Systematic review: the use of vaginal mold in current vaginoplasty surgeries - techniques and materials

This paper presents a study of the techniques and materials used in vaginoplasty surgeries performed around the world. It consists of a systematic review that covered the identification, selection and critique of primary studies of topics involving the use of vaginal molds in surgeries for different patients: women with Mayer-Rokitansky syndrome; and transgender patients who underwent sex reassignment surgery (CRS), that is, patients with gender dysphoria. The researches made in the chosen databases, after applying the criteria of inclusion and exclusion of articles, resulted in 19 publications, which represented the basis of the construction of this work. It also focuses on the description of the technologies, materials and methods used in the manufacture of vaginal molds used in surgery. In all studies, the molds have the function of maintaining the structure of the neovagina, thus avoiding vaginal stenosis, besides fixing the material used as a graft in the new cavity, covering it, favoring epithelization

Resistance exercise leading to failure versus not to failure : effects on cardiovascular control

Background: The aim of the present study was to evaluate the acute effects of resistance exercise (RE) leading to failure and RE that was not to failure on 24 h blood pressure (BP) and heart rate variability (HRV) in sedentary normotensive adult women. Methods: Ten women (33.2 ± 5.8 years; 159.3 ± 9.4 cm; 58.0 ±6.4 kg; body fat 28.4 ± 2.8%) randomly underwent three experimental sessions: control (40 minutes of seated rest), RE leading to failure with 3 sets of 10 repetitions maximum (10-RM), and RE not to failure at 60% of 10-RM with 3 sets of 10 repetitions. Immediately post session BP and HRV were measured for 24 h. Results: Ratings of perceived exertion and heart rate were higher during the 10-RM session when compared with 60% of 10-RM (6.4 ± 0.5 vs 3.5 ± 0.8 and 123.7 ± 13.9 vs 104.5 ± 7.3 bpm, respectively). The systolic, diastolic and mean BP decreased at 07:00 a.m. after the 10-RM session when compared with the control session (−9.0 ± 7.8 mmHg, -16.0 ± 12.9 mmHg and −14.3 ± 11.2 mmHg, respectively). The root mean square of the squared differences between R-R intervals decreased after both the 60% of 10-RM and 10-RM sessions compared with the control session. Conclusions: An acute RE session leading to failure induced a higher drop of BP upon awakening, while both RE sessions reduced cardiac parasympathetic modulation. RE may be an interesting training strategy to acutely decrease BP in adult women

Estudo comparativo entre metodologias para o diagnóstico da leishmaniose visceral humana: uma revisão integrativa / Comparative study methodologies for the diagnosis of human visceral leishmaniasis: an integrative review

Objetivo: Discutir e comparar os testes utilizados no diagnóstico da Leishmaniose Visceral (LV). Métodos: O presente estudo trata-se de uma revisão integrativa de literatura. Para a seleção dos artigos utilizou-se a base de dados Pubmed e a amostra desta revisão constituiu-se de sete artigos. Resultados: Existem várias metodologias, destacando-se os testes rápidos, ELISA (Enzimaimunoensaio), DAT (teste de aglutinação direta), RIFI (ensaio de imunofluorescência indireta), aspiração esplênica, teste de aglutinação em látex (KAtex), PCR (Reação em cadeia da polimerase) convencional e PCR. Em maioria apresentam uma diferença se sensibilidade e especificidade a depender do fabricante, todavia os métodos de biologia molecular mostraram-se mais efetivos em relação aos demais e os testes rápidos apresentaram um grande diferencial quanto a praticidade. Considerações finais: os testes convencionalmente usados para o diagnóstico da LV apresentaram variações significativas em relação à sua sensibilidade e existe a necessidade de mais de uma metodologia diferente para a confirmação do resultado

Investigating the role of symptom valorisation in tuberculosis patient delay in urban areas in Portugal

URBANTB group: Patrícia Soares (Representative of the consortium), Mário Carreira, Sofia Pereira, Catarina Alves, Filipe Alves, Ana Rodrigues, Ana Moreira, Márcia Cardoso, Sandra Mota, Ana Gomes, Liliana Ferreira, Marta Lopes, Isabel Correia, Juan Rachadell, Maria Gameiro, Ângela Dias, Manuel Pereira, Jorge Gonçalves, Maria Gonçalves, Adriana Taveira, Celene Neves, Lucinda Silva, Maria Mendes, Maria Teixeira, Maria Pereira, Milena Piedade, Antónia Teixeira & Carlos Carvalho.Background: Diagnosis delay contributes to increased tuberculosis (TB) transmission and morbimortality. TB incidence has been decreasing in Portugal, but median patient delay (PD) has risen. Symptom valorisation may determine PD by influencing help-seeking behaviour. We aimed to analyse the association between symptom valorisation and PD, while characterising individuals who disregarded their symptoms. Methods: A cross-sectional study was conducted among TB patients in Lisbon and Oporto in 2019 - 2021. Subjects who delayed seeking care because they did not value their symptoms or thought these would go away on their own were considered to have disregarded their symptoms. PD was categorised using a 21-day cut-off, and a 30-day cut-off for sensitivity analysis. We estimated the effect of symptom valorisation on PD through a directed acyclic graph. Then, a multivariable regression analysis characterised patients that disregarded their symptoms, adjusting for relevant variables. We fitted Poisson regression models to estimate crude and adjusted prevalence ratios (PR). Results: The study included 75 patients. Median PD was 25 days (IQR 11.5-63.5), and 56.0% of participants had PD exceeding 21 days. Symptom disregard was reported by 38.7% of patients. Patients who did not value their symptoms had higher prevalence of PD exceeding 21 days compared to those who valued their symptoms [PR 1.59 (95% CI 1.05-2.42)]. The sensitivity analysis showed consistent point estimates but wider confidence intervals [PR 1.39 (95% CI 0.77-2.55)]. Being a smoker was a risk factor for symptom disregard [PR 2.35 (95% CI 1.14-4.82)], while living in Oporto [PR 0.35 (95% CI 0.16-0.75)] and having higher household incomes [PR 0.39 (95% CI 0.17-0.94)] were protective factors. Conclusions: These findings emphasise the importance of symptom valorisation in timely TB diagnosis. Patients who did not value their symptoms had longer PD, indicating a need for interventions to improve symptom recognition. Our findings also corroborate the importance of the socioeconomic determinants of health, highlighting tobacco as a risk factor both for TB and for PD.This work was supported by the Fundação para a Ciência e Tecnologia (FCT, Portugal) [Grant: PTDC/SAU-PUB/31346/2017]. The present publication was funded by Fundação para a Ciência e Tecnologia (FCT, Portugal) national support through Comprehensive Health Research Centre (CHRC) [UIDP/04923/2020].info:eu-repo/semantics/publishedVersio

