Stable Magnetic Universes Revisited

A regular class of static, cylindrically symmetric pure magnetic field metrics is rederived in a different metric ansatz in all dimensions. Radial, time dependent perturbations show that for dimensions d>3 such spacetimes are stable at both near r\approx0 and large radius r\rightarrow\infty. In a different gauge these stability analysis and similar results were known beforehand. For d=3, however, simultaneous stability requirement at both, near and far radial distances can not be reconciled for time - dependent perturbations. Restricted, numerical geodesics for neutral particles reveal a confinement around the center in the polar plane. Charged, time-like geodesics for d=4 on the other hand are shown numerically to run toward infinity.Comment: 11 pages, 3figure

The Decay of Magnetic Fields in Kaluza-Klein Theory

Magnetic fields in five-dimensional Kaluza-Klein theory compactified on a circle correspond to ``twisted'' identifications of five dimensional Minkowski space. We show that a five dimensional generalisation of the Kerr solution can be analytically continued to construct an instanton that gives rise to two possible decay modes of a magnetic field. One decay mode is the generalisation of the ``bubble decay" of the Kaluza-Klein vacuum described by Witten. The other decay mode, rarer for weak fields, corresponds in four dimensions to the creation of monopole-anti-monopole pairs. An instanton for the latter process is already known and is given by the analytic continuation of the \KK\ Ernst metric, which we show is identical to the five dimensional Kerr solution. We use this fact to illuminate further properties of the decay process. It appears that fundamental fermions can eliminate the bubble decay of the magnetic field, while allowing the pair production of Kaluza-Klein monopoles.Comment: 25 pages, one figure. The discussion of fermions has been revised: We show how fundamental fermions can eliminate the bubble-type instability but still allow pair creation of monopole

New Charged Dilaton Solutions in 2+1 Dimensions and Solutions with Cylindrical Symmetry in 3+1 Dimensions

We report a new family of solutions to Einstein-Maxwell-dilaton gravity in 2+1 dimensions and Einstein-Maxwell gravity with cylindrical symmetry in 3+1 dimensions. A set of static charged solutions in 2+1 dimensions are obtained by a compactification of charged solutions in 3+1 dimensions with cylindrical symmetry. These solutions contain naked singularities for certain values of the parameters considered. New rotating charged solutions in 2+1 dimensions and 3+1 dimensions are generated treating the static charged solutions as seed metrics and performing $SL(2;R)$ transformations.Comment: Latex. No figure

Decay Modes of Intersecting Fluxbranes

Just as the single fluxbrane is quantum mechanically unstable to the nucleation of a locally charged spherical brane, so intersecting fluxbranes are unstable to various decay modes. Each individual element of the intersection can decay via the nucleation of a spherical brane, but uncharged spheres can also be nucleated in the region of intersection. For special values of the fluxes, however, intersecting fluxbranes are supersymmetric, and so are expected to be stable. We explicitly consider the instanton describing the decay modes of the two--element intersection (an F5-brane in the string theory context), and show that in dimensions greater than four the action for the decay mode of the supersymmetric intersection diverges. This observation allows us to show that stable intersecting fluxbranes should also exist in type 0A string theory.Comment: 19 pages, 6 figures. References adde

Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency.

Autosomal recessive mutations in the 17 beta-hydroxysteroid dehydrogenase 3 gene impair the formation of testosterone in the fetal testis and give rise to genetic males with female external genitalia. Such individuals are usually raised as females, but virilize at the time of expected puberty as the result of increases in serum testosterone. Here we describe mutations in 12 additional subjects/families with this disorder. The 14 mutations characterized to date include 10 missense mutations, 3 splice junction abnormalities, and 1 small deletion that results in a frame shift. Three of these mutations have occurred in more than 1 family. Complementary DNAs incorporating 9 of the 10 missense mutations have been constructed and expressed in reporter cells; 8 of the 9 missense mutations cause almost complete loss of enzymatic activity. In 2 subjects with loss of function, missense mutations testosterone levels in testicular venous blood were very low. Considered together, these findings strongly suggest that the common mechanism for testosterone formation in postpubertal subjects with this disorder is the conversion of circulating androstenedione to testosterone by one or more of the unaffected 17 beta-hydroxysteroid dehydrogenase isoenzymes

To exclose nests or not: structured decision making for the conservation of a threatened species

Decisions regarding endangered species recovery often face sparse data and multiple sources of uncertainty about the effects of management. Structured decision making (SDM) provides a framework for assembling knowledge and expert opinion and evaluating the tradeoffs between different objectives while formally incorporating uncertainty. The Atlantic Coast piping plover provides an illustrative case for the utility of SDM in endangered species management because its population growth is simple to model, most populations are monitored, decision alternatives are well defined, and many managers are open to recovery recommendations. We built a model to evaluate the decision to use nest exclosures to protect piping plover eggs from predators, where the objective was to maximize λ and the tradeoff was between nest survival and adult survival. The latter can be reduced by exclosures. We used a novel mixed multinomial logistic exposure model to predict daily nest fates and incorporated the results into a stochastic projection matrix that included renesting after nest failure, and adult mortality associated with abandonment. In our test data set (n = 329 nests from 28 sites over four years), the mean nest survival over 34 days was markedly higher for exclosed nests (0.76 ± 0.03 SE) than for unexclosed nests (0.37 ± 0.07). Abandonment rates were also higher for exclosed nests (0.092 ± 0.017) than for unexclosed nests (0.045 ± 0.017), but the difference was not statistically signifi- cant and the loss rate to “other sources” (mostly predators) was much lower for exclosed nests (0.15 ± 0.03) than for unexclosed nests (0.58 ± 0.07). Population growth rate (λ) was clearly improved by exclosure use at the sites with high background nest loss rates, but λ was still \u3c1 with exclosure use. Where the background nest loss rates were low, the decision to use exclosures was ambiguous, and λ could benefit from reducing uncertainty in vital rates. Our process demonstrated that geographic and temporal variation in nest mortality determines whether exclosures will be useful in attaining positive population growth rates and that other management options must be considered where the background nest mortality rates are high

Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors.

Inhibition of PIKfyve phosphoinositide kinase selectively kills autophagy-dependent cancer cells by disrupting lysosome homeostasis. Here, we show that PIKfyve inhibitors can also selectively eliminate pluripotent embryonal carcinoma cells (ECCs), embryonic stem cells, and induced pluripotent stem cells under conditions where differentiated cells remain viable. PIKfyve inhibitors prevented lysosome fission, induced autophagosome accumulation, and reduced cell proliferation in both pluripotent and differentiated cells, but they induced death only in pluripotent cells. The ability of PIKfyve inhibitors to distinguish between pluripotent and differentiated cells was confirmed with xenografts derived from ECCs. Pretreatment of ECCs with the PIKfyve specific inhibitor WX8 suppressed their ability to form teratocarcinomas in mice, and intraperitoneal injections of WX8 into mice harboring teratocarcinoma xenografts selectively eliminated pluripotent cells. Differentiated cells continued to proliferate, but at a reduced rate. These results provide a proof of principle that PIKfyve specific inhibitors can selectively eliminate pluripotent stem cells in vivo as well as in vitro

Galaxy Zoo: Are Bars Responsible for the Feeding of Active Galactic Nuclei at 0.2 < z < 1.0?

We present a new study investigating whether active galactic nuclei (AGN) beyond the local universe are preferentially fed via large-scale bars. Our investigation combines data from Chandra and Galaxy Zoo: Hubble (GZH) in the AEGIS, COSMOS, and GOODS-S surveys to create samples of face-on, disc galaxies at 0.2 < z < 1.0. We use a novel method to robustly compare a sample of 120 AGN host galaxies, defined to have 10^42 erg/s < L_X < 10^44 erg/s, with inactive control galaxies matched in stellar mass, rest-frame colour, size, Sersic index, and redshift. Using the GZH bar classifications of each sample, we demonstrate that AGN hosts show no statistically significant enhancement in bar fraction or average bar likelihood compared to closely-matched inactive galaxies. In detail, we find that the AGN bar fraction cannot be enhanced above the control bar fraction by more than a factor of two, at 99.7% confidence. We similarly find no significant difference in the AGN fraction among barred and non-barred galaxies. Thus we find no compelling evidence that large-scale bars directly fuel AGN at 0.2<z<1.0. This result, coupled with previous results at z=0, implies that moderate-luminosity AGN have not been preferentially fed by large-scale bars since z=1. Furthermore, given the low bar fractions at z>1, our findings suggest that large-scale bars have likely never directly been a dominant fueling mechanism for supermassive black hole growth.Comment: 13 pages, 5 figures, 2 tables, accepted by MNRA