870 research outputs found

    Effects of 1- and 2-MeV electrons on photomultiplier tubes

    Get PDF
    Various types of photomultiplier tubes useful for space applications were irradiated with 1- and 2-MeV electrons at Van Allen radiation belt fluxes of 100,000 to 10 millions electrons/sq cm-sec. The increase in the dark current due to electron irradiation was observed at various bias voltages under worst-case conditions (no shielding). Results were presented in the form of dark current plotted against electron flux. All the tubes tested showed extremely large increases in dark current. Tube types 541A, 6217, 6199, and 6903 exhibited the largest increases under irradiation, whereas type 1P22 was affected the least. All the damage observed was transient. The luminescence produced in the optical window probably accounts for a large part of the dark-current increases, but there were some effects possibly due to direct irradiation of the photocathode and dynode chain

    Reconstructing the three-dimensional GABAergic microcircuit of the striatum

    Get PDF
    A system's wiring constrains its dynamics, yet modelling of neural structures often overlooks the specific networks formed by their neurons. We developed an approach for constructing anatomically realistic networks and reconstructed the GABAergic microcircuit formed by the medium spiny neurons (MSNs) and fast-spiking interneurons (FSIs) of the adult rat striatum. We grew dendrite and axon models for these neurons and extracted probabilities for the presence of these neurites as a function of distance from the soma. From these, we found the probabilities of intersection between the neurites of two neurons given their inter-somatic distance, and used these to construct three-dimensional striatal networks. The MSN dendrite models predicted that half of all dendritic spines are within 100 mu m of the soma. The constructed networks predict distributions of gap junctions between FSI dendrites, synaptic contacts between MSNs, and synaptic inputs from FSIs to MSNs that are consistent with current estimates. The models predict that to achieve this, FSIs should be at most 1% of the striatal population. They also show that the striatum is sparsely connected: FSI-MSN and MSN-MSN contacts respectively form 7% and 1.7% of all possible connections. The models predict two striking network properties: the dominant GABAergic input to a MSN arises from neurons with somas at the edge of its dendritic field; and FSIs are interconnected on two different spatial scales: locally by gap junctions and distally by synapses. We show that both properties influence striatal dynamics: the most potent inhibition of a MSN arises from a region of striatum at the edge of its dendritic field; and the combination of local gap junction and distal synaptic networks between FSIs sets a robust input-output regime for the MSN population. Our models thus intimately link striatal micro-anatomy to its dynamics, providing a biologically grounded platform for further study

    Researchers' experience with project management in health and medical research: Results from a post-project review

    Get PDF
    <p>Abstract</p> <p>Background</p> <p>Project management is widely used to deliver projects on time, within budget and of defined quality. However, there is little published information describing its use in managing health and medical research projects. We used project management in the <it>Alcohol and Pregnancy Project </it>(2006-2008) <url>http://www.ichr.uwa.edu.au/alcoholandpregnancy</url> and in this paper report researchers' opinions on project management and whether it made a difference to the project.</p> <p>Methods</p> <p>A national interdisciplinary group of 20 researchers, one of whom was the project manager, formed the Steering Committee for the project. We used project management to ensure project outputs and outcomes were achieved and all aspects of the project were planned, implemented, monitored and controlled. Sixteen of the researchers were asked to complete a self administered questionnaire for a post-project review.</p> <p>Results</p> <p>The project was delivered according to the project protocol within the allocated budget and time frame. Fifteen researchers (93.8%) completed a questionnaire. They reported that project management increased the effectiveness of the project, communication, teamwork, and application of the interdisciplinary group of researchers' expertise. They would recommend this type of project management for future projects.</p> <p>Conclusions</p> <p>Our post-project review showed that researchers comprehensively endorsed project management in the <it>Alcohol and Pregnancy Project </it>and agreed that project management had contributed substantially to the research. In future, we will project manage new projects and conduct post-project reviews. The results will be used to encourage continuous learning and continuous improvement of project management, and provide greater transparency and accountability of health and medical research. The use of project management can benefit both management and scientific outcomes of health and medical research projects.</p

