Foreign Tourists in World Heritage Sites: A Motivation-Based Segmentation

The inclusion on the lists published by the United Nations Educational, Scientific, and Cultural Organization (UNESCO)—World Heritage Site (WHS), Intangible Cultural Heritage (ICH), and World Heritage Sites in Danger—suggests, first of all, the acknowledgement of something worth protecting and, secondly, an increase in the strength of tourist attraction to the affected destination, especially among specific visitors. The identification and classification of tourists that are seen to be more interested in heritage is the stated aim of this work, based on models already proposed in the scientific literature. For this purpose, a survey was conducted that interviewed a representative sample of international tourists visiting the city of Córdoba. A multi-variant technique of case-cluster was applied. In addition, a discriminant analysis was used to validate the clusters of the cases obtained. For analyzing the differences between the different groups obtained, some non-parametrical statistical procedures were applied. The results obtained allowed for the visualization of a model that shows the empirical evidence regarding the presence of four types of foreign tourists that are considered valid for segmentation in the city of Córdoba as a WHS tourist destination: the alternative tourist, emotional tourist, cultural tourist, and heritage tourist. These results allow public and private managers to design specific strategies to increase visitor satisfaction

The 2011 Philip C. Jessup International Law

The State of Rigalia and the State of Ardenia submit the present dispute concerning the Zetian Provinces to the International Court of Justice by Special Agreement, dated 5 May 2010, pursuant to article 40(1) of the Statute of the International Court ofJustice

Petrology and Geochemistry of Mafic-Ultramafic Fragments from the Aguablanca Ni-Cu Ore Breccia, Southwest Spain

Aguablanca (southwest Spain) is the first economic Ni-Cu-(PGE) deposit found in southern Europe. Two features make it an unusual example of magmatic sulfide ore: it is related to the development of an Andeantype continental magmatic arc, and it is hosted by a subvertical magmatic breccia. The structural style and the geodynamic context of the deposit contrast with most plutonic Ni-Cu-PGE deposits elsewhere, which occur at specific levels of layered mafic intrusions in rift environments. The Ni-Cu deposit is hosted by the Aguablanca intrusion, a mafic body composed of gabbronorite and minor quartz-diorite, gabbro, and norite. Sulfides are concentrated in a gabbronorite matrix along a subvertical (dipof 70º–80º N), funnel-like magmatic breccia that contains barren or slightly mineralized ultramafic-mafic cumulate fragments. Modal compositions of the fragments reflect a wide variety of rock types, including peridotite (hornblende-rich werhlite, dunite, and hornblende-rich harzburgite), pyroxenite (ortho- and clinopyroxenite), gabbro (gabbro, gabbronorite, and hornblende gabbro), and anorthosite. The primary silicate assemblage includes olivine (Fo91–Fo79), orthopyroxene (Mg no. 0.85–0.73), clinopyroxene (Mg no. 0.93–0.62), plagioclase (An99–An38), amphibole (Mg no. 0.87–0.68) and phlogopite (Mg no. 0.89–0.64). The wide range of rock types and the Fe-enrichment trends in the primary ferromagnesian silicates suggest magmatic differentiation processes from the parent melts, with the fragments representing different stages of cumulate formation. The ore-bearing breccia contains both semimassive and disseminated sulfides in the gabbronorite matrix. Textures vary between meso- and orthocumulate, and the rock-forming magmatic silicates are orthopyroxene (Mg no. 0.83–0.74), clinopyroxene (Mg no. 0.89–0.78), plagioclase (An50-An77), and intercumulus amphibole (Mg no. 0.86–0.70), phlogopite (0.84–0.69) and minor quartz. The gabbronorite in the matrix of the breccia is petrographically and chemically very similar to that of the unmineralized parts of the main Aguablanca intrusion and exhibits a similar differentiation trend, suggesting that the matrix of the ore-bearing breccia and the unmineralized rocks belong to a same magmatic suite. The local presence of mafic-ultramafic fragments in the barren Aguablanca intrusion supports this suggestion. The presence of highly Ni depleted olivine, whole-rock Cu/Zr ratios below 1, and the local occurrence of disseminations of magmatic sulfides in the peridotite fragments point to sulfide segregation before and/or during the formation of the peridotite cumulates. Mantle-normalized incompatible trace element patterns of the fragments along with published sulfur isotope data are consistent with crustal contamination, suggesting that addition of crustal sulfur from pyrite-bearing black slates led to sulfide saturation. These results support a model in which sulfides segregated and settled during the differentiation of an unexposed mafic-ultramafic complex, now sampled as fragments in the breccia, whereas the overlying silicate magma, most probably fed by successive fresh magma injections, underwent fractional crystallization, giving rise to this cumulate sequence. The emplacement of the ore breccia took place at temperatures above the (monosulfide solid solution (mss) solidus but below the olivine and pyroxene solidus, likely owing to the explosive injection of a new pulse of magma into the chamber, which mingled with the sulfide liquid and disrupted the overlying cumulate sequence. As a consequence, fragments reached their current position in the breccia, injected along with the sulfide and the silicate melts, which subsequently formed the sulfide-rich gabbronorite

