An Analysis Of The Position Of Assistant Principal Of The Year In Indiana: An Analysis Of What Is Really Important

This work is an analysis of the alignment between schools associated with an Indiana Assistant Principal of the Year, as selected by the Indiana Association of School Principals, and increases in academic performance of those schools on state mandated “high stakes” academic tests.  The focus was on school improvement using annual school report card data. Using a design looking for association and a Chi Square analysis, a significant positive correlation was identified.  The results shed some light on the potential excellent practices of assistant-principals and student academic achievement gains.  Although a positive correlation was found, the results can only give ideas for leadership consideration.  They are not considered predictive because of the ex-post facto nature of the data allowing for no manipulation of variables

Estimating the horizontal and vertical direction-of-arrival of water-borne seismic signals in the northern Philippine Sea

Author Posting. © Acoustical Society of America, 2013. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 134 (2013): 3282, doi:10.1121/1.4818843.Conventional and adaptive plane-wave beamforming with simultaneous recordings by large-aperture horizontal and vertical line arrays during the 2009 Philippine Sea Engineering Test (PhilSea09) reveal the rate of occurrence and the two-dimensional arrival structure of seismic phases that couple into the deep ocean. A ship-deployed, controlled acoustic source was used to evaluate performance of the horizontal array for a range of beamformer adaptiveness levels. Ninety T-phases from unique azimuths were recorded between Yeardays 107 to 119. T-phase azimuth and S-minus-P-phase time-of-arrival range estimates were validated using United States Geological Survey seismic monitoring network data. Analysis of phases from a seismic event that occurred on Yearday 112 near the east coast of Taiwan approximately 450 km from the arrays revealed a 22° clockwise evolution of T-phase azimuth over 90 s. Two hypotheses to explain such evolution—body wave excitation of multiple sources or in-water scattering—are presented based on T-phase origin sites at the intersection of azimuthal great circle paths and ridge/coastal bathymetry. Propagation timing between the source, scattering region, and array position suggests the mechanism behind the evolution involved scattering of the T-phase from the Ryukyu Ridge and a T-phase formation/scattering location estimation error of approximately 3.2 km.This research is supported by the Office of Naval Research, both the Applied Research Laboratory program and Code 322(OA)

SCCharts: Sequentially Constructive Statecharts for Safety-Critical Applications

We present a new visual language, SCCharts, designed for specifying safety-critical reactive systems. SCCharts uses a new statechart notation and provides deterministic concurrency based on a synchronous model of computation (MoC), without restrictions common to previous synchronous MoCs. Specifically, we lift earlier limitations on sequential accesses to shared variables, by leveraging the sequentially constructive MoC. The key features of SCCharts are defined by a very small set of elements, the Core SCCharts, consisting of state machines plus fork/join concurrency. Conversely, Extended SCCharts contain a rich set of advanced features, such as different abort types, signals, history transitions, etc., all of which can be reduced via model-to-model transformations into Core SCCharts. This approach enables a simple yet efficient compilation strategy and aids verification and certification

Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents

AbstractThe adipose tissue hormone, leptin, and the neuropeptide glucagon-like peptide-1 (7–36) amide (GLP-1) both reduce food intake and body weight in rodents. Using dual in situ hybridization, long isoform leptin receptor (OB-Rb) was localized to GLP-1 neurons originating in the nucleus of the solitary tract. ICV injection of the specific GLP-1 receptor antagonist, exendin(9–39), at the onset of dark phase, did not affect feeding in saline pre-treated controls, but blocked the reduction in food intake and body weight of leptin pre-treated rats. These findings suggest that GLP-1 neurons are a potential target for leptin in its control of feeding