    Measurements of double-helicity asymmetries in inclusive J/ψJ/\psi production in longitudinally polarized p+pp+p collisions at s=510\sqrt{s}=510 GeV

    Full text link
    We report the double helicity asymmetry, ALLJ/ψA_{LL}^{J/\psi}, in inclusive J/ψJ/\psi production at forward rapidity as a function of transverse momentum pTp_T and rapidity y|y|. The data analyzed were taken during s=510\sqrt{s}=510 GeV longitudinally polarized pp++pp collisions at the Relativistic Heavy Ion Collider (RHIC) in the 2013 run using the PHENIX detector. At this collision energy, J/ψJ/\psi particles are predominantly produced through gluon-gluon scatterings, thus ALLJ/ψA_{LL}^{J/\psi} is sensitive to the gluon polarization inside the proton. We measured ALLJ/ψA_{LL}^{J/\psi} by detecting the decay daughter muon pairs μ+μ\mu^+ \mu^- within the PHENIX muon spectrometers in the rapidity range 1.2<y<2.21.2<|y|<2.2. In this kinematic range, we measured the ALLJ/ψA_{LL}^{J/\psi} to be 0.012±0.0100.012 \pm 0.010~(stat)~±\pm~0.0030.003(syst). The ALLJ/ψA_{LL}^{J/\psi} can be expressed to be proportional to the product of the gluon polarization distributions at two distinct ranges of Bjorken xx: one at moderate range x0.05x \approx 0.05 where recent RHIC data of jet and π0\pi^0 double helicity spin asymmetries have shown evidence for significant gluon polarization, and the other one covering the poorly known small-xx region x2×103x \approx 2\times 10^{-3}. Thus our new results could be used to further constrain the gluon polarization for x<0.05x< 0.05.Comment: 335 authors, 10 pages, 4 figures, 3 tables, 2013 data. Version accepted for publication by Phys. Rev. D. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm

    Observation of direct-photon collective flow in sqrt(s_NN)=200 GeV Au+Au collisions

    Get PDF
    The second Fourier component v_2 of the azimuthal anisotropy with respect to the reaction plane was measured for direct photons at midrapidity and transverse momentum (p_T) of 1--13 GeV/c in Au+Au collisions at sqr(s_NN)=200 GeV. Previous measurements of this quantity for hadrons with p_T < 6 GeV/c indicate that the medium behaves like a nearly perfect fluid, while for p_T > 6 GeV/c a reduced anisotropy is interpreted in terms of a path-length dependence for parton energy loss. In this measurement with the PHENIX detector at the Relativistic Heavy Ion Collider we find that for p_T > 4 GeV/c the anisotropy for direct photons is consistent with zero, as expected if the dominant source of direct photons is initial hard scattering. However, in the p_T < 4 GeV/c region dominated by thermal photons, we find a substantial direct photon v_2 comparable to that of hadrons, whereas model calculations for thermal photons in this kinematic region significantly underpredict the observed v_2.Comment: 384 authors, 6 pages, 3 figures, and 1 table. Submitted to Phys. Rev. Lett. v2 has minor changes to match the submission version. Plain text data tables for the points plotted in the figures are publicly available at http://www.phenix.bnl.gov/phenix/WWW/info/data/ppg126_data.htm

    J/psi suppression at forward rapidity in Au+Au collisions at sqrt(s_NN)=39 and 62.4 GeV

    Get PDF
    We present measurements of the J/psi invariant yields in sqrt(s_NN)=39 and 62.4 GeV Au+Au collisions at forward rapidity (1.2<|y|<2.2). Invariant yields are presented as a function of both collision centrality and transverse momentum. Nuclear modifications are obtained for central relative to peripheral Au+Au collisions (R_CP) and for various centrality selections in Au+Au relative to scaled p+p cross sections obtained from other measurements (R_AA). The observed suppression patterns at 39 and 62.4 GeV are quite similar to those previously measured at 200 GeV. This similar suppression presents a challenge to theoretical models that contain various competing mechanisms with different energy dependencies, some of which cause suppression and others enhancement.Comment: 365 authors, 10 pages, 11 figures, 4 tables. Submitted to Phys. Rev. C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.htm
    corecore