Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Título: La Jarana de Colón

Periodistas: Aurora de Andrés y Eufrasio Zúñiga. Entrevistados: Tomás Iriarte. Daniel Vázquez Díaz. Ana María Parra. Julio Guillén. Elsa Mercado SousaMin. 0.58: Reportaje sobre el Monasterio de la Rábida con motivo del Día de la Hispanidad, habla su prior Tomás Iriarte -- Min. 04.45: Entrevista con el pintor de los frescos de la Rábida, Daniel Vázquez Díaz -- Min. 08.25: Las tres carabelas de Augusto Algueró interpretada por Ana María Parra -- Min. 10.46: Entrevista con Julio Guillén, director del Museo Naval sobre Cristobal Colón y su época en las tierras de Palos de la Frontera -- Min. 20.04: La Jarana de Colón, zumba popular -- Min. 21.52: Palabras de la Embajadora de Panamá Elsa Mercado Sousa sobre el porqué de llamar día de la Hispanidad a la conmemoración del descubrimiento de América -- Min. 22.14:Posdata de novedades: Se reunen en Tarragona hispanistas y representantes diplomáticos y oficales españoles con motivo del Día de la Hispanidad. La Confederación de las Cajas de Ahorros emite un informe donde dicen que el ahorro español aumenta. Nicolás Lindey, peruano asegura que España con su industria supera a muchos países tanto españoles como americanos. France Press redacta una crónica donde muestra el auge del turismo de las Costas Catalanas. Se descubren piezas de la antiguedad en Ibiza. Se inicia el curso escolar con 5 millones de niños en primaria. Chrisler y Barreiros se fusionan para lanza al mercado el Dodge Dark -- Min. 28.00: Despedid

[Carta de España]

Min. 0.58: Reportaje sobre el Monasterio de la Rábida con motivo del Día de la Hispanidad, habla su prior Tomás Iriarte -- Min. 04.45: Entrevista con el pintor de los frescos de la Rábida, Daniel Vázquez Díaz -- Min. 08.25: Las tres carabelas de Augusto Algueró interpretada por Ana María Parra -- Min. 10.46: Entrevista con Julio Guillén, director del Museo Naval sobre Cristobal Colón y su época en las tierras de Palos de la Frontera -- Min. 20.04: La Jarana de Colón, zumba popular -- Min. 21.52: Palabras de la Embajadora de Panamá Elsa Mercado Sousa sobre el porqué de llamar día de la Hispanidad a la conmemoración del descubrimiento de América -- Min. 22.14:Posdata de novedades: Se reunen en Tarragona hispanistas y representantes diplomáticos y oficales españoles con motivo del Día de la Hispanidad. La Confederación de las Cajas de Ahorros emite un informe donde dicen que el ahorro español aumenta. Nicolás Lindey, peruano asegura que España con su industria supera a muchos países tanto españoles como americanos. France Press redacta una crónica donde muestra el auge del turismo de las Costas Catalanas. Se descubren piezas de la antiguedad en Ibiza. Se inicia el curso escolar con 5 millones de niños en primaria. Chrisler y Barreiros se fusionan para lanza al mercado el Dodge Dark -- Min. 28.00: DespedidaPeriodistas: Aurora de Andrés y Eufrasio Zúñiga. Entrevistados: Tomás Iriarte. Daniel Vázquez Díaz. Ana María Parra. Julio Guillén. Elsa Mercado Sous

Otro título: Elementos folklóricos y creación estética del Lazarillo de Tormes

Gregorio Marañón Moya, Dir. ICH. Dámaso Alonso, escritor. Elsa Mercado, Embajadora de Panamá en España.Cinta 1: Presentación por parte de Marañón -- Min. 0.24: El secretario general entrega las condecoraciones: Miembros de honor: Yolanda de Arzate Avendeyo. José Solís Ruiz, Mº Scret. Gral. del Movimiento. Antonio Garrigues, Embajador de España en Washington. José Antonio Giménez-Arnau, Embajador de España en Guatemala. James A. Farley, Ex-presidente del partido demócrata de EE.UU. Edmundo Correa, Ex-rector de la Universidad de Cuya. Francisco Javier Sánchez Cantón, Miembro de la Real Academia de la Historia. Federico García Sanchís, Miembro de la RAE. Juán José López Ibor, Catedrático Facultad de Medicina Madrid. Hermenegildo Arruga, Conde de Arruga. José de la Peña, Dir. Archivo de Indias. José Antonio Elola-Olaso, Delegado Nal. de Educación Física y Deportes. Alfonso de la Peña, Catedrático Facultad de Medicina de Madrid. Miembros titulares del ICH: Elvira Pérez Peña, Inst. Cuyano de Cultura Hispánica. Alberico Praga, Rector de la Unv. de Bahía. Francisco Monterde, de la Academia Mexicana de la Lengua. José Barroso, Presidente del Inst. Hispano-Mexicano. Jorge Montoya, Dir. Inst. Antioqueño de Cultura Hispánica. Paul Bouchard, Prof. Hª Precolombina Unv. Laval Canadá. George Age Ornstein, Dir. United Airlines. Luis Alfonso D'Escargnolle, Arquitecto Brasileño de la Casa de Brasil. Juán José Espinosa, Dir. Gral. PSOE. Marcos Peña Royo, Gobernador Civil de Asturias. Plácido Careaga, Pdte. Diputación Vizcaya. José Burgos y Rosado, Marqués de la Liseda. Gabriel Cañadas, Scre. Gral. Mº Infomación y Turismo. Jose María Mor, Dir. Personal Mº Asuntos Exteriores. Fernando Luis Ybarra y López de Dóriga, Marqués de de Agridulce y Pte. Del Ins. Cultura Vascongadas. Antonio Fondán, Dir. Escuela Periodismo Vascongadas. Jose Ignacio Ramos, Delegado de Prensa Embajada de España en Buenos Aires. Salvador Bermúdez, Delegado de Prensa Embajada de España en Lima. Jaime de Abrisqueta, Scre. Embajada de España en Quito. Tomás Lozano, Embajador de España en Honduras. Francisco Javier Chapa, Embajador de España en México. Amaro González de Mesa, Embajador de España en la Santa Sede. Jose Luís Aparicio, Cónsul España en Nueva Orleans. Joaquín Tomás, Cónsul de España en Mendoza. Enrique de la Hoz Díaz, Scret. Gral. Mº de Información -- MIn. 11.35: Conferencia de Dámaso Alonso "Elementos folklóricos y creación estética del Lazarillo de Tormes" -- Cinta 2: Continuación de la conferencia de Dámaso Alonso -- Min. 27.56: Discurso de Elsa Mercado, Embajadora de Panamá en España -- Min. 33.14: Palabras de clausura de Gregorion Marañó

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study (Intensive Care Medicine, (2021), 47, 2, (160-169), 10.1007/s00134-020-06234-9)

The original version of this article unfortunately contained a mistake. The members of the ESICM Trials Group Collaborators were not shown in the article but only in the ESM. The full list of collaborators is shown below. The original article has been corrected

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat