divided in their views on the nature of this response advocating either (1) homogeneously distributed deformation with the lithosphere deforming as a fluid continuum or (2) deformation is highly localized with the lithosphere that deforms as a system of blocks. The resolution of this issue has broad implications for understanding the tectonic response of continental lithosphere in general. Homogeneous deformation is supported by relatively low decadal, geodetic slip-rate estimates for the Altyn Tagh and Karakorum Faults. Localized deformation is supported by high millennial, geomorphic slip-rates constrained by both cosmogenic and radiocarbon dating on these faults. Based upon the agreement of rates determined by radiocarbon and cosmogenic dating, the overall linearity of offset versus age correlations, and on the plateau-wide correlation of landscape evolution and climate history, the disparity between geomorphic and geodetic slip-rate determinations is unlikely to be due to the effects of surface erosion on the cosmogenic age determinations. Similarly, based upon the consistency of slip-rates over various observation intervals, secular variations in slip-rate appear to persist no longer than 2000 years and are unlikely to provide reconciliation. Conversely, geodetic and geomorphic slip-rate estimates on the Kunlun fault, which does not have significant splays or associated thrust faults, are in good agreement, indicating that there is no fundamental reason why these complementary geodetic and geomorphic methods should disagree. Similarly, the geodetic and geomorphic estimates of shortening rates across the northeastern edge of the plateau are in reasonable agreement, and the geomorphic rates on individual thrust faults demonstrate a significant eastward decrease in the shortening rate. This rate decrease is consistent with the transfer of slip from the Altyn Tagh Fault (ATF) to genetically-related thrust mountain building at its terminus. Rates on the ATF suggest a similar decrease in rate, but the current data set is too small to be definitive. Overall, the high, late Pleistocene-Holocene, geomorphic slip velocities on the major strike-slip faults of Tibet, suggests that they absorb as much of India's convergence relative to Siberia as the Himalayan Main Frontal Thrust on the southern edge of the plateau

An international parentage and identification panel for the domestic cat (Felis catus)

Seventeen commercial and research laboratories participated in two comparison tests under the auspices of the International Society for Animal Genetics to develop an internationally tested, microsatellite-based parentage and identification panel for the domestic cat (Felis catus). Genetic marker selection was based on the polymorphism information content and allele ranges from seven random-bred populations (n = 261) from the USA, Europe and Brazil and eight breeds (n = 200) from the USA. Nineteen microsatellite markers were included in the comparison test and genotyped across the samples. Based on robustness and efficiency, nine autosomal microsatellite markers were ultimately selected as a single multiplex ‘core’ panel for cat identification and parentage testing. Most markers contained dinucleotide repeats. In addition to the autosomal markers, the panel included two gender-specific markers, amelogenin and zinc-finger XY, which produced genotypes for both the X and Y chromosomes. This international cat parentage and identification panel has a power of exclusion comparable to panels used in other species, ranging from 90.08% to 99.79% across breeds and 99.47% to 99.87% in random-bred cat populations

Localization of Secondary Metabolites in Marine Invertebrates: Contribution of MALDI MSI for the Study of Saponins in Cuvierian Tubules of H. forskali

BACKGROUND: Several species of sea cucumbers of the family Holothuriidae possess a particular mechanical defense system called the Cuvierian tubules (Ct). It is also a chemical defense system as triterpene glycosides (saponins) appear to be particularly concentrated in Ct. In the present study, the precise localization of saponins in the Ct of Holothuria forskali is investigated. Classical histochemical labeling using lectin was firstly performed but did not generate any conclusive results. Thus, MALDI mass spectrometry Imaging (MALDI-MSI) was directly applied and completed by statistical multivariate tests. A comparison between the tubules of relaxed and stressed animals was realized. RESULTS: These analyses allowed the detection of three groups of ions, corresponding to the isomeric saponins of the tubules. Saponins detected at m/z 1287 and 1303 were the most abundant and were apparently localized in the connective tissue of the tubules of both relaxed and stressed individuals. Saponins at m/z 1125 and 1141 were detected in lower amount and were present in tissues of relaxed animals. Finally, saponin ions at 1433, 1449, 1463 and 1479 were observed in some Ct of stressed holothuroids in the outer part of the connective tissue. The saponin group m/z 14xx seems therefore to be stress-specific and could originate from modifications of the saponins with m/z of 11xx. CONCLUSIONS: All the results taken together indicate a complex chemical defense mechanism with, for a single organ, different sets of saponins originating from different cell populations and presenting different responses to stress. The present study also reflects that MALDI-MSI is a valuable tool for chemical ecology studies in which specific chemical signalling molecules like allelochemicals or pheromones have to be tracked. This report represents one of the very first studies using these tools to provide a functional and ecological understanding of the role of natural products from marine invertebrates

Multiple Changes in Peptide and Lipid Expression Associated with Regeneration in the Nervous System of the Medicinal Leech

peer reviewe

Utilisation de marqueurs génétiques en sélection : les activités de Labogena

National audienceLe diagnostic génétique appliqué à la sélection animale n’est pas récent, mais des progrès fantastiques ont été réalisés ces dernières années grâce à l’émergence des techniques de biologie moléculaire. L’évolution du nombre d’analyses réalisées par LABOGENA, 45 000 en 1988 pour plus de 100 000 en 1998, est bien la preuve de cet essor. Si deux tiers des activités demeurent traditionnelles, 30 % sont réalisées grâce aux marqueurs de l’ADN et la tendance va encore s’accentuer. La biologie moléculaire permet de réaliser des progrès et d’augmenter les possibilités de diagnostic : les supports biologiques utilisables sont nombreux (sang, poil, peau, viande, embryon, sperme …) ; l’émergence de nouveaux marqueurs polymorphes comme les marqueurs microsatellites de l’ADN permet l’identification et le contrôle de filiations pour de nouvelles espèces (Porc, Chien, Turbot …) ; les diagnostics peuvent être réalisés très précocement par l’analyse directe des variations des gènes impliqués (exemple de la qualité fromagère du lait déterminée sur les futurs reproducteurs mâles) ; les pathologies d’origine génétique peuvent être recherchées par les mutations causales (hyperthermie maligne, tremblante …). Ces informations sur les génotypes aident les sélectionneurs à définir leurs stratégies et permettent d’assurer une bonne gestion des reproducteurs et des populations animales