Exploring innovative moments with adolescents treated for depression

Introdução: Momentos de Inovação (MIs) denotam formas inovadoras e maisajustadas de pensar, agir, sentir e relacionar-se, que emergem no discurso declientes de psicoterapia. Contrariamente, marcadores de ambivalência (MAs) sãoindicadores de resistência contra mudanças. Estudos com adultos encontraramproporções mais elevadas de MIs e decréscimos progressivos de ambivalência emcasos recuperados, mas não em casos inalterados. Não existem estudos comadolescentes. Objetivos: Explorar associações entre MIs, MAs e melhoriasintomática, e contrastar a produção de MIs e MAs em casos de sucesso vs.insucesso, e em casos tratados com Terapia Cognitivo-comportamental (CBT) vs.Psicoterapia Psicanalítica Breve (STPP), numa amostra de adolescentesdeprimidos. Método: Entrevistas semiestruturadas pós-intervenção de 24adolescentes (12-18 anos), participantes de IMPACT-ME (um estudo longitudinal,qualitativo, sobre as vivências de jovens envolvidos num ensaio clínico sobredepressão adolescente), foram codificadas segundo o Sistema de Codificação deMomentos de Inovação. Identificaram-se MIs de nível 2 (significados centrados namudança), MIs de nível 3 (meta-reflexões que articulam contrastes entre passadoe presente com processos de mudança), e MAs. Resultados: MIs e MAsemergiram nas entrevistas, as proporções de MIs encontram-se significativamentecorrelacionadas com melhorias sintomáticas, e foram significativamente superioresnos casos de sucesso do que de insucesso. No grupo de CBT a proporção de MIsde nível 3 foi significativamente superior face ao grupo de STPP. Conclusão: Esteprimeiro estudo de MIs com adolescentes sugere que futura investigação quearticule achados empíricos à luz deste modelo poderá aprofundar a compreensãode processos de mudança na psicoterapia com jovens

Stress e coping académico: Contributos para a adaptação da escala MMC

Este estudo enquadra-se na investigação do coping perante dificuldades associadas ao quotidiano escolar. Utilizando entrevistas a 30 alunos, o estudo (1) identificou as principais situações geradoras de stress, reconhecendo a importância relativa do stress académico na vida dos alunos, e (2) analisou a validade cultural para o contexto português das situações stressantes usadas na escala Multidimensional Measure of Coping (MMC), avaliando as perceções dos alunos quanto ao nível de stress induzido e controlo percebido relativamente a essas situações. Os resultados confirmaram a importância da escola enquanto fonte significativa de stress, e a adequação da MMC ao contexto português

Academic stress and coping: Contributions to the adaptation of the MMC

Este estudo enquadra-se na investiga??o das estrat?gias de coping utilizadas perante dificuldades associadas ao quotidiano escolar. Utilizando entrevistas a 30 alunos, o estudo (1) identificou as principais situa??es geradoras de stress, reconhecendo a import?ncia relativa do stress acad?mico na vida dos alunos, e (2) analisou a validade cultural para o contexto portugu?s das situa??es stressantes usadas na escala Multidimensional Measure of Coping (MMC), avaliando as perce??es dos alunos quanto ao n?vel de stress induzido e controlo percebido relativamente a essas situa??es. Os resultados confirmaram a import?ncia da escola enquanto fonte significativa de stress, e a adequa??o da MMC ao contexto portugu?s.8C1E-AFB9-6BE1 | Maria Teresa Martins Gon?alvesN/

Rac and Rho GTPases in cancer cell motility control

Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has now emerged as a major switch control mainly carried out by Rho and Rac GTPase subfamilies, playing an acknowledged role in adaptation of cell motility to the microenvironment. Cells exhibit three distinct modes of migration when invading the 3 D environment. Collective motility leads to movement of cohorts of cells which maintain the adherens junctions and move by photolytic degradation of matrix barriers. Single cell mesenchymal-type movement is characterized by an elongated cellular shape and again requires extracellular proteolysis and integrin engagement. In addition it depends on Rac1-mediated cell polarization and lamellipodia formation. Conversely, in amoeboid movement cells have a rounded morphology, the movement is independent from proteases but requires high Rho GTPase to drive elevated levels of actomyosin contractility. These two modes of cell movement are interconvertible and several moving cells, including tumor cells, show an high degree of plasticity in motility styles shifting ad hoc between mesenchymal or amoeboid movements. This review will focus on the role of Rac and Rho small GTPases in cell motility and in the complex relationship driving the reciprocal control between Rac and Rho granting for the opportunistic motile behaviour of aggressive cancer cells. In addition we analyse the role of these GTPases in cancer progression and metastatic dissemination