Deep water towed array measurements at close range

Author Posting. © Acoustical Society of America, 2013. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 134 (2013): 3230, doi:10.1121/1.4818869.During the North Pacific Acoustic Laboratory Philippine Sea 2009 experiment, towed array receptions were made from a towed source as the two ships transited from a separation of several Convergence Zones through a Closest Point of Approach at 3 km. A combination of narrowband tones and broadband pulses were transmitted covering the frequency band 79–535 Hz. The received energy arrives from two general paths—direct path and bottom bounce. Bearing-time records of the narrowband arrivals at times show a 35° spread in the angle of arrival of the bottom bounce energy. Doppler processing of the tones shows significant frequency spread of the bottom bounce energy. Two-dimensional modeling using measured bathymetry, a geoacoustic parameterization based upon the geological record, and measured sound-speed field was performed. Inclusion of the effects of seafloor roughness and surface waves shows that in-plane scattering from rough interfaces can explain much of the observed spread in the arrivals. Evidence of out-of-plane scattering does exist, however, at short ranges. The amount of out-of-plane scattering is best observed in the broadband impulse-beam response analysis, which in-plane surface roughness modeling cannot explain.This work was supported by the Office of Naval Research, Ocean Acoustics, under contract N00014-11-M-0170

Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials

Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites. Artemisinins are embryotoxic in animal models and induce apoptosis in sensitive mammalian cells. Understanding the cytotoxic propensities of antimalarial drug candidates is crucial to their successful development and utilization. Here, we demonstrate that, similarly to the model artemisinin artesunate (ARS), a synthetic tetraoxane drug candidate (RKA182) and a trioxolane equivalent (FBEG100) induce embryotoxicity and depletion of primitive erythroblasts in a rodent model. We also show that RKA182, FBEG100 and ARS are cytotoxic toward a panel of established and primary human cell lines, with caspase-dependent apoptosis and caspase-independent necrosis underlying the induction of cell death. Although the toxic effects of RKA182 and FBEG100 proceed more rapidly and are relatively less cell-selective than that of ARS, all three compounds are shown to be dependent upon heme, iron and oxidative stress for their ability to induce cell death. However, in contrast to previously studied artemisinins, the toxicity of RKA182 and FBEG100 is shown to be independent of general chemical decomposition. Although tetraoxanes and trioxolanes have shown promise as next-generation antimalarials, the data described here indicate that adverse effects associated with artemisinins, including embryotoxicity, cannot be ruled out with these novel compounds, and a full understanding of their toxicological actions will be central to the continuing design and development of safe and effective drug candidates which could prove important in the fight against malaria

Data formats for numerical relativity waves

This document proposes data formats to exchange numerical relativity results, in particular gravitational waveforms. The primary goal is to further the interaction between gravitational-wave source modeling groups and the gravitational-wave data-analysis community. We present a simple and extendable format which is applicable to various kinds of gravitational wave sources including binaries of compact objects and systems undergoing gravitational collapse, but is nevertheless sufficiently general to be useful for other purposes

Searching for a Stochastic Background of Gravitational Waves with LIGO

The Laser Interferometer Gravitational-wave Observatory (LIGO) has performed the fourth science run, S4, with significantly improved interferometer sensitivities with respect to previous runs. Using data acquired during this science run, we place a limit on the amplitude of a stochastic background of gravitational waves. For a frequency independent spectrum, the new limit is $\Omega_{\rm GW} < 6.5 \times 10^{-5}$. This is currently the most sensitive result in the frequency range 51-150 Hz, with a factor of 13 improvement over the previous LIGO result. We discuss complementarity of the new result with other constraints on a stochastic background of gravitational waves, and we investigate implications of the new result for different models of this background.Comment: 37 pages, 16 figure

Search for gravitational wave bursts in LIGO's third science run

We report on a search for gravitational wave bursts in data from the three LIGO interferometric detectors during their third science run. The search targets subsecond bursts in the frequency range 100-1100 Hz for which no waveform model is assumed, and has a sensitivity in terms of the root-sum-square (rss) strain amplitude of hrss ~ 10^{-20} / sqrt(Hz). No gravitational wave signals were detected in the 8 days of analyzed data.Comment: 12 pages, 6 figures. Amaldi-6 conference proceedings to be published in Classical and Quantum Gravit