Integrating Preclinical and Clinical Models of Negative Urgency

Overwhelming evidence suggests that negative urgency is robustly associated with rash, ill-advised behavior, and this trait may hamper attempts to treat patients with substance use disorder. Research applying negative urgency to clinical treatment settings has been limited, in part, due to the absence of an objective, behavioral, and translational model of negative urgency. We suggest that development of such a model will allow for determination of prime neurological and physiological treatment targets, the testing of treatment effectiveness in the preclinical and the clinical laboratory, and, ultimately, improvement in negative-urgency-related treatment response and effectiveness. In the current paper, we review the literature on measurement of negative urgency and discuss limitations of current attempts to assess this trait in human models. Then, we review the limited research on animal models of negative urgency and make suggestions for some promising models that could lead to a translational measurement model. Finally, we discuss the importance of applying objective, behavioral, and translational models of negative urgency, especially those that are easily administered in both animals and humans, to treatment development and testing and make suggestions on necessary future work in this field. Given that negative urgency is a transdiagnostic risk factor that impedes treatment success, the impact of this work could be large in reducing client suffering and societal costs

Differential effects of angiotensin II type 2 receptor antagonism in mice models of obesity

Angiotensin II ( ang II) is a vasoactive hormone derived from the renin angiotensin system (RAS), which regulates blood pressure and fluid balance in the body. Ang II effects are mediated via two major receptors: type 1 (AT 1) and type 2 (AT 2). Adipocytes contain a local RAS in which ang II upregulates adipogenesis, fatty acid and triglyceride synthesis primarily mediated via the AT 2 receptor in cultured adipocytes. Preliminary studies from our lab tested the importance of AT 2 receptors in vivo and reported a decrease in adiposity by AT 2 antagonism in the lean, but not the genetically obese db/db mouse. To further explore these effects, we used another genetic model of obesity (ob/ob) and diet-induced obese (DIO) mice and treated them for 2-3 weeks with the AT 2 receptor antagonist, PD 123,319. Body weight, fat pad weight and plasma glucose, leptin and insulin levels and fatty acid synthase (FAS) and glycerol-3-phosphate dehydrogenase (GPDH) activity were measured. Consistent with previous findings in lean mice, the AT 2 antagonist decreased abdominal fat pad weight in ob/ob mice and accelerated weight loss in D10 mice. Also, correlated with these effects, AT2 blockade decreased FAS activity in ob/ob mice and lowered blood glucose levels in DIO mice. No significant changes were seen in the other parameters that were measured. In combination with recently published data, this research further supports the role of the AT 2 receptor in modulating ang II effects on adipocyte metabolism. Defining this role is crucial in determining and preventing the contribution of adipocyte-derived RAS to systemic disorders such as obesity-related hypertension

The Commonwealth Honors College Residential Community at the University of Massachusetts Amherst

This article provides a project overview of the newly constructed Commonwealth Honors College Residential Community, an historical context for the honors college at the University of Massachusetts Amherst, a description of the facility design, information on the collaborative planning process, and a brief discussion of initial impacts on the operations and services of the honors college

The Commonwealth Honors College Residential Community at the University of Massachusetts Amherst

This article provides a project overview of the newly constructed Commonwealth Honors College Residential Community, an historical context for the honors college at the University of Massachusetts Amherst, a description of the facility design, information on the collaborative planning process, and a brief discussion of initial impacts on the operations and services of the honors college

Responses to intimate partners’ attempts to change health behavior: The role of readiness

Intimate partners seeking to influence one another’s health may do so by providing support for positive health behavior and attempting to change negative health behavior (social control). Research findings examining the effectiveness of intimate partners’ attempts to influence health behavior are mixed however, and the purpose of the present research is to examine individuals’ responses to hypothetical health behavior influence attempts by an intimate partner. Specifically, we examine the role of readiness to change, cognitive appraisals, and affective responses to partner change attempts. Undergraduate students (n = 185) who reported infrequent exercise or unhealthy eating habits were asked to respond to a variety of tactics an intimate partner might use to try to change their health behavior. In the first phase of the study, we examine a model wherein individuals’ readiness to change influences their perceptions of, and affective reactions to, attempts to influence health behavior and the subsequent likelihood of making a behavioral change. In Phase 2, we use a within-subjects experimental design to simulate changes in readiness and assess resulting changes to affective and perceptual responses to a variety of hypothetical support and control attempts by an intimate partner. The findings indicate that a comprehensive model that includes readiness to change more fully accounts for variance in how individuals respond to partners’ change attempts. Theoretical and clinical implications are discussed