Human land occupation regulates the effect of the climate on the burned area of the Brazilian Cerrado

Human activities and climate change are transforming fire regimes globally. The interaction between these two drivers is poorly understood, yet critical if we aim at predicting how biomes will respond to novel fire regimes. In the Brazilian Cerrado, altered fire regimes are threatening its unique biodiversity and ecosystem functioning. Here, using geospatial data for the period 1985-2020 and a causal inference framework to design Bayesian statistical models, we demonstrate that a larger human presence in the landscape (≥40% land-use area) reduces the Cerrado’s burned area and hinders its responsiveness to climate; while climatic effects only become apparent in landscapes with little human presence, where hotter and drier conditions increase burned area. Finally, we find spatially heterogeneous burned area trends over time, with increases associated to climate change in landscapes that have remained mostly intact, and decreases caused by anthropic expansion. Both diverging trends have important implications for the conservation of the Cerrado as land-use expansion and climate change continue to unfold

Metastatic myocardial abscess on the posterior wall of the left ventricle: a case report

<p>Abstract</p> <p>Introduction</p> <p>Myocardial abscess is a rare and potentially fatal condition. Metastatic myocardial abscess in the setting of infective endocarditis has been infrequently reported in the medical literature. To the best of the authors' knowledge no case of myocardial abscess affecting the free wall of the left ventricle secondary to infective endocarditis of a right-sided heart valve has been reported previously.</p> <p>Case presentation</p> <p>We report a case of tricuspid valve endocarditis caused by <it>Staphylococcus aureus </it>and resulting in a myocardial abscess on the posterior wall of the left ventricle, far from the active valvular infection. We also briefly discuss the role of different investigation modalities including cardiac magnetic resonance imaging in diagnosing myocardial abscess.</p> <p>Conclusion</p> <p>Myocardial abscess is a life-threatening illness. A high index of clinical suspicion is required to make a prompt diagnosis. Final diagnosis may need multi-modality imaging. An early diagnosis, aggressive medical therapy, multidisciplinary care and timely surgical intervention may save life in this otherwise fatal condition.</p

Andean grasslands are as productive as tropical cloud forests

We aim to assess net primary productivity (NPP) and carbon cycling in Andean tropical alpine grasslands (puna) and compare it with NPP of tropical montane cloud forests. We ask the following questions: (1) how do NPP and soil respiration of grasslands vary over the seasonal cycle? (2) how do burning and grazing affect puna productivity? (3) if the montane forest expands into the puna, what will be the resulting change in productivity? The study sites are located at the South-eastern Peruvian Andes; one grassland site and the forest sites are in Wayqecha biological station, and another grassland site in Manu National Park. At each grassland site, we selected a burnt and an unburnt area, installed unfenced and fenced transects in each area, and monitored above-ground productivity (NPPAG), below-ground productivity (NPPBG) and soil respiration (Rs) for 2 yr. In the forest, we monitored NPPAG, NPPBG and Rs for 2–4 yr. Grassland NPP varied between 4.6 ± 0.25 (disturbed areas) to 15.3 ± 0.9 Mg C ha-1 yr-1 (undisturbed areas) and cloud forest NPP was between 7.05 ± 0.39 and 8.0 ± 0.47 Mg C ha-1 yr-1, while soil carbon stocks were in the range of 126 ± 22 to 285 ± 31Mg C ha-1. There were no significant differences on NPP between the puna and forest sites. The most undisturbed site had significantly higher NPP than other grassland sites, but no differences were found when relating grazing and fire at other sites. There were lower residence times of above-ground biomass compared to below-ground biomass. There was a strong seasonal signal on grassland NPPAG and NPPBG, with a shift on allocation at the beginning of the austral summer. High elevation tropical grasslands can be as productive as adjacent cloud forests, but have very different carbon cycling and retention properties than cloud forests. S Online supplementary data available from stacks.iop.org/ERL/9/115011/mmedia Keywords: tropical alpine wetlands, above-ground productivity, below-ground productivity, fire, grazing, disturbances, pun

Multi-antigen Vaccination With Simultaneous Engagement of the OX40 Receptor Delays Malignant Mesothelioma Growth and Increases Survival in Animal Models

Malignant Mesothelioma (MM) is a rare and highly aggressive cancer that develops from mesothelial cells lining the pleura and other internal cavities, and is often associated with asbestos exposure. To date, no effective treatments have been made available for this pathology. Herein, we propose a novel immunotherapeutic approach based on a unique vaccine targeting a series of antigens that we found expressed in different MM tumors, but largely undetectable in normal tissues. This vaccine, that we term p-Tvax, is comprised of a series of immunogenic peptides presented by both MHC-I and -II to generate robust immune responses. The peptides were designed using in silico algorithms that discriminate between highly immunogenic T cell epitopes and other harmful epitopes, such as suppressive regulatory T cell epitopes and autoimmune epitopes. Vaccination of mice with p-Tvax led to antigen-specific immune responses that involved both CD8+ and CD4+ T cells, which exhibited cytolytic activity against MM cells in vitro. In mice carrying MM tumors, p-Tvax increased tumor infiltration of CD4+ T cells. Moreover, combining p-Tvax with an OX40 agonist led to decreased tumor growth and increased survival. Mice treated with this combination immunotherapy displayed higher numbers of tumor-infiltrating CD8+ and CD4+ T cells and reduced T regulatory cells in tumors. Collectively, these data suggest that the combination of p-Tvax with an OX40 agonist could be an effective strategy for MM treatment

Relation between anaerobic oxidation of methane and authigenic carbonates chimneys of Gulf of Cadiz: mineralogical, geochemical and petrological evidences

A partir de datos mineralógicos, geoquímicos y petrológicos procedentes de chimeneas de carbonatos autigénicos del Golfo de Cádiz se ha establecido la relación entre el metano, y en concreto de la oxidación anaeróbica del mismo en el interior de los sedimentos, y la formación de las chimeneas. La composición mineralógica de las chimeneas (dolomita rica en hierro y ankerita), la presencia de sulfuros y oxihidróxidos de hierro pseudomorfos con textura framboidal, los valores de δ13C (-9,24‰ y -38,36‰), los compuestos orgánicos encontrados en el interior de las chimeneas (hidrocarburos alcanos con menos de 20 carbonos y los isoprenoides regulares farnesano, pristano y fitano) y las microfábricas de carbonatos (pelloides, pellets, grumos de carbonatos y nódulos esféricos de carbonato) indican una estrecha relación entre oxidación anaeróbica del metano y la formación de las chimeneas.From mineralogical, geochemical and petrological data of authigenic carbonates chimneys of the Gulf of Cadiz, we are established the relation between methane, and more specifically the anaerobic oxidation of methane inner of sediments, and the formation of chimneys. The mineralogical composition of chimneys (rich Fe dolomite and ankerite), presence of iron sulphides and pseudomorf oxyhydroxides with framboidal texture, the δ13C values (-9.24‰ y -38.36‰), the organic compounds found inner of chimneys (n-alkanes with n<20 and the regular isoprenoids crocetane, pristane and phytane) and the microfabrics of carbonates (pelloids, pellets, clotted carbonates and spherical nodules of carbonate) indicate a close relation between anaerobic oxidation of methane and the formation of the chimneys.Depto. de Mineralogía y PetrologíaFac. de Ciencias GeológicasTRUEpu