Genomic history of coastal societies from eastern South America

Sambaqui (shellmound) societies are among the most intriguing archaeological phenomena in pre-colonial South America, extending from approximately 8,000 to 1,000 years before present (yr bp) across 3,000 km on the Atlantic coast. However, little is known about their connection to early Holocene hunter-gatherers, how this may have contributed to different historical pathways and the processes through which late Holocene ceramists came to rule the coast shortly before European contact. To contribute to our understanding of the population history of indigenous societies on the eastern coast of South America, we produced genome-wide data from 34 ancient individuals as early as 10,000 yr bp from four different regions in Brazil. Early Holocene hunter-gatherers were found to lack shared genetic drift among themselves and with later populations from eastern South America, suggesting that they derived from a common radiation and did not contribute substantially to later coastal groups. Our analyses show genetic heterogeneity among contemporaneous Sambaqui groups from the southeastern and southern Brazilian coast, contrary to the similarity expressed in the archaeological record. The complex history of intercultural contact between inland horticulturists and coastal populations becomes genetically evident during the final horizon of Sambaqui societies, from around 2,200 yr bp, corroborating evidence of cultural change

Perspectivas epidemiológicas, clínicas e terapêuticas do transtorno bipolar em comorbidade com o uso de drogas: revisão de sistemática: Epidemiological, clinical and therapeutic perspectives of bipolar disorder in comorbidity with drug use: a systematic review

Conhecida como transtorno maníaco-depressivo, atualmente possui um novo nome: Transtorno Afetivo Bipolar, visto que com o passar do tempo foi se percebendo que esse transtorno não se tratava de uma alteração psicótica, e mais de um prejuízo afetivo. O transtorno bipolar possui alguns tipos, não se caracterizando em apenas uma forma, sua manifestação varia conforme o indivíduo e suas tendências, disforia e/ou euforia porém independente da forma expressa o paciente bipolar pode ter sua vida social comprometida, se não tratada, visto a irregularidade no estado de humor; bem como pode fazer uso de substâncias psicoativas, o que prejudica a sua condição clínica. Objetivo central da pesquisa é de apresentar a correlação do transtorno bipolar com o uso de drogas, mediante uma revisão de literatura integrativa realizada entre os meses de março de 2022 a julho de 2022, através da busca de artigos científicos nos bancos de dados online PubMed, Scielo e Google Acadêmico, utilizando como critério de refinamento de pesquisa artigos de todas as línguas publicados entre os anos 2000 e 2022

Repercussões e manejo relacionados a Distúrbios Hidroeletroliticos nos pacientes graves: uma revisão sistemática com metanálise

Os distúrbios hidroeletrolíticos são eventos comumente observados na prática médica, inclusive em situações de emergência, podendo representar risco de vida ou possibilidade de sequelas para o paciente a depender da magnitude do caso. Independentemente da etiologia, a desidratação tem sua importância definida pela intensidade das perdas líquidas e pela proporção de perdas salinas em relação à perda de água. Isto evidencia a importância de se avaliar corretamente o quadro para se desenvolver um tratamento adequado. Este estudo tem como objetivo explorar o tema das repercussões e manejo de distúrbios hidroeletrolíticos nos pacientes graves a partir de uma revisão sistemática com meta análise com o emprego das palavras chave “unidade de terapia intensiva”, “gerenciamento hidroeletrolítico”, “distúrbios hidroeletrolíticos” e “controle de líquidos e eletrólitos” nos bancos de dados PubMed, BVS, Lilacs, Medline e Scielo objetivando acessar artigos publicados entre 2015 e 2022. A equipe de enfermagem está diretamente responsável pelo manejo de pacientes de alta complexidade, o que pode envolver casos que exigem o gerenciamento hidroeletrolítico, isto requer um conhecimento aprofundado dos mecanismos envolvidos no metabolismo da água e dos eletrólitos. O monitoramento diário da função renal pela equipe de enfermagem é um cuidado importante para se evitar o quadro de insuficiência renal aguda