Health Management: Occupational Therapy’s Key Role in Educating Clients About Reliable Online Health Information

Background: Only 12% of Americans possess proficient health literacy skills. Among those with the lowest health literacy are individuals with chronic health conditions. Occupational therapists are well prepared to assist these clients with health literacy, given our roles in teaching new health management skills and health promotion. Methods: An educational course was designed and taught to over 100 individuals and caregivers with chronic health conditions to assist in finding and determining trustworthy health information online. An author designed pre postsurvey was used to evaluate effectiveness. Results: There was a significant pre-post change in four categories: finding quality health information online (M = 0.703), judging trustworthiness of online health information (M = 0.624), understanding health information (M = 0.489), and retrieving information using email alerts (M = 0.826). Conclusion: The ability to find and evaluate health information online empowers clients to fully participate in medical care. Evidence shows that this skill can be efficiently taught to clients or client groups for improved health management. Providing training in finding trustworthy health information online is a skill that occupational therapists can successfully teach in conjunction with overall health management skills for improved occupational participation

Regressive Evolution in the Mexican Cave Tetra, Astyanax mexicanus

Cave adapted animals generally have reduced pigmentation and eyes, but the evolutionary forces driving the reductions are unknown; Darwin famously questioned the role of natural selection in eye loss in cave fishes; “As it is difficult to imagine that eyes, although useless, could be in any way injurious to animals living in darkness, I attribute their loss wholly to disuse” [1]. We studied the genetic basis of this phenomenon in the Mexican cave tetra, Astyanax mexicanus, by mapping the quantitative trait loci (QTL) determining differences in eye/lens sizes and melanophore number between cave and surface fish. In addition, we mapped QTL for the putatively constructive traits of jaw size, tooth number, and numbers of taste buds. The data suggest that eyes and pigmentation regressed through different mechanisms. Cave alleles at each eye/lens QTL we detected caused size reductions. This uniform negative polarity is consistent with evolution by natural selection and inconsistent with evolution by drift. In contrast, QTL polarities for melanophore number were mixed, consistent with evolution by genetic drift or indirect selection through pleiotropy. Past arguments against a role for selection in regression of cave fish eyes cited the insignificant cost of their development [2,3], but we argue that the energetic cost of their maintenance is sufficiently high for eyes to be detrimental in the cave environment. Regression, a ubiquitous aspect of all evolutionary change, can be caused either by selection or genetic drift/pleiotropy

Treatment intensity and characteristics of MRSA infection in CF

Background: Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and interchange of hospital-associated strains carrying the staphylococcal chromosomal cassette mec-II (SCCmec-II) with those in the community (SCCmec-IV) has increased. This study assesses the impact of MRSA and different MRSA types on clinical outcomes, medication use, and antibiotic sensitivities. Methods: MRSA isolates from CF patients at our center were typed by SCCmec- and pvl status. Patient characteristics, lung function and nutrition are compared between MRSA types and to age, gender and Pseudomonas aeruginosa matched patients with chronic methicillin sensitive S. aureus (MSSA) infection. Results: Seventy-two percent of patients carry pvl negative SCCmec-II isolates. Seventeen percent of all MRSA were SCCmec-IV pvl positive (USA300). These patients were younger and fewer had chronic P. aeruginosa infection, whereas pvl-negative SCCmec-IV isolates show highest antibiotic resistance. Nutritional outcomes and FEV1 percent predicted (75.1±2.7 versus 77.9±2.7) did not differ in patients with MRSA compared to those with MSSA but MRSA patients received more pulmonary maintenance but not oral antibiotic medications. Conclusion: Patients with chronic MRSA are treated more intensely than age, gender and Pseudomonas aeruginosa matched MSSA-positive patients but clinical characteristics within MRSA patients vary depending on MRSA types