Innovative moments with young patients treated for depression: An analysis of post-therapy interviews

Introduction: Innovative moments (IMs) pinpoint new and more adaptative meanings that emerge in clients' discourse during psychotherapy. Studies with adult clients have found a greater proportion of IMs in recovered compared to unchanged cases, but similar studies have yet to be conducted with adolescents. // Aims: The paper aims (1) to study retrospectively the emergence of IMs in therapy, using a post-therapy interview, in adolescents that underwent psychotherapy for depression, and (2) to characterize the themes present in IMs identified retrospectively in the interviews. // Method: Semi-structured post-treatment interviews conducted with 24 adolescents on the experience of taking part in a clinical trial of youth depression, were coded using the Innovative Moments Coding System. After identifying IMs, a thematic analysis identified the prominent themes within them. // Results: Higher presence of IMs were found in recovered compared to unchanged cases. Two main themes emerged in the IMs, changes that occurred with therapy and attributions of changes. Recovered cases presented more IMs centred on the self, whereas unchanged cases identified more non-specific changes. // Conclusion: This study suggests that it is possible to code IMs, identified retrospectively, based on post-therapy interviews with adolescents. Meaningful differences were found between recovered compared to unchanged cases. Therapeutic recovery was associated with a higher focus on the self and more specificity in clients' representations of the change process

Undressing of Phosphine Gold(I) Complexes as Irreversible Inhibitors of Human Disulfide Reductases

International audienc

Gold(I)-Phosphinkomplexe für die irreversible Hemmung von humanen Disulfid-Reduktasen

Redox-basierte Chemotherapie: Die irreversible Hemmung der humanen Glutathion-Reduktase resultiert in einem einmaligen S-AuI-S-Strukturmotiv, das kristallographisch charakterisiert wurde. Eine kinetische Analyse der schnellen und effektiven Hemmung von Redoxenzymen sowie DNA-Wechselwirkungsstudien, ergänzt durch Zellproliferationstests, belegen das chemotherapeutische Potenzial von Phosphinmetallkomplexe

Reverse convection and cusp proton aurora: Cluster, polar and image observation

On April 21, 2001 an interplanetary CME started to interact with the magnetosphere when CLUSTER spacecraft were travelling in the cusp region. This interaction produced a strong magnetic storm (Dst = 103 nT) at Earth. Cusp proton aurora was caused by the leading phase of the CME. Cusp proton aurora generally appear during northward IMF, this paper demonstrates that they can also be triggered during southward IMF when the reverse convection has been generated by an IMF dominated Y component. The location of the cusp proton aurora shifted about 30° from dawnside to duskside when IMF By changed from −10 to 5 nT. The requirement to produce proton cusp aurora seems to be a reverse convection in the cusp region instead of the northward IMF (not only northward IMF, but IMF By is also an important parameter!)

Arbeitsvorgänge in Bibliotheken: 2. Wissenschaftliche Bibliotheken (AVWB) und Staatliche Bücherei- und Bibliotheksfachstellen (AVBF)

Die Tarifparteien der Länder haben 2020 eine geänderte Entgeltordnung vereinbart, wodurch statt bibliotheksspezifischer nun die allgemeinen Tätigkeitsmerkmale für den Verwaltungsdienst auch auf Tätigkeiten in Bibliotheken angewendet werden. Dadurch sowie durch allgemeine aktuelle Entwicklungen im Bibliothekswesen ergeben sich in etlichen Entgeltgruppen Veränderungen. Das neue Standardwerk für die Erstellung von Stellenbeschreibungen und Stellenbewertungen in wissenschaftlichen Bibliotheken führt neben neuen auch umfassend aktualisierte Arbeitsvorgänge auf und versteht sich als Instrument, um Tätigkeiten in Bibliotheken den unbestimmten Rechtsbegriffen bzw. Entgeltgruppen der derzeit gültigen Entgeltordnung zuzuordnen. Ergänzt wird das Werk durch Grundlagenwissen zum Thema Eingruppierung, Stellenbeschreibung und Stellenbewertung. Nachdem Ende 2020 die Arbeitsvorgänge in Bibliotheken, 1. Öffentliche Bibliotheken (AVÖB) erschienen sind, folgt hiermit die Neufassung der Arbeitsvorgänge in wissenschaftlichen Bibliotheken (AVWB) sowie erstmals eine Zusammenstellung von Arbeitsvorgängen in staatlichen Bücherei- und Bibliotheksfachstellen (AVBF)