Rasgos generales estratigráficos y sedimentológicos del macizo urgoniano de Gorbea, Región Vasco-Cantábrica Central

Se diferencian 8 unidades urgonianas dentro de un esquema de plataforma mixta con individualización final de un banco carbona-iado, en el Aptiense-Albiense medio del macizo de Gorbea (Vizca ya). Pulsaciones tectónicas sinsedimentarias, incluyendo fracturación blandel zócalo y halocinesis, además de variaciones relativas del nivel del tectómar, constituyen los principales controles en el desarrollo y evolución de la plataforma

Rasgos generales estratigráficos y sedimentológicos del macizo urgoniano de Gorbea, Región Vasco-Cantábrica Central

Se diferencian 8 unidades urgonianas dentro de un esquema de plataforma mixta con individualización final de un banco carbona-iado, en el Aptiense-Albiense medio del macizo de Gorbea (Vizca ya). Pulsaciones tectónicas sinsedimentarias, incluyendo fracturación blandel zócalo y halocinesis, además de variaciones relativas del nivel del tectómar, constituyen los principales controles en el desarrollo y evolución de la plataforma

Leading in Crisis

How different are the requirements for leadership during crisis from leadership during “normal” times? The chapter highlights studies and cases, that differentiates the leadership role in a crisis - the element of urgency makes the time window for decisions and actions much narrower and the intensity of the situation also evoke more passionate emotions from stakeholders that the leader has to deal with. A summary of what effective crisis leadership may look like, as reported in the academic and business management literature as well as the real-life experiences in the local scenario is discussed. In this summary, the phases are compressed into three: Pre crisis which consists of Preparedness, Crisis, where the focus is Containment of the situation, and Post Crisis where the goal is Adaptive Resolution and Learning. Throughout this chapter, it is apparent that leadership during crisis is replete with major challenges of time pressure, surprises, intense emotions and being in the public eye. In the recent months of the pandemic worldwide, the public has had a good occasion to distinguish between the leaders who deliver and those who disappoint. An experienced and seasoned leader with ample competencies and the commitment to serve is likely to perform successfully during a crisis, but unexpected circumstances may also still cause him to falter. There is no foolproof formula for success. But, future leaders are fortunate that they can learn from the lessons and best practices of others and emulate those who shine during crises

Development of HPLC-DAD-MS/MS methods for the simultaneous determination of several fat - and water-soluble vitamins in green leafy vegetables

Trabajo presentado a las 13as Jornadas de Análisis Instrumental celebradas en la Fira de Barcelona del 14 al 16 de noviembre de 2011.Joana Santos is grateful to FCT Ph.D grant (SFRH/BD/66476/2009). M.H. thanks MICINN for a “Ramón y Cajal” contract.Peer reviewe

Vicarious Trauma and Natural Disasters: A Transcendental Phenomenological Analysis of the Experiences of Families of Typhoon Haiyan Survivors

Using transcendental phenomenology, we examined the experience of vicarious trauma in the context of natural disasters. We specifically looked at the narratives of domestic migrants whose family members were Typhoon Haiyan survivors. Findings show that the survivors’ families experienced painful and intrusive psychological distress. The gravity of the pain and loss experienced by the participants was relative to the amount of pain, loss, or damage sustained by the subject of their attachment. Vicarious trauma was experienced as a void-filling phenomenon occupying the emotional space created by the physical distance of the participants from their families experiencing the disaster. This phenomenon and the concurrent traumatic experience improved as the participants made sense of the significance of the event in their lives. Our findings may help in developing interventions to address the effects of vicarious trauma on families of disaster victims and survivors

Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS) is the leading cause of non-traumatic neurological disability in young adults. Immune mediated destruction of myelin and oligodendrocytes is considered the primary pathology of MS, but progressive axonal loss is the major cause of neurological disability. In an effort to understand microglia function during CNS inflammation, our laboratory focuses on the fractalkine/CX3CR1 signaling as a regulator of microglia neurotoxicity in various models of neurodegeneration. Fractalkine (FKN) is a transmembrane chemokine expressed in the CNS by neurons and signals through its unique receptor CX3CR1 present in microglia. During experimental autoimmune encephalomyelitis (EAE), CX3CR1 deficiency confers exacerbated disease defined by severe inflammation and neuronal loss. The CX3CR1 human polymorphism I249/M280 present in ∼20% of the population exhibits reduced adhesion for FKN conferring defective signaling whose role in microglia function and influence on neurons during MS remains unsolved. The aim of this study is to assess the effect of weaker signaling through hCX3CR1I249/M280 during EAE. We hypothesize that dysregulated microglial responses due to impaired CX3CR1 signaling enhance neuronal/axonal damage. We generated an animal model replacing the mouse CX3CR1 locus for the hCX3CR1I249/M280 variant. Upon EAE induction, these mice exhibited exacerbated EAE correlating with severe inflammation and neuronal loss. We also observed that mice with aberrant CX3CR1 signaling are unable to produce FKN and ciliary neurotrophic factor during EAE in contrast to wild type mice. Our results provide validation of defective function of the hCX3CR1I249/M280 variant and the foundation to broaden the understanding of microglia dysfunction during neuroinflammation. © 2018 Cardona et al

Membrane lipids and maximum lifespan in clownfish

The longevity-homeoviscous adaptation (LHA) theory of ageing states that lipid composition of cell membranes is linked to metabolic rate and lifespan, which has been widely shown in mammals and birds but not sufficiently in fish. In this study, two species of the genus Amphiprion (Amphiprion percula and Amphiprion clarkii, with estimated maximum lifespan potentials [MLSP] of 30 and 9–16 years, respectively) and the damselfish Chromis viridis (estimated MLSP of 1–2 years) were chosen to test the LHA theory of ageing in a potential model of exceptional longevity. Brain, livers and samples of skeletal muscle were collected for lipid analyses and integral part in the computation of membrane peroxidation indexes (PIn) from phospholipid (PL) fractions and PL fatty acid composition. When only the two Amphiprion species were compared, results pointed to the existence of a negative correlation between membrane PIn value and maximum lifespan, well in line with the predictions from the LHA theory of ageing. Nevertheless, contradictory data were obtained when the two Amphiprion species were compared to the shorter-lived C. viridis. These results along with those obtained in previous studies on fish denote that the magnitude (and sometimes the direction) of the differences observed in membrane lipid composition and peroxidation index with MLSP cannot explain alone the diversity in longevity found among fishes

An Experimental Study of Coconut Shell with Sugarcane Bagasse Ash as Partial Replacement of Coarse Aggregates and Cement to Concrete

High building material costs and demand can be a significant disadvantage for builders and contractors. The cost of raw materials such as wood, steel, and concrete is always growing, increasing the cost of projects. Due to the high demand for certain materials, they can be difficult to get on time, causing project delays. This is especially true when working on large-scale projects with short deadlines. This research presents an idea to minimize the problem by partially replacing the cement and coarse aggregates with sugarcane bagasse ash and coconut shell. The study has 3 main objectives: (1) To determine the effects of workability (slump cone test) and durability (water absorption test) of concrete when Coconut Shell and Sugarcane Bagasse Ash are used as partial replacements of cement and coarse aggregates after 7, 14, and 28 days of curing.The samples were tested using a Universal Testing Machine (UTM) and the outcomes of the experiment revealed that CS and SCBA have a positive result on the properties of standard concrete