Asymptotic Giant Branch Variables in the Galaxy and the Local Group

AGB variables, particularly the large amplitude Mira type, are a vital step on the distance scale ladder. They will prove particularly important in the era of space telescopes and extremely large ground-based telescopes with adaptive optics, which will be optimized for infrared observing. Our current understanding of the distances to these stars is reviewed with particular emphasis on improvements that came from Hipparcos as well as on recent work on Local Group galaxies. In addition to providing the essential calibration for extragalactic distances Gaia may also provide unprecedented insight into the poorly understood mass-loss process itself.Comment: Accepted for publication in Astrophysics and Space Science. From a presentation at the conference "The Fundamental Cosmic Distance Scale: State of the Art and Gaia Perspective, Naples May 2011. 8 Pages, 9 Figure

Metal-rich carbon stars in the Sagittarius dwarf spheroidal galaxy

‘The definitive version is available at: www3.interscience.wiley.com '. Copyright Blackwell / Royal Astronomical Society. DOI: 10.1111/j.1365-2966.2009.14736.xWe present spectroscopic observations from the Spitzer Space Telescope of six carbon-rich asymptotic giant branch (AGB) stars in the Sagittarius dwarf spheroidal galaxy (Sgr dSph) and two foreground Galactic carbon stars. The band strengths of the observed C2H2 and SiC features are very similar to those observed in Galactic AGB stars. The metallicities are estimated from an empirical relation between the acetylene optical depth and the strength of the SiC feature. The metallicities are higher than those of the Large Magellanic Cloud, and close to Galactic values. While the high metallicity could imply an age of around 1 Gyr, for the dusty AGB stars, the pulsation periods suggest ages in excess of 2 or 3 Gyr. We fit the spectra of the observed stars using the dusty radiative transfer model and determine their dust mass-loss rates to be in the range 1.0–3.3 × 10−8 M⊙ yr−1 . The two Galactic foreground carbon-rich AGB stars are located at the far side of the solar circle, beyond the Galactic Centre. One of these two stars shows the strongest SiC feature in our present Local Group sample.Peer reviewe

A Spitzer mid-infrared spectral survey of mass-losing carbon stars in the Large Magellanic Cloud

‘The definitive version is available at www.blackwell-synergy.com.’ Copyright Blackwell Publishing DOI: 10.1111/j.1365-2966.2006.10623.xPeer reviewe

The DA+dMe eclipsing binary EC13471-1258: its cup runneth over...just

EC13471-1258 is a detached eclipsing binary with Porb = 3h37m, comprising a DA white dwarf and a dMe dwarf. Total eclipses of the white dwarf lasting 14 min, and a large amplitude ellipsoidal variation are seen in the light curve. Flares from the dMe star occur regularly. Each star contributes roughly equal amounts of light at 5500 Ang. HST STIS spectra show strong Ly alpha with weak metal lines, and yield Teff = 14220 K, log g = 8.34, Z = 1/30th solar, K = 138 km/s and V sin i = 400 km/s for the white dwarf. Optical spectra yield the spectral type (M3.5-4.0), Teff = 3100 K, Z = solar, K = 266 km/s and V sin i = 140 km/s for the dMe star. The H alpha emission line comprises 2 or more components and implies that very weak mass transfer is occurring. The dynamical solution also implies that the dMe star just fills its Roche lobe. Accurate masses and radii for each star were derived: the dMe values favour the Clemens et al. (1998) mass-radius relation. The large rotational velocity of the white dwarf (400 km/s) suggests that the system has transferred mass in the past so that it is presently a hibernating cataclysmic variable. The metallicity contrast between the component stars provides an opportunity for tests of diffusion theory.Comment: 25 pages, 18 figures, accepted for publication in MNRA

Perspectives in visual imaging for marine biology and ecology: from acquisition to understanding

Durden J, Schoening T, Althaus F, et al. Perspectives in Visual Imaging for Marine Biology and Ecology: From Acquisition to Understanding. In: Hughes RN, Hughes DJ, Smith IP, Dale AC, eds. Oceanography and Marine Biology: An Annual Review. 54. Boca Raton: CRC Press; 2016: 1-72

The criminal justice voluntary sector: concepts and an agenda for an emerging field

This is the peer reviewed version of the following article: Tomczak, P. & Buck, G. (2019). The criminal justice voluntary sector: concepts and an agenda for an emerging field. Howard Journal of Crime and Justice, 58(3), which has been published in final form at https://doi.org/10.1111/hojo.12326. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.Volunteers and voluntary organisations play significant roles pervading criminal justice. They are key actors, with unrecognised potential to shore up criminal justice and/or collaboratively reshape social justice. Unlike public and for-profit agents, criminal justice volunteers and voluntary organisations (CJVVOs) have been neglected by scholars. We call for analyses of diverse CJVVOs, in national and comparative contexts. We provide three categories to highlight distinctive organising auspices, which hold across criminal justice: statutory volunteers, quasi-statutory volunteers and voluntary organisations. The unknown implications of these different forms of non-state, non-profit justice involvement deserve far greater attention from academics, policymakers and practitioners

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brain–gut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

500 MW demonstration of advanced wall-fired combustion techniques for the reduction of nitrogen oxide emissions from coal-fired boilers

Technology project demonstrating advanced wall-fired combustion techniques for the reduction of nitrogen oxide NOx emissions from coal-fired boilers. The primary objective of the demonstration is to determine the long-term NOx reduction performance of advanced overfire air (AOFA), low NOx burners (LNB), and advanced digital control/optimization methodologies applied in a stepwise fashion to a 500 MW boiler. The focus of this paper is to report (1) on the installation of three on-line carbon-in-ash monitors and (2) the design and results to date from the advanced digital control/optimization phase